# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	mRNA catabolic process	10	3.541315e-13	4.6600164085e-10	2.80591	66	0.03386352	85	0.00015661423808235292	2.085971	46	213	0.02366255	
GO Biological Process	RNA catabolic process	13	7.125215e-13	7.212361860384615e-10	2.622006	72	0.03694202	63	0.00004408563688412699	2.084089	52	241	0.02674897	
GO Biological Process	nuclear-transcribed mRNA catabolic process	15	1.134616e-12	9.953607962666665e-10	2.867883	61	0.0312981	124	0.0005039091541854838	2.048868	42	198	0.02160494	
GO Biological Process	ncRNA metabolic process	16	1.362347e-12	1.1204452608125e-9	2.0174	120	0.06157004	260	0.018937795094615385	1.444492	83	555	0.04269547	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	20	3.398909e-12	2.23631217655e-9	3.773393	40	0.02052335	140	0.0006843189441285714	2.37381	29	118	0.0149177	
GO Biological Process	protein targeting to ER	21	4.710984e-12	2.9519923074285714e-9	3.984918	37	0.01898409	109	0.0003275353571100917	2.582096	27	101	0.01388889	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	22	8.329551e-12	4.9822073458636365e-9	3.343667	45	0.02308876	178	0.0018932762601685392	2.307891	27	113	0.01388889	
GO Biological Process	negative regulation of protein ubiquitination	24	1.594921e-11	8.744818932916667e-9	3.003578	51	0.02616727	50	0.000010084812842600002	2.589719	37	138	0.01903292	
GO Biological Process	establishment of protein localization to endoplasmic reticulum	26	4.848176e-11	2.453736460923077e-8	3.587217	38	0.01949718	100	0.00024774199279	2.57572	28	105	0.01440329	
GO Biological Process	regulation of gene expression, epigenetic	27	7.367903e-11	3.590897613962963e-8	2.378389	71	0.03642894	275	0.02406492559018182	1.674737	43	248	0.02211934	
GO Biological Process	regulation of DNA-templated transcription in response to stress	28	1.278516e-10	6.008568587142856e-8	3.021627	46	0.02360185	176	0.0018503849348295456	2.272694	28	119	0.01440329	
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	32	2.455803e-10	1.00987223990625e-7	3.877047	32	0.01641868	162	0.0012173049740740742	2.519726	24	92	0.01234568	
GO Biological Process	translation	33	2.643354e-10	1.0540574329090909e-7	2.079755	89	0.04566444	73	0.00009619593125753423	1.817544	70	372	0.03600823	
GO Biological Process	cotranslational protein targeting to membrane	37	3.073993e-10	1.0932614564054052e-7	3.744538	33	0.01693176	125	0.0005056785786959999	2.562579	26	98	0.01337449	
GO Biological Process	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	38	3.35725e-10	1.1625803355263158e-7	4.043976	30	0.01539251	142	0.0007256035697464788	2.817194	21	72	0.01080247	
GO Biological Process	negative regulation of protein modification by small protein conjugation or removal	41	4.981777e-10	1.598907403487805e-7	2.682843	52	0.02668035	59	0.00002373323784915254	2.463357	38	149	0.01954733	
GO Biological Process	protein localization to endoplasmic reticulum	42	6.958071e-10	2.180029911642857e-7	3.139045	40	0.02052335	170	0.001563252819235294	2.258948	29	124	0.0149177	
GO Biological Process	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	44	1.217149e-9	3.6401053843181817e-7	3.932455	29	0.01487943	172	0.0017267193896511627	2.720831	20	71	0.01028807	
GO Biological Process	negative regulation of ubiquitin-protein transferase activity	46	1.437156e-9	4.111203435652174e-7	3.600488	32	0.01641868	179	0.002306028738659218	2.529725	22	84	0.01131687	
GO Biological Process	response to endoplasmic reticulum stress	49	2.059658e-9	5.531232575918368e-7	2.166415	73	0.03745511	148	0.0008213610404527027	1.900121	48	244	0.02469136	
GO Cellular Component	mitochondrial matrix	20	3.4809e-14	3.0074976e-12	2.167761	116	0.0595177	30	0.0005200847424000001	1.638192	77	454	0.03960905	
GO Cellular Component	ribosomal subunit	26	4.859926e-10	3.2299815876923074e-8	2.818195	48	0.02462801	31	0.0015755134761290324	1.984001	38	185	0.01954733	
GO Cellular Component	ribosome	27	7.778171e-9	4.97802944e-7	2.352029	57	0.02924577	29	0.00048376796027586205	1.923605	47	236	0.02417695	
GO Cellular Component	ESCRT complex	32	1.079773e-7	0.000005830774200000001	5.775194	15	0.007696254	61	0.04212597718032787	3.104663	9	28	0.00462963	
GO Cellular Component	large ribosomal subunit	34	1.272424e-7	0.000006466907858823529	3.017584	31	0.01590559	51	0.02109363162352941	2.015781	24	115	0.01234568	
GO Cellular Component	CCR4-NOT complex	36	3.329161e-7	0.0000159799728	6.213264	13	0.006670087	50	0.021421338623999996	4.225791	7	16	0.003600823	
GO Cellular Component	spliceosomal complex	39	8.243005e-7	0.00003652285292307692	2.151116	50	0.02565418	52	0.023902975384615385	1.765615	34	186	0.01748971	
GO Cellular Component	proteasome complex	41	0.000001411502	0.00005948964526829268	3.264815	23	0.01180092	44	0.01722804218181818	2.414738	17	68	0.008744856	
GO Cellular Component	endopeptidase complex	42	0.000001424644	0.00005861392457142857	3.262972	23	0.01180092	47	0.019366365140425532	2.379741	17	69	0.008744856	
GO Cellular Component	late endosome membrane	43	0.00000154112	0.00006193152	2.425557	37	0.01898409	54	0.0264775872	1.947369	25	124	0.01286008	
GO Cellular Component	peptidase complex	47	0.000002949233	0.0001084313749787234	2.809274	27	0.01385326	48	0.019903186800000004	2.195216	20	88	0.01028807	
GO Cellular Component	proteasome accessory complex	77	0.00008775825	0.001969431896103896	4.6167	10	0.005130836	43	0.01657546225116279	3.622106	9	24	0.00462963	
GO Cellular Component	chromocenter	129	0.00251561	0.03369747348837209	3.193646	9	0.004617753	40	0.00968350032	4.829475	7	14	0.003600823	
GO Molecular Function	ribonucleoprotein complex binding	3	1.037463e-11	1.4600562619999999e-8	3.435495	43	0.0220626	10	0.0005720459574	2.519726	30	115	0.0154321	
GO Molecular Function	structural constituent of ribosome	13	5.847658e-8	0.000018991393904615385	2.623257	41	0.02103643	15	0.013001840397333335	2.027187	34	162	0.01748971	
GO Molecular Function	ribosomal small subunit binding	35	0.00002113532	0.0025495234582857142	4.953689	11	0.00564392	14	0.006639227691428571	5.5194	8	14	0.004115226	
Mouse Phenotype Single KO	decreased interscapular fat pad weight	3	1.551956e-8	0.00004737087030666667	6.207637	16	0.008209338	14	0.040812991006428566	5.634388	7	12	0.003600823