# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	34	1.483865e-65	5.742993980882352e-63	2.568386	434	0.01773528	785	0.01780793221401274	1.210821	89	113	0.00728672	
GO Biological Process	regulation of DNA-templated transcription in response to stress	40	5.177755e-60	1.7033519511250002e-57	2.385657	456	0.0186343	640	0.0062259958015625	1.227284	95	119	0.00777796	
GO Biological Process	endoplasmic reticulum unfolded protein response	60	1.20866e-50	2.6507928233333333e-48	2.385822	383	0.01565118	658	0.008112103531914895	1.22717	91	114	0.007450467	
GO Biological Process	liver regeneration	75	1.907163e-47	3.3461810555999996e-45	3.163757	222	0.009071963	411	0.00018157095563503653	1.49341	34	35	0.002783691	
GO Biological Process	cellular response to topologically incorrect protein	87	2.69215e-46	4.0719542356321836e-44	2.160316	431	0.01761268	660	0.008301839640454545	1.205535	109	139	0.008924185	
GO Biological Process	cellular response to unfolded protein	100	1.610918e-42	2.1198069962e-40	2.169212	391	0.0159781	664	0.008471169666867472	1.219703	96	121	0.007859833	
GO Biological Process	multi-organism metabolic process	105	1.409906e-41	1.7669479099047616e-39	2.110368	407	0.01663193	122	8.842678658770491e-11	1.390921	133	147	0.01088914	
GO Biological Process	cellular response to epidermal growth factor stimulus	139	9.566134e-37	9.056169590359711e-35	2.447749	261	0.01066569	908	0.03467805182599119	1.335053	33	38	0.002701818	
GO Biological Process	positive regulation of mRNA catabolic process	152	1.837264e-35	1.5905629589473683e-33	2.981579	179	0.007314781	893	0.031729723480403135	1.414347	23	25	0.001883085	
GO Biological Process	viral gene expression	162	1.082792e-34	8.795345634567902e-33	2.163852	318	0.01299497	171	9.748079465497077e-9	1.379969	114	127	0.009333552	
GO Biological Process	response to epidermal growth factor	164	1.150601e-34	9.23216985304878e-33	2.337722	269	0.0109926	922	0.035586688654013016	1.317715	36	42	0.002947437	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	187	1.421062e-31	9.99986890802139e-30	2.163838	288	0.01176903	471	0.0008166098231210192	1.263741	97	118	0.007941706	
GO Biological Process	regulation of mitochondrial membrane permeability	198	3.793524e-30	2.5211607230303033e-28	2.124844	286	0.0116873	570	0.002910366795614035	1.305681	62	73	0.005076142	
GO Biological Process	viral transcription	210	4.757058e-29	2.9808631534285713e-27	2.092848	285	0.01164644	202	1.7049386692079208e-7	1.374077	101	113	0.008269199	
GO Biological Process	cotranslational protein targeting to membrane	223	4.197639e-28	2.4769834798654706e-26	2.205131	244	0.009970986	273	0.0000035122200065201464	1.364776	87	98	0.007122974	
GO Biological Process	translational elongation	247	4.370285e-26	2.328282603846154e-24	2.041489	270	0.01103347	377	0.00008151777111140583	1.303989	95	112	0.00777796	
GO Biological Process	triglyceride homeostasis	260	1.135006e-25	5.744439982307693e-24	2.92345	131	0.005353275	769	0.01668312051703511	1.393209	29	32	0.002374325	
GO Biological Process	protein targeting to ER	276	8.642307e-25	4.120439051195652e-23	2.084414	243	0.009930121	355	0.000057873282	1.324238	87	101	0.007122974	
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	282	1.553535e-24	7.249279101063829e-23	2.15187	223	0.009112827	325	0.000019284194635076923	1.353523	81	92	0.006631734	
GO Biological Process	protein-lipid complex subunit organization	283	1.69464e-24	7.879776593639575e-23	2.350356	184	0.007519104	877	0.028667129075256557	1.30837	40	47	0.00327493	
GO Cellular Component	mitochondrial ribosome	58	3.936152e-26	1.1727018372413791e-24	2.413562	187	0.007641698	104	0.0020921892923076923	1.284126	71	85	0.005813001	
GO Cellular Component	large ribosomal subunit	63	2.217977e-25	6.083594057142857e-24	2.038983	263	0.01074742	55	1.8889220421818184e-7	1.363549	102	115	0.008351073	
GO Cellular Component	high-density lipoprotein particle	65	1.127615e-24	2.9977211076923073e-23	3.582011	94	0.003841282	139	0.013082302618705037	1.423458	25	27	0.002046832	
GO Cellular Component	mitochondrial large ribosomal subunit	80	1.61785e-21	3.494556e-20	2.69265	124	0.005067222	111	0.0025738793513513515	1.356471	45	51	0.003684297	
GO Cellular Component	cleavage furrow	91	1.068892e-19	2.0297201934065935e-18	2.011041	207	0.008458992	125	0.006249042432000001	1.330385	45	52	0.003684297	
GO Cellular Component	DNA-directed RNA polymerase III complex	92	5.942804e-19	1.1162136208695653e-17	4.285151	57	0.002329288	119	0.004085754352941177	1.537334	19	19	0.001555592	
GO Cellular Component	endopeptidase complex	101	1.97734e-18	3.3830133861386137e-17	2.056444	182	0.007437375	167	0.026547181221556887	1.247692	56	69	0.004584903	
GO Cellular Component	proteasome complex	103	3.890712e-18	6.52733042330097e-17	2.046301	181	0.00739651	173	0.032353523791907514	1.243432	55	68	0.004503029	
GO Cellular Component	nuclear ubiquitin ligase complex	105	8.265209e-18	1.3602172525714287e-16	2.50263	115	0.00469944	144	0.015632568	1.345167	35	40	0.002865564	
GO Cellular Component	chylomicron	122	6.097291e-15	8.636162990163935e-14	3.361338	59	0.002411017	164	0.02551597463414634	1.537334	14	14	0.001146226	
GO Cellular Component	cytoplasmic exosome (RNase complex)	175	1.632991e-10	1.6124619702857143e-9	3.862979	33	0.001348535	181	0.03555555712707183	1.537334	13	13	0.001064352	
GO Molecular Function	unfolded protein binding	18	2.196263e-25	5.151456881111111e-23	2.088805	248	0.01013444	90	0.003930101709555556	1.261774	87	106	0.007122974	
GO Molecular Function	RNA polymerase III activity	44	1.331239e-17	1.2773843313636363e-15	4.252379	53	0.002165829	123	0.035142143089430894	1.537334	16	16	0.001309972	
GO Molecular Function	rRNA binding	59	1.897702e-15	1.357982685423729e-13	2.329944	113	0.004617711	97	0.006444491268041238	1.332356	52	60	0.00425741	
GO Molecular Function	mitogen-activated protein kinase binding	94	5.727266e-13	2.5723954310638296e-11	2.162031	109	0.004454252	125	0.035543768288	1.423458	25	27	0.002046832	
GO Molecular Function	mRNA 5'-UTR binding	155	5.933705e-10	1.6162646780645162e-8	2.23984	74	0.003023988	122	0.0343562135409836	1.467455	21	22	0.001719338	
Human Phenotype	Nephrocalcinosis	10	1.018187e-24	6.794361850999999e-22	2.823639	133	0.005435005	172	0.023605163311627906	1.37551	34	38	0.002783691	
Human Phenotype	External ophthalmoplegia	84	8.650854e-13	6.872279612142857e-11	2.076162	118	0.004822034	126	0.008934945750793651	1.441251	30	32	0.002456198	
Mouse Phenotype Single KO	pale liver	90	9.494986e-29	9.660620755777777e-27	2.053878	295	0.01205509	376	0.027241855816489358	1.249084	65	80	0.005321762	
Mouse Phenotype Single KO	increased respiratory quotient	228	4.7514e-18	1.908270605263158e-16	2.041942	181	0.00739651	291	0.009687976983848797	1.349089	43	49	0.00352055	
Mouse Phenotype Single KO	increased liver adenoma incidence	460	2.057604e-11	4.0959738756521736e-10	2.32972	80	0.003269176	432	0.045611483328703704	1.460467	19	20	0.001555592	
Mouse Phenotype	extramedullary hematopoiesis	21	2.56319e-68	1.1669837899999998e-65	2.014999	757	0.03093458	558	0.019475619924731184	1.168374	133	175	0.01088914	
Mouse Phenotype	pancytopenia	253	1.791995e-20	6.772041183794467e-19	2.3859	147	0.00600711	658	0.038813969279635256	1.3783	26	29	0.002128705	
Mouse Phenotype	increased liver adenoma incidence	298	2.777746e-18	8.912090438255034e-17	2.578822	112	0.004576846	344	0.0026060323201744185	1.482429	27	28	0.002210578	
Mouse Phenotype	increased cellular sensitivity to ultraviolet irradiation	519	2.734774e-12	5.037991178034682e-11	2.236763	95	0.003882146	432	0.007814057015972223	1.434845	28	30	0.002292451