# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	ncRNA metabolic process	11	2.491475e-37	2.980483593181818e-34	2.015659	395	0.0615169	67	2.0631505092537312e-10	1.496435	230	555	0.04423077	
GO Biological Process	ncRNA processing	23	1.090336e-32	6.2381440973913045e-30	2.155782	295	0.045943	103	9.181374134368932e-9	1.541042	169	396	0.0325	
GO Biological Process	rRNA processing	27	3.181327e-31	1.5504845182592592e-28	2.502333	208	0.03239371	137	3.4241658232116785e-7	1.619201	113	252	0.02173077	
GO Biological Process	rRNA metabolic process	28	6.995176e-30	3.287482892285714e-27	2.435634	209	0.03254945	152	9.595274425657893e-7	1.589381	114	259	0.02192308	
GO Biological Process	mRNA catabolic process	34	1.286623e-27	4.979609428529412e-25	2.451843	190	0.02959041	149	6.748184249530201e-7	1.661381	98	213	0.01884615	
GO Biological Process	ribosome biogenesis	36	2.621396e-27	9.581930545555556e-25	2.135463	250	0.03893475	155	0.0000011870054725806453	1.520405	136	323	0.02615385	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	37	3.16103e-27	1.1242160478378378e-24	2.999655	133	0.02071328	387	0.008291281884496123	1.565815	49	113	0.009423077	
GO Biological Process	nuclear-transcribed mRNA catabolic process	38	8.365276e-27	2.896807023263158e-24	2.511617	176	0.02741006	129	2.1708687921705426e-7	1.714295	94	198	0.01807692	
GO Biological Process	RNA catabolic process	39	1.116227e-26	3.7662643828205126e-24	2.299184	208	0.03239371	138	3.554976319855072e-7	1.633173	109	241	0.02096154	
GO Biological Process	cotranslational protein targeting to membrane	40	3.86722e-26	1.2722186995e-23	3.513126	102	0.01588538	133	2.911451506165414e-7	2.02656	55	98	0.01057692	
GO Biological Process	viral life cycle	41	1.127086e-25	3.617396261951219e-23	2.046097	259	0.0403364	90	1.3483457076666667e-9	1.660073	137	298	0.02634615	
GO Biological Process	protein targeting to ER	42	5.088635e-25	1.5943178086904762e-22	3.367162	103	0.01604112	139	3.6744746655395684e-7	2.002117	56	101	0.01076923	
GO Biological Process	regulation of DNA-templated transcription in response to stress	44	8.939873e-25	2.6736315637954546e-22	2.751511	138	0.02149198	314	0.0024797221913375796	1.608243	53	119	0.01019231	
GO Biological Process	establishment of protein localization to endoplasmic reticulum	47	6.75787e-24	1.892059815531915e-21	3.123271	109	0.01697555	119	8.209295228319328e-8	2.029016	59	105	0.01134615	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	48	7.119382e-24	1.9517489112083332e-21	3.121101	109	0.01697555	136	3.1407543197794116e-7	1.927886	63	118	0.01211538	
GO Biological Process	liver regeneration	49	7.633141e-24	2.0498878044693875e-21	4.127744	76	0.01183616	224	0.00017986661128571426	2.372918	23	35	0.004423077	
GO Biological Process	regulation of intrinsic apoptotic signaling pathway	52	5.017366e-23	1.269683061423077e-20	2.417319	161	0.02507398	209	0.00006510116181818182	1.654053	71	155	0.01365385	
GO Biological Process	cellular response to epidermal growth factor stimulus	54	2.240723e-22	5.460309992037036e-20	3.323979	93	0.01448373	334	0.0034976539263772456	2.090557	22	38	0.004230769	
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	56	4.05185e-22	9.521123955357143e-20	3.346583	91	0.01417225	142	5.236606442887324e-7	2.040978	52	92	0.01	
GO Biological Process	protein localization to endoplasmic reticulum	57	1.161603e-21	2.68167261e-19	2.786972	117	0.01822146	156	0.0000011966457189743589	1.863722	64	124	0.01230769	
GO Cellular Component	intracellular ribonucleoprotein complex	16	7.9352e-68	8.570016000000001e-66	2.075979	665	0.1035664	20	1.285884288e-19	1.548189	349	814	0.06711538	
GO Cellular Component	ribonucleoprotein complex	17	1.260821e-67	1.2815874635294118e-65	2.073336	665	0.1035664	19	6.813632235789474e-20	1.551343	351	817	0.0675	
GO Cellular Component	ribosomal subunit	32	1.899639e-23	1.02580506e-21	2.584086	145	0.02258215	31	5.513575308387097e-8	1.756684	90	185	0.01730769	
GO Cellular Component	ribosome	34	4.913194e-22	2.497058597647059e-20	2.241971	179	0.02787728	32	2.36397204e-7	1.637173	107	236	0.02057692	
GO Cellular Component	large ribosomal subunit	44	9.66292e-14	3.794892218181818e-12	2.511457	85	0.01323781	48	0.000047085084	1.758381	56	115	0.01076923	
GO Cellular Component	mitochondrial ribosome	45	2.38248e-13	9.1487232e-12	3.000515	61	0.009500078	82	0.011977650965853659	1.614312	38	85	0.007307692	
GO Cellular Component	small ribosomal subunit	56	2.308086e-11	7.122093942857144e-10	2.677212	61	0.009500078	69	0.0031710778434782608	1.755329	35	72	0.006730769	
GO Cellular Component	cytosolic ribosome	60	8.76479e-11	2.52425952e-9	2.115156	92	0.01432799	44	0.000017249940654545454	1.805481	56	112	0.01076923	
GO Cellular Component	catalytic step 2 spliceosome	63	2.522177e-10	6.917971200000001e-9	2.21207	79	0.01230338	76	0.005514759663157895	1.61741	43	96	0.008269231	
GO Cellular Component	ficolin-1-rich granule lumen	64	5.294515e-10	1.4295190500000001e-8	2.029894	93	0.01448373	74	0.005065386810810811	1.543395	53	124	0.01019231	
GO Cellular Component	cytoplasmic stress granule	79	9.223137e-9	2.0174152830379746e-7	2.492232	51	0.007942688	90	0.01787236416	1.847469	22	43	0.004230769	
GO Cellular Component	cytosolic small ribosomal subunit	92	5.136499e-8	9.64768507826087e-7	2.647969	41	0.006385298	94	0.025350201191489362	1.805481	22	44	0.004230769	
GO Cellular Component	endopeptidase complex	102	4.085624e-7	0.00000692152771764706	2.196164	51	0.007942688	85	0.014147548687058822	1.674649	32	69	0.006153846	
GO Cellular Component	cytosolic large ribosomal subunit	103	5.152092e-7	0.000008643509685436893	2.239369	48	0.007475471	60	0.001069935552	1.894275	32	61	0.006153846	
GO Cellular Component	proteasome complex	107	9.004342e-7	0.00001454159156635514	2.154319	50	0.007786949	92	0.02239940660869565	1.646174	31	68	0.005961538	
GO Cellular Component	ISWI-type complex	221	0.0003892193	0.0030433074678733033	2.63725	17	0.002647563	89	0.01730951579325843	2.708221	9	12	0.001730769	
GO Molecular Function	structural constituent of ribosome	8	3.376831e-21	1.78212256025e-18	2.563539	132	0.02055755	18	0.000030957064422222225	1.694031	76	162	0.01461538	
GO Molecular Function	ribonuclease activity	9	6.46142e-19	3.0311239155555553e-16	2.787155	101	0.01572964	77	0.014023334618181818	1.604872	44	99	0.008461538	
GO Molecular Function	ribonucleoprotein complex binding	13	2.082179e-17	6.7622767215384615e-15	2.570608	106	0.01650833	55	0.007095657474181819	1.601383	51	115	0.009807692	
GO Molecular Function	protein transporter activity	22	8.063888e-12	1.5475334152727272e-9	2.217173	92	0.01432799	75	0.013653796008	1.61741	43	96	0.008269231	
GO Molecular Function	NF-kappaB binding	23	9.064085e-12	1.6638507334782607e-9	3.598559	41	0.006385298	78	0.01389439631282051	2.19237	17	28	0.003269231	
GO Molecular Function	protein phosphatase activator activity	37	7.608253e-10	8.681633558378377e-8	4.44955	26	0.004049214	45	0.003233186959111111	3.610962	8	8	0.001538462	
GO Molecular Function	neutral amino acid transmembrane transporter activity	134	0.000005882713	0.00018534936034328358	2.291145	37	0.005762342	96	0.045045441562500003	1.969615	18	33	0.003461538	
GO Molecular Function	thyroid hormone receptor binding	164	0.0000197956	0.0005096159951219513	2.477167	28	0.004360691	94	0.04466869262765958	2.063407	16	28	0.003076923	
GO Molecular Function	ubiquitin-protein transferase inhibitor activity	194	0.00006982822	0.0015196636331958762	5.30995	9	0.001401651	85	0.022359180524705882	3.610962	6	6	0.001153846	
Mouse Phenotype Single KO	abnormal rostral-caudal body axis extension	38	1.296772e-12	3.1248792642105264e-10	3.690504	43	0.006696776	63	0.004610745721428572	3.055429	11	13	0.002115385	
Mouse Phenotype Single KO	abnormal osteoblast differentiation	65	2.887198e-10	4.067395705538461e-8	2.180615	81	0.01261486	147	0.045501463150340135	1.845603	23	45	0.004423077	
Mouse Phenotype Single KO	spontaneous chromosome breakage	326	0.0001128373	0.00316948207392638	2.358455	25	0.003893475	145	0.04484859886482759	2.166577	15	25	0.002884615	
Mouse Phenotype Single KO	decreased mitotic index	352	0.0001733962	0.004510764214204545	2.833226	17	0.002647563	150	0.046104719707333326	3.159591	7	8	0.001346154	
Mouse Phenotype	extramedullary hematopoiesis	1	2.419118e-28	2.3129187197999997e-24	2.282499	225	0.03504127	279	0.04993415588172043	1.382482	67	175	0.01288462	
Mouse Phenotype	pale lung	102	1.282732e-10	1.2023726129411764e-8	5.798928	22	0.003426258	201	0.021412325658208952	3.610962	6	6	0.001153846	
Mouse Phenotype	bowed tibia	248	4.124277e-7	0.000015900085643951614	2.158096	53	0.008254166	211	0.024877980282938392	2.347125	13	20	0.0025