# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	18	6.53136e-64	4.774787013333333e-61	2.626349	406	0.01813553	197	7.589363074111675e-9	1.414433	102	113	0.008512059	
GO Biological Process	regulation of DNA-templated transcription in response to stress	26	3.662092e-56	1.8534411010769231e-53	2.401863	420	0.01876089	193	4.847228103782384e-9	1.408956	107	119	0.008929317	
GO Biological Process	endoplasmic reticulum unfolded protein response	36	4.947532e-51	1.8084603774444446e-48	2.464925	362	0.0161701	905	0.04179449619447514	1.195845	87	114	0.007260285	
GO Biological Process	cellular response to topologically incorrect protein	44	1.218927e-47	3.645422816590909e-45	2.240883	409	0.01826953	664	0.011428107946385541	1.206229	107	139	0.008929317	
GO Biological Process	nuclear-transcribed mRNA catabolic process	52	4.268307e-45	1.0801279194807691e-42	2.017876	493	0.02202171	160	2.4757145215e-10	1.345378	170	198	0.01418676	
GO Biological Process	cellular response to unfolded protein	58	4.51257e-44	1.0238087694827586e-41	2.255922	372	0.01661679	778	0.023831710124678666	1.204365	93	121	0.007760995	
GO Biological Process	cellular response to epidermal growth factor stimulus	79	1.005741e-38	1.6752589644303798e-36	2.573095	251	0.01121186	788	0.024868522790609134	1.36079	33	38	0.002753901	
GO Biological Process	response to epidermal growth factor	83	4.888917e-38	7.750995036506024e-36	2.488844	262	0.01170322	791	0.025172984005056888	1.343117	36	42	0.003004256	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	91	1.717831e-37	2.484059135054945e-35	2.357056	287	0.01281994	232	1.1908991423706898e-7	1.381058	104	118	0.008678962	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to hypoxia	94	4.491037e-37	6.286974030106383e-35	2.454021	262	0.01170322	245	3.074136293836735e-7	1.446434	72	78	0.006008512	
GO Biological Process	multi-organism metabolic process	112	2.361181e-32	2.774176855267857e-30	2.006424	354	0.01581275	208	1.2014590871634616e-8	1.364436	128	147	0.0106818	
GO Biological Process	cotranslational protein targeting to membrane	118	1.339147e-31	1.4933758790677968e-29	2.361012	239	0.01067584	283	0.000003922121321908128	1.375096	86	98	0.007176834	
GO Biological Process	regulation of mitochondrial membrane permeability	122	2.878077e-31	3.1043127248360654e-29	2.208949	272	0.01214991	479	0.0015131902222338205	1.330851	62	73	0.005173996	
GO Biological Process	protein targeting to ER	128	4.881301e-31	5.0182062389843753e-29	2.306581	246	0.01098852	228	8.590264457894735e-8	1.411824	91	101	0.007594092	
GO Biological Process	viral gene expression	145	1.401416e-29	1.2718091823448276e-27	2.112392	284	0.01268593	222	2.725196891621622e-8	1.381895	112	127	0.009346574	
GO Biological Process	regulation of cellular amino acid metabolic process	152	5.166665e-29	4.472904258881579e-27	2.789306	161	0.007191674	371	0.00013918763772237196	1.410273	54	60	0.004506384	
GO Biological Process	regulation of membrane permeability	161	6.6742e-28	5.45501849689441e-26	2.049744	287	0.01281994	475	0.0014685538190736841	1.315481	68	81	0.005674706	
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	165	1.576673e-27	1.2574206064848484e-25	2.299448	218	0.009737794	268	0.0000016309834168656714	1.396647	82	92	0.006843028	
GO Biological Process	viral transcription	167	1.777063e-27	1.4002617974251496e-25	2.111079	263	0.01174789	260	5.416355745384615e-7	1.372832	99	113	0.008261704	
GO Biological Process	regulation of endoplasmic reticulum unfolded protein response	170	6.576608e-27	5.090681451294118e-25	2.773437	150	0.006700317	642	0.009334471929439252	1.498841	22	23	0.001835934	
GO Cellular Component	mitochondrial ribosome	43	3.284524e-27	1.3199203423255815e-25	2.525374	179	0.007995712	48	1.8861948e-9	1.474795	80	85	0.006676125	
GO Cellular Component	large ribosomal subunit	48	8.148536e-24	2.9334729599999998e-22	2.050827	242	0.01080984	49	1.9787765289795918e-9	1.417086	104	115	0.008678962	
GO Cellular Component	PcG protein complex	58	2.109835e-20	6.28585324137931e-19	2.096762	194	0.008665744	184	0.04168520139130435	1.294453	38	46	0.003171159	
GO Cellular Component	nuclear ubiquitin ligase complex	66	7.558053e-19	1.9788356945454545e-17	2.640448	111	0.004958235	123	0.0025188297365853663	1.410273	36	40	0.003004256	
GO Cellular Component	mitochondrial large ribosomal subunit	67	8.788359e-19	2.2666096047761194e-17	2.634736	111	0.004958235	59	0.0000014075939471186442	1.50552	49	51	0.004089126	
GO Cellular Component	cleavage furrow	74	4.682265e-18	1.0933721513513514e-16	2.007096	189	0.0084424	127	0.0032553247748031496	1.356032	45	52	0.00375532	
GO Cellular Component	DNA-directed RNA polymerase III complex	100	2.6531e-14	4.5845568e-13	3.862291	47	0.002099433	166	0.024016097927710846	1.484498	18	19	0.001502128	
GO Cellular Component	mitochondrial nucleoid	132	3.005582e-11	3.934580072727273e-10	2.081989	101	0.004511547	112	0.0013629161828571429	1.417735	38	42	0.003171159	
GO Cellular Component	mitochondrial small ribosomal subunit	170	4.463313e-9	4.536826390588234e-8	2.348071	60	0.002680127	106	0.0009413390852830188	1.511007	27	28	0.002253192	
GO Cellular Component	spliceosomal tri-snRNP complex	173	5.428968e-9	5.422691736416185e-8	2.247747	65	0.002903471	158	0.019496345924050633	1.40487	26	29	0.00216974	
GO Cellular Component	methylosome	213	1.334435e-7	0.0000010825838873239436	3.164852	29	0.001295395	187	0.042083166802139034	1.56697	12	12	0.001001419	
GO Molecular Function	rRNA binding	22	1.809009e-21	3.471652726363636e-19	2.727145	121	0.005404922	85	0.0035232013821176475	1.358041	52	60	0.004339481	
GO Molecular Function	oxidoreductase activity, acting on the CH-NH group of donors	61	5.903397e-13	4.08592494e-11	2.300983	95	0.004243534	106	0.027650061218867927	1.450898	25	27	0.002086289	
Human Phenotype	Decreased activity of mitochondrial respiratory chain	114	5.800166e-10	3.395132255964912e-8	2.661312	53	0.002367445	166	0.04752538739156626	1.56697	15	15	0.001251773	
Human Phenotype	Abnormal activity of mitochondrial respiratory chain	122	1.277279e-9	6.98629735e-8	2.52197	56	0.002501452	152	0.03310796218618421	1.56697	16	16	0.001335225	
Mouse Phenotype Single KO	decreased circulating free fatty acid level	21	1.670285e-38	7.283237973809525e-36	2.138561	364	0.01625944	208	0.01376991799326923	1.263685	75	93	0.006258867	
Mouse Phenotype	extramedullary hematopoiesis	2	3.798426e-72	1.8158375493e-68	2.100739	722	0.03225086	297	0.00612111315959596	1.199851	134	175	0.01118251	
Mouse Phenotype	decreased circulating free fatty acid level	20	1.204116e-48	5.756276537999999e-46	2.105078	481	0.02148568	222	0.001974319367432432	1.26411	96	119	0.008011349	
Mouse Phenotype	increased cellular sensitivity to ultraviolet irradiation	504	5.020515e-10	9.524036491071429e-9	2.136143	83	0.003707509	422	0.02841347948815166	1.410273	27	30	0.002253192	
Mouse Phenotype	increased liver adenoma incidence	610	1.240792e-8	1.9447889036065575e-7	2.013488	80	0.003573502	485	0.0497881091072165	1.39908	25	28	0.002086289