# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process negative regulation of intracellular signal transduction 24 1.001561e-131 5.491475499583334e-129 2.619064 801 0.1315055 82 0.00031422616813414633 1.38499 162 493 0.03636364 GO Biological Process regulation of organ morphogenesis 37 1.660062e-107 5.903988069729729e-105 2.817063 588 0.09653587 115 0.0013643365626086956 1.5065 89 249 0.01997755 GO Biological Process negative regulation of protein phosphorylation 39 1.772912e-102 5.981986925128206e-100 2.425445 720 0.1182072 277 0.029603213232851984 1.295285 126 410 0.02828283 GO Biological Process negative regulation of protein modification process 45 2.606579e-96 7.622216235777778e-94 2.1806 832 0.136595 184 0.007596504757608696 1.274086 185 612 0.04152637 GO Biological Process negative regulation of phosphorylation 47 2.312795e-95 6.475333915957448e-93 2.303279 740 0.1214907 214 0.011773129784579438 1.310647 139 447 0.0312009 GO Biological Process positive regulation of apoptotic process 49 5.070962e-95 1.3618120195510203e-92 2.19591 810 0.1329831 206 0.011178001980097088 1.269437 178 591 0.03995511 GO Biological Process positive regulation of cell death 50 2.724929e-94 7.1714681422e-92 2.133754 853 0.1400427 203 0.01076397124827586 1.258545 192 643 0.04309764 GO Biological Process positive regulation of programmed cell death 54 2.266721e-93 5.523663266481481e-91 2.17687 811 0.1331473 220 0.01294396399590909 1.263738 179 597 0.04017957 GO Biological Process negative regulation of transferase activity 59 6.30817e-87 1.4069357462711865e-84 2.590026 548 0.08996881 328 0.04472904575609756 1.299568 111 360 0.02491582 GO Biological Process negative regulation of phosphate metabolic process 68 8.069548e-81 1.5615762078235293e-78 2.022275 830 0.1362666 242 0.019236919158264462 1.258591 172 576 0.03860831 GO Biological Process negative regulation of phosphorus metabolic process 69 8.620559e-81 1.6440280562463768e-78 2.021979 830 0.1362666 249 0.02048671334136546 1.256409 172 577 0.03860831 GO Biological Process kidney development 85 1.794886e-73 2.7786946910588232e-71 2.279651 588 0.09653587 118 0.001476019381101695 1.499341 90 253 0.02020202 GO Biological Process renal system development 93 9.917271e-69 1.4032405278387096e-66 2.176155 606 0.09949105 88 0.00048050028686363633 1.51984 97 269 0.02177329 GO Biological Process urogenital system development 100 2.967223e-67 3.9045687457e-65 2.095126 644 0.1057298 92 0.000680667154076087 1.479372 106 302 0.02379349 GO Biological Process embryonic placenta development 133 2.529705e-57 2.5028863229323306e-55 3.495672 232 0.03808898 237 0.01844646942658228 1.704869 36 89 0.008080808 GO Biological Process cellular response to decreased oxygen levels 144 2.010445e-55 1.837183732986111e-53 2.899126 292 0.04793958 248 0.020160421049596772 1.464094 66 190 0.01481481 GO Biological Process cellular response to hypoxia 162 1.272565e-51 1.0336841256172838e-49 2.844024 280 0.04596946 330 0.04600039480909091 1.42797 62 183 0.01391695 GO Biological Process cellular response to oxygen levels 163 2.797497e-51 2.2584210443558283e-49 2.736117 296 0.04859629 266 0.02610553161992481 1.432219 70 206 0.01571268 GO Biological Process in utero embryonic development 183 1.31999e-46 9.491665797814208e-45 2.082408 456 0.07486455 96 0.0007262598768020832 1.467779 109 313 0.02446689 GO Biological Process positive regulation of cellular protein localization 191 3.559733e-46 2.4524883008900526e-44 2.037986 475 0.07798391 335 0.048050697349253726 1.281388 121 398 0.02716049 GO Cellular Component nuclear chromatin 23 8.41014e-55 6.318574747826087e-53 2.396305 400 0.06567066 31 0.00399617057032258 1.400492 105 316 0.02356902 GO Cellular Component chromatin 26 5.967213e-50 3.965901563076922e-48 2.057701 502 0.08241668 28 0.0007987667657142857 1.352904 156 486 0.03501684 GO Cellular Component epsilon DNA polymerase complex 124 2.594028e-7 0.000003614903535483871 7.921691 11 0.001805943 50 0.025938054144 4.214815 5 5 0.001122334 GO Cellular Component preribosome, large subunit precursor 154 0.00000217838 0.00002444312103896104 3.09488 24 0.00394024 72 0.048670032 2.191704 13 25 0.00291807 GO Cellular Component U1 snRNP 226 0.0001782163 0.0013626449840707965 2.729175 18 0.00295518 65 0.03828203224615385 2.440156 11 19 0.002469136 GO Cellular Component nucleotide-excision repair complex 253 0.0005699166 0.0038925529043478263 2.547125 17 0.002791003 44 0.0198036144 2.809877 10 15 0.002244669 GO Cellular Component NuA4 histone acetyltransferase complex 262 0.000777779 0.005129779053435115 2.336616 19 0.003119356 51 0.026132452517647058 2.57572 11 18 0.002469136 GO Molecular Function cadherin binding 13 1.685759e-39 5.474826536923077e-37 2.162234 355 0.05828271 6 1.293431513666667e-9 1.760794 127 304 0.0285073 GO Molecular Function protein phosphatase binding 50 6.39446e-18 5.399482024e-16 2.143252 158 0.02593991 36 0.009121209972777778 1.693452 45 112 0.01010101 Mouse Phenotype Single KO decreased embryo size 14 2.247126e-106 1.469780913e-103 2.305262 819 0.1344607 10 0.000026197536010000003 1.449628 173 503 0.03883277 Mouse Phenotype Single KO abnormal embryo size 19 4.904716e-97 2.3638149690526314e-94 2.137406 873 0.1433262 9 0.000028454115868888888 1.404938 204 612 0.04579125 Mouse Phenotype Single KO embryonic lethality during organogenesis, incomplete penetrance 49 4.381933e-70 8.188849077755103e-68 2.462818 485 0.07962568 47 0.011340346372553193 1.469064 84 241 0.01885522 Mouse Phenotype Single KO abnormal embryonic hematopoiesis 73 2.238969e-58 2.808525908630137e-56 4.386085 181 0.02971597 59 0.024817518684745764 1.98812 25 53 0.005611672 Mouse Phenotype Single KO decreased erythroid progenitor cell number 97 4.510058e-50 4.257587742886598e-48 4.091494 167 0.0274175 48 0.013895173279791666 2.066086 25 51 0.005611672 Mouse Phenotype Single KO enlarged inguinal lymph nodes 167 4.096067e-31 2.245969192754491e-29 9.334703 50 0.008208833 29 0.003155323164862069 4.214815 8 8 0.001795735 Mouse Phenotype Single KO decreased cell migration 374 3.235698e-14 7.922269140641712e-13 2.457009 92 0.01510425 34 0.003243807998823529 2.241923 25 47 0.005611672 Mouse Phenotype Single KO decreased fibroblast cell migration 390 9.776803e-14 2.2955432069487178e-12 2.559958 82 0.01346249 50 0.017031479736999998 2.288042 19 35 0.004264871 Mouse Phenotype Single KO abnormal fibroblast migration 422 3.228463e-12 7.005458694549762e-11 2.371602 83 0.01362666 75 0.05003939103733334 2.056007 20 41 0.004489338 Mouse Phenotype Single KO short vibrissae 753 0.000008804703 0.00010707126875298806 2.2483 37 0.006074536 41 0.010241610915365854 2.883821 13 19 0.00291807 Mouse Phenotype abnormal fibroblast physiology 15 5.942967e-143 3.7880471658e-140 3.675606 541 0.08881957 101 0.012318231472277227 1.432704 86 253 0.01930415 Mouse Phenotype decreased embryo size 31 7.068056e-102 2.179925271483871e-99 2.124369 925 0.1518634 11 0.000007985267235272726 1.416232 209 622 0.04691358 Mouse Phenotype small liver 37 1.278253e-95 3.3030748467567572e-93 2.963776 486 0.07978985 110 0.01661687893090909 1.448843 77 224 0.01728395 Mouse Phenotype enlarged lymph nodes 72 1.833616e-71 2.434889246666667e-69 2.928858 371 0.06090954 94 0.011923757039361703 1.46851 77 221 0.01728395 Mouse Phenotype embryonic lethality during organogenesis, incomplete penetrance 118 7.568486e-56 6.132397851355933e-54 2.094551 538 0.08832704 140 0.025907025113571427 1.348741 104 325 0.02334456 Mouse Phenotype abnormal lymph node size 129 2.292245e-52 1.6989267011627909e-50 2.352671 396 0.06501396 95 0.011802994114736842 1.409885 95 284 0.02132435 Mouse Phenotype abnormal embryonic hematopoiesis 131 5.819662e-52 4.247464761984733e-50 3.888389 184 0.0302085 183 0.04444754252131147 1.796478 26 61 0.005836139 Mouse Phenotype abnormal lymph node morphology 174 1.595745e-43 8.768343646551723e-42 2.011608 462 0.07584961 107 0.015880043610280375 1.328809 128 406 0.02873176 Mouse Phenotype decreased erythroid progenitor cell number 195 2.258129e-40 1.1071780189230769e-38 3.25814 178 0.02922344 129 0.022021169430232558 1.774659 32 76 0.007182941 Mouse Phenotype enlarged inguinal lymph nodes 262 5.686713e-31 2.0752161447709923e-29 9.266556 50 0.008208833 82 0.008277776214878048 3.746502 8 9 0.001795735 Mouse Phenotype decreased tumor growth/size 278 6.503857e-29 2.2368121142805757e-27 2.575251 182 0.02988015 133 0.02303093936842105 1.607345 45 118 0.01010101 Mouse Phenotype extramedullary hematopoiesis 414 6.571636e-19 1.5176669515942027e-17 2.031869 190 0.03119356 195 0.04839726227384615 1.445079 60 175 0.01346801 Mouse Phenotype decreased fibroblast cell migration 586 3.345153e-12 5.4578511660409557e-11 2.315503 87 0.01428337 86 0.009638645325697675 2.156417 22 43 0.004938272 Mouse Phenotype abnormal fibroblast migration 623 4.793635e-11 7.356652365168539e-10 2.161182 90 0.0147759 84 0.008290410254642857 2.066086 25 51 0.005611672 Mouse Phenotype abnormal epidermis stratum granulosum morphology 630 6.540848e-11 9.926515512380952e-10 2.098197 95 0.01559678 93 0.011991704338709677 1.813971 34 79 0.007631874 Mouse Phenotype abnormal cell adhesion 635 7.900839e-11 1.1896050658110235e-9 2.022143 103 0.0169102 77 0.005607905214935065 1.885575 34 76 0.007631874 Mouse Phenotype dermal-epidermal separation 871 6.266034e-7 0.000006878249262227326 3.557392 22 0.003611886 192 0.047546608995312496 3.278189 7 9 0.001571268 Mouse Phenotype abnormal hair follicle orientation 972 0.000005227403 0.000051418930126543204 2.002227 51 0.008373009 149 0.02785872629798658 2.247901 16 30 0.00359147 Mouse Phenotype dry skin 996 0.000007333869 0.00007040072440662651 2.187471 40 0.006567066 185 0.04453352038216216 2.002037 19 40 0.004264871 Mouse Phenotype short vibrissae 1144 0.0000914922 0.000764647661013986 2.004644 37 0.006074536 142 0.027127398367605634 2.490572 13 22 0.00291807