# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	nuclear-transcribed mRNA catabolic process	87	2.133415e-45	3.2268514925287353e-43	2.082321	459	0.02272502	137	1.4008706405839413e-10	1.388507	164	198	0.01464155	
GO Biological Process	mRNA catabolic process	89	1.768654e-44	2.6150244928089884e-42	2.010154	490	0.02425983	114	3.486785247631579e-12	1.400909	178	213	0.01589144	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	107	2.733348e-38	3.3615071338317754e-36	2.457759	270	0.01336766	333	0.00011375801385585587	1.335412	94	118	0.008392108	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	143	3.847264e-29	3.5402899983216785e-27	2.079275	290	0.01435786	634	0.007553992443217665	1.260985	85	113	0.007588608	
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	168	3.93671e-25	3.083521838690476e-23	2.303142	197	0.009753441	456	0.001358888375263158	1.330162	73	92	0.006517275	
GO Biological Process	cotranslational protein targeting to membrane	185	4.457914e-24	3.170902179783784e-22	2.222715	203	0.0100505	470	0.0015512002786808512	1.317146	77	98	0.006874386	
GO Biological Process	viral transcription	220	1.121307e-21	6.706944915e-20	2.019585	227	0.01123874	261	0.000009528003350191571	1.379666	93	113	0.00830283	
GO Biological Process	establishment of protein localization to endoplasmic reticulum	228	2.667484e-21	1.5395360507017545e-19	2.02223	222	0.01099119	597	0.0058079197206030156	1.277233	80	105	0.007142219	
GO Biological Process	protein targeting to ER	229	3.049152e-21	1.7521306186899565e-19	2.09929	202	0.01000099	624	0.006962707372275641	1.278023	77	101	0.006874386	
GO Biological Process	signal transduction involved in mitotic G1 DNA damage checkpoint	310	9.842586e-18	4.178019005612903e-16	2.034271	179	0.008862264	595	0.005759720839159665	1.35706	51	63	0.004553165	
GO Biological Process	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	312	1.744952e-17	7.359558771794872e-16	2.03534	176	0.008713734	631	0.00744468652393027	1.35191	50	62	0.004463887	
GO Biological Process	positive regulation of transcription from RNA polymerase II promoter in response to stress	435	1.408954e-13	4.262166824367816e-12	2.532058	83	0.004109318	926	0.044876694754859614	1.466822	21	24	0.001874833	
GO Biological Process	gene silencing by miRNA	439	1.891538e-13	5.6698743831435076e-12	2.042566	130	0.006436281	812	0.023901589493842364	1.371574	36	44	0.003213999	
GO Biological Process	histone ubiquitination	454	4.524153e-13	1.3113068133700441e-11	2.028628	128	0.006337261	717	0.013368277652719664	1.418465	33	39	0.002946166	
GO Biological Process	positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	477	1.311779e-12	3.61880500230608e-11	2.326285	90	0.004455887	593	0.005680400784485666	1.676368	16	16	0.001428444	
GO Biological Process	DNA damage response, detection of DNA damage	484	1.731552e-12	4.7077464396694215e-11	2.012177	124	0.006139222	950	0.04793922046210526	1.367564	31	38	0.00276761	
GO Biological Process	positive regulation of mRNA catabolic process	530	9.904357e-12	2.4590836559056605e-10	2.098795	104	0.005149025	638	0.007814274146238245	1.542259	23	25	0.002053388	
GO Biological Process	positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress	572	4.767772e-11	1.096837617972028e-9	3.771173	36	0.001782355	939	0.04760284365921193	1.676368	11	11	0.0009820552	
GO Biological Process	maintenance of protein localization in organelle	638	5.043062e-10	1.0401512987147335e-8	2.324005	69	0.00341618	744	0.0159649109030914	1.460063	27	31	0.002410499	
GO Biological Process	negative regulation of cell aging	651	7.1539e-10	1.4460548402457758e-8	2.287994	70	0.00346569	778	0.020302358075835476	1.583237	17	18	0.001517722	
GO Cellular Component	intrinsic component of mitochondrial membrane	76	1.528506e-17	3.4753399578947367e-16	2.098322	164	0.008119616	88	0.0026949436363636363	1.366885	53	65	0.00473172	
GO Cellular Component	integral component of mitochondrial membrane	79	7.942367e-17	1.7372671108860758e-15	2.074301	161	0.007971086	91	0.0035957952	1.362049	52	64	0.004642443	
GO Cellular Component	mitochondrial ribosome	86	1.372447e-15	2.7576609488372095e-14	2.142303	137	0.00678285	74	0.0012231967913513514	1.341095	68	85	0.006070887	
GO Cellular Component	cytoplasmic stress granule	87	2.228399e-15	4.4260614620689646e-14	2.128301	137	0.00678285	130	0.02721019126153846	1.364486	35	43	0.003124721	
GO Cellular Component	small ribosomal subunit	92	3.438787e-14	6.458939060869565e-13	2.009138	144	0.007129419	73	0.001023709098082192	1.373691	59	72	0.005267387	
GO Cellular Component	spliceosomal snRNP complex	99	6.775977e-13	1.1827159854545456e-11	2.083772	118	0.005842163	101	0.006107665615841583	1.35191	50	62	0.004463887	
GO Cellular Component	intercellular bridge	117	1.112587e-11	1.6432054153846155e-10	2.010659	115	0.005693633	153	0.048250492235294117	1.333475	35	44	0.003124721	
GO Cellular Component	mitochondrial small ribosomal subunit	141	7.169581e-10	8.786550331914893e-9	2.515796	58	0.002871571	139	0.03543046446043165	1.436887	24	28	0.002142666	
GO Cellular Component	precatalytic spliceosome	234	0.00000615982	0.00004548790153846153	2.058718	47	0.002326963	139	0.03543046446043165	1.436887	24	28	0.002142666	
GO Cellular Component	PRC1 complex	271	0.00003767898	0.00024025563630996312	2.656132	23	0.001138727	128	0.027344358000000003	1.676368	12	12	0.001071333	
GO Molecular Function	Ral GTPase binding	203	4.976606e-7	0.000010350359867980297	2.3405	44	0.002178434	140	0.03642225912857142	1.676368	13	13	0.001160611	
GO Molecular Function	rRNA methyltransferase activity	260	0.000008771606	0.00014243738666153849	2.105534	43	0.002128924	122	0.01628053033442623	1.59255	19	20	0.001696277	
Human Phenotype	Neonatal death	310	1.424857e-8	3.06711960032258e-7	2.048004	76	0.003762749	221	0.021743659495927603	1.676368	14	14	0.001249888	
Mouse Phenotype Single KO	increased integument system tumor incidence	33	3.323013e-23	9.220857588181817e-21	2.137691	213	0.0105456	495	0.0310330545010101	1.279334	58	76	0.005178109	
Mouse Phenotype Single KO	thin interventricular septum	118	1.863737e-14	1.446291500762712e-12	2.549288	88	0.004356867	409	0.01684467986992665	1.588138	18	19	0.001606999	
Mouse Phenotype Single KO	persistent right dorsal aorta	241	4.488282e-10	1.7053609242323652e-8	2.00797	97	0.004802456	405	0.016281783598518517	1.676368	14	14	0.001249888	
Mouse Phenotype Single KO	athymia	631	0.000002438452	0.00003538653718541997	2.046576	52	0.002574512	514	0.036084779680933855	1.676368	12	12	0.001071333	
Mouse Phenotype	abnormal cellular replicative senescence	17	2.343304e-39	1.3179017378823531e-36	2.443402	281	0.01391227	784	0.0280886448252551	1.257276	63	84	0.005624498	
Mouse Phenotype	abnormal liver sinusoid morphology	43	3.838903e-28	8.535756182093024e-26	2.020203	300	0.01485296	779	0.027325202992297817	1.268022	59	78	0.005267387	
Mouse Phenotype	increased skin papilloma incidence	52	1.475061e-26	2.7121265809615387e-24	2.504957	177	0.008763244	646	0.01323450788359133	1.396973	35	42	0.003124721	
Mouse Phenotype	decreased cellular sensitivity to ultraviolet irradiation	90	2.159104e-21	2.293688149333333e-19	3.967894	71	0.0035152	920	0.04978809689347826	1.56461	14	15	0.001249888	
Mouse Phenotype	increased embryonic neuroepithelium apoptosis	464	6.102644e-9	1.2574866225000002e-7	2.047944	80	0.003960788	557	0.0065033115236983845	1.542259	23	25	0.002053388	
Mouse Phenotype	decreased activated T cell number	546	3.943123e-8	6.904798352197802e-7	2.429876	49	0.002425983	846	0.03838915541843972	1.676368	11	11	0.0009820552