# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	7	4.362562e-30	8.200993336857143e-27	2.752885	170	0.01900928	338	0.0025556023822485203	1.481964	63	113	0.00891846	
GO Biological Process	regulation of DNA-templated transcription in response to stress	13	2.980054e-27	3.0165023527692307e-24	2.533873	177	0.01979202	291	0.0011562202830927835	1.496592	67	119	0.009484711	
GO Biological Process	rRNA processing	16	9.156121e-26	7.530337264937501e-23	2.107614	244	0.02728391	114	2.3201233135087718e-8	1.518929	144	252	0.02038505	
GO Biological Process	rRNA metabolic process	18	2.845939e-25	2.0805395167222224e-22	2.07509	248	0.02773119	119	2.8065360388235294e-8	1.508666	147	259	0.02080974	
GO Biological Process	regulation of intrinsic apoptotic signaling pathway	25	1.887107e-22	9.9329764052e-20	2.156043	200	0.02236386	237	0.00024394304112658225	1.474831	86	155	0.01217441	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to hypoxia	27	1.548919e-21	7.548972267037036e-19	2.766761	118	0.01319468	274	0.0007337410374452555	1.63577	48	78	0.006795017	
GO Biological Process	negative regulation of intrinsic apoptotic signaling pathway	30	3.389286e-20	1.4866538158e-17	2.4114	141	0.01576652	303	0.001332651016138614	1.555286	55	94	0.007785957	
GO Biological Process	cellular response to topologically incorrect protein	33	1.199626e-19	4.783599555757576e-17	2.221895	162	0.01811473	443	0.013176985946952595	1.376871	72	139	0.01019253	
GO Biological Process	cellular response to unfolded protein	36	3.272969e-19	1.1963610853055555e-16	2.277115	150	0.0167729	488	0.022168142165983607	1.383983	63	121	0.00891846	
GO Biological Process	translational elongation	37	3.766675e-19	1.3396128736486487e-16	2.524129	122	0.01364195	157	7.565495488471338e-7	1.708795	72	112	0.01019253	
GO Biological Process	liver regeneration	38	6.386801e-19	2.2116819568157896e-16	3.197661	82	0.009169183	392	0.006668229257142856	1.822715	24	35	0.003397508	
GO Biological Process	mitochondrial translational termination	45	6.812586e-18	1.9921515372e-15	2.809609	94	0.01051101	174	0.000002712390556091954	1.772084	58	87	0.008210646	
GO Biological Process	mitochondrial translational elongation	49	2.047744e-17	5.4992374073469396e-15	2.79542	92	0.01028738	187	0.00000804598962566845	1.751236	56	85	0.00792752	
GO Biological Process	translational termination	58	4.44188e-16	1.0077706710344827e-13	2.519227	101	0.01129375	163	0.0000010295803425153373	1.762757	63	95	0.00891846	
GO Biological Process	protein targeting to ER	65	2.974549e-15	6.02186004476923e-13	2.417595	103	0.01151739	357	0.0033620931690476192	1.50013	57	101	0.008069083	
GO Biological Process	mitochondrial translation	70	4.7239e-15	8.880257157142857e-13	2.376239	105	0.01174103	191	0.000009090967490052356	1.664434	67	107	0.009484711	
GO Biological Process	anaphase-promoting complex-dependent catabolic process	71	4.839405e-15	8.969257802112676e-13	2.422562	101	0.01129375	453	0.015452671797130245	1.495196	45	80	0.006370328	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	88	1.311617e-13	1.961314557159091e-11	2.220365	108	0.01207648	223	0.00007933974162780269	1.576854	70	118	0.0099094	
GO Biological Process	translational initiation	90	1.457169e-13	2.130542985666667e-11	2.015431	135	0.01509561	209	0.00003367688427416268	1.542828	83	143	0.01174972	
GO Biological Process	cotranslational protein targeting to membrane	93	1.704653e-13	2.411992346989247e-11	2.34929	95	0.01062283	339	0.002549761592507375	1.518929	56	98	0.00792752	
GO Cellular Component	endopeptidase complex	31	9.406081e-20	5.243131602580646e-18	2.968146	96	0.01073465	78	0.0005975248984615385	1.656513	43	69	0.006087203	
GO Cellular Component	mitochondrial ribosome	34	1.954837e-19	9.935171576470588e-18	3.107907	88	0.009840098	67	0.00008191436991044776	1.65742	53	85	0.007502831	
GO Cellular Component	proteasome complex	36	2.726666e-19	1.30879968e-17	2.938888	95	0.01062283	83	0.0009433430978313253	1.641784	42	68	0.00594564	
GO Cellular Component	ribosomal subunit	37	5.49989e-19	2.568597275675676e-17	2.149649	168	0.01878564	43	4.9005959441860473e-8	1.580507	110	185	0.01557191	
GO Cellular Component	peptidase complex	40	6.77086e-18	2.92501152e-16	2.539668	112	0.01252376	72	0.0003278592	1.600917	53	88	0.007502831	
GO Cellular Component	mitochondrial large ribosomal subunit	44	7.340555e-17	2.8828361454545456e-15	3.624571	61	0.006820977	70	0.00016885675337142858	1.824204	35	51	0.0049547	
GO Cellular Component	large ribosomal subunit	45	2.483624e-16	9.537116160000001e-15	2.397203	113	0.01263558	50	0.000004406811263999999	1.641104	71	115	0.01005096	
GO Cellular Component	catalytic step 2 spliceosome	48	4.442713e-14	1.59937668e-12	2.231589	111	0.01241194	64	0.000048277566	1.63364	59	96	0.008352208	
GO Cellular Component	methyltransferase complex	52	5.056659e-13	1.6803666830769228e-11	2.144935	111	0.01241194	62	0.00003071358348387097	1.66498	57	91	0.008069083	
GO Cellular Component	PcG protein complex	61	1.176355e-9	3.332363016393443e-8	2.137407	79	0.008833725	105	0.006734852022857142	1.675775	29	46	0.004105323	
GO Cellular Component	preribosome	70	1.134508e-8	2.8006140342857145e-7	2.080038	74	0.008274628	82	0.0008786635551219511	1.608866	46	76	0.006511891	
GO Cellular Component	proteasome accessory complex	73	2.090042e-8	4.947387090410958e-7	3.219662	32	0.003578218	138	0.046159700869565216	1.772084	16	24	0.002265006	
GO Cellular Component	spliceosomal snRNP complex	74	2.986991e-8	6.975027632432433e-7	2.27336	57	0.0063737	122	0.02774786990163934	1.500555	35	62	0.0049547	
GO Cellular Component	DNA-directed RNA polymerase III complex	81	5.046427e-8	0.0000010765710933333334	4.319953	21	0.002348205	99	0.005086120145454546	2.09852	15	19	0.002123443	
GO Cellular Component	retromer complex	86	1.397656e-7	0.0000028083134511627905	2.701414	37	0.004137314	120	0.0249285456	1.898661	15	21	0.002123443	
GO Cellular Component	Bcl-2 family protein complex	93	4.671321e-7	0.000008679615793548387	4.096298	19	0.002124567	112	0.016424470285714286	2.658126	7	7	0.00099094	
GO Cellular Component	very-low-density lipoprotein particle	145	0.00004257857	0.000507419096275862	2.513716	25	0.002795483	136	0.042512446588235296	1.860688	14	20	0.00198188	
GO Cellular Component	outer mitochondrial membrane protein complex	177	0.0002399096	0.0023421682983050846	2.859676	16	0.001789109	92	0.0025139150608695653	2.303709	13	15	0.001840317	
GO Cellular Component	mitochondrial outer membrane translocase complex	235	0.0007746389	0.005696068166808511	2.900166	13	0.001453651	106	0.00667683876226415	2.416478	10	11	0.001415629	
GO Cellular Component	LUBAC complex	284	0.002914666	0.017734305802816902	2.601818	12	0.001341832	132	0.037063060363636366	2.658126	6	6	0.0008493771	
GO Molecular Function	rRNA binding	5	4.807777e-21	4.059686898799999e-18	3.949423	70	0.007827351	60	0.0010796723573333333	1.727782	39	60	0.005520951	
GO Molecular Function	ribonucleoprotein complex binding	7	3.804289e-18	2.294529736857143e-15	2.333212	134	0.01498379	38	0.000014167243205263157	1.641104	71	115	0.01005096	
GO Molecular Function	structural constituent of ribosome	10	1.726416e-16	7.288928352e-14	2.105535	151	0.01688471	28	4.0435526464285717e-7	1.608002	98	162	0.01387316	
GO Molecular Function	NF-kappaB binding	18	6.087741e-12	1.4279134723333332e-9	3.150897	50	0.005590965	85	0.014486710181176471	1.898661	20	28	0.002831257	
GO Molecular Function	RNA polymerase III activity	75	0.000001516762	0.00008538358885333334	3.951819	18	0.002012747	93	0.021161599195698926	2.159727	13	16	0.001840317	
GO Molecular Function	ribosomal small subunit binding	84	0.000003127346	0.0001571863668095238	2.748038	28	0.00313094	88	0.014904509197727274	2.278393	12	14	0.001698754	
Human Phenotype	Increased serum lactate	5	1.231333e-16	1.6433370218e-13	2.400773	115	0.01285922	42	0.000012127103464761905	1.7012	64	100	0.009060023	
Human Phenotype	Exercise intolerance	7	7.186332e-16	6.850627633714285e-13	2.816183	82	0.009169183	50	0.00006801421885	1.784742	47	70	0.006653454	
Human Phenotype	Nevus	14	3.029111e-11	1.4438041216428571e-8	2.74032	58	0.006485519	141	0.026590949009929078	1.870533	19	27	0.002689694	
Human Phenotype	Abnormality of glycolysis	20	1.388859e-10	4.6339280535000004e-8	4.497233	28	0.00313094	132	0.020705237165151515	2.416478	10	11	0.001415629	
Human Phenotype	Increased serum pyruvate	23	2.793363e-10	8.104396216956521e-8	4.673595	26	0.002907302	158	0.04204885364556962	2.392313	9	10	0.001274066	
Human Phenotype	Abnormal CSF metabolite level	52	6.162893e-8	0.000007908650959423077	2.205663	58	0.006485519	96	0.0054347310109375	1.645506	39	63	0.005520951	
Human Phenotype	Increased CSF lactate	53	7.302839e-8	0.000009194687669245282	2.267583	54	0.006038242	109	0.008272401781651376	1.649871	36	58	0.005096263	
Human Phenotype	Death in infancy	56	1.332227e-7	0.000015874912091071426	2.092815	62	0.006932797	110	0.008290250080909091	1.661329	35	56	0.0049547	
Human Phenotype	CNS hypomyelination	75	5.303545e-7	0.00004718740771333334	2.632999	35	0.003913676	128	0.0167658603671875	1.860688	21	30	0.00297282	
Human Phenotype	Glycosuria	117	0.000004330336	0.00024697719767521366	2.240011	40	0.004472772	111	0.008988164285585586	1.92485	21	29	0.00297282	
Mouse Phenotype	abnormal hair follicle outer root sheath morphology	60	1.044248e-8	0.000001664009188	2.22102	64	0.007156435	110	0.02535018316090909	1.898661	20	28	0.002831257	
Mouse Phenotype	increased cellular sensitivity to ultraviolet irradiation	65	2.020372e-8	0.0000029718117987692307	2.705915	42	0.004696411	114	0.026972000342105264	1.860688	21	30	0.00297282