# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	17	6.354794e-80	4.918984367411765e-77	2.652846	502	0.01831849	545	0.0006193511519816514	1.267121	94	113	0.007625537	
GO Biological Process	endoplasmic reticulum unfolded protein response	25	2.304736e-71	1.21312084096e-68	2.592167	466	0.01700482	536	0.0004924699284141791	1.269368	95	114	0.00770666	
GO Biological Process	regulation of DNA-templated transcription in response to stress	27	5.630747e-71	2.7442592508518513e-68	2.433989	521	0.01901182	520	0.0003940892748076923	1.267235	99	119	0.008031151	
GO Biological Process	mRNA catabolic process	30	5.42507e-67	2.3796165376666667e-64	2.080253	688	0.02510582	131	7.395527761145039e-15	1.373063	192	213	0.01557557	
GO Biological Process	cellular response to topologically incorrect protein	31	2.033758e-66	8.63297468451613e-64	2.345358	524	0.0191213	425	0.0000662879825835294	1.271194	116	139	0.009410238	
GO Biological Process	IRE1-mediated unfolded protein response	33	5.947699e-66	2.3716900345757573e-63	3.474308	274	0.00999854	1045	0.03952326427368421	1.260614	48	58	0.003893891	
GO Biological Process	response to topologically incorrect protein	38	4.191314e-63	1.451407919105263e-60	2.107215	628	0.02291636	304	4.845026927302631e-7	1.286293	152	180	0.01233066	
GO Biological Process	nuclear-transcribed mRNA catabolic process	39	2.742139e-61	9.25225823102564e-59	2.086479	624	0.0227704	149	1.7036957299999998e-13	1.369379	178	198	0.01443985	
GO Biological Process	cellular response to unfolded protein	40	4.13046e-61	1.3588180784999999e-58	2.358142	476	0.01736973	542	0.0006042183068819188	1.258877	100	121	0.008112274	
GO Biological Process	regulation of intrinsic apoptotic signaling pathway	47	2.602958e-57	7.287728579148937e-55	2.075624	590	0.0215297	374	0.000010304872713636363	1.277558	130	155	0.01054596	
GO Biological Process	response to unfolded protein	53	1.858596e-55	4.614578257358491e-53	2.074843	571	0.02083637	363	0.000008326826696418733	1.275715	134	160	0.01087045	
GO Biological Process	regulation of necrotic cell death	61	3.126671e-52	6.744895686721312e-50	4.975087	143	0.005218216	898	0.018825663979955456	1.410409	25	27	0.002028068	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	65	2.411124e-50	4.881227802461539e-48	2.442144	364	0.01328273	207	4.757688577439613e-10	1.407062	109	118	0.008842379	
GO Biological Process	mitochondrial membrane organization	66	1.281501e-49	2.5550411604545456e-47	2.060498	518	0.01890235	324	0.000001913774291296296	1.326694	108	124	0.008761256	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to hypoxia	74	1.848766e-47	3.287555647837838e-45	2.502112	327	0.01193256	581	0.0010852684807401032	1.308426	67	78	0.005435223	
GO Biological Process	cellular response to epidermal growth factor stimulus	78	7.210567e-47	1.2164596301666667e-44	2.571002	307	0.01120274	826	0.012449522797094431	1.3629	34	38	0.002758173	
GO Biological Process	cotranslational protein targeting to membrane	80	1.090928e-46	1.794440194e-44	2.534031	314	0.01145818	197	2.1996323891878172e-10	1.445525	93	98	0.007544415	
GO Biological Process	positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	83	6.437011e-46	1.0205376837228916e-43	3.524412	185	0.006750839	880	0.017741322681818182	1.523242	16	16	0.001297964	
GO Biological Process	protein targeting to ER	87	3.739972e-45	5.6568151204597695e-43	2.458785	321	0.01171362	210	5.811383478619047e-10	1.432752	95	101	0.00770666	
GO Biological Process	response to epidermal growth factor	93	2.942316e-44	4.163218950967742e-42	2.452253	316	0.01153116	700	0.004025967852142857	1.378171	38	42	0.003082664	
GO Cellular Component	ribosomal subunit	39	5.573512e-45	2.4694945476923075e-43	2.029382	486	0.01773464	41	4.6936483902439024e-14	1.383268	168	185	0.01362862	
GO Cellular Component	mitochondrial ribosome	41	4.88625e-40	2.0593756097560976e-38	2.719986	236	0.008611881	66	4.568232436363636e-7	1.397798	78	85	0.006327574	
GO Cellular Component	large ribosomal subunit	44	8.638982e-39	3.3927638400000003e-37	2.256904	326	0.01189607	47	1.985626784680851e-12	1.443768	109	115	0.008842379	
GO Cellular Component	mitochondrial large ribosomal subunit	54	7.392925e-30	2.365736e-28	2.947404	152	0.005546636	73	0.000004139128109589041	1.463507	49	51	0.003975014	
GO Cellular Component	cleavage furrow	63	4.339725e-28	1.1903245714285713e-26	2.17752	251	0.009159247	124	0.000538694384516129	1.376776	47	52	0.003812769	
GO Cellular Component	PRC1 complex	67	3.917094e-27	1.0102594674626867e-25	5.532604	65	0.002371917	223	0.04956943899551569	1.523242	12	12	0.0009734729	
GO Cellular Component	nuclear ubiquitin ligase complex	88	1.22603e-20	2.4074770909090907e-19	2.545704	131	0.004780324	131	0.0010505142522137403	1.408999	37	40	0.003001541	
GO Cellular Component	spliceosomal snRNP complex	97	7.588439e-19	1.3518373806185568e-17	2.160582	166	0.00605751	153	0.00441813345882353	1.302126	53	62	0.004299505	
GO Cellular Component	spliceosomal tri-snRNP complex	131	4.345624e-15	5.73224295572519e-14	2.570735	91	0.003320683	157	0.006968032326114649	1.418191	27	29	0.002190314	
GO Cellular Component	DNA-directed RNA polymerase III complex	146	2.003785e-13	2.3716030684931504e-12	3.423728	51	0.001861042	151	0.0038360844715231786	1.523242	19	19	0.001541332	
GO Cellular Component	ESCRT complex	148	3.802008e-13	4.439101232432433e-12	2.409661	88	0.00321121	215	0.035898364130232556	1.360037	25	28	0.002028068	
GO Cellular Component	CCR4-NOT complex	152	5.670554e-13	6.446524547368421e-12	2.583378	76	0.002773318	173	0.011850683930635838	1.523242	16	16	0.001297964	
GO Cellular Component	mitochondrial nucleoid	156	1.484781e-12	1.6446804923076923e-11	2.037626	121	0.004415414	94	0.00009843581412765956	1.450706	40	42	0.00324491	
GO Cellular Component	methylosome	159	1.577475e-12	1.714387924528302e-11	3.744438	42	0.001532623	223	0.04956943899551569	1.523242	12	12	0.0009734729	
GO Cellular Component	U1 snRNP	242	1.39946e-8	9.992838347107438e-8	2.190518	65	0.002371917	209	0.030365193186602867	1.443071	18	19	0.001460209	
GO Cellular Component	precatalytic spliceosome	255	2.977308e-8	2.0175640094117647e-7	2.130773	66	0.002408408	215	0.035898364130232556	1.360037	25	28	0.002028068	
GO Cellular Component	INO80-type complex	314	0.000001533002	0.000008436393171974523	2.153844	48	0.001751569	163	0.008598470753374231	1.457014	22	23	0.0017847	
GO Cellular Component	DNA-directed RNA polymerase I complex	320	0.000002128268	0.0000114926472	2.311649	40	0.001459641	198	0.02404436072727273	1.523242	14	14	0.001135718	
GO Cellular Component	cytosolic proteasome complex	339	0.000004019755	0.0000204900785840708	2.366305	36	0.001313677	223	0.04956943899551569	1.523242	12	12	0.0009734729	
GO Cellular Component	Ino80 complex	367	0.00001289987	0.00006073835247956403	2.300113	34	0.001240695	173	0.011850683930635838	1.523242	16	16	0.001297964	
GO Molecular Function	unfolded protein binding	9	1.74838e-42	8.201844844444444e-40	2.391724	318	0.01160415	167	0.03936744488622755	1.207097	84	106	0.00681431	
GO Molecular Function	structural constituent of ribosome	12	1.498766e-39	5.273158376666668e-37	2.0022	440	0.01605605	25	2.6164527736000003e-12	1.391603	148	162	0.01200617	
GO Molecular Function	NF-kappaB binding	42	2.839862e-19	2.854737467619048e-17	2.529523	123	0.004488396	150	0.025413307276	1.414439	26	28	0.002109191	
GO Molecular Function	exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	44	8.923688e-19	8.562684258181819e-17	2.168187	164	0.005984528	154	0.029576617857142856	1.309988	43	50	0.003488278	
GO Molecular Function	endoribonuclease activity	51	1.297963e-17	1.0745097619607844e-15	2.047862	175	0.006385929	122	0.00660634335409836	1.332836	49	56	0.003975014	
GO Molecular Function	DNA polymerase binding	120	4.365871e-12	1.536058946833333e-10	3.278215	48	0.001751569	159	0.03150408603773585	1.523242	16	16	0.001297964	
GO Molecular Function	RNA polymerase III activity	158	3.475734e-10	9.287689207594938e-9	3.080792	43	0.001569114	159	0.03150408603773585	1.523242	16	16	0.001297964	
Human Phenotype	Abnormal CSF metabolite level	31	1.192287e-19	2.5664939196774195e-17	2.159383	174	0.006349438	256	0.007745283327343751	1.305636	54	63	0.004380628	
Human Phenotype	Exercise intolerance	36	1.008948e-18	1.8701972233333332e-16	2.062216	184	0.006714348	158	0.0004554879991139241	1.349157	62	70	0.00502961	
Human Phenotype	Increased CSF lactate	62	8.773405e-16	9.442730897580645e-14	2.069263	151	0.005510145	349	0.021916847088825218	1.286877	49	58	0.003975014	
Human Phenotype	External ophthalmoplegia	63	1.00006e-15	1.0592699015873014e-13	2.152472	137	0.00499927	354	0.02291142504519774	1.380438	29	32	0.002352559	
Human Phenotype	Short femoral neck	89	8.965469e-14	6.722087037865168e-12	2.3814	95	0.003466647	326	0.01660231346564417	1.457014	22	23	0.0017847	
Human Phenotype	Glycosuria	111	1.690473e-12	1.0162636332432434e-10	2.08336	114	0.004159977	209	0.0025627359567464113	1.470716	28	29	0.002271437	
Mouse Phenotype Single KO	decreased circulating free fatty acid level	20	2.806344e-41	1.2848846004e-38	2.059015	429	0.01565465	182	0.009451276798351648	1.261179	77	93	0.006246451	
Mouse Phenotype Single KO	prenatal lethality prior to heart atrial septation	112	1.561394e-23	1.2765790051785714e-21	2.024606	247	0.009013283	265	0.039608620777358494	1.286877	49	58	0.003975014	
Mouse Phenotype Single KO	absent segment of posterior cerebral artery	126	2.065915e-22	1.501395528174603e-20	2.805014	121	0.004415414	267	0.040692473348314606	1.454003	21	22	0.001703578	
Mouse Phenotype Single KO	increased cellular sensitivity to ultraviolet irradiation	438	4.066465e-10	8.501511416666667e-9	2.124623	85	0.003101737	229	0.022134164444541485	1.459773	23	24	0.001865823	
Mouse Phenotype	prenatal lethality prior to heart atrial septation	166	1.561394e-23	8.993065080722892e-22	2.024606	247	0.009013283	449	0.02440840253452116	1.286877	49	58	0.003975014	
Mouse Phenotype	absent segment of posterior cerebral artery	179	2.065915e-22	1.103475604189944e-20	2.805014	121	0.004415414	456	0.024877722	1.454003	21	22	0.001703578	
Mouse Phenotype	absent hypoglossal nerve	219	1.105796e-19	4.827632673972603e-18	3.33338	81	0.002955773	497	0.034781090444668004	1.523242	15	15	0.001216841	
Mouse Phenotype	increased cellular sensitivity to ultraviolet irradiation	237	9.210218e-19	3.715565160253164e-17	2.522989	120	0.004378923	240	0.00216552427225	1.472467	29	30	0.002352559