# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	17	1.32477e-38	1.0254499076470588e-35	2.652467	236	0.01831587	473	0.006259716825792812	1.373453	70	113	0.008265439	
GO Biological Process	endoplasmic reticulum unfolded protein response	19	4.054832e-34	2.80829127831579e-31	2.57907	218	0.0169189	647	0.0249215799366306	1.322507	68	114	0.008029283	
GO Biological Process	regulation of DNA-templated transcription in response to stress	21	1.239205e-33	7.765094569047619e-31	2.414442	243	0.01885914	435	0.0038308541301149425	1.378729	74	119	0.008737749	
GO Biological Process	cellular response to unfolded protein	30	8.019101e-30	3.517445001966667e-27	2.360155	224	0.01738456	616	0.021023234959253248	1.319293	72	121	0.008501594	
GO Biological Process	regulation of intrinsic apoptotic signaling pathway	51	1.322117e-25	3.411321098627451e-23	2.02018	270	0.0209546	437	0.0038952115494279176	1.330287	93	155	0.01098123	
GO Biological Process	regulation of necrotic cell death	56	2.40379e-25	5.648477251785714e-23	4.957571	67	0.005199845	351	0.0007569116784045584	1.888679	23	27	0.002715787	
GO Biological Process	response to unfolded protein	57	2.440293e-25	5.633651857368421e-23	2.032518	263	0.02041133	462	0.005378242803030303	1.31643	95	160	0.01121738	
GO Biological Process	mitochondrial membrane organization	59	4.038325e-25	9.006833673728813e-23	2.081168	246	0.01909197	221	0.000006319636544343891	1.519817	85	124	0.0100366	
GO Biological Process	mitochondrial translational termination	63	2.320875e-24	4.847681607142857e-22	2.779852	134	0.01039969	280	0.00009441347517857142	1.55455	61	87	0.007202739	
GO Biological Process	translational elongation	66	1.042957e-23	2.0794350246969696e-21	2.412458	168	0.01303842	228	0.000007150767973245614	1.544083	78	112	0.00921006	
GO Biological Process	mitochondrial translational elongation	67	1.263655e-23	2.481856141044776e-21	2.762672	131	0.01016686	273	0.0000820038031062271	1.565043	60	85	0.007084662	
GO Biological Process	translational termination	69	2.01933e-23	3.851067169565218e-21	2.562161	148	0.01148622	264	0.00006511461988636363	1.540332	66	95	0.007793128	
GO Biological Process	regulation of necroptotic process	71	3.000949e-23	5.561899702957747e-21	5.649157	54	0.00419092	374	0.0012994980453743313	1.99543	18	20	0.002125399	
GO Biological Process	mitochondrial translation	72	3.708112e-23	6.777089695555555e-21	2.466036	157	0.01218471	230	0.000008097156076521738	1.554074	75	107	0.008855827	
GO Biological Process	cellular protein complex disassembly	84	1.137153e-21	1.781404324642857e-19	2.129082	199	0.01544432	278	0.00009336925848920864	1.4605	83	126	0.009800449	
GO Biological Process	regulation of mitochondrial membrane permeability	91	4.429074e-21	6.404635688571428e-19	2.299937	163	0.01265037	274	0.00008172517013868612	1.609708	53	73	0.006258118	
GO Biological Process	cotranslational protein targeting to membrane	92	4.613594e-21	6.598943852826087e-19	2.454414	143	0.01109818	259	0.000049459198930115824	1.538427	68	98	0.008029283	
GO Biological Process	multi-organism metabolic process	93	4.771793e-21	6.751830546989247e-19	2.058151	209	0.01622041	199	0.0000010124375898492462	1.508262	100	147	0.01180777	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	96	8.515215e-21	1.16720535609375e-18	2.297341	161	0.01249515	294	0.00014557913596258503	1.46557	78	118	0.00921006	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to hypoxia	99	1.244166e-20	1.6537353933333333e-18	2.392246	147	0.01140861	646	0.02463032769504644	1.392822	49	78	0.005785807	
GO Cellular Component	ribosomal subunit	34	1.513081e-26	7.690011670588235e-25	2.149179	242	0.01878153	58	5.498919062068966e-7	1.450133	121	185	0.0142874	
GO Cellular Component	mitochondrial ribosome	37	7.504562e-26	3.504833279999999e-24	3.039526	124	0.009623593	80	0.0001065810312	1.538959	59	85	0.006966584	
GO Cellular Component	mitochondrial large ribosomal subunit	42	7.77097e-21	3.1971990857142855e-19	3.422974	83	0.006441599	114	0.0030790428631578947	1.565043	36	51	0.004250797	
GO Cellular Component	large ribosomal subunit	43	1.456099e-20	5.851486213953489e-19	2.311664	157	0.01218471	65	0.000018287469193846152	1.503803	78	115	0.00921006	
GO Cellular Component	spliceosomal snRNP complex	51	1.01128e-16	3.4264545882352943e-15	2.657439	96	0.007450524	57	2.9481404968421056e-7	1.78802	50	62	0.005903885	
GO Cellular Component	catalytic step 2 spliceosome	52	1.82006e-16	6.048199384615385e-15	2.107012	151	0.01171905	106	0.001489951046037736	1.431906	62	96	0.007320817	
GO Cellular Component	azurophil granule lumen	54	2.979702e-15	9.5350464e-14	2.062125	146	0.01133101	176	0.04260214145454545	1.315668	54	91	0.006376196	
GO Cellular Component	small nuclear ribonucleoprotein complex	63	6.82715e-13	1.872589714285714e-11	2.259449	98	0.007605743	67	0.000027960226388059703	1.638759	51	69	0.006021962	
GO Cellular Component	PcG protein complex	69	6.244097e-12	1.5637390747826085e-10	2.065626	110	0.008537059	78	0.00009931418584615385	1.735157	36	46	0.004250797	
GO Cellular Component	spliceosomal tri-snRNP complex	75	3.180624e-11	7.328157696e-10	3.004108	50	0.003880481	112	0.002750260114285714	1.758425	23	29	0.002715787	
GO Cellular Component	intrinsic component of mitochondrial membrane	79	1.224785e-10	2.6790233924050633e-9	2.025692	101	0.007838572	127	0.006730942337007874	1.466727	43	65	0.005077341	
GO Cellular Component	integral component of mitochondrial membrane	80	1.758181e-10	3.79767096e-9	2.019621	100	0.007760962	135	0.00943456896	1.455001	42	64	0.004959263	
GO Cellular Component	nuclear ubiquitin ligase complex	88	1.553137e-9	3.049796290909091e-8	2.438474	59	0.004578968	145	0.01515557296551724	1.552001	28	40	0.003306175	
GO Cellular Component	commitment complex	94	4.306171e-9	7.916024987234042e-8	5.923244	18	0.001396973	152	0.01943386105263158	2.217145	8	8	0.0009446216	
GO Cellular Component	U2 snRNP	104	4.831495e-8	8.027714769230769e-7	3.102144	32	0.002483508	129	0.007257470065116279	1.867069	16	19	0.001889243	
GO Cellular Component	U1 snRNP	129	5.898874e-7	0.000007901747497674418	2.580272	36	0.002793946	102	0.0012557538635294117	1.983761	17	19	0.002007321	
GO Cellular Component	precatalytic spliceosome	130	5.957892e-7	0.000007919413366153847	2.540532	37	0.002871556	177	0.04276533477966102	1.583675	20	28	0.002361554	
GO Cellular Component	prespliceosome	132	6.888506e-7	0.000009017680581818182	2.692379	33	0.002561118	109	0.002356667009174312	1.90041	18	21	0.002125399	
GO Cellular Component	anaphase-promoting complex	219	0.00005237158	0.00041323328876712327	2.383922	27	0.00209546	172	0.03845458046511628	1.689253	16	21	0.001889243	
GO Cellular Component	U2-type prespliceosome	224	0.00007202333	0.0005556085457142857	2.483259	24	0.001862631	99	0.0010417511563636365	2.078573	15	16	0.001771165	
GO Molecular Function	unfolded protein binding	9	6.563549e-24	3.079033764222222e-21	2.511385	157	0.01218471	71	0.003477310557746479	1.422319	68	106	0.008029283	
GO Molecular Function	structural constituent of ribosome	10	3.986071e-23	1.6829191762000002e-20	2.109798	218	0.0169189	24	6.151193643333334e-7	1.505469	110	162	0.01298855	
GO Molecular Function	ribonucleoprotein complex binding	14	1.137125e-17	3.429244107142857e-15	2.066543	171	0.01327125	45	0.0001660390631111111	1.484523	77	115	0.009091983	
GO Molecular Function	hexosaminidase activity	76	3.519773e-8	0.0000019553265271052632	3.375916	29	0.002250679	117	0.040859794290598286	1.921526	13	15	0.00153501	
GO Molecular Function	NF-kappaB binding	115	0.000001357341	0.000049832119147826086	2.143182	49	0.003802872	123	0.0440861926504065	1.662859	21	28	0.002479632	
Human Phenotype	Increased serum lactate	8	1.139647e-20	9.50608053875e-18	2.303824	159	0.01233993	60	0.0003389123278	1.507659	68	100	0.008029283	
Human Phenotype	Abnormal CSF metabolite level	10	2.896127e-20	1.9325855471e-17	2.824189	107	0.00830423	57	0.0002144023192982456	1.65406	47	63	0.005549652	
Human Phenotype	Increased CSF lactate	18	9.306959e-17	3.450296522611111e-14	2.710511	93	0.007217695	68	0.0006513660535882353	1.643745	43	58	0.005077341	
Human Phenotype	Abnormality of the mitochondrion	37	2.687978e-11	4.847804647027027e-9	2.00642	111	0.008614668	111	0.006368458708108108	1.498915	48	71	0.005667729	
Human Phenotype	Abnormality of mitochondrial metabolism	43	3.041537e-11	4.720041023488372e-9	2.016447	109	0.008459449	129	0.012568983465116278	1.478097	46	69	0.005431574	
Human Phenotype	Leukodystrophy	88	1.857818e-8	0.0000014087749447727273	2.012378	78	0.006053551	137	0.01569944532992701	1.552001	35	50	0.004132719	
Human Phenotype	Acute encephalopathy	246	0.00005855647	0.0015884037573577236	2.009237	39	0.003026775	116	0.007851141160344828	1.847621	20	24	0.002361554	
Mouse Phenotype Single KO	decreased circulating free fatty acid level	12	2.575413e-27	1.9652547367499998e-24	2.266129	222	0.01722934	113	0.00998412020619469	1.430416	60	93	0.007084662	
Mouse Phenotype Single KO	abnormal T follicular helper cell number	99	5.269618e-10	4.8741305076767675e-8	4.23273	28	0.002173069	166	0.04250935354698795	2.217145	9	9	0.001062699	
Mouse Phenotype Single KO	increased skin tumor incidence	118	3.433126e-9	2.664163964576271e-7	2.108373	77	0.005975941	159	0.03396747108427673	1.562079	31	44	0.003660409	
Mouse Phenotype	extramedullary hematopoiesis	5	5.57536e-38	1.0661203392e-34	2.032228	402	0.03119907	301	0.027675823295681065	1.26694	100	175	0.01180777	
Mouse Phenotype	decreased circulating free fatty acid level	16	7.349329e-29	4.3916834105625e-26	2.106272	277	0.02149787	231	0.010641239858441558	1.360097	73	119	0.008619672	
Mouse Phenotype	increased keratinocyte proliferation	48	6.441148e-18	1.28299616725e-15	2.411645	124	0.009623593	334	0.039542521203592806	1.493179	33	49	0.003896564	
Mouse Phenotype	early cellular replicative senescence	68	8.178134e-15	1.149869693735294e-12	2.095149	136	0.01055491	192	0.00591481305625	1.488221	49	73	0.005785807