# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	negative regulation of anoikis	16	2.710816e-77	2.229476734e-74	9.049572	131	0.01984247	708	0.037319630274011306	2.438825	10	16	0.002078138	
GO Biological Process	response to reactive oxygen species	29	2.545611e-62	1.1550929361724138e-59	3.004457	312	0.04725841	446	0.005878246268385651	1.471291	69	183	0.01433915	
GO Biological Process	response to corticosteroid	42	5.440668e-56	1.7046131002857143e-53	2.726834	326	0.04937898	557	0.016693313676840214	1.454206	60	161	0.01246883	
GO Biological Process	response to glucocorticoid	57	6.283947e-51	1.450709799526316e-48	2.705981	300	0.04544078	673	0.03020639651263001	1.44325	54	146	0.01122195	
GO Biological Process	cellular response to corticosteroid stimulus	93	5.575448e-45	7.888959164731183e-43	3.514171	180	0.02726447	352	0.0017926472054829543	1.920091	31	63	0.006442228	
GO Biological Process	response to oxidative stress	96	1.810875e-44	2.4822191796875e-42	2.04793	454	0.06876704	445	0.005847809329662921	1.325448	125	368	0.02597672	
GO Biological Process	response to decreased oxygen levels	100	5.725978e-43	7.5348144502e-41	2.06747	429	0.06498031	494	0.01058116255506073	1.319667	116	343	0.0241064	
GO Biological Process	cellular response to glucocorticoid stimulus	103	1.912856e-42	2.4438128256310678e-40	3.445066	174	0.02635565	342	0.001654768490263158	1.95106	30	60	0.006234414	
GO Biological Process	negative regulation of MAPK cascade	111	8.630113e-42	1.0230960087117115e-39	2.533363	275	0.04165404	468	0.00791241953568376	1.504739	59	153	0.01226101	
GO Biological Process	response to hypoxia	114	1.766045e-41	2.038542645175439e-39	2.057006	419	0.06346562	523	0.01314181026998088	1.316237	113	335	0.02348296	
GO Biological Process	response to oxygen levels	115	2.11624e-41	2.4215306226086956e-39	2.015569	439	0.066495	499	0.010726386121643285	1.307795	123	367	0.0255611	
GO Biological Process	protein-DNA complex disassembly	116	2.286519e-41	2.593819269051724e-39	7.451255	79	0.01196607	630	0.024636446898412698	2.341272	12	20	0.002493766	
GO Biological Process	regulation of leukocyte differentiation	130	1.567934e-38	1.5871110389230766e-36	2.068211	384	0.05816419	508	0.011858895980708661	1.373546	88	250	0.01828761	
GO Biological Process	positive regulation of kidney development	143	2.009568e-37	1.849224147692308e-35	3.547044	147	0.02226598	576	0.018170059142881945	1.95106	20	40	0.004156276	
GO Biological Process	cellular response to reactive oxygen species	153	8.223206e-36	7.0724946244444445e-34	2.814055	196	0.02968797	566	0.017464159817667847	1.52833	47	120	0.009767249	
GO Biological Process	cellular response to decreased oxygen levels	154	9.792211e-36	8.367253542142857e-34	2.39077	261	0.03953347	629	0.02436429644992051	1.396548	68	190	0.01413134	
GO Biological Process	interaction with host	170	1.210899e-34	9.373070553529413e-33	2.659844	208	0.0315056	690	0.03223785267971015	1.428227	56	153	0.01163757	
GO Biological Process	positive regulation of hemopoiesis	171	1.315349e-34	1.0122033620467838e-32	2.236827	289	0.04377461	301	0.0007436596819601329	1.584497	67	165	0.01392352	
GO Biological Process	cellular response to hypoxia	179	3.943843e-34	2.899275421061452e-32	2.370876	253	0.03832172	617	0.02317643270988655	1.407322	66	183	0.01371571	
GO Biological Process	cellular response to oxygen levels	191	1.335187e-33	9.198809284293194e-32	2.285551	268	0.04059376	612	0.023178632428104577	1.38279	73	206	0.01517041	
GO Cellular Component	focal adhesion	20	3.646504e-54	3.150579456e-52	2.131901	504	0.0763405	21	0.0000033622601142857143	1.47943	149	393	0.03096426	
GO Cellular Component	cell-substrate adherens junction	21	9.268591e-54	7.626726308571429e-52	2.124759	504	0.0763405	22	0.000005606157469090909	1.468222	149	396	0.03096426	
GO Cellular Component	cell-substrate junction	22	1.902408e-52	1.4942550109090908e-50	2.092488	509	0.07709785	20	0.00000262901376	1.479108	152	401	0.0315877	
GO Cellular Component	cis-Golgi network	105	2.299051e-12	3.783581074285714e-11	2.518659	75	0.01136019	34	0.014763366211764703	1.996433	22	43	0.004571904	
GO Cellular Component	Bcl-2 family protein complex	212	0.00001456032	0.0001186803441509434	4.088591	14	0.00212057	52	0.05131262769230768	3.344674	6	7	0.001246883	
GO Cellular Component	fibrinogen complex	320	0.003063352	0.0165421008	2.297344	15	0.002272039	55	0.04934772130909091	3.034982	7	9	0.001454697	
GO Molecular Function	cadherin binding	12	1.694744e-44	5.962674306666667e-42	2.191553	390	0.05907301	19	0.0000038198611663157896	1.565982	122	304	0.02535328	
GO Molecular Function	activating transcription factor binding	18	1.019089e-39	2.3903298655555556e-37	3.067655	191	0.02893063	72	0.022068341225	1.773691	30	66	0.006234414	
GO Molecular Function	protein phosphatase activator activity	53	1.760991e-23	1.4028120758490565e-21	7.323566	44	0.006664647	76	0.024954275436842106	3.414355	7	8	0.001454697	
GO Molecular Function	phosphatase activator activity	82	2.470784e-18	1.2721524448780488e-16	4.765709	49	0.007421993	63	0.010361451457142857	3.192643	9	11	0.001870324	
GO Molecular Function	histone acetyltransferase binding	160	9.556289e-13	2.521665759875e-11	2.842598	63	0.009542563	67	0.01379535979402985	2.312367	16	27	0.003325021	
GO Molecular Function	RNA polymerase binding	189	3.649752e-11	8.153043885714285e-10	2.491944	68	0.01029991	65	0.011916731403076924	1.95106	25	50	0.005195345	
Mouse Phenotype Single KO	abnormal T cell physiology	16	1.5204e-67	8.70143925e-65	2.122055	632	0.09572857	283	0.008545561548056538	1.263544	170	525	0.03532835	
Mouse Phenotype Single KO	abnormal artery development	36	1.512315e-56	3.8467412375000004e-54	2.713223	332	0.05028779	111	0.00010021008322522523	1.800978	54	117	0.01122195	
Mouse Phenotype Single KO	abnormal placenta labyrinth morphology	48	4.052809e-52	7.731577502708334e-50	2.755775	298	0.04513784	310	0.01234492979548387	1.485323	59	155	0.01226101	
Mouse Phenotype Single KO	abnormal keratinocyte physiology	69	2.177448e-45	2.8896943965217394e-43	4.217641	146	0.02211451	461	0.04233952480911062	1.672337	27	63	0.005610973	
Mouse Phenotype Single KO	abnormal placenta morphology	82	2.303788e-42	2.5726569165853657e-40	2.023527	445	0.06740382	344	0.01872140131860465	1.317119	107	317	0.02223608	
Mouse Phenotype Single KO	abnormal classified tumor incidence	99	4.789673e-41	4.430205622323232e-39	2.01984	433	0.06558619	200	0.0019098626702000001	1.383479	117	330	0.02431421	
Mouse Phenotype Single KO	abnormal dorsal aorta morphology	100	6.473273e-41	5.9275760861e-39	2.790722	228	0.03453499	206	0.0021959588396116506	1.824368	36	77	0.007481297	
Mouse Phenotype Single KO	increased classified tumor incidence	101	6.751048e-41	6.12072737980198e-39	2.020653	431	0.06528325	209	0.002223170634449761	1.380018	116	328	0.0241064	
Mouse Phenotype Single KO	abnormal mammary gland growth during pregnancy	133	2.411248e-36	1.6601351831578947e-34	4.059897	121	0.01832778	315	0.013042780217460317	2.059452	19	36	0.003948462	
Mouse Phenotype Single KO	abnormal skin physiology	138	6.097481e-36	4.0459879360144925e-34	2.256429	295	0.04468343	300	0.010435536968	1.404763	81	225	0.01683292	
Mouse Phenotype Single KO	abnormal white adipose tissue amount	164	1.694963e-33	9.463887921341462e-32	2.205508	288	0.04362314	196	0.001770494737346939	1.499337	78	203	0.01620948	
Mouse Phenotype Single KO	abnormal lymph node secondary follicle morphology	174	3.98683e-33	2.0981265695402303e-31	5.389923	82	0.01242048	392	0.02765572845918367	2.185187	14	25	0.002909393	
Mouse Phenotype Single KO	abnormal white adipose tissue morphology	188	4.053868e-32	1.974535599787234e-30	2.02844	334	0.05059073	173	0.0009850534242196534	1.469219	93	247	0.01932668	
Mouse Phenotype Single KO	lacrimal gland inflammation	190	1.47991e-30	7.132387299999999e-29	6.625852	63	0.009542563	453	0.04058847324944812	2.438825	10	16	0.002078138	
Mouse Phenotype Single KO	abnormal lymph node germinal center morphology	200	1.424406e-29	6.521642871e-28	5.217419	75	0.01136019	426	0.03400243445539906	2.205546	13	23	0.002701579	
Mouse Phenotype Single KO	abnormal pregnancy	203	2.923043e-29	1.3185371798522168e-27	2.17143	259	0.03923054	204	0.002167966881617647	1.58194	60	148	0.01246883	
Mouse Phenotype Single KO	abnormal exocrine gland physiology	204	3.130111e-29	1.4050209032843138e-27	2.235069	243	0.03680703	340	0.018287582055	1.451398	61	164	0.01267664	
Mouse Phenotype Single KO	abnormal large intestine morphology	212	2.217467e-28	9.577993075e-27	2.119277	265	0.04013935	235	0.0042713742200000005	1.526916	63	161	0.01309227	
Mouse Phenotype Single KO	abnormal incidence of induced tumors	227	2.622518e-27	1.0579029659030837e-25	2.056878	273	0.04135111	158	0.0007261558955696201	1.526916	81	207	0.01683292	
Mouse Phenotype Single KO	increased incidence of tumors by chemical induction	236	8.272306e-27	3.2097248322881352e-25	2.536121	173	0.02620418	116	0.0001131361559137931	1.825762	51	109	0.0105985	
Mouse Phenotype	abnormal liver parenchyma morphology	34	1.941131e-67	5.45857455617647e-65	2.730558	392	0.05937595	469	0.01030382038784648	1.367278	89	254	0.01849543	
Mouse Phenotype	abnormal liver lobule morphology	38	1.966627e-64	4.9481370386842105e-62	2.788591	362	0.05483187	634	0.02482456344321767	1.338803	82	239	0.01704073	
Mouse Phenotype	abnormal lymph node size	39	2.774284e-63	6.801263929230769e-61	2.444635	446	0.06755529	574	0.020237455552264808	1.319026	96	284	0.01995012	
Mouse Phenotype	pale kidney	59	3.300946e-56	5.349210967118644e-54	4.884397	156	0.0236292	331	0.0019043874209365556	2.081131	24	45	0.004987531	
Mouse Phenotype	enlarged lymph nodes	65	9.671874e-53	1.422658266369231e-50	2.534643	348	0.0527113	470	0.010449461010638298	1.394875	79	221	0.01641729	
Mouse Phenotype	abnormal lymph node morphology	77	2.321361e-50	2.882406820909091e-48	2.052747	511	0.07740079	462	0.00984723605909091	1.287892	134	406	0.02784705	
Mouse Phenotype	abnormal liver physiology	97	1.566622e-47	1.5441724682474226e-45	2.035835	492	0.07452287	271	0.0007193657591512915	1.345559	150	435	0.03117207	
Mouse Phenotype	abnormal intercellular signaling peptide or protein level	105	8.380059e-46	7.630642295142858e-44	2.011563	488	0.07391699	819	0.04989799512454212	1.215134	142	456	0.02950956	
Mouse Phenotype	altered tumor pathology	110	5.21035e-45	4.528741486363637e-43	2.16034	407	0.06164799	434	0.007901862486635946	1.349207	102	295	0.02119701	
Mouse Phenotype	abnormal wound healing	112	2.610684e-44	2.2286383682142855e-42	2.330332	342	0.05180248	305	0.0011745447123934427	1.476478	84	222	0.01745636	
Mouse Phenotype	abnormal artery development	119	7.961653e-43	6.396753305294117e-41	2.203103	371	0.05619509	132	0.000007263890075	1.762248	70	155	0.01454697	
Mouse Phenotype	abnormal exocrine gland physiology	123	1.565944e-42	1.2172350068292683e-40	2.245098	354	0.05362012	509	0.013758887598035362	1.383479	78	220	0.01620948	
Mouse Phenotype	abnormal B cell activation	127	3.924801e-42	2.9547261701574805e-40	2.432251	299	0.04528931	389	0.004483528949614396	1.446639	76	205	0.01579385	
Mouse Phenotype	abnormal placenta labyrinth morphology	129	5.009064e-42	3.712531853023256e-40	2.323566	326	0.04937898	594	0.021924692868686868	1.389236	68	191	0.01413134	
Mouse Phenotype	abnormal T cell proliferation	141	1.246429e-40	8.451849410638298e-39	2.021	428	0.06482884	322	0.0015224606812732921	1.357259	128	368	0.02660017	
Mouse Phenotype	abnormal spleen white pulp morphology	145	7.352148e-40	4.847854277793104e-38	2.024651	418	0.06331415	355	0.002763538372394366	1.343705	125	363	0.02597672	
Mouse Phenotype	decreased tumor incidence	154	4.825897e-39	2.996129949155844e-37	2.227235	330	0.04998485	356	0.0028152310786516855	1.44987	81	218	0.01683292	
Mouse Phenotype	abnormal hepatocyte morphology	161	3.045686e-38	1.8086834686956523e-36	2.544969	249	0.03771584	557	0.018653356513464992	1.407322	66	183	0.01371571	
Mouse Phenotype	abnormal keratinocyte physiology	179	3.305489e-36	1.7655743200558658e-34	2.861642	193	0.02923357	429	0.0069562247839160835	1.588474	46	113	0.009559435	
Mouse Phenotype	increased B cell proliferation	183	6.514588e-36	3.4036052386885243e-34	3.450189	146	0.02211451	673	0.029023246582466564	1.589752	33	81	0.006857855