# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	53	1.55681e-26	3.865294866037736e-24	2.530634	173	0.01376402	237	0.00000338423384092827	1.490692	87	118	0.009367934	
GO Biological Process	translational elongation	70	4.621328e-22	8.687436450285714e-20	2.370064	161	0.01280929	242	0.000004521790194297521	1.498342	83	112	0.008937224	
GO Biological Process	termination of RNA polymerase II transcription	80	5.640335e-20	9.277646033125e-18	2.797111	107	0.008513008	374	0.00033684288572727273	1.523719	52	69	0.005599225	
GO Biological Process	cotranslational protein targeting to membrane	90	1.045276e-17	1.5283096537777778e-15	2.322573	132	0.01050203	364	0.0002830987855302198	1.444185	70	98	0.007537418	
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	93	1.393921e-17	1.9723232730107526e-15	2.367188	126	0.01002466	379	0.00038830195221635884	1.450464	66	92	0.007106708	
GO Biological Process	protein targeting to ER	95	1.940205e-17	2.6874902731578944e-15	2.271264	136	0.01082027	357	0.00024125751145938375	1.441325	72	101	0.007752773	
GO Biological Process	RNA 3'-end processing	105	1.422501e-16	1.7827324437142857e-14	2.170422	142	0.01129764	862	0.03442988234222737	1.284919	68	107	0.007322063	
GO Biological Process	DNA-templated transcription, termination	108	2.246867e-16	2.7376410049074076e-14	2.138101	145	0.01153632	612	0.007155115943137254	1.33554	72	109	0.007752773	
GO Biological Process	establishment of protein localization to endoplasmic reticulum	112	3.97996e-16	4.6760976464285716e-14	2.122527	145	0.01153632	298	0.00006193459980872482	1.46344	76	105	0.008183482	
GO Biological Process	mitochondrial translational elongation	134	3.476414e-14	3.4138904347761196e-12	2.291646	106	0.008433447	414	0.0007452189623188407	1.450981	61	85	0.006568321	
GO Biological Process	mitochondrial translational termination	135	4.072002e-14	3.969146245777777e-12	2.27554	107	0.008513008	433	0.0008723095021939954	1.440865	62	87	0.006675999	
GO Biological Process	mRNA 3'-end processing	138	6.113741e-14	5.829762160797102e-12	2.240995	109	0.00867213	739	0.017849462336941815	1.365411	52	77	0.005599225	
GO Biological Process	mitochondrial translation	152	3.075885e-13	2.662866494407895e-11	2.044971	127	0.01010422	380	0.0003962992143157895	1.417191	75	107	0.008075805	
GO Biological Process	cytoplasmic translation	154	3.453842e-13	2.9512407063636365e-11	2.888116	64	0.005091893	705	0.01389762120283688	1.504639	32	43	0.003445677	
GO Biological Process	heterochromatin organization	155	3.906944e-13	3.3168694255483866e-11	3.632901	46	0.003659798	791	0.025108386790139065	1.866331	12	13	0.001292129	
GO Biological Process	intrinsic apoptotic signaling pathway in response to DNA damage	161	1.212841e-12	9.912903552173915e-11	2.084562	115	0.009149495	437	0.0008837828308237987	1.494417	51	69	0.005491547	
GO Biological Process	cytoplasmic microtubule organization	176	4.075647e-12	3.0472408450568184e-10	2.351075	84	0.006683109	671	0.011076761807600597	1.528722	31	41	0.003337999	
GO Biological Process	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	180	5.432315e-12	3.971324060277778e-10	2.062789	111	0.008831251	649	0.009599575658397535	1.434867	44	62	0.004737806	
GO Biological Process	signal transduction involved in mitotic G1 DNA damage checkpoint	183	7.189938e-12	5.170076182622951e-10	2.045415	112	0.008910812	608	0.006999897585361841	1.444185	45	63	0.004845483	
GO Biological Process	snRNA transcription from RNA polymerase II promoter	184	7.39048e-12	5.285398169565218e-10	2.125696	102	0.008115204	729	0.01670536674567901	1.386417	48	70	0.005168515	
GO Cellular Component	ribosomal subunit	27	2.341007e-21	1.49824448e-19	2.021128	222	0.0176625	40	6.7658976e-7	1.409836	129	185	0.01389038	
GO Cellular Component	large ribosomal subunit	36	3.529181e-17	1.69400688e-15	2.188652	145	0.01153632	50	0.000019607419008	1.459254	83	115	0.008937224	
GO Cellular Component	mitochondrial ribosome	37	1.150262e-16	5.372034421621622e-15	2.563115	102	0.008115204	75	0.0013980623616	1.427194	60	85	0.006460644	
GO Cellular Component	catalytic step 2 spliceosome	38	1.032389e-14	4.694653136842106e-13	2.045548	143	0.0113772	119	0.02844228463865546	1.305784	62	96	0.006675999	
GO Cellular Component	mitochondrial large ribosomal subunit	54	1.027143e-10	3.2868576e-9	2.578927	61	0.00485321	117	0.026336196923076927	1.427194	36	51	0.003876386	
GO Cellular Component	cytosolic large ribosomal subunit	67	6.82825e-9	1.7610770149253733e-7	2.002007	84	0.006683109	78	0.002061554953846154	1.491535	45	61	0.004845483	
GO Cellular Component	INO80-type complex	75	3.942037e-8	9.082453248e-7	3.130662	32	0.002545946	108	0.017473392	1.670231	19	23	0.002045871	
GO Cellular Component	MLL1 complex	147	0.00004143845	0.00048711320816326534	2.064998	38	0.003023311	140	0.0420005952	1.533824	22	29	0.002368903	
GO Cellular Component	cyclin/CDK positive transcription elongation factor complex	262	0.004404954	0.02905252103816794	2.366059	13	0.001034291	143	0.0432055586013986	2.021859	8	8	0.0008614192	
GO Molecular Function	ribonucleoprotein complex binding	8	4.493988e-16	2.371702167e-13	2.019387	163	0.01296841	82	0.0011273594697560976	1.388929	79	115	0.008506514	
GO Molecular Function	rRNA binding	10	1.339225e-15	5.654207949999999e-13	2.970639	74	0.005887501	92	0.0064450252630434786	1.482696	44	60	0.004737806	
GO Molecular Function	endoribonuclease activity	18	3.302554e-10	7.746323882222221e-8	2.143163	84	0.006683109	109	0.026667124222018345	1.444185	40	56	0.004307096	
GO Molecular Function	Ral GTPase binding	72	0.00001422841	0.0008343381530555555	2.478915	29	0.002307264	128	0.049782954359375	1.866331	12	13	0.001292129	
GO Molecular Function	profilin binding	203	0.0008403051	0.01747669030640394	2.019195	26	0.002068581	115	0.03208105790782609	2.021859	10	10	0.001076774	
Human Phenotype	Neonatal respiratory distress	21	0.000001883332	0.0005984511636190476	2.524954	34	0.002705068	286	0.023629582975524477	1.783993	15	17	0.001615161	
Mouse Phenotype Single KO	abnormal cellular replicative senescence	3	3.589839e-21	1.0957385241000001e-17	2.649253	125	0.009945103	377	0.009442771267374004	1.448999	43	60	0.004630128	
Mouse Phenotype Single KO	early cellular replicative senescence	4	5.848071e-21	1.338769653675e-17	2.763968	115	0.009149495	476	0.023472622882352943	1.43863	37	52	0.003984064	
Mouse Phenotype Single KO	absent egg cylinders	79	0.000001180525	0.00013683629651898733	2.215975	46	0.003659798	597	0.04993844341038526	1.752277	13	15	0.001399806	
Mouse Phenotype Single KO	increased lactate dehydrogenase level	80	0.000001205322	0.000137964169425	2.214205	46	0.003659798	520	0.03250173253269231	1.654248	18	22	0.001938193	
Mouse Phenotype Single KO	abnormal third pharyngeal arch artery morphology	97	0.000003239856	0.0003058490865154639	2.130429	46	0.003659798	337	0.0058016741264094954	2.021859	12	12	0.001292129	
Mouse Phenotype Single KO	abnormal sensorimotor gating	108	0.000005757899	0.0004881951957685185	2.266233	38	0.003023311	457	0.020292613301969364	1.783993	15	17	0.001615161	
Mouse Phenotype Single KO	abnormal thymus development	168	0.00004122708	0.0022471212592857144	2.02289	40	0.003182433	517	0.03227941686073501	1.769126	14	16	0.001507484	
Mouse Phenotype	early cellular replicative senescence	1	3.860743e-30	3.6912563823000004e-26	2.732158	173	0.01376402	358	0.00044104652639664806	1.495621	54	73	0.00581458	
Mouse Phenotype	abnormal cellular replicative senescence	2	4.544882e-28	2.1726808401000003e-24	2.543125	182	0.01448007	392	0.0008389492133418367	1.444185	60	84	0.006460644	
Mouse Phenotype	abnormal third pharyngeal arch artery morphology	14	3.417103e-12	2.333637270214286e-9	2.319317	87	0.006921792	230	0.000015596988165652174	2.021859	21	21	0.002261225	
Mouse Phenotype	abnormal third pharyngeal arch morphology	30	3.677505e-10	1.1720208435e-7	2.014556	97	0.0077174	336	0.000302591706875	1.805231	25	28	0.002691935	
Mouse Phenotype	polyploidy	84	3.056495e-7	0.000034789462732142854	2.041774	62	0.004932771	471	0.0026118378471337578	1.684882	25	30	0.002691935	
Mouse Phenotype	abnormal parotid gland morphology	88	5.554485e-7	0.00006034821714204545	4.248817	18	0.001432095	906	0.037731758344370855	2.021859	8	8	0.0008614192	
Mouse Phenotype	ectopic ureteric bud	90	5.695458e-7	0.00006050474882000001	2.015708	61	0.00485321	506	0.004034435896837945	2.021859	12	12	0.001292129