# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	nuclear-transcribed mRNA catabolic process	21	5.950277e-32	3.7285569068095236e-29	2.275188	259	0.02482983	269	0.0000792054885464684	1.409836	113	198	0.01486646	
GO Biological Process	mRNA catabolic process	22	8.19085e-32	4.899245234090909e-29	2.200369	277	0.02655546	255	0.00005051058928235294	1.403335	121	213	0.01591896	
GO Biological Process	rRNA processing	26	6.959816e-31	3.5224699516923074e-28	2.132804	288	0.02761001	193	9.519486507253886e-7	1.431225	146	252	0.019208	
GO Biological Process	RNA catabolic process	28	2.287646e-30	1.075111918357143e-27	2.068525	304	0.0291439	240	0.000019816390314166666	1.394047	136	241	0.01789238	
GO Biological Process	rRNA metabolic process	29	4.56498e-30	2.0713990282758624e-27	2.094717	292	0.02799348	197	0.0000012629834527918779	1.421157	149	259	0.01960268	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	33	4.235756e-28	1.689039794060606e-25	2.767309	157	0.01505129	288	0.00023216318610763887	1.507322	72	118	0.009472438	
GO Biological Process	viral gene expression	39	4.318871e-25	1.4572313715128206e-22	2.554149	160	0.01533889	191	8.350301807329842e-7	1.61447	83	127	0.01091962	
GO Biological Process	viral transcription	44	2.927554e-23	8.755382519545453e-21	2.549649	148	0.01418848	202	0.000001461625502029703	1.639601	75	113	0.009867123	
GO Biological Process	protein targeting to ER	45	2.97e-23	8.68494e-21	2.696549	134	0.01284632	241	0.00002031313878755187	1.614277	66	101	0.008683068	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	49	2.650919e-22	7.119070024693877e-20	2.332414	168	0.01610584	517	0.009337056261508703	1.399127	64	113	0.008419945	
GO Biological Process	multi-organism metabolic process	51	4.847049e-22	1.2506336821764706e-19	2.226079	183	0.01754386	210	0.000002991067018	1.546059	92	147	0.01210367	
GO Biological Process	plasma lipoprotein particle assembly	55	9.634335e-22	2.3050584411818184e-19	4.351455	65	0.006231426	600	0.01688515288283333	1.805243	19	26	0.002499671	
GO Biological Process	cotranslational protein targeting to membrane	56	1.227751e-21	2.88499560875e-19	2.671412	126	0.01207938	246	0.00003078290754105691	1.613279	64	98	0.008419945	
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	58	3.06298e-21	6.9492679e-19	2.716553	120	0.01150417	264	0.0000686888335719697	1.611087	60	92	0.007893698	
GO Biological Process	protein-lipid complex assembly	61	4.383131e-21	9.455347676885245e-19	3.910871	71	0.006806634	545	0.01195973944440367	1.788862	21	29	0.002762794	
GO Biological Process	establishment of protein localization to endoplasmic reticulum	64	4.116174e-20	8.463239635312499e-18	2.434104	138	0.0132298	244	0.000022285920609016392	1.599835	68	105	0.008946191	
GO Biological Process	regulation of DNA-templated transcription in response to stress	65	5.48002e-20	1.1094089719999999e-17	2.160138	176	0.01687278	456	0.004931098618859649	1.411619	68	119	0.008946191	
GO Biological Process	translational initiation	67	1.180735e-19	2.3189987858208958e-17	2.175907	170	0.01629757	249	0.000034912496977510035	1.50293	87	143	0.01144586	
GO Biological Process	mitochondrial translation	74	4.820377e-19	8.571802830135135e-17	2.46412	127	0.01217525	259	0.000058904307432432434	1.569931	68	107	0.008946191	
GO Biological Process	positive regulation of mRNA catabolic process	75	5.820841e-19	1.0212859562533333e-16	3.204298	82	0.007861183	667	0.02784623930584708	1.77864	18	25	0.002368109	
GO Cellular Component	ribosomal subunit	30	9.764962e-26	5.624618112e-24	2.270837	207	0.01984469	53	1.5046374158490563e-7	1.522259	114	185	0.01499803	
GO Cellular Component	large ribosomal subunit	35	1.866163e-22	9.213513325714285e-21	2.5645	141	0.0135174	63	0.000013906420114285715	1.568124	73	115	0.009603999	
GO Cellular Component	outer mitochondrial membrane protein complex	39	1.232156e-19	5.459398892307692e-18	6.282579	41	0.003930592	126	0.029771259428571426	1.976266	12	15	0.00157874	
GO Cellular Component	mitochondrial outer membrane translocase complex	40	1.635268e-19	7.06435776e-18	7.076825	37	0.003547119	116	0.012198467420689656	2.245757	10	11	0.001315616	
GO Cellular Component	ficolin-1-rich granule lumen	42	1.81141e-16	7.452658285714286e-15	2.082567	155	0.01485955	85	0.0011217541722352941	1.434387	72	124	0.009472438	
GO Cellular Component	mitochondrial ribosome	45	1.531598e-15	5.88133632e-14	2.664559	88	0.008436392	90	0.0017483184000000001	1.511262	52	85	0.006841205	
GO Cellular Component	mitochondrial large ribosomal subunit	49	1.82639e-14	6.440820244897959e-13	3.158462	62	0.005943821	103	0.006763049755339806	1.598451	33	51	0.004341534	
GO Cellular Component	PcG protein complex	53	2.03494e-13	6.634672301886793e-12	2.296427	99	0.00949094	64	0.0000261058248	1.879601	35	46	0.004604657	
GO Cellular Component	spliceosomal snRNP complex	57	1.056099e-12	3.201647494736842e-11	2.564554	75	0.007190106	140	0.04710202148571428	1.434387	36	62	0.004736219	
GO Cellular Component	cytosolic large ribosomal subunit	79	1.010152e-9	2.209547665822785e-8	2.182603	76	0.007285974	106	0.007623647456603773	1.538896	38	61	0.004999342	
GO Cellular Component	mitochondrial intermembrane space	81	1.380172e-9	2.9443669333333335e-8	2.075643	84	0.008052919	74	0.00017565502962162163	1.615218	51	78	0.006709643	
GO Cellular Component	proton-transporting ATP synthase complex	115	1.23375e-7	0.0000018538434782608697	3.102264	30	0.002876043	131	0.03368427334351145	1.749819	17	24	0.002236548	
GO Cellular Component	sex chromosome	160	0.000009809792	0.0001059457536	2.211104	38	0.003642987	115	0.011568558803478261	1.805243	19	26	0.002499671	
GO Cellular Component	U1 snRNP	173	0.00001970151	0.00019678733687861268	2.479017	28	0.002684306	137	0.04396811491970803	1.820245	14	19	0.001841863	
GO Cellular Component	methylosome	189	0.00004115037	0.00037623195428571434	3.513311	15	0.001438021	136	0.039582127058823524	2.058611	10	12	0.001315616	
GO Cellular Component	nucleotide-excision repair complex	215	0.0001468386	0.0011801725618604652	2.27477	26	0.00249257	126	0.029771259428571426	1.976266	12	15	0.00157874	
GO Molecular Function	unfolded protein binding	10	9.973856e-22	4.2109620032e-19	2.608231	132	0.01265459	99	0.02400462025858586	1.398302	60	106	0.007893698	
GO Molecular Function	structural constituent of ribosome	11	1.271537e-21	4.880390194545455e-19	2.199686	184	0.01763973	33	0.00001079683616	1.509648	99	162	0.0130246	
GO Molecular Function	ribonucleoprotein complex binding	12	8.093601e-17	2.8475986185000005e-14	2.164586	145	0.01390087	44	0.000048649424722727265	1.568124	73	115	0.009603999	
GO Molecular Function	protein transporter activity	14	1.347131e-15	4.0625622014285716e-13	2.106574	142	0.01361327	45	0.00005096152903111111	1.621156	63	96	0.008288383	
GO Molecular Function	ribonuclease activity	20	3.747617e-14	7.911219486999998e-12	2.123374	125	0.01198351	65	0.002621089049230769	1.497171	60	99	0.007893698	
GO Molecular Function	endoribonuclease activity	30	3.706837e-12	5.216755271333333e-10	2.428722	79	0.007573579	75	0.005345832788533333	1.632184	37	56	0.004867781	
Human Phenotype	Increased serum lactate	2	2.689678e-18	8.974110647e-15	2.362569	132	0.01265459	49	0.00022600021071428572	1.581013	64	100	0.008419945	
Human Phenotype	Abnormality of the mitochondrion	10	1.724822e-12	1.1509737206e-9	2.21051	99	0.00949094	59	0.0003850543810338983	1.670084	48	71	0.006314959	
Human Phenotype	Abnormality of mitochondrial metabolism	11	2.465634e-12	1.495743243818182e-9	2.216616	97	0.009299204	56	0.0003703909421964286	1.68269	47	69	0.006183397	
Human Phenotype	Abnormal CSF metabolite level	28	1.366615e-10	3.256936391071429e-8	2.347475	72	0.006902502	91	0.004997540226813186	1.607677	41	63	0.005394027	
Human Phenotype	Increased CSF lactate	41	2.754642e-9	4.48334782097561e-7	2.304128	64	0.006135557	98	0.00685931288367347	1.618494	38	58	0.004999342	
Human Phenotype	Abnormality of glycolysis	77	2.068056e-7	0.000017922256737662338	3.442585	25	0.002396702	156	0.03502805703717949	2.245757	10	11	0.001315616	
Human Phenotype	Leukodystrophy	82	4.25663e-7	0.00003463962437804878	2.007771	63	0.006039689	92	0.005489695043152174	1.679826	34	50	0.004473096	
Human Phenotype	Progressive macrocephaly	156	0.00001697849	0.0007262657933974359	2.454193	29	0.002780174	146	0.029064996499315068	1.85275	18	24	0.002368109	
Human Phenotype	Abnormal mitochondria in muscle tissue	214	0.00006464806	0.0020158715157943927	2.352922	27	0.002588438	118	0.014485951983050846	1.933304	18	23	0.002368109	
Mouse Phenotype Single KO	increased integument system tumor incidence	17	1.68278e-11	9.064244976470589e-9	2.059936	106	0.01016202	121	0.024410480863636362	1.495201	46	76	0.006051835	
Mouse Phenotype Single KO	increased skin tumor incidence	35	9.723655e-10	2.543985966714286e-7	2.29998	68	0.00651903	106	0.016011265021698116	1.684318	30	44	0.003946849	
Mouse Phenotype	abnormal cellular replicative senescence	16	3.063011e-13	1.8303405106874999e-10	2.070981	123	0.01179177	57	0.000017895524984210527	1.705706	58	84	0.007630575	
Mouse Phenotype	early cellular replicative senescence	22	1.304692e-12	5.670072823636363e-10	2.112309	111	0.01064136	68	0.00004899793159411764	1.725849	51	73	0.006709643	
Mouse Phenotype	abnormal hair follicle outer root sheath morphology	79	2.655928e-8	0.0000032143452668354425	2.082705	70	0.006710766	244	0.03524257091188524	1.764523	20	28	0.002631233	
Mouse Phenotype	dry eyes	98	8.899872e-8	0.00000868282410122449	2.386167	48	0.004601668	259	0.03943916191505792	2.007145	13	16	0.001710301	
Mouse Phenotype	decreased liver cholesterol level	136	6.961847e-7	0.00004894280821102941	2.029121	59	0.005656217	266	0.04080979858646616	1.698354	22	32	0.002894356	
Mouse Phenotype	increased cellular sensitivity to ultraviolet irradiation	146	0.000001089593	0.00007135341556849314	2.319911	42	0.00402646	176	0.014650852673863636	1.811577	22	30	0.002894356	
Mouse Phenotype	abnormal extraembryonic coelom morphology	232	0.00002334525	0.0009620859278017242	2.502694	27	0.002588438	294	0.047946398734693876	2.090282	11	13	0.001447178