# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process negative regulation of transcription, DNA-templated 17 7.522799e-15 5.823088943588235e-12 2.094632 115 0.2613636 4 1.0275757828e-9 2.246949 90 1150 0.1376147 GO Biological Process negative regulation of RNA biosynthetic process 18 7.863588e-15 5.748719694e-12 2.074585 117 0.2659091 6 7.475774842166668e-10 2.206714 93 1210 0.1422018 GO Biological Process negative regulation of cellular macromolecule biosynthetic process 21 1.109029e-14 6.9493869576190475e-12 2.004396 124 0.2818182 9 1.3878342583444444e-9 2.103916 99 1351 0.1513761 GO Biological Process negative regulation of nucleic acid-templated transcription 22 1.147853e-14 6.8657261940909096e-12 2.072578 116 0.2636364 7 7.582697043428572e-10 2.212239 92 1194 0.1406728 GO Biological Process negative regulation of RNA metabolic process 23 1.810998e-14 1.0361270731304347e-11 2.032425 119 0.2704545 8 8.898392138999999e-10 2.166438 95 1259 0.1452599 GO Biological Process negative regulation of transcription from RNA polymerase II promoter 38 3.754894e-12 1.3002802670000001e-9 2.125064 92 0.2090909 2 1.9280468107500004e-9 2.560907 71 796 0.1085627 GO Biological Process cellular senescence 70 5.43643e-7 0.00010219711767142857 7.273436 11 0.025 202 0.04749690889455446 5.383314 6 32 0.009174312 GO Biological Process regulation of transforming growth factor beta receptor signaling pathway 73 0.000001073689 0.00019354347330136984 3.813255 19 0.04318182 201 0.046916594499004975 3.158211 11 100 0.01681957 GO Biological Process mammary gland epithelium development 90 0.00001951555 0.002853390249444444 3.714067 15 0.03409091 189 0.03649377811322752 4.253483 8 54 0.01223242 GO Biological Process positive regulation of epithelial to mesenchymal transition 94 0.00003367954 0.004714777307021276 3.744021 14 0.03181818 206 0.0479892696461165 4.567661 7 44 0.01070336 GO Biological Process anterior/posterior pattern specification 113 0.0001669754 0.019444506978761062 2.265084 25 0.05681818 104 0.00223582924125 2.929695 20 196 0.03058104 GO Biological Process orbitofrontal cortex development 120 0.0001873834 0.020548151338333334 14.58256 4 0.009090909 152 0.01418811171513158 21.53326 3 4 0.004587156 GO Biological Process response to starvation 121 0.000188943 0.020547941628099177 2.600964 19 0.04318182 137 0.009838859433576643 2.854311 17 171 0.02599388 GO Biological Process cellular response to steroid hormone stimulus 126 0.0002854004 0.029806221139682544 2.227384 24 0.05454545 197 0.04132091656446701 2.452699 17 199 0.02599388 GO Biological Process ectodermal placode formation 132 0.0004109032 0.040962690975757575 5.339472 7 0.01590909 132 0.007754594712424243 10.25393 5 14 0.00764526 GO Molecular Function transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding 11 1.027729e-7 0.00003944610761818182 2.625897 38 0.08636364 11 0.000009483763454545455 3.430076 27 226 0.0412844 GO Molecular Function retinoic acid-responsive element binding 16 6.346716e-7 0.00016747396845 14.91238 7 0.01590909 27 0.0256271178 21.53326 3 4 0.004587156 GO Molecular Function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding 20 0.000002324917 0.0004907899786999999 2.873793 26 0.05909091 23 0.0029211247026086963 3.453956 16 133 0.02446483 GO Molecular Function chromatin binding 21 0.00000269952 0.0005427320685714285 2.049716 48 0.1090909 16 0.0018428098521249998 2.169023 38 503 0.05810398 Mouse Phenotype Single KO abnormal sternebra number 1 5.327916e-10 0.0000048787726812 29.53161 8 0.01818182 41 0.0005425093684390243 13.25124 6 13 0.009174312 Mouse Phenotype Single KO increased sternebra number 2 8.413068e-8 0.00038519231838 29.24771 6 0.01363636 73 0.00588702777369863 16.40629 4 7 0.006116208 Mouse Phenotype Single KO abnormal rib joint 3 6.062686e-7 0.0018505338567333335 4.163045 18 0.04090909 6 0.000004961667034166667 6.292824 16 73 0.02446483 Mouse Phenotype Single KO abnormal sublingual duct morphology 4 0.000001202958 0.0027538716015 28.34686 5 0.01136364 69 0.005582559741594203 28.71101 3 3 0.004587156 Mouse Phenotype Single KO lymphoid hyperplasia 5 0.000002698317 0.0049416977538 8.011036 9 0.02045455 76 0.005798000343157895 6.930244 7 29 0.01070336 Mouse Phenotype Single KO abnormal salivary gland duct morphology 6 0.000005428675 0.008285062829166667 10.73205 7 0.01590909 156 0.02322738205576923 10.44037 4 11 0.006116208 Mouse Phenotype Single KO abnormal sternocostal joint morphology 7 0.000006687928 0.008748765242285714 4.075299 15 0.03409091 33 0.00019976070420909091 5.839527 12 59 0.01834862 Mouse Phenotype Single KO abnormal submandibular duct morphology 8 0.000006955335 0.007961250324375 13.55413 6 0.01363636 118 0.012717932255084746 21.53326 3 4 0.004587156 Mouse Phenotype Single KO large lymphoid organs 9 0.000007664373 0.007798073729 7.025366 9 0.02045455 98 0.008854491964285715 6.280533 7 32 0.01070336 Mouse Phenotype Single KO lethality throughout fetal growth and development 11 0.00001410388 0.011740839014545453 2.033981 42 0.09545455 7 0.000008435263574 2.961594 36 349 0.05504587 Mouse Phenotype Single KO ventricular hypoplasia 12 0.00001694404 0.012929714523333332 6.347921 9 0.02045455 140 0.018062032063571428 6.380224 6 27 0.009174312 Mouse Phenotype Single KO rib fusion 14 0.00002444222 0.01598695775285714 4.118757 13 0.02954545 47 0.0009394183834680851 4.921887 12 70 0.01834862 Mouse Phenotype Single KO vertebral transformation 15 0.00002771353 0.016918186280666665 4.068198 13 0.02954545 62 0.002590115050483871 4.05699 13 92 0.01987768 Mouse Phenotype Single KO abnormal sternebra morphology 22 0.00005173572 0.02153381763818182 3.823525 13 0.02954545 34 0.0001976731554970588 6.445329 11 49 0.01681957 Mouse Phenotype Single KO abnormal interventricular septum morphology 23 0.00005233713 0.020837004322173912 2.071589 35 0.07954545 11 0.000017871392242727274 3.122952 31 285 0.04740061 Mouse Phenotype Single KO ventricular septal defect 28 0.00007504055 0.02454093986964286 2.146456 31 0.07045455 8 0.00000966869087075 3.605569 27 215 0.0412844 Mouse Phenotype Single KO submandibular gland hypoplasia 30 0.00008550857 0.026100065849666666 8.610961 6 0.01363636 157 0.023276353274522293 17.22661 3 5 0.004587156 Mouse Phenotype Single KO abnormal palate development 31 0.00008959748 0.026465939495483867 2.674204 20 0.04545455 37 0.00031147683991891896 4.439847 15 97 0.02293578 Mouse Phenotype Single KO abnormal corpus callosum morphology 32 0.00009117389 0.0260899784603125 2.670682 20 0.04545455 53 0.0014366121857169812 4.060143 14 99 0.02140673 Mouse Phenotype Single KO abnormal dorsal telencephalic commissure morphology 36 0.000114372 0.029091788999999996 2.625121 20 0.04545455 57 0.0018987489317543861 3.940727 14 102 0.02140673 Mouse Phenotype abnormal sternebra number 1 5.327916e-10 0.000005094020487599999 29.53161 8 0.01818182 58 0.0004004176472068965 13.25124 6 13 0.009174312 Mouse Phenotype increased sternebra number 2 8.413068e-8 0.00040218671574 29.24771 6 0.01363636 121 0.0037083752895867767 16.40629 4 7 0.006116208 Mouse Phenotype abnormal rib joint 3 0.000001216309 0.0038763767829999994 3.622911 20 0.04545455 11 0.0000017820287233636365 5.348129 19 102 0.02905199 Mouse Phenotype thoracic vertebral transformation 4 0.00000148276 0.00354416709 6.550618 11 0.025 107 0.0021561252358878505 5.037019 10 57 0.01529052 Mouse Phenotype lymphoid hyperplasia 5 0.000006313511 0.012072695734199999 7.200031 9 0.02045455 154 0.005883274431818182 6.280533 7 32 0.01070336 Mouse Phenotype abnormal submandibular duct morphology 6 0.000006955335 0.011083326322500002 13.55413 6 0.01363636 183 0.008562439755737705 21.53326 3 4 0.004587156 Mouse Phenotype abnormal hypodermis morphology 7 0.000007588461 0.010364753660142858 3.197903 20 0.04545455 270 0.025570717444444443 2.697679 14 149 0.02140673 Mouse Phenotype large lymphoid organs 10 0.00001632788 0.015611086068 6.378269 9 0.02045455 199 0.010005687394974875 5.582696 7 36 0.01070336 Mouse Phenotype decreased erythrocyte cell number 11 0.00001837224 0.015968816967272727 2.54941 26 0.05909091 133 0.004432866353233082 2.610092 21 231 0.03211009 Mouse Phenotype abnormal sternocostal joint morphology 13 0.00002081691 0.015310036654615385 3.505242 16 0.03636364 55 0.00029732206756363636 4.976575 13 75 0.01987768 Mouse Phenotype abnormal sublingual gland morphology 14 0.00002098938 0.01433424729857143 11.12381 6 0.01363636 257 0.021475066266536967 9.570336 4 12 0.006116208 Mouse Phenotype rib fusion 15 0.00002458271 0.015669019354 3.300111 17 0.03863636 35 0.00007112477070857142 4.687512 16 98 0.02446483 Mouse Phenotype abnormal salivary gland duct morphology 16 0.00002774429 0.016578947293125 8.305929 7 0.01590909 298 0.0354264567181208 8.203145 4 14 0.006116208 Mouse Phenotype abnormal sublingual duct morphology 20 0.00004008134 0.019160884587 13.62747 5 0.01136364 275 0.027030768805090907 14.3555 3 6 0.004587156 Mouse Phenotype abnormal rib development 26 0.00005613551 0.020642754273461537 6.235324 8 0.01818182 165 0.006761736214545454 6.090214 7 33 0.01070336 Mouse Phenotype decreased myeloid cell number 35 0.00008075447 0.02205981393342857 2.051305 34 0.07727273 171 0.007105114573684211 2.118624 29 393 0.04434251 Mouse Phenotype submandibular gland hypoplasia 36 0.00008550857 0.022709651049166665 8.610961 6 0.01363636 236 0.016167865717372883 17.22661 3 5 0.004587156 Mouse Phenotype abnormal sternebra morphology 38 0.00008683072 0.021847066155789473 3.421242 14 0.03181818 34 0.00007094886277058823 5.831924 13 64 0.01987768 Mouse Phenotype abnormal platelet morphology 41 0.00009562863 0.02230013003487805 2.18364 29 0.06590909 221 0.014529064323529411 2.129897 25 337 0.0382263 Mouse Phenotype ventricular hypoplasia 44 0.00009996047 0.021720955765227274 5.027426 9 0.02045455 271 0.025723369517712178 5.383314 6 32 0.009174312