# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process immune response-activating signal transduction 40 8.313233e-51 2.7348458261749998e-48 2.014266 546 0.06260032 161 0.0000020466495111801243 1.391449 184 382 0.02830769 GO Biological Process regulation of innate immune response 43 5.701227e-49 1.7447080486744186e-46 2.013111 527 0.06042192 255 0.00013553088828235295 1.312446 189 416 0.02907692 GO Biological Process regulation of antigen receptor-mediated signaling pathway 54 1.098641e-44 2.6772253553703705e-42 3.772423 164 0.01880303 300 0.0004755438897 1.853173 34 53 0.005230769 GO Biological Process immune response-activating cell surface receptor signaling pathway 55 2.307108e-44 5.5198607585454544e-42 2.141033 413 0.04735152 222 0.00004290147563558559 1.403698 138 284 0.02123077 GO Biological Process regulation of immune effector process 58 3.882068e-43 8.807609105517241e-41 2.01818 461 0.05285485 235 0.00006472828106382978 1.348624 169 362 0.026 GO Biological Process adaptive immune response 76 1.56199e-37 2.704503475e-35 2.092436 367 0.04207751 360 0.001427805598111111 1.341601 124 267 0.01907692 GO Biological Process regulation of B cell activation 81 4.72601e-35 7.67772414691358e-33 2.387239 258 0.02958037 507 0.009747169778303748 1.457167 57 113 0.008769231 GO Biological Process antigen receptor-mediated signaling pathway 85 6.33674e-35 9.810019018823528e-33 2.228426 296 0.03393717 274 0.0002680607403357664 1.477975 88 172 0.01353846 GO Biological Process negative regulation of protein serine/threonine kinase activity 95 3.164357e-33 4.3831340803157895e-31 2.321695 258 0.02958037 534 0.01381373417696629 1.421088 61 124 0.009384615 GO Biological Process negative regulation of immune response 98 1.409311e-32 1.8923595356122447e-30 2.457748 226 0.02591149 505 0.008978555073267327 1.433012 63 127 0.009692308 GO Biological Process regulation of lymphocyte differentiation 103 6.989972e-32 8.93019820854369e-30 2.089872 311 0.03565696 181 0.000006137564072707182 1.604872 85 153 0.01307692 GO Biological Process negative regulation of leukocyte activation 109 4.814238e-31 5.811977783669725e-29 2.141267 286 0.03279064 177 0.000004618499726327683 1.617711 84 150 0.01292308 GO Biological Process negative regulation of cell activation 128 2.053493e-29 2.111087061484375e-27 2.039929 303 0.03473974 172 0.000003022365240465116 1.589678 93 169 0.01430769 GO Biological Process lymphocyte costimulation 144 4.393148e-27 4.0145440647222227e-25 2.965117 135 0.0154781 573 0.018728421590226876 1.546102 38 71 0.005846154 GO Biological Process positive regulation of leukocyte differentiation 145 4.638723e-27 4.209721100482759e-25 2.012706 287 0.0329053 247 0.00010713152119838058 1.575692 72 132 0.01107692 GO Biological Process positive T cell selection 153 1.530991e-26 1.3167523247712418e-24 3.943098 90 0.01031873 734 0.04784721759536785 1.88398 15 23 0.002307692 GO Biological Process interferon-gamma-mediated signaling pathway 162 5.203669e-26 4.226856813024691e-24 3.134197 119 0.01364366 672 0.03481534592261905 1.534659 34 64 0.005230769 GO Biological Process negative regulation of lymphocyte activation 183 4.40133e-25 3.164868932786885e-23 2.107864 237 0.02717267 307 0.0005411739478501629 1.534659 68 128 0.01046154 GO Biological Process B cell receptor signaling pathway 186 7.165859e-25 5.0696526118817204e-23 3.201885 110 0.01261179 456 0.004927098975438597 1.898334 23 35 0.003538462 GO Biological Process regulation of leukocyte mediated immunity 193 1.896111e-24 1.2927940232642485e-22 2.106473 231 0.02648475 523 0.01254208192581262 1.372165 76 160 0.01169231 GO Cellular Component extrinsic component of cytoplasmic side of plasma membrane 31 8.659292e-24 4.8268569600000005e-22 2.248237 194 0.0222426 45 0.0008526493440000001 1.563646 59 109 0.009076923 GO Cellular Component MHC protein complex 115 1.104275e-8 1.6592932173913046e-7 4.524555 22 0.002522357 79 0.029253355746835442 2.022138 14 20 0.002153846 GO Molecular Function chemokine binding 13 8.18195e-23 2.657245607692308e-20 4.208515 71 0.008140335 116 0.04948107567241379 1.925846 16 24 0.002461538 GO Molecular Function non-membrane spanning protein tyrosine kinase activity 47 2.881929e-14 2.5888306889361705e-12 2.317522 104 0.01192387 49 0.0009592134126530612 1.869204 33 51 0.005076923 GO Molecular Function NAD+ ADP-ribosyltransferase activity 212 0.000003458989 0.00006888609225471699 2.348674 37 0.004242146 102 0.026409773119607842 2.063407 15 21 0.002307692 Human Phenotype Premature birth 110 3.598767e-7 0.000021831429264545454 2.030454 62 0.007108461 1 0.038357818676 1.969615 30 44 0.004615385 Mouse Phenotype Single KO abnormal adaptive immunity 1 2.213756e-219 2.0271363692e-215 2.107908 1949 0.2234579 7 5.4824332549999996e-27 1.433012 630 1270 0.09692308 Mouse Phenotype Single KO abnormal immune cell physiology 2 1.898577e-217 8.6926347945e-214 2.118564 1915 0.2195597 6 5.341162111333333e-27 1.439718 617 1238 0.09492308 Mouse Phenotype Single KO abnormal cell-mediated immunity 3 5.000312e-217 1.5262618994666667e-213 2.113381 1921 0.2202476 5 6.3216558224000005e-27 1.437452 622 1250 0.09569231 Mouse Phenotype Single KO abnormal leukocyte physiology 4 3.948084e-216 9.038151297e-213 2.120203 1902 0.2180693 4 5.45662196125e-27 1.445573 608 1215 0.09353846 Mouse Phenotype Single KO abnormal hematopoietic system physiology 5 2.035021e-210 3.7269374594e-207 2.005484 2080 0.2384774 2 4.960859692e-29 1.431861 686 1384 0.1055385 Mouse Phenotype Single KO abnormal blood cell physiology 6 2.411948e-209 3.681034639333333e-206 2.047532 1984 0.2274708 8 8.6431137385e-27 1.421458 651 1323 0.1001538 Mouse Phenotype Single KO abnormal lymphocyte physiology 7 2.868154e-209 3.7519551682857145e-206 2.343728 1532 0.1756478 1 6.124349027699999e-29 1.559868 466 863 0.07169231 Mouse Phenotype Single KO abnormal immune serum protein physiology 9 1.256408e-169 1.2783253395555557e-166 2.170933 1463 0.1677368 35 7.210064822857144e-18 1.40923 461 945 0.07092308 Mouse Phenotype Single KO abnormal T cell physiology 13 8.519448e-155 6.000968102769231e-152 2.546635 1002 0.1148819 9 3.880149534555556e-24 1.656228 301 525 0.04630769 Mouse Phenotype Single KO abnormal professional antigen presenting cell physiology 19 6.724981e-139 3.241086895631579e-136 2.093832 1313 0.1505389 44 3.2347643595454544e-16 1.41206 415 849 0.06384615 Mouse Phenotype Single KO abnormal B cell physiology 25 3.193959e-129 1.16988330252e-126 2.363501 964 0.1105251 55 3.932848254545455e-14 1.487023 279 542 0.04292308 Mouse Phenotype Single KO abnormal T cell morphology 26 8.503412e-129 2.9948362955384614e-126 2.033739 1305 0.1496216 24 1.8689772756666667e-20 1.470457 423 831 0.06507692 Mouse Phenotype Single KO abnormal hemopoiesis 28 1.039357e-128 3.399068588928571e-126 2.040233 1295 0.1484751 22 2.4726730345454545e-21 1.513165 385 735 0.05923077 Mouse Phenotype Single KO abnormal cytokine secretion 29 5.077091e-128 1.603135251275862e-125 2.392642 934 0.1070855 42 1.8392165896190476e-16 1.512683 299 571 0.046 Mouse Phenotype Single KO abnormal humoral immune response 31 2.776474e-120 8.201345941290323e-118 2.410486 868 0.09951846 60 7.897115841e-13 1.48851 253 491 0.03892308 Mouse Phenotype Single KO abnormal immunoglobulin level 34 1.559887e-119 4.2011427232352946e-117 2.48606 816 0.09355652 72 2.3289710311111112e-11 1.479614 231 451 0.03553846 Mouse Phenotype Single KO increased lymphocyte cell number 35 4.666567e-116 1.2209072576857143e-113 2.155164 1045 0.119812 20 8.6397897475e-22 1.57183 333 612 0.05123077 Mouse Phenotype Single KO abnormal alpha-beta T cell morphology 39 6.748645e-103 1.5845472375641025e-100 2.064235 1024 0.1174043 46 5.203660333913044e-16 1.484053 318 619 0.04892308 Mouse Phenotype Single KO abnormal B cell morphology 40 2.086538e-102 4.7766071165e-100 2.075592 1007 0.1154552 32 2.494430899e-18 1.551473 297 553 0.04569231 Mouse Phenotype Single KO abnormal lymphopoiesis 41 2.126059e-102 4.748371283658536e-100 2.204635 885 0.1014676 17 2.387589716235294e-22 1.693416 255 435 0.03923077 Mouse Phenotype abnormal adaptive immunity 1 2.085745e-236 1.9941807945000003e-232 2.007662 2290 0.2625545 7 3.4076810832857146e-32 1.423804 761 1544 0.1170769 Mouse Phenotype abnormal cell-mediated immunity 2 1.016059e-235 4.8572700495e-232 2.016123 2265 0.2596881 5 3.094016088e-32 1.428262 753 1523 0.1158462 Mouse Phenotype abnormal immune cell physiology 4 2.498572e-235 5.972211723e-232 2.01826 2257 0.2587709 6 2.673472316e-32 1.430046 748 1511 0.1150769 Mouse Phenotype abnormal leukocyte physiology 5 4.90122e-233 9.372112884e-230 2.01893 2237 0.2564779 4 1.037730144825e-32 1.438537 738 1482 0.1135385 Mouse Phenotype abnormal lymphocyte physiology 7 4.388873e-218 5.994573536142856e-215 2.182941 1812 0.2077505 3 1.9669880357e-33 1.525143 576 1091 0.08861538 Mouse Phenotype abnormal immune serum protein physiology 11 2.074608e-185 1.8032115534545453e-182 2.078052 1731 0.1984637 45 2.344248842e-21 1.399481 561 1158 0.08630769 Mouse Phenotype abnormal hemopoiesis 22 3.051671e-163 1.3262284741363636e-160 2.017976 1645 0.1886035 18 7.036885376666667e-27 1.487544 517 1004 0.07953846 Mouse Phenotype abnormal professional antigen presenting cell physiology 25 2.407256e-160 9.206309846400001e-158 2.049963 1565 0.1794313 44 1.9335260277954545e-21 1.427491 507 1026 0.078 Mouse Phenotype abnormal T cell physiology 26 4.139849e-157 1.5223498572692308e-154 2.297182 1222 0.1401055 20 3.0444442152000003e-26 1.585503 382 696 0.05876923 Mouse Phenotype abnormal lymphopoiesis 28 9.037356e-153 3.0859343112857143e-150 2.245216 1244 0.1426278 10 1.1630401962e-31 1.668475 376 651 0.05784615 Mouse Phenotype abnormal B cell physiology 30 4.904013e-149 1.5629089431e-146 2.296578 1164 0.1334556 49 4.578917046734694e-20 1.517247 354 674 0.05446154 Mouse Phenotype abnormal leukopoiesis 31 3.406455e-148 1.0506166533870968e-145 2.1333 1340 0.1536345 13 3.101434688538462e-30 1.603171 419 755 0.06446154 Mouse Phenotype abnormal cytokine secretion 33 4.782634e-147 1.3856595052727274e-144 2.294986 1151 0.1319651 60 3.064504468e-17 1.462465 364 719 0.056 Mouse Phenotype decreased B cell number 35 7.721809e-144 2.1093775956857145e-141 2.387828 1047 0.1200413 25 1.58102722932e-25 1.698572 284 483 0.04369231 Mouse Phenotype abnormal B cell number 37 1.049347e-143 2.711569369459459e-141 2.1942 1230 0.1410227 34 3.3054907852941174e-24 1.579312 357 653 0.05492308 Mouse Phenotype abnormal mature B cell morphology 38 2.816821e-143 7.087269889736844e-141 2.19029 1231 0.1411374 35 4.230649621714286e-24 1.576493 358 656 0.05507692 Mouse Phenotype abnormal humoral immune response 39 7.519714e-143 1.843486809076923e-140 2.358675 1064 0.1219904 67 1.2146203071044777e-16 1.499845 311 599 0.04784615 Mouse Phenotype abnormal B cell morphology 40 8.505246e-143 2.0329664251499997e-140 2.121581 1310 0.1501949 26 2.7108751931538458e-25 1.562253 391 723 0.06015385 Mouse Phenotype abnormal immunoglobulin level 41 3.962543e-135 9.240456981219512e-133 2.391661 984 0.1128182 72 2.2554571629166668e-15 1.50216 286 550 0.044 Mouse Phenotype increased lymphocyte cell number 44 3.86243e-124 8.392884825e-122 2.021251 1279 0.1466407 30 1.3349648234000002e-24 1.525937 421 797 0.06476923