# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	actin polymerization or depolymerization	10	2.019693e-123	2.6577140187e-120	6.215404	280	0.02352348	530	0.04021829860943396	1.532933	29	43	0.003510471	
GO Biological Process	actin filament organization	42	3.418604e-61	1.0710811913333333e-58	2.261868	512	0.04301437	471	0.02377268340658174	1.256415	110	199	0.01331558	
GO Biological Process	activation of signaling protein activity involved in unfolded protein response	43	3.599686e-61	1.101587629627907e-58	10.8472	92	0.007729144	514	0.03586628816536965	2.272969	8	8	0.0009684058	
GO Biological Process	placenta development	63	3.755216e-51	7.843632911746031e-49	2.293174	415	0.03486516	300	0.0023018236001	1.370009	88	146	0.01065246	
GO Biological Process	regulation of endoplasmic reticulum unfolded protein response	121	2.750109e-38	2.9908003579338845e-36	4.242544	122	0.01024952	478	0.024039648537656905	1.778846	18	23	0.002178913	
GO Biological Process	regulation of intrinsic apoptotic signaling pathway	144	1.663523e-34	1.5201596636805557e-32	2.275939	281	0.02360749	480	0.02448047449854167	1.29046	88	155	0.01065246	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	213	4.055994e-26	2.505766434084507e-24	2.564104	166	0.01394606	552	0.046295388295289855	1.309847	68	118	0.008231449	
GO Biological Process	nuclear-transcribed mRNA catabolic process	238	3.349823e-24	1.8521143217226887e-22	2.001522	260	0.02184323	370	0.008431067325135135	1.28572	112	198	0.01355768	
GO Biological Process	translational initiation	257	3.180676e-23	1.6285803690272372e-21	2.209669	197	0.01655045	317	0.002950941864605678	1.366961	86	143	0.01041036	
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	264	1.040491e-22	5.186295859469697e-21	2.658345	134	0.01125767	278	0.001516998867410072	1.482371	60	92	0.007263043	
GO Biological Process	protein targeting to ER	276	1.10255e-21	5.256686757246377e-20	2.504156	142	0.01192977	275	0.0013760591199272728	1.462802	65	101	0.007868297	
GO Biological Process	viral gene expression	281	1.767229e-21	8.275788758362989e-20	2.308233	165	0.01386205	330	0.004553823477878788	1.3781	77	127	0.009320905	
GO Biological Process	cotranslational protein targeting to membrane	301	2.379799e-20	1.0403911973754154e-18	2.489686	134	0.01125767	413	0.01380118150338983	1.391614	60	98	0.007263043	
GO Biological Process	establishment of protein localization to endoplasmic reticulum	304	3.248539e-20	1.4061685756907896e-18	2.33403	151	0.01268588	240	0.0007626446488750001	1.472018	68	105	0.008231449	
GO Biological Process	multi-organism metabolic process	310	7.061469e-20	2.99747969583871e-18	2.068048	194	0.01629841	318	0.003087931906698113	1.360689	88	147	0.01065246	
GO Biological Process	viral transcription	331	5.797382e-19	2.3047658531117824e-17	2.264537	150	0.01260187	406	0.01229686834408867	1.367805	68	113	0.008231449	
GO Biological Process	mitochondrial translation	339	2.009799e-18	7.801458714159291e-17	2.329422	137	0.0115097	246	0.0007994269023170732	1.465747	69	107	0.0083525	
GO Biological Process	translational elongation	342	3.221075e-18	1.2393604071637427e-16	2.253962	145	0.0121818	488	0.027432308434426227	1.339428	66	112	0.007989348	
GO Biological Process	mitochondrial translational termination	359	3.573639e-17	1.3099029415320333e-15	2.492688	111	0.00932538	326	0.004031761387331289	1.463061	56	87	0.00677884	
GO Biological Process	protein localization to endoplasmic reticulum	360	4.17837e-17	1.5273103008333332e-15	2.081651	162	0.01361001	319	0.003134390885924765	1.39311	76	124	0.009199855	
GO Cellular Component	ribosomal subunit	40	3.88746e-24	1.67938272e-22	2.134215	222	0.01865076	38	0.000009504859452631578	1.425213	116	185	0.01404188	
GO Cellular Component	large ribosomal subunit	59	1.451885e-15	4.252300474576271e-14	2.151725	135	0.01134168	61	0.0012211583370491804	1.423076	72	115	0.008715652	
GO Cellular Component	mitochondrial ribosome	76	4.298191e-12	9.772729010526316e-11	2.308508	87	0.007309082	79	0.010695368506329114	1.417263	53	85	0.006415688	
GO Cellular Component	small ribosomal subunit	77	4.36126e-12	9.787347116883117e-11	2.225497	94	0.007897169	81	0.011106961066666666	1.452175	46	72	0.005568333	
GO Cellular Component	DNA-directed RNA polymerase III complex	101	1.422763e-9	2.4341925386138617e-8	4.173019	27	0.002268336	77	0.00861241708051948	1.914079	16	19	0.001936812	
GO Cellular Component	proteasome regulatory particle, base subcomplex	103	1.47711e-9	2.4781029902912622e-8	5.071859	22	0.001848274	91	0.01620003038241758	2.083555	11	12	0.001331558	
GO Cellular Component	cytosolic large ribosomal subunit	106	2.783159e-9	4.537074294339622e-8	2.06369	82	0.00688902	115	0.04536105182608696	1.415948	38	61	0.004599927	
GO Cellular Component	cytoplasmic stress granule	109	7.699765e-9	1.2206599926605506e-7	2.05617	78	0.00655297	82	0.011870177795121952	1.585793	30	43	0.003631522	
GO Cellular Component	mitochondrial large ribosomal subunit	125	6.261724e-8	8.656207257599999e-7	2.321437	52	0.004368647	110	0.035943311127272726	1.470745	33	51	0.003994674	
GO Cellular Component	mRNA cleavage factor complex	149	0.000001259887	0.000014611306953020135	2.573023	34	0.002856423	99	0.019746065454545457	1.818375	16	20	0.001936812	
GO Cellular Component	retromer complex	193	0.00001561636	0.00013981901595854922	2.139345	39	0.003276485	113	0.042924835115044246	1.731786	16	21	0.001936812	
GO Cellular Component	Bcl-2 family protein complex	236	0.00008050944	0.0005894928488135593	2.915663	18	0.001512224	117	0.047052672000000004	2.272969	7	7	0.000847355	
GO Molecular Function	structural constituent of ribosome	17	7.600763e-26	1.8876718462352942e-23	2.241951	214	0.01797866	42	0.0016505999471428572	1.375006	98	162	0.01186297	
Human Phenotype	Premature birth	14	7.068741e-14	3.3692649066428574e-11	2.351729	98	0.008233219	60	0.038550221285	1.60141	31	44	0.003752572	
Mouse Phenotype Single KO	abnormal body temperature	78	2.716879e-25	3.189546282435897e-23	2.086657	246	0.02066706	113	0.008291023320353983	1.426177	64	102	0.007747246	
Mouse Phenotype Single KO	midline facial cleft	469	4.082678e-7	0.000007971232930916844	2.079217	58	0.004872721	192	0.04046391499270833	1.969907	13	15	0.001573659	
Mouse Phenotype	abnormal fibroblast physiology	20	4.548687e-65	2.17449982035e-62	2.138154	615	0.05166765	301	0.021903015375747507	1.230817	137	253	0.01658395	
Mouse Phenotype	abnormal keratinocyte morphology	128	2.520614e-25	1.88278050421875e-23	2.165708	226	0.01898681	231	0.010608028835064936	1.423728	57	91	0.006899891	
Mouse Phenotype	abnormal epidermis stratum basale morphology	175	1.929221e-18	1.0540161132e-16	2.101638	172	0.01445014	142	0.0014374263257746478	1.618046	42	59	0.00508413	
Mouse Phenotype	abnormal epidermis stratum granulosum morphology	186	1.418805e-17	7.293115379032258e-16	2.023056	179	0.01503823	320	0.0278597471071875	1.409816	49	79	0.005931485	
Mouse Phenotype	absent fibroblast proliferation	253	4.681549e-14	1.7691814224901185e-12	3.506032	52	0.004368647	234	0.01106689835897436	2.272969	10	10	0.001210507	
Mouse Phenotype	abnormal cardiac neural crest cell morphology	972	0.000329375	0.00323987075617284	2.029017	30	0.002520373	355	0.03773128800845071	2.272969	8	8	0.0009684058