# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process platelet activation 73 3.101764e-53 5.591248284383562e-51 2.254015 450 0.03030915 373 0.0003589164876407506 1.423749 86 141 0.0106912 GO Biological Process cellular response to topologically incorrect protein 125 9.528416e-43 1.0030754091520001e-40 2.470155 299 0.02013875 950 0.04400206151368421 1.2763 76 139 0.009448036 GO Biological Process negative regulation of tumor necrosis factor superfamily cytokine production 142 2.513392e-40 2.3291355864788732e-38 3.431359 167 0.01124806 705 0.013675349827375885 1.556191 32 48 0.00397812 GO Biological Process response to topologically incorrect protein 149 2.0677e-39 1.8260982751677853e-37 2.186247 353 0.02377585 918 0.04042681317973857 1.244953 96 180 0.01193436 GO Biological Process negative regulation of tumor necrosis factor production 154 5.954007e-39 5.0875829943506495e-37 3.400954 163 0.01097865 831 0.028782786795427198 1.522361 30 46 0.003729488 GO Biological Process cellular response to unfolded protein 156 2.602973e-38 2.195674468397436e-36 2.459748 269 0.01811814 855 0.031609580189473685 1.31183 68 121 0.008453506 GO Biological Process response to unfolded protein 170 1.774972e-35 1.3739327381176472e-33 2.166341 323 0.02175524 772 0.02129231881088083 1.283858 88 160 0.01093983 GO Biological Process mitochondrial membrane organization 201 3.699879e-31 2.422224266716418e-29 2.136539 291 0.01959992 648 0.008959321395679013 1.355392 72 124 0.008950771 GO Biological Process erythrocyte homeostasis 214 6.098383e-30 3.7499356026635517e-28 2.340952 229 0.01542399 375 0.00036209392210666665 1.576401 52 77 0.006464446 GO Biological Process erythrocyte differentiation 235 4.591951e-28 2.5712971578297875e-26 2.361968 210 0.01414427 466 0.0015371174738626609 1.556191 46 69 0.005718548 GO Biological Process myeloid cell homeostasis 238 5.491384e-28 3.0361815989915967e-26 2.082336 276 0.01858961 405 0.0006852950518271606 1.498858 61 95 0.007583292 GO Biological Process negative regulation of collagen biosynthetic process 281 3.759848e-25 1.7607060438434162e-23 6.673875 51 0.003435037 899 0.03870221447385984 2.334286 7 7 0.0008702138 GO Biological Process regulation of mitochondrial membrane permeability 288 1.875971e-24 8.571493885069444e-23 2.314386 189 0.01272984 728 0.016533970792994505 1.438944 45 73 0.005594232 GO Biological Process positive regulation of blood vessel endothelial cell migration 308 1.352091e-23 5.776677100324675e-22 2.414717 167 0.01124806 338 0.00020077052260355027 1.909871 27 33 0.003356539 GO Biological Process regulation of membrane permeability 325 5.696486e-23 2.3064633622769232e-21 2.175335 202 0.01360544 651 0.009391550001075269 1.440918 50 81 0.006215813 GO Biological Process regulation of megakaryocyte differentiation 422 2.001123e-19 6.239994681753555e-18 2.172101 169 0.01138277 788 0.02341615661294416 1.412858 46 76 0.005718548 GO Biological Process regulation of podosome assembly 426 2.296579e-19 7.09405705657277e-18 3.802731 67 0.004512696 773 0.021609495306597674 2.000817 12 14 0.001491795 GO Biological Process platelet-derived growth factor receptor signaling pathway 474 3.840234e-18 1.0661105317721519e-16 2.215802 150 0.01010305 817 0.02664538045777234 1.626927 23 33 0.002859274 GO Biological Process cotranslational protein targeting to membrane 497 2.158599e-17 5.715292603822938e-16 2.189651 147 0.00990099 492 0.0021986172207520325 1.452974 61 98 0.007583292 GO Biological Process cytokine production involved in immune response 515 6.5144e-17 1.6645240699029127e-15 2.880865 85 0.005725062 888 0.03740459086824324 1.725342 17 23 0.002113376 GO Cellular Component uropod 65 1.674803e-21 4.45239936e-20 4.969915 56 0.003771806 115 0.03855216083478261 1.975165 11 13 0.001367479 GO Cellular Component podosome 102 7.025946e-16 1.1902779105882353e-14 2.490827 102 0.006870075 102 0.020585376 1.690345 21 29 0.002610641 GO Cellular Component cytoplasmic stress granule 125 1.392445e-13 1.9249159679999998e-12 2.240207 106 0.007139489 67 0.0025065831546268657 1.682858 31 43 0.003853804 GO Cellular Component RISC complex 381 0.0007812211 0.003543176012598425 2.029896 26 0.001751196 121 0.042551571570247936 2.100858 9 10 0.001118846 GO Molecular Function S100 protein binding 73 4.448487e-15 2.5728098786301375e-13 3.918154 49 0.00330033 86 0.014680974046511627 2.154726 12 13 0.001491795 GO Molecular Function 14-3-3 protein binding 111 3.5314e-12 1.3432045765765768e-10 2.145803 103 0.006937428 102 0.032643953484313724 1.774058 19 25 0.002362009 GO Molecular Function small ribosomal subunit rRNA binding 235 1.000679e-7 0.0000017978156331914894 4.791426 18 0.001212366 109 0.0438524808440367 2.334286 8 8 0.0009945301 Mouse Phenotype Single KO abnormal T cell physiology 15 3.308029e-122 2.0194414368666667e-119 2.002189 1341 0.09032128 108 0.000001851686994351852 1.276077 287 525 0.03567877 Mouse Phenotype Single KO abnormal T cell activation 30 1.241517e-89 3.789523723e-87 2.178806 817 0.05502795 213 0.00026963560330985916 1.300416 161 289 0.02001492 Mouse Phenotype Single KO abnormal T cell proliferation 34 1.840009e-81 4.955577180294118e-79 2.170951 749 0.0504479 277 0.0012038390545487366 1.287882 144 261 0.01790154 Mouse Phenotype Single KO autoimmune response 36 9.724185e-78 2.47345450125e-75 2.100519 770 0.05186233 350 0.0035121595011428576 1.234139 175 331 0.02175535 Mouse Phenotype Single KO abnormal immune tolerance 41 1.092658e-75 2.440358367317073e-73 2.067488 778 0.05240116 331 0.0027888044637462235 1.236205 179 338 0.02225261 Mouse Phenotype Single KO abnormal self tolerance 42 1.447172e-75 3.155179524761905e-73 2.071749 773 0.05206439 346 0.003482131860693642 1.233737 176 333 0.02187966 Mouse Phenotype Single KO altered susceptibility to autoimmune disorder 43 3.344834e-75 7.122940683255813e-73 2.22937 653 0.04398195 581 0.023593995547332186 1.216333 136 261 0.01690701 Mouse Phenotype Single KO decreased T cell proliferation 51 3.250887e-68 5.836935737058824e-66 2.401366 509 0.03428302 237 0.0006275037094936709 1.400572 90 150 0.01118846 Mouse Phenotype Single KO abnormal CD4-positive, alpha-beta T cell physiology 54 1.565561e-66 2.6547855698148145e-64 2.496553 461 0.03105004 463 0.011446863103671706 1.315974 84 149 0.01044257 Mouse Phenotype Single KO abnormal neutrophil cell number 63 2.785794e-59 4.0491294695238094e-57 2.041446 628 0.04229811 260 0.0009450351538846153 1.289084 148 268 0.01839881 Mouse Phenotype Single KO abnormal erythropoiesis 71 2.609067e-54 3.364961481549295e-52 2.342959 424 0.02855796 78 7.720624762179488e-8 1.676442 79 110 0.009820985 Mouse Phenotype Single KO decreased erythroid progenitor cell number 72 3.059299e-54 3.8908334643055555e-52 2.90478 289 0.01946521 80 1.3494373297499999e-7 1.968124 43 51 0.005345599 Mouse Phenotype Single KO abnormal mean corpuscular hemoglobin 77 1.128991e-50 1.3426195567532466e-48 2.169486 465 0.03131946 192 0.00015916158472395833 1.400572 105 175 0.01305321 Mouse Phenotype Single KO enlarged lymph nodes 85 2.899267e-48 3.123363284588235e-46 2.26213 404 0.02721088 282 0.0013436829183333333 1.404082 80 133 0.009945301 Mouse Phenotype Single KO abnormal platelet activation 90 2.507191e-46 2.550927554111111e-44 2.666098 283 0.01906109 176 0.00010027997190909092 1.592807 58 85 0.007210343 Mouse Phenotype Single KO abnormal embryonic hematopoiesis 93 1.211533e-45 1.1929040517204302e-43 2.704066 272 0.0183202 207 0.00024160226930434783 1.717682 39 53 0.004848334 Mouse Phenotype Single KO abnormal erythroid progenitor cell morphology 98 7.302873e-45 6.823715108265306e-43 2.270122 372 0.02505557 96 4.333735297708334e-7 1.730118 63 85 0.007831924 Mouse Phenotype Single KO cortical renal glomerulopathies 104 1.790247e-43 1.576278055673077e-41 2.151322 405 0.02727824 293 0.0018693865487713311 1.393604 80 134 0.009945301 Mouse Phenotype Single KO abnormal platelet physiology 109 3.04738e-41 2.560078776146789e-39 2.279867 338 0.02276554 135 0.00001283916535925926 1.570338 74 110 0.009199403 Mouse Phenotype Single KO abnormal platelet aggregation 112 1.028739e-40 8.410859841964287e-39 2.576338 263 0.01771402 214 0.0002751741400887851 1.586118 53 78 0.006588762 Mouse Phenotype altered susceptibility to autoimmune disorder 53 2.483513e-71 4.480163734528302e-69 2.023736 772 0.05199704 870 0.02556602608275862 1.181038 170 336 0.02113376 Mouse Phenotype abnormal CD4-positive, alpha-beta T cell physiology 62 2.742716e-63 4.229533496129032e-61 2.231369 548 0.03690981 465 0.002513194179354839 1.322762 102 180 0.01268026 Mouse Phenotype decreased T cell proliferation 64 9.088152e-63 1.357684707375e-60 2.058484 652 0.0439146 197 0.000006147164870558376 1.413723 129 213 0.0160368 Mouse Phenotype abnormal platelet physiology 66 9.915103e-62 1.4363378755e-59 2.510077 423 0.0284906 168 0.0000014953682862500001 1.556191 88 132 0.01093983 Mouse Phenotype abnormal erythropoiesis 79 3.563614e-57 4.3128751207594934e-55 2.219769 500 0.03367684 119 1.7023497085714284e-8 1.597968 102 149 0.01268026 Mouse Phenotype decreased erythroid progenitor cell number 92 1.218542e-52 1.2663565284782608e-50 2.575691 343 0.02310231 202 0.000008030965476237624 1.689286 55 76 0.006837394 Mouse Phenotype abnormal mean corpuscular hemoglobin 97 6.614609e-51 6.519822334948453e-49 2.116775 494 0.03327272 207 0.000012494744352173914 1.433556 113 184 0.01404774 Mouse Phenotype extramedullary hematopoiesis 98 1.380569e-50 1.3469000213265305e-48 2.127815 485 0.03266653 326 0.00039420618892638037 1.373894 103 175 0.01280457 Mouse Phenotype cortical renal glomerulopathies 100 1.999933e-50 1.9121359413000002e-48 2.046404 530 0.03569745 423 0.001494631349007092 1.326858 108 190 0.01342616 Mouse Phenotype abnormal platelet activation 101 2.49199e-50 2.359001622772277e-48 2.677355 306 0.02061022 310 0.00019330115212258067 1.517286 65 100 0.008080557 Mouse Phenotype abnormal platelet aggregation 107 5.434197e-48 4.855734347383177e-46 2.647923 297 0.02000404 300 0.00015922159576999998 1.539636 62 94 0.007707608 Mouse Phenotype abnormal erythroid progenitor cell morphology 114 9.367823e-47 7.856645237105263e-45 2.161064 432 0.02909679 203 0.00000825800996453202 1.549652 79 119 0.009820985 Mouse Phenotype abnormal tumor necrosis factor level 120 4.03911e-45 3.2181608924999997e-43 2.044892 474 0.03192564 824 0.022930573296116506 1.245759 103 193 0.01280457 Mouse Phenotype decreased platelet aggregation 122 6.660271e-44 5.219577953360655e-42 2.923624 230 0.01549135 647 0.008822731203709428 1.458929 45 72 0.005594232 Mouse Phenotype abnormal embryonic erythropoiesis 127 2.04781e-42 1.5416623157480314e-40 3.476344 173 0.01165219 1005 0.042663807707462684 1.581291 21 31 0.002610641 Mouse Phenotype abnormal embryonic hematopoiesis 130 1.226112e-41 9.017582178461538e-40 2.488191 287 0.0193305 282 0.00011393664007446808 1.683748 44 61 0.005469915 Mouse Phenotype abnormal embryonic erythrocyte morphology 140 1.360964e-39 9.294412002857143e-38 3.168809 183 0.01232572 866 0.025161847098152428 1.556191 26 39 0.003232223 Mouse Phenotype decreased neutrophil cell number 165 1.821401e-34 1.0554190885454544e-32 2.16757 313 0.0210817 1034 0.0477262280860735 1.258197 76 141 0.009448036 Mouse Phenotype altered susceptibility to parasitic infection 176 1.309897e-33 7.115866600568181e-32 2.136657 315 0.02121641 727 0.014521580843191197 1.318605 74 131 0.009199403 Mouse Phenotype abnormal fetal derived definitive erythrocyte cell number 184 1.303881e-32 6.775220783152174e-31 4.773286 91 0.006129184 762 0.017495538389763778 2.122079 10 11 0.001243163