# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	regulation of intrinsic apoptotic signaling pathway	108	9.836526e-101	1.1985078299444444e-98	2.036324	1105	0.02112205	587	0.0002893381641056218	1.158594	143	155	0.009563938	
GO Biological Process	mitochondrial membrane organization	130	2.211962e-85	2.239015996769231e-83	2.010748	965	0.01844595	592	0.0003104479282094594	1.174798	116	124	0.007758159	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	143	2.044057e-78	1.8809612631468534e-76	2.294938	653	0.01248208	1010	0.0126516397719802	1.138751	107	118	0.007156233	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	166	3.742957e-69	2.967082600180723e-67	2.05123	741	0.0141642	841	0.004119324027824019	1.155798	104	113	0.006955591	
GO Biological Process	negative regulation of intrinsic apoptotic signaling pathway	173	1.392497e-67	1.059183122716763e-65	2.069857	708	0.0135334	918	0.007289263204139434	1.1623	87	94	0.00581862	
GO Biological Process	regulation of mitochondrial membrane permeability	189	4.200024e-63	2.9242389320634917e-61	2.133805	614	0.0117366	869	0.005254146416915995	1.187007	69	73	0.004614767	
GO Biological Process	gene silencing by miRNA	193	1.110142e-62	7.56909770880829e-61	2.553859	421	0.008047405	924	0.007667569859090909	1.227277	43	44	0.002875869	
GO Biological Process	posttranscriptional gene silencing by RNA	202	7.727688e-60	5.034091405544554e-58	2.376021	461	0.008812004	997	0.011460524182647943	1.206571	49	51	0.003277154	
GO Biological Process	posttranscriptional gene silencing	206	4.325422e-59	2.7630207814563105e-57	2.355768	463	0.008850234	974	0.009680310267864476	1.207518	50	52	0.003344034	
GO Biological Process	adherens junction assembly	240	7.685141e-51	4.213698767458333e-49	2.258269	433	0.008276785	1257	0.04371032462688942	1.218883	33	34	0.002207063	
GO Biological Process	intrinsic apoptotic signaling pathway in response to DNA damage	253	1.046037e-49	5.4406327600790515e-48	2.120902	487	0.009308994	1161	0.028482955856158485	1.164817	64	69	0.004280364	
GO Biological Process	cotranslational protein targeting to membrane	256	2.744207e-49	1.4105867153515624e-47	2.096774	496	0.009481028	1148	0.0264198332369338	1.140488	89	98	0.005952381	
GO Biological Process	mitochondrial transmembrane transport	286	6.445057e-46	2.96540227493007e-44	2.037922	494	0.009442798	1174	0.03018153395996593	1.149906	76	83	0.005082932	
GO Biological Process	mRNA transcription	299	6.454875e-45	2.84079264632107e-43	3.399563	190	0.003631846	1208	0.036492717448675493	1.255819	25	25	0.001672017	
GO Biological Process	snRNA metabolic process	307	2.167498e-44	9.290588332899022e-43	2.090779	448	0.00856351	650	0.000675584477123077	1.197408	82	86	0.005484216	
GO Biological Process	snRNA transcription from RNA polymerase II promoter	347	2.413292e-40	9.151731823631124e-39	2.072888	414	0.0079136	756	0.002215885088359788	1.201998	67	70	0.004481006	
GO Biological Process	axo-dendritic transport	401	7.675499e-36	2.518750407506235e-34	2.072189	366	0.006996081	1138	0.025964788388400703	1.201218	44	46	0.00294275	
GO Biological Process	production of miRNAs involved in gene silencing by miRNA	452	2.85362e-32	8.307695924778761e-31	2.338946	250	0.004778744	1130	0.024719437692920353	1.255819	27	27	0.001805778	
GO Biological Process	positive regulation of mRNA catabolic process	495	1.704814e-30	4.532049985050506e-29	2.166025	278	0.005313963	1208	0.036492717448675493	1.255819	25	25	0.001672017	
GO Biological Process	production of small RNA involved in gene silencing by RNA	618	5.10344e-26	1.0866693682847896e-24	2.057752	265	0.005065469	1028	0.013703933646887158	1.255819	30	30	0.002006421	
GO Cellular Component	axon cytoplasm	76	2.18524e-46	4.968545684210526e-45	2.38022	353	0.006747587	243	0.04858530133333333	1.193028	38	40	0.002541466	
GO Cellular Component	cleavage furrow	84	1.365373e-43	2.8087673142857143e-42	2.063155	454	0.008678199	195	0.006349426116923076	1.207518	50	52	0.003344034	
GO Cellular Component	telomerase holoenzyme complex	138	9.068933e-27	1.135588132173913e-25	2.824807	145	0.002771672	240	0.0478158984	1.255819	22	22	0.001471375	
GO Cellular Component	intrinsic component of mitochondrial outer membrane	179	1.705242e-19	1.6461777519553071e-18	2.325952	147	0.002809902	233	0.039207615450643774	1.255819	23	23	0.001538256	
GO Cellular Component	integral component of mitochondrial outer membrane	194	2.240626e-17	1.9957740865979378e-16	2.249257	139	0.002656982	240	0.0478158984	1.255819	22	22	0.001471375	
GO Molecular Function	cyclin-dependent protein serine/threonine kinase regulator activity	127	2.196381e-23	7.301669749606299e-22	2.087953	228	0.004358215	153	0.03711430504575163	1.255819	29	29	0.00193954	
GO Molecular Function	snRNA binding	222	4.969034e-15	9.450117814414414e-14	2.030647	150	0.002867246	162	0.04828696187654321	1.222771	37	38	0.002474585	
Human Phenotype	Slender long bone	148	4.637092e-20	2.0907645213513513e-18	2.155762	179	0.003421581	381	0.029593984364829393	1.255819	28	28	0.001872659	
Mouse Phenotype Single KO	abnormal liver sinusoid morphology	22	5.503527e-99	2.2907180335909092e-96	2.474478	712	0.01360986	469	0.005241492181876333	1.198736	63	66	0.004213483	
Mouse Phenotype Single KO	abnormal Mullerian duct morphology	69	4.239149e-54	5.625780781594203e-52	2.285699	450	0.008601739	486	0.006443909022633744	1.255819	35	35	0.002340824	
Mouse Phenotype Single KO	abnormal interventricular septum thickness	133	1.206295e-36	8.30529572556391e-35	2.024222	397	0.007588646	779	0.04623269384082156	1.197408	41	43	0.002742108	
Mouse Phenotype Single KO	increased hemangiosarcoma incidence	140	1.708776e-35	1.1176615594285713e-33	2.460247	250	0.004778744	792	0.04865723410479798	1.255819	24	24	0.001605136	
Mouse Phenotype Single KO	increased squamous cell carcinoma incidence	160	1.303336e-33	7.459154845000001e-32	2.433966	241	0.004606709	710	0.03439299555211268	1.255819	26	26	0.001738898	
Mouse Phenotype Single KO	thoracic vertebral transformation	178	3.252799e-32	1.6733640698314607e-30	2.03261	343	0.006556437	645	0.021848332258914728	1.203493	46	48	0.003076512	
Mouse Phenotype	abnormal liver sinusoid morphology	40	6.520964e-105	1.5586734201e-102	2.290508	881	0.01684029	487	0.000547449902587269	1.207518	75	78	0.005016051	
Mouse Phenotype	abnormal pulmonary valve cusp morphology	210	1.615886e-34	7.356898117142857e-33	2.083945	347	0.006632897	967	0.020987996739400206	1.255819	27	27	0.001805778