# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	ncRNA metabolic process	10	2.243837e-62	2.9526651082999997e-59	2.44049	439	0.07448252	28	3.1153495433214286e-36	1.806215	331	555	0.0533871	
GO Biological Process	ncRNA processing	16	3.957416e-52	3.2547273215000002e-49	2.603293	327	0.05548015	43	6.2058333637209305e-27	1.827836	239	396	0.03854839	
GO Biological Process	rRNA processing	20	1.452053e-43	9.5537827135e-41	2.935772	224	0.03800475	55	1.975165421490909e-20	1.91087	159	252	0.02564516	
GO Biological Process	rRNA metabolic process	21	2.169392e-43	1.359382348952381e-40	2.894631	228	0.03868341	53	8.786080570566037e-21	1.905998	163	259	0.02629032	
GO Biological Process	ribonucleoprotein complex biogenesis	22	6.572914e-41	3.9314988784545457e-38	2.17411	363	0.06158806	42	1.1901729611190477e-27	1.781107	267	454	0.04306452	
GO Biological Process	ribosome biogenesis	25	4.175526e-38	2.19782986536e-35	2.456679	264	0.04479131	51	2.4541153130980393e-22	1.837757	196	323	0.0316129	
GO Biological Process	translation	33	7.105959e-34	2.8335549842727273e-31	2.217715	287	0.04869359	40	4.3681629475e-29	1.888772	232	372	0.03741935	
GO Biological Process	peptide biosynthetic process	34	1.310008e-29	5.070116256470588e-27	2.053869	297	0.05039023	41	7.447612068048781e-28	1.846487	239	392	0.03854839	
GO Biological Process	mitochondrial translation	38	3.571123e-27	1.2366423041315788e-24	3.571144	104	0.01764506	68	1.814790200470588e-16	2.264335	80	107	0.01290323	
GO Biological Process	translational elongation	42	7.234226e-26	2.2665519031904761e-23	3.358989	107	0.01815405	91	1.433566765769231e-12	2.082127	77	112	0.01241935	
GO Biological Process	mitochondrial translational elongation	43	1.221324e-25	3.737535468837209e-23	3.964887	86	0.01459111	76	4.1996861927631574e-14	2.315949	65	85	0.01048387	
GO Biological Process	mitochondrial translational termination	44	3.538739e-25	1.058324238659091e-22	3.900225	86	0.01459111	80	2.96658798825e-13	2.262709	65	87	0.01048387	
GO Biological Process	viral gene expression	46	5.767332e-25	1.649833082347826e-22	3.164172	112	0.01900238	116	1.2660024332758622e-10	1.931594	81	127	0.01306452	
GO Biological Process	RNA splicing, via transesterification reactions	48	7.513489e-24	2.0597917031458334e-21	2.050227	238	0.04038005	66	1.2555683775454546e-16	1.766653	168	288	0.02709677	
GO Biological Process	cotranslational protein targeting to membrane	49	8.626502e-24	2.316655914653061e-21	3.489547	93	0.01577876	98	4.9886359812244894e-12	2.132345	69	98	0.01112903	
GO Biological Process	mRNA splicing, via spliceosome	50	1.118276e-23	2.9430787768e-21	2.047287	237	0.04021038	65	8.68692599676923e-17	1.774623	167	285	0.02693548	
GO Biological Process	viral transcription	51	2.330044e-23	6.0119703913725486e-21	3.170792	104	0.01764506	121	1.6333603312396693e-10	1.983297	74	113	0.01193548	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	52	4.785032e-23	1.2108891555384616e-20	3.181808	102	0.01730573	107	2.1879690666355138e-11	2.001922	78	118	0.01258065	
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	53	7.006727e-23	1.7396513319433963e-20	3.52562	88	0.01493044	113	8.798138841858406e-11	2.106816	64	92	0.01032258	
GO Biological Process	RNA catabolic process	54	7.869047e-23	1.9175701754259257e-20	2.239834	186	0.03155752	88	1.0171035216249999e-12	1.73419	138	241	0.02225806	
GO Cellular Component	ribonucleoprotein complex	16	2.146143e-60	2.3178344400000003e-58	2.054925	605	0.1026468	15	1.600091136e-38	1.671818	451	817	0.07274194	
GO Cellular Component	intracellular ribonucleoprotein complex	17	1.458941e-59	1.4829706164705883e-57	2.047342	602	0.1021378	16	2.94646032e-38	1.670538	449	814	0.07241935	
GO Cellular Component	ribosomal subunit	18	2.265276e-40	2.1746649600000004e-38	3.339334	172	0.02918222	23	7.830920347826087e-25	2.16091	132	185	0.02129032	
GO Cellular Component	ribosome	21	2.433871e-31	2.002728137142857e-29	2.619816	192	0.0325755	28	2.901839657142857e-20	1.924925	150	236	0.02419355	
GO Cellular Component	mitochondrial ribosome	23	5.551678e-28	4.1709998191304347e-26	4.447711	83	0.01408212	40	2.29352688e-12	2.209059	62	85	0.01	
GO Cellular Component	large ribosomal subunit	24	8.479309e-28	6.105102479999999e-26	3.508536	109	0.01849338	33	1.4161227054545457e-17	2.238492	85	115	0.01370968	
GO Cellular Component	mitochondrial large ribosomal subunit	34	1.905525e-20	9.684550588235295e-19	4.868482	54	0.00916186	47	1.2953665225531917e-9	2.375332	40	51	0.006451613	
GO Cellular Component	spliceosomal complex	40	2.76835e-15	1.1959272000000001e-13	2.06283	145	0.02460129	45	1.855842048e-10	1.742229	107	186	0.01725806	
GO Cellular Component	mitochondrial membrane part	41	7.833686e-15	3.3016120507317076e-13	2.034802	145	0.02460129	59	2.7615926562711867e-7	1.571417	110	212	0.01774194	
GO Cellular Component	cytosolic ribosome	44	1.269435e-14	4.985417454545455e-13	2.429511	97	0.01645741	44	1.1820105163636365e-10	1.973965	73	112	0.01177419	
GO Cellular Component	small ribosomal subunit	45	2.640803e-14	1.014068352e-12	3.060029	64	0.0108585	57	1.558704202105263e-7	2.019032	48	72	0.007741935	
GO Cellular Component	mitochondrial protein complex	47	4.592222e-14	1.6883743863829785e-12	2.182243	116	0.01968103	52	2.1968250092307694e-8	1.711788	91	161	0.01467742	
GO Cellular Component	preribosome	49	4.225714e-13	1.4902109779591837e-11	2.814858	66	0.01119783	61	5.35260464262295e-7	1.952617	49	76	0.007903226	
GO Cellular Component	chromosome, telomeric region	51	2.220767e-12	7.524481129411765e-11	2.139391	105	0.01781473	152	0.04486297263157895	1.305721	72	167	0.0116129	
GO Cellular Component	methyltransferase complex	52	1.308875e-11	4.3494923076923084e-10	2.345601	80	0.01357313	70	0.000016116925165714285	1.76388	53	91	0.008548387	
GO Cellular Component	nuclear chromosome, telomeric region	53	1.4991e-11	4.887631698113208e-10	2.258843	86	0.01459111	142	0.04023317002816902	1.353669	59	132	0.009516129	
GO Cellular Component	cytosolic large ribosomal subunit	54	1.572558e-11	5.0321856e-10	2.846197	56	0.009501188	54	7.3469472e-8	2.134878	43	61	0.006935484	
GO Cellular Component	catalytic step 2 spliceosome	55	2.930335e-11	9.206579781818181e-10	2.348849	77	0.01306413	66	0.0000026066749090909094	1.798201	57	96	0.009193548	
GO Cellular Component	mitochondrial proton-transporting ATP synthase complex	57	4.79622e-10	1.4540119578947367e-8	4.726676	25	0.004241602	120	0.0224453952	1.97514	15	23	0.002419355	
GO Cellular Component	inner mitochondrial membrane protein complex	58	6.780914e-10	2.0202447227586207e-8	2.036598	91	0.01543943	67	0.0000032133887999999996	1.657964	75	137	0.01209677	
GO Molecular Function	structural constituent of ribosome	6	4.848577e-32	3.411782015666667e-29	3.131269	148	0.02511028	8	1.385282531e-22	2.20598	118	162	0.01903226	
GO Molecular Function	rRNA binding	8	8.245502e-19	4.3515636805e-16	4.537165	53	0.008992195	20	0.0000010442699022	2.119984	42	60	0.006774194	
GO Molecular Function	ribonucleoprotein complex binding	10	8.523213e-13	3.5985005286e-10	2.351325	89	0.0151001	29	0.00006777540203448275	1.685453	64	115	0.01032258	
GO Molecular Function	snRNA binding	11	1.980673e-11	7.602183096363636e-9	4.085434	34	0.005768578	66	0.00856494110909091	1.912767	24	38	0.003870968	
GO Molecular Function	protein transporter activity	13	1.7892e-10	5.810771076923076e-8	2.179126	83	0.01408212	51	0.0012591990823529412	1.640464	52	96	0.008387097	
GO Molecular Function	snoRNA binding	18	1.71334e-7	0.000040187341555555554	3.122299	29	0.004920258	94	0.028709963810638298	1.918081	19	30	0.003064516	
GO Molecular Function	aminoacyl-tRNA ligase activity	26	0.000002627582	0.0004266788924615385	2.376805	37	0.00627757	23	0.0000065687069173913045	2.220935	33	45	0.005322581	
GO Molecular Function	NADH dehydrogenase activity	28	0.000005243477	0.0007906414247857143	2.616603	29	0.004920258	72	0.009643388105555557	1.804242	28	47	0.004516129	
GO Molecular Function	tRNA binding	30	0.000007848625	0.0011045631583333332	2.13432	42	0.007125891	53	0.0018131179849056602	1.863722	32	52	0.00516129	
GO Molecular Function	RNA methyltransferase activity	40	0.00001624019	0.0017141520545	2.067592	42	0.007125891	70	0.009281083877142857	1.72314	33	58	0.005322581	
GO Molecular Function	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	55	0.00005718921	0.004390051720363637	2.12755	34	0.005768578	83	0.020988075761445783	1.670923	32	58	0.00516129	
GO Molecular Function	NADH dehydrogenase (ubiquinone) activity	58	0.00007089652	0.005160777714482759	2.382899	26	0.004411266	89	0.02592743482696629	1.749828	26	45	0.004193548	
GO Molecular Function	mRNA 5'-UTR binding	59	0.00008620764	0.006168960272542373	2.639041	21	0.003562945	99	0.0332582378020202	2.064919	15	22	0.002419355	
Human Phenotype	Exercise intolerance	3	1.530323e-10	3.4039484596666666e-7	2.761824	53	0.008992195	89	0.002087920968202247	1.730599	40	70	0.006451613	
Human Phenotype	Increased serum lactate	4	4.291255e-10	7.15888615375e-7	2.280652	72	0.01221581	44	0.00010226546907954547	1.726273	57	100	0.009193548	
Human Phenotype	Distal amyotrophy	5	5.717071e-10	7.6300029566e-7	2.146851	81	0.01374279	171	0.017547071050292396	1.531289	45	89	0.007258065	
Human Phenotype	Increased CSF lactate	9	2.672816e-8	0.000019817445742222223	2.676035	42	0.007125891	127	0.008085295788188977	1.72314	33	58	0.005322581	
Human Phenotype	Abnormal CSF metabolite level	14	1.415667e-7	0.00006747675636428571	2.481148	43	0.007295555	173	0.018429256109248553	1.634455	34	63	0.005483871	
Human Phenotype	Leukodystrophy	15	2.570296e-7	0.00011434390138666667	2.425257	43	0.007295555	112	0.004793000814910714	1.817129	30	50	0.00483871	
Human Phenotype	Increased muscle lipid content	19	5.083566e-7	0.00017854018904210527	4.071143	19	0.003223617	155	0.014564274541935483	2.231562	14	19	0.002258065	
Human Phenotype	Mitochondrial inheritance	20	5.445288e-7	0.00018168203412	2.672477	34	0.005768578	118	0.006113101369491525	1.762065	32	55	0.00516129	
Human Phenotype	Increased intramyocellular lipid droplets	24	0.000001264473	0.000351576180375	4.002877	18	0.003053953	148	0.01375797208310811	2.315949	13	17	0.002096774	
Human Phenotype	Cytochrome C oxidase-negative muscle fibers	26	0.000001579489	0.0004053819268076923	4.140366	17	0.002884289	196	0.02605791860255102	2.187285	13	18	0.002096774	
Human Phenotype	Muscle abnormality related to mitochondrial dysfunction	28	0.000002129967	0.00050761677825	3.294737	22	0.003732609	183	0.02159200842240437	1.892843	20	32	0.003225806	
Human Phenotype	Abnormality of the mitochondrion	36	0.000004387179	0.0008132123740833333	2.015316	51	0.008652867	145	0.013115335099310345	1.620913	38	71	0.006129032	
Human Phenotype	Renal Fanconi syndrome	40	0.000006306534	0.0010520875345500001	4.141269	15	0.002544961	188	0.022273725062234042	2.379574	11	14	0.001774194	
Human Phenotype	Abnormality of renal resorption	48	0.0000126623	0.0017603234979166667	3.52198	17	0.002884289	148	0.01375797208310811	2.315949	13	17	0.002096774	
Human Phenotype	Abnormal lower motor neuron morphology	66	0.00006009512	0.006075980844848485	3.393359	15	0.002544961	220	0.038396229677272735	2.477903	9	11	0.001451613	
Human Phenotype	Steppage gait	81	0.0001295403	0.010671881751851853	2.178713	29	0.004920258	189	0.022568442599470898	1.918081	19	30	0.003064516	
Human Phenotype	Abnormal mitochondria in muscle tissue	88	0.0001453016	0.011018154281818182	2.776081	18	0.003053953	230	0.04522286297391304	1.97514	15	23	0.002419355	
Mouse Phenotype Single KO	abnormal cellular replicative senescence	7	2.326628e-7	0.00030435617994285715	2.259821	50	0.008483203	68	0.018439019982352943	1.716177	34	60	0.005483871	
Mouse Phenotype Single KO	early cellular replicative senescence	13	0.000002857229	0.0020125881502307693	2.203912	43	0.007295555	82	0.02422711041585366	1.747239	30	52	0.00483871	
Mouse Phenotype	increased lung adenoma incidence	14	0.000001877622	0.0012822817101428572	2.062828	52	0.008822531	138	0.03238554574782609	1.676518	31	56	0.005	
Mouse Phenotype	abnormal lung adenoma incidence	17	0.000002153783	0.0012113128978235295	2.052635	52	0.008822531	159	0.04227408777735849	1.647105	31	57	0.005	
Mouse Phenotype	increased fibroblast apoptosis	38	0.00003485398	0.00876944481	2.037194	40	0.006786563	165	0.04436907212181818	1.703558	27	48	0.004354839