# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process regulation of gene expression, epigenetic 68 1.939545e-69 3.753304802205882e-67 2.121523 678 0.03249461 571 0.00892784914816112 1.211103 153 248 0.01599582 GO Biological Process regulation of intrinsic apoptotic signaling pathway 132 2.35757e-50 2.3502472446969698e-48 2.162411 468 0.02242991 807 0.036246066001239155 1.228517 97 155 0.01014114 GO Biological Process platelet aggregation 150 4.993928e-47 4.3810065701333336e-45 3.288985 208 0.009968847 882 0.04619562434807257 1.436411 30 41 0.003136435 GO Biological Process negative regulation of immune response 165 2.456336e-43 1.9589651772121213e-41 2.054779 452 0.02166307 824 0.036930302319174754 1.252052 81 127 0.008468374 GO Biological Process response to hydrogen peroxide 176 1.24927e-41 9.340422687499999e-40 2.092596 415 0.01988977 309 0.00014936418921035602 1.422793 79 109 0.008259279 GO Biological Process cellular response to topologically incorrect protein 196 3.029907e-38 2.0342115414795917e-36 2.133929 363 0.01739756 387 0.0007602685355555556 1.341683 95 139 0.009932044 GO Biological Process endoplasmic reticulum unfolded protein response 217 3.589584e-35 2.1767435878341015e-33 2.220988 304 0.01456985 348 0.000353927564683908 1.39483 81 114 0.008468374 GO Biological Process cellular response to hydrogen peroxide 239 1.015382e-32 5.590548844351464e-31 2.277364 267 0.01279655 703 0.019720867314367 1.393164 44 62 0.004600105 GO Biological Process cellular response to unfolded protein 247 9.292368e-32 4.950537267692308e-30 2.075627 319 0.01528876 319 0.00020262941838557994 1.395257 86 121 0.008991113 GO Biological Process regulation of tyrosine phosphorylation of STAT protein 265 2.420887e-30 1.2021302653962264e-28 2.126737 287 0.01375509 795 0.03431269665534591 1.346122 48 70 0.005018296 GO Biological Process T-helper cell lineage commitment 267 3.077684e-30 1.5168256088389514e-28 6.196987 66 0.003163192 818 0.037084828929095356 1.963095 9 9 0.0009409305 GO Biological Process monocyte differentiation 275 2.315904e-29 1.1081811176727273e-27 3.072692 140 0.006709801 851 0.0404568584159812 1.717708 14 16 0.00146367 GO Biological Process homotypic cell-cell adhesion 302 3.102427e-27 1.3518157911589405e-25 2.204025 236 0.01131081 625 0.01342719726352 1.444541 39 53 0.004077365 GO Biological Process Fc-gamma receptor signaling pathway involved in phagocytosis 306 4.398451e-27 1.8914776702287584e-25 2.043467 280 0.0134196 407 0.0011824541606879607 1.465409 53 71 0.005541035 GO Biological Process Fc-gamma receptor signaling pathway 319 1.904788e-26 7.857399778056425e-25 2.022797 280 0.0134196 575 0.009093674559652173 1.387254 53 75 0.005541035 GO Biological Process positive regulation of actin filament polymerization 322 2.587783e-26 1.0575352949378883e-24 2.04816 270 0.01294033 658 0.01563391592218845 1.371477 51 73 0.005331939 GO Biological Process negative regulation of endoplasmic reticulum unfolded protein response 332 4.855394e-26 1.9244617363253013e-24 4.887837 70 0.003354901 818 0.037084828929095356 1.963095 9 9 0.0009409305 GO Biological Process organelle transport along microtubule 370 5.97001e-24 2.123225988918919e-22 2.084161 234 0.01121495 467 0.0025602651963597435 1.457449 49 66 0.005122844 GO Biological Process regulation of megakaryocyte differentiation 397 4.413096e-23 1.4627690242821156e-21 2.076058 227 0.01087946 885 0.04652661085084746 1.31734 51 76 0.005331939 GO Biological Process negative regulation of oligodendrocyte differentiation 435 8.588272e-22 2.598001637885057e-20 2.726547 123 0.00589504 721 0.021422614736477115 1.963095 10 10 0.001045478 GO Cellular Component ribosomal subunit 55 4.493409e-34 1.4117474094545455e-32 2.018232 368 0.01763719 109 0.033671126311926605 1.209691 114 185 0.01191845 GO Cellular Component podosome 122 8.093745e-16 1.1463927344262293e-14 2.2242 128 0.006134675 103 0.026711189126213595 1.556937 23 29 0.0024046 GO Molecular Function nucleosomal DNA binding 27 8.329585e-27 1.3025002914814814e-24 2.723389 154 0.007380781 118 0.04429736711864407 1.450983 34 46 0.003554626 GO Molecular Function nucleosome binding 46 6.405467e-20 5.87910471173913e-18 2.073782 194 0.009297867 101 0.026522474413861387 1.397961 47 66 0.004913748 GO Molecular Function protein binding involved in protein folding 69 6.065756e-17 3.711539395942029e-15 2.865069 86 0.004121735 110 0.03988964790909091 1.599559 22 27 0.002300052 Human Phenotype Gastrointestinal hemorrhage 139 7.482088e-9 3.5919405197122307e-7 2.02794 81 0.003882099 91 0.027293471954945057 1.66108 22 26 0.002300052 Mouse Phenotype Single KO abnormal T cell activation 28 2.836749e-109 9.277182354642858e-107 2.091214 1102 0.05281572 156 0.0000033645641408333333 1.304201 192 289 0.02007318 Mouse Phenotype Single KO abnormal T cell proliferation 32 3.95824e-101 1.132675115e-98 2.095473 1016 0.04869399 181 0.000016309143148066296 1.301208 173 261 0.01808677 Mouse Phenotype Single KO abnormal CD4-positive, alpha-beta T cell physiology 39 3.13032e-81 7.349830830769231e-79 2.385343 619 0.02966691 555 0.01713535385765766 1.251638 95 149 0.009932044 Mouse Phenotype Single KO decreased T cell proliferation 45 5.231886e-78 1.0646306689333332e-75 2.249239 670 0.03211119 252 0.0002707353896150794 1.347992 103 150 0.01076843 Mouse Phenotype Single KO abnormal circulating cytokine level 55 1.704037e-69 2.8370666925454546e-67 2.037273 747 0.03580158 449 0.007396539217817372 1.206329 161 262 0.0168322 Mouse Phenotype Single KO abnormal erythropoiesis 62 6.475373e-65 9.563708155e-63 2.229473 567 0.02717469 113 7.313623778495576e-8 1.552629 87 110 0.009095661 Mouse Phenotype Single KO abnormal embryonic hematopoiesis 69 6.453498e-59 8.564446548695652e-57 2.63155 372 0.0178289 201 0.000052068888746268654 1.629739 44 53 0.004600105 Mouse Phenotype Single KO abnormal mean corpuscular hemoglobin 73 2.76329e-58 3.4662255520547947e-56 2.048375 617 0.02957105 208 0.00006711328188942308 1.346122 120 175 0.01254574 Mouse Phenotype Single KO abnormal circulating interleukin level 82 1.038249e-54 1.1594202552439024e-52 2.036201 587 0.02813324 666 0.031917617201201204 1.197009 125 205 0.01306848 Mouse Phenotype Single KO decreased erythroid progenitor cell number 83 4.12084e-54 4.5463291421686744e-52 2.560464 358 0.01715792 318 0.001392774228836478 1.539682 40 51 0.004181913 Mouse Phenotype Single KO abnormal platelet activation 87 9.162455e-53 9.643747176436781e-51 2.480343 370 0.01773305 262 0.0003568332613358779 1.455 63 85 0.006586513 Mouse Phenotype Single KO abnormal circulating tumor necrosis factor level 89 4.892147e-52 5.033414615617977e-50 2.520347 354 0.01696621 527 0.013571344702466792 1.30873 70 105 0.007318348 Mouse Phenotype Single KO enlarged lymph nodes 94 1.131581e-49 1.1023284273404254e-47 2.059905 517 0.02477834 246 0.0002336519848495935 1.37269 93 133 0.009722948 Mouse Phenotype Single KO abnormal embryonic erythrocyte morphology 98 2.508271e-49 2.3436977088775514e-47 3.221737 225 0.01078361 582 0.021084448776632302 1.514387 27 35 0.002822791 Mouse Phenotype Single KO abnormal platelet aggregation 108 2.593351e-47 2.1988254728703704e-45 2.418783 347 0.01663072 288 0.0006144076741319444 1.459737 58 78 0.006063774 Mouse Phenotype Single KO abnormal platelet physiology 114 5.487615e-47 4.407902680263158e-45 2.140662 446 0.02137551 182 0.00001625762961648352 1.463398 82 110 0.008572922 Mouse Phenotype Single KO decreased platelet aggregation 125 1.101911e-43 8.0721592216e-42 2.678111 265 0.01270069 376 0.002833385242021276 1.472321 45 60 0.004704652 Mouse Phenotype Single KO thymus hyperplasia 135 5.152973e-40 3.495242500814815e-38 3.429913 166 0.007955907 606 0.024058430891089107 1.556937 23 29 0.0024046 Mouse Phenotype Single KO abnormal spleen secondary B follicle morphology 154 2.088864e-36 1.2420602368831168e-34 2.087748 363 0.01739756 731 0.04249266390971272 1.270238 66 102 0.006900157 Mouse Phenotype Single KO increased IgG1 level 189 4.456613e-31 2.1592172085185186e-29 2.134074 292 0.01399473 256 0.00028777843401171874 1.499586 55 72 0.005750131 Mouse Phenotype abnormal CD4-positive, alpha-beta T cell physiology 61 7.152349e-74 1.1210427670327868e-71 2.112217 729 0.03493889 557 0.0015476296291561937 1.276012 117 180 0.0122321 Mouse Phenotype abnormal platelet physiology 67 4.834075e-70 6.898297175373134e-68 2.33925 554 0.02655164 246 0.000003592992318658537 1.442577 97 132 0.01014114 Mouse Phenotype abnormal erythropoiesis 68 6.109985e-70 8.590818615441175e-68 2.132366 675 0.03235083 148 2.1612957046621622e-9 1.51514 115 149 0.012023 Mouse Phenotype abnormal circulating tumor necrosis factor level 79 2.944971e-64 3.564160472278481e-62 2.398181 483 0.02314881 641 0.002978002406864275 1.290802 96 146 0.01003659 Mouse Phenotype abnormal tumor necrosis factor level 86 3.366215e-63 3.742369955232558e-61 2.050638 668 0.03201534 481 0.000725499214989605 1.281606 126 193 0.01317303 Mouse Phenotype extramedullary hematopoiesis 89 3.032319e-61 3.25752831e-59 2.041692 654 0.03134436 222 0.0000010252548852702703 1.40221 125 175 0.01306848 Mouse Phenotype abnormal mean corpuscular hemoglobin 92 5.672562e-60 5.895148400217392e-58 2.015439 661 0.03167985 270 0.0000069420260922222225 1.365631 128 184 0.01338212 Mouse Phenotype decreased erythroid progenitor cell number 93 7.203151e-60 7.405303947419355e-58 2.399199 449 0.02151929 494 0.0008101935272672065 1.446491 56 76 0.005854679 Mouse Phenotype abnormal platelet activation 109 2.367489e-55 2.0766570944036698e-53 2.459246 395 0.01893122 476 0.0006853752634663866 1.393797 71 100 0.007422896 Mouse Phenotype abnormal embryonic hematopoiesis 110 3.361442e-55 2.921704269272727e-53 2.449134 397 0.01902708 292 0.000015046073665068492 1.609094 50 61 0.005227392 Mouse Phenotype abnormal platelet aggregation 113 1.071317e-53 9.064479501769912e-52 2.448818 386 0.01849988 436 0.0004023376251605505 1.420111 68 94 0.007109252 Mouse Phenotype increased circulating tumor necrosis factor level 114 1.170916e-53 9.820287610526315e-52 2.59686 346 0.01658279 795 0.008647465090943395 1.322084 66 98 0.006900157 Mouse Phenotype decreased platelet aggregation 134 3.760303e-48 2.6830042524626866e-46 2.668309 295 0.01413851 533 0.001255946413564728 1.445056 53 72 0.005541035 Mouse Phenotype abnormal embryonic erythrocyte morphology 143 1.989011e-46 1.3298555364335667e-44 2.957172 240 0.01150252 651 0.003299734617511521 1.560409 31 39 0.003240983 Mouse Phenotype abnormal spleen secondary B follicle morphology 145 9.680351e-46 6.383023166275862e-44 2.022319 497 0.02381979 536 0.001279989220858209 1.318078 94 140 0.009827496 Mouse Phenotype abnormal spleen germinal center morphology 167 1.654568e-42 9.47264948982036e-41 2.004816 471 0.02257369 552 0.001463609138423913 1.318283 92 137 0.0096184 Mouse Phenotype abnormal liver sinusoid morphology 187 2.799424e-38 1.4312990836363638e-36 2.203334 338 0.01619938 511 0.000999341914520548 1.434569 57 78 0.005959226 Mouse Phenotype decreased mean corpuscular volume 219 1.821773e-33 7.95341171369863e-32 2.014082 363 0.01739756 677 0.004007759361004432 1.333423 72 106 0.007527444 Mouse Phenotype increased respiratory quotient 220 3.094044e-33 1.3446433947272726e-31 2.514371 223 0.01068775 753 0.007042181849003983 1.437266 41 56 0.004286461 Mouse Phenotype increased susceptibility to weight loss 221 3.937716e-33 1.703552157285068e-31 2.643447 203 0.009729212 421 0.0002932849240617577 1.578174 41 51 0.004286461