# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	endoplasmic reticulum unfolded protein response	16	2.504483e-53	2.0597807373125e-50	2.63858	334	0.01730929	448	0.0006213735608258929	1.318643	88	114	0.008005822	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	17	7.447794e-53	5.765030661529412e-50	2.581746	344	0.01782753	228	6.535838668859649e-8	1.45125	96	113	0.008733624	
GO Biological Process	regulation of DNA-templated transcription in response to stress	21	1.12162e-48	7.028284561904762e-46	2.401796	362	0.01876036	191	7.813586845549738e-9	1.464208	102	119	0.009279476	
GO Biological Process	cellular response to topologically incorrect protein	25	3.033182e-46	1.59654567752e-43	2.326514	366	0.01896766	535	0.00221554368964486	1.26582	103	139	0.009370451	
GO Biological Process	cellular response to unfolded protein	26	3.13853e-46	1.588458318076923e-43	2.406223	342	0.01772388	431	0.0005200613881670533	1.312947	93	121	0.008460699	
GO Biological Process	regulation of intrinsic apoptotic signaling pathway	28	2.050337e-43	9.635851636785713e-41	2.11341	423	0.02192164	568	0.0031029779188380285	1.245364	113	155	0.0102802	
GO Biological Process	response to topologically incorrect protein	29	2.550312e-43	1.157226055448276e-40	2.082463	437	0.02264718	395	0.00018632457733164554	1.271692	134	180	0.01219068	
GO Biological Process	response to unfolded protein	31	1.453383e-42	6.1693764183870965e-40	2.120985	411	0.02129975	335	0.000030328144365074625	1.313211	123	160	0.01118996	
GO Biological Process	positive regulation of transcription from RNA polymerase II promoter in response to stress	40	2.646375e-40	8.70591215625e-38	4.183193	131	0.006788972	828	0.036309892515700486	1.494712	21	24	0.00191048	
GO Biological Process	nuclear-transcribed mRNA catabolic process	41	7.543214e-39	2.421003732341463e-36	2.013455	424	0.02197347	160	4.71076738175e-10	1.389025	161	198	0.01464702	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	49	1.094354e-36	2.9388988338775513e-34	2.458308	258	0.01337065	237	1.4524931961603375e-7	1.433186	99	118	0.00900655	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to hypoxia	62	1.769438e-33	3.7554894583870967e-31	2.48852	229	0.01186774	310	0.000006595401165806452	1.467336	67	78	0.006095342	
GO Biological Process	multi-organism metabolic process	66	6.979059e-33	1.3914763239545454e-30	2.104254	320	0.01658375	157	2.5254937193630574e-10	1.452587	125	147	0.01137191	
GO Biological Process	viral gene expression	81	5.654582e-31	9.186252412098766e-29	2.243666	260	0.0134743	229	7.59157075720524e-8	1.425777	106	127	0.009643377	
GO Biological Process	viral transcription	90	7.549727e-29	1.1038539732555555e-26	2.244369	241	0.01248964	172	9.73841740755814e-10	1.496602	99	113	0.00900655	
GO Biological Process	translational elongation	92	4.814457e-28	6.886243441630434e-26	2.243797	234	0.01212687	209	2.5301992980382775e-8	1.464208	96	112	0.008733624	
GO Biological Process	RNA phosphodiester bond hydrolysis	93	5.314209e-28	7.519320024838709e-26	2.051796	287	0.01487355	377	0.00011507199945358089	1.322925	103	133	0.009370451	
GO Biological Process	regulation of necrotic cell death	96	1.677056e-27	2.2987895733333334e-25	4.249225	86	0.004456882	869	0.04478037985385501	1.455169	23	27	0.002092431	
GO Biological Process	cotranslational protein targeting to membrane	97	1.71885e-27	2.3317883659793814e-25	2.361001	206	0.01067579	273	9.976874231501832e-7	1.446777	83	98	0.007550946	
GO Biological Process	protein targeting to ER	108	2.911292e-26	3.547193650740741e-24	2.284449	210	0.01088308	245	3.566907006408163e-7	1.454543	86	101	0.007823872	
GO Cellular Component	ribosomal subunit	35	9.348727e-34	4.6156000731428576e-32	2.057803	347	0.017983	42	5.5352818285714284e-11	1.412763	153	185	0.01391921	
GO Cellular Component	cytoplasmic side of endoplasmic reticulum membrane	41	4.451077e-30	1.8759661112195121e-28	5.259184	76	0.00393864	189	0.04313696914285714	1.708242	10	10	0.0009097525	
GO Cellular Component	large ribosomal subunit	44	6.597394e-26	2.590976552727273e-24	2.20237	224	0.01160862	56	1.632170057142857e-8	1.45572	98	115	0.008915575	
GO Cellular Component	mitochondrial ribosome	46	5.396808e-24	2.0273226573913043e-22	2.537073	155	0.008032753	71	0.00001640432018028169	1.426885	71	85	0.006459243	
GO Cellular Component	proteasome core complex	50	3.7867e-19	1.30868352e-17	4.195784	59	0.003057629	138	0.005104192695652174	1.565889	22	24	0.002001456	
GO Cellular Component	cleavage furrow	57	4.681867e-18	1.4193449431578948e-16	2.094517	170	0.008810116	158	0.018230618734177216	1.346883	41	52	0.003729985	
GO Cellular Component	mitochondrial large ribosomal subunit	62	1.973726e-17	5.500965367741935e-16	2.698788	98	0.005078773	82	0.00007838089990243903	1.507273	45	51	0.004093886	
GO Cellular Component	spliceosomal snRNP complex	73	7.391456e-15	1.749648762739726e-13	2.218148	120	0.006218905	85	0.00008861041694117647	1.460272	53	62	0.004821689	
GO Cellular Component	endopeptidase complex	74	9.7759e-15	2.282804756756757e-13	2.049114	143	0.007410862	106	0.0009016061705660377	1.3864	56	69	0.005094614	
GO Cellular Component	proteasome complex	79	3.99332e-14	8.73475564556962e-13	2.021596	141	0.007307214	114	0.0011727196294736841	1.381667	55	68	0.005003639	
GO Cellular Component	U5 snRNP	121	6.17985e-10	8.825438677685951e-9	2.71592	51	0.002643035	194	0.046147682969072165	1.4753	19	22	0.00172853	
GO Cellular Component	mitochondrial nucleoid	138	6.030189e-9	7.550845356521739e-8	2.008931	84	0.004353234	161	0.019499524770186336	1.382863	34	42	0.003093159	
GO Cellular Component	U2 snRNP	152	1.813583e-8	2.0617575157894737e-7	2.718807	42	0.002176617	180	0.0365816736	1.528427	17	19	0.001546579	
GO Cellular Component	Ino80 complex	153	1.842891e-8	2.0813827764705885e-7	3.170523	33	0.001710199	167	0.024190365125748504	1.601477	15	16	0.001364629	
GO Cellular Component	spliceosomal tri-snRNP complex	164	5.884248e-8	6.199988136585366e-7	2.246729	56	0.002902156	130	0.00361976256	1.531528	26	29	0.002365357	
GO Cellular Component	INO80-type complex	188	5.166361e-7	0.000004748655217021277	2.485331	39	0.002021144	175	0.03406277046857143	1.485428	20	23	0.001819505	
GO Cellular Component	nuclear pore outer ring	360	0.0006707757	0.0032197233599999997	2.308488	20	0.001036484	189	0.04313696914285714	1.708242	10	10	0.0009097525	
GO Molecular Function	unfolded protein binding	10	1.920016e-34	8.106307551999999e-32	2.499462	234	0.01212687	89	0.0006508265182022472	1.337586	83	106	0.007550946	
GO Molecular Function	structural constituent of ribosome	11	2.744415e-31	1.0533563754545455e-28	2.061542	319	0.01653192	32	4.28981851375e-9	1.412991	134	162	0.01219068	
GO Molecular Function	ribonuclease activity	12	5.852006e-26	2.0589307776666668e-23	2.157958	235	0.01217869	133	0.007863284533834586	1.294123	75	99	0.006823144	
GO Molecular Function	protein phosphatase 2A binding	16	5.623764e-21	1.4839707255e-18	2.52719	135	0.006996269	153	0.017809988218300654	1.518438	24	27	0.002183406	
GO Molecular Function	rRNA binding	17	7.210641e-21	1.790783900117647e-18	2.850218	109	0.005648839	123	0.004107769156097561	1.395065	49	60	0.004457787	
GO Molecular Function	endoribonuclease activity	20	3.063148e-17	6.466305428000001e-15	2.260207	136	0.007048093	146	0.013320707853424658	1.372695	45	56	0.004093886	
Human Phenotype	Increased serum lactate	9	1.040565e-22	7.715211383333333e-20	2.099564	217	0.01124585	116	0.004585183974482759	1.315347	77	100	0.007005095	
Human Phenotype	Abnormality of mitochondrial metabolism	17	1.651093e-17	6.481025640588236e-15	2.075328	168	0.008706468	177	0.01686198107966102	1.336885	54	69	0.004912664	
Human Phenotype	Abnormality of the mitochondrion	18	2.92846e-17	1.085645198888889e-14	2.051941	170	0.008810116	154	0.010489960333116884	1.347346	56	71	0.005094614	
Human Phenotype	Abnormality of transition element cation homeostasis	41	3.604042e-12	5.865798113658537e-10	2.840617	60	0.003109453	159	0.011428880674842766	1.531528	26	29	0.002365357	
Human Phenotype	Increased serum ferritin	53	8.380749e-11	1.0551837373018869e-8	3.083818	46	0.002383914	166	0.013540911898192773	1.62283	19	20	0.00172853	
Human Phenotype	Abnormality of iron homeostasis	69	5.821271e-10	5.629759620724638e-8	2.690145	52	0.002694859	172	0.015814486247093026	1.565889	22	24	0.002001456	
Human Phenotype	Decreased activity of mitochondrial respiratory chain	220	2.905872e-7	0.000008814038116363638	2.446796	42	0.002176617	165	0.01308801373151515	1.708242	15	15	0.001364629	
Human Phenotype	Abnormal activity of mitochondrial respiratory chain	224	3.29958e-7	0.000009829507741071428	2.351219	45	0.00233209	146	0.008653848056164383	1.708242	16	16	0.001455604	
Human Phenotype	Aplasia/Hypoplasia involving the femoral head and neck	261	9.218056e-7	0.00002356784968888889	2.011968	59	0.003057629	139	0.007808783005755397	1.576839	24	26	0.002183406	
Mouse Phenotype Single KO	absent segment of posterior cerebral artery	66	4.067915e-17	5.643923887121212e-15	2.864281	87	0.004508706	234	0.03946287414957264	1.552948	20	22	0.001819505	
Mouse Phenotype	pancytopenia	54	9.886038e-20	1.7503779503333333e-17	2.552355	124	0.006426202	360	0.03566871809166667	1.472623	25	29	0.002274381	
Mouse Phenotype	absent segment of posterior cerebral artery	77	4.067915e-17	5.051082508441558e-15	2.864281	87	0.004508706	343	0.028109981116618075	1.552948	20	22	0.001819505	
Mouse Phenotype	abnormal sebaceous gland physiology	112	1.589645e-14	1.3570174861607142e-12	2.659609	82	0.004249585	335	0.025464413500298506	1.61334	17	18	0.001546579	
Mouse Phenotype	heterochrony	236	1.330314e-9	5.389462777118644e-8	2.237911	71	0.003679519	370	0.03737632632972973	1.607758	16	17	0.001455604