# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	ncRNA metabolic process	10	3.494652e-45	4.5986125667999996e-42	2.507512	298	0.07652799	48	2.1048020626458333e-21	1.789644	241	555	0.05289728	
GO Biological Process	ncRNA processing	14	1.333886e-38	1.2537575624285715e-35	2.699216	224	0.0575244	54	1.0776285248888889e-18	1.883761	181	396	0.03972783	
GO Biological Process	ribonucleoprotein complex biogenesis	16	5.480402e-36	4.5072881198749996e-33	2.375147	262	0.067283	35	3.374515766342857e-26	1.978988	218	454	0.04784899	
GO Biological Process	ribosome biogenesis	18	1.147194e-34	8.38662547e-32	2.746587	195	0.05007704	45	3.0146888851111113e-22	2.079829	163	323	0.035777	
GO Biological Process	rRNA metabolic process	19	2.225208e-33	1.5411322143157895e-30	3.055411	159	0.04083205	57	2.3696103878947368e-17	2.068646	130	259	0.0285338	
GO Biological Process	rRNA processing	20	2.296271e-33	1.51083150445e-30	3.094661	156	0.04006163	58	3.987567232413793e-17	2.077044	127	252	0.02787533	
GO Biological Process	translation	21	6.716731e-33	4.208831582333333e-30	2.514644	215	0.05521315	47	1.662357151468085e-21	1.983136	179	372	0.03928885	
GO Biological Process	mitochondrion organization	22	2.100477e-32	1.256371674681818e-29	2.14258	291	0.07473035	53	4.339138041886792e-19	1.755402	230	540	0.05048288	
GO Biological Process	peptide biosynthetic process	26	1.377115e-28	6.969790878846154e-26	2.302783	220	0.05649718	49	1.3504880286734695e-20	1.934525	184	392	0.0403863	
GO Biological Process	mitochondrial translation	34	2.74131e-25	1.0609675967647058e-22	4.157939	80	0.02054443	68	8.910916797794118e-13	2.465124	64	107	0.01404741	
GO Biological Process	mitochondrial translational termination	36	2.157239e-24	7.885307778055555e-22	4.667822	68	0.01746276	89	5.307381027977528e-11	2.510725	53	87	0.01163301	
GO Biological Process	mitochondrial translational elongation	37	4.286042e-24	1.5243250453513514e-21	4.675428	67	0.01720596	91	6.81635476978022e-11	2.521314	52	85	0.01141352	
GO Biological Process	amide biosynthetic process	38	1.903793e-23	6.592634759736842e-21	2.003333	244	0.0626605	56	3.304831153928572e-18	1.801988	202	462	0.04433714	
GO Biological Process	translational termination	40	2.380687e-23	7.83186505825e-21	4.18173	73	0.01874679	77	4.156429083376623e-12	2.51621	58	95	0.01273047	
GO Biological Process	translational elongation	41	6.230678e-23	1.9997437024878052e-20	3.801272	80	0.02054443	100	8.030929804599999e-10	2.244679	61	112	0.01338894	
GO Biological Process	cellular protein complex disassembly	43	4.04992e-20	1.2393697041860465e-17	3.150777	89	0.02285568	80	7.524094141874999e-12	2.289655	70	126	0.01536435	
GO Biological Process	viral gene expression	49	1.21396e-18	3.2601019673469385e-16	3.29266	77	0.01977401	126	5.305860232936508e-8	2.044463	63	127	0.01382792	
GO Biological Process	macromolecular complex disassembly	50	5.483026e-18	1.44302278268e-15	2.498646	115	0.02953261	92	7.439858305217391e-11	1.985167	92	191	0.02019315	
GO Biological Process	translational initiation	51	8.39416e-18	2.1658578713725494e-15	2.948627	86	0.02208526	135	1.0555555208148148e-7	1.959816	68	143	0.01492537	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	54	3.610729e-17	8.798811650185185e-15	3.305111	70	0.01797637	137	1.1591782310218977e-7	2.060689	59	118	0.01294996	
GO Cellular Component	intracellular ribonucleoprotein complex	11	3.838326e-51	6.029661207272728e-49	2.208337	429	0.1101695	16	1.80409572e-30	1.761965	348	814	0.07638279	
GO Cellular Component	ribonucleoprotein complex	12	5.262632e-51	7.57819008e-49	2.205526	429	0.1101695	15	1.8848160000000004e-30	1.76054	349	817	0.07660228	
GO Cellular Component	ribosomal subunit	18	3.299464e-34	3.16748544e-32	3.70268	126	0.03235747	22	1.2629205818181819e-17	2.272328	102	185	0.02238806	
GO Cellular Component	ribosome	20	1.129314e-30	9.75727296e-29	3.035995	147	0.03775039	25	1.5897793535999998e-16	2.078153	119	236	0.0261194	
GO Cellular Component	organelle inner membrane	24	7.166837e-25	5.16012264e-23	2.014166	256	0.06574217	37	2.2058050767567565e-11	1.557628	209	553	0.04587357	
GO Cellular Component	mitochondrial inner membrane	26	1.735012e-23	1.1531156676923079e-21	2.054706	230	0.05906523	36	1.99870608e-11	1.592162	192	497	0.04214223	
GO Cellular Component	mitochondrial ribosome	27	1.422494e-22	9.1039616e-21	4.86658	60	0.01540832	43	1.248196286511628e-7	2.230393	46	85	0.01009658	
GO Cellular Component	large ribosomal subunit	29	8.404826e-22	5.0081170096551726e-20	3.751494	77	0.01977401	35	6.0348375771428566e-12	2.329475	65	115	0.0142669	
GO Cellular Component	mitochondrial membrane part	33	1.622343e-18	8.495177890909091e-17	2.5064	118	0.03030303	41	1.0994374712195121e-8	1.807963	93	212	0.02041264	
GO Cellular Component	mitochondrial large ribosomal subunit	35	1.8833e-16	9.298121142857143e-15	5.322046	39	0.01001541	48	0.00000109469088	2.505152	31	51	0.006804214	
GO Cellular Component	small ribosomal subunit	38	1.065746e-14	4.846339705263157e-13	3.69088	51	0.01309707	49	0.000001652676127346939	2.232413	39	72	0.00856014	
GO Cellular Component	cytosolic ribosome	39	1.456288e-13	6.452476061538461e-12	2.729568	72	0.01848998	40	3.5676953279999998e-9	2.171083	59	112	0.01294996	
GO Cellular Component	cytosolic part	40	5.243768e-13	2.265307776e-11	2.057322	121	0.03107345	45	1.5423106560000002e-7	1.700069	99	240	0.02172959	
GO Cellular Component	mitochondrial protein complex	41	5.691714e-13	2.3988492175609754e-11	2.42035	85	0.02182845	53	0.00000499830520754717	1.766305	69	161	0.01514486	
GO Cellular Component	spliceosomal complex	45	9.934593e-11	3.814883712e-9	2.067192	96	0.02465331	46	2.061417224347826e-7	1.794794	81	186	0.01777875	
GO Cellular Component	endopeptidase complex	46	1.299614e-10	4.88202824347826e-9	3.124309	44	0.01129944	88	0.0068902213090909084	1.791904	30	69	0.006584723	
GO Cellular Component	preribosome	47	2.485966e-10	9.139892017021276e-9	2.969509	46	0.01181305	62	0.00009025330064516129	2.006461	37	76	0.008121159	
GO Cellular Component	inner mitochondrial membrane protein complex	48	3.405458e-10	1.2259648799999999e-8	2.337369	69	0.01771957	63	0.000148957248	1.714734	57	137	0.01251097	
GO Cellular Component	proteasome complex	49	4.063888e-10	1.4331425436734695e-8	3.055028	43	0.01104263	93	0.01195255556129032	1.757647	29	68	0.006365233	
GO Cellular Component	catalytic step 2 spliceosome	50	1.250954e-9	4.323297024e-8	2.539459	55	0.01412429	59	0.000032991210305084745	1.931896	45	96	0.009877085	
GO Molecular Function	structural constituent of ribosome	6	1.977763e-23	1.3916858976666666e-20	3.234403	101	0.02593734	8	8.9680082525e-14	2.238773	88	162	0.01931519	
GO Molecular Function	rRNA binding	7	9.758525e-16	5.88578465e-13	5.053444	39	0.01001541	16	0.0000203422345775	2.335448	34	60	0.007462687	
GO Molecular Function	snRNA binding	9	4.269798e-11	2.003009684e-8	4.91063	27	0.006933744	31	0.0054504780638709675	2.277604	21	38	0.004609306	
GO Molecular Function	ribonucleoprotein complex binding	11	4.462906e-9	0.0000017129444665454546	2.359331	59	0.01515152	30	0.0036870205286666665	1.720228	48	115	0.01053556	
GO Molecular Function	protein N-terminus binding	13	6.781786e-8	0.000022025154224615385	2.048848	68	0.01746276	23	0.00022902147217391305	1.884059	48	105	0.01053556	
GO Molecular Function	protein transporter activity	14	3.667594e-7	0.0001106041562	2.145913	54	0.01386749	59	0.04405253405423729	1.631379	38	96	0.00834065	
GO Molecular Function	translation release factor activity	15	6.310454e-7	0.00017761824525333334	9.653987	9	0.002311248	33	0.00631233267030303	4.121378	7	7	0.001536435	
GO Molecular Function	RNA methyltransferase activity	16	6.34543e-7	0.000167440034125	2.607942	35	0.008988187	36	0.007033504857777779	1.989631	28	58	0.006145742	
GO Molecular Function	translation factor activity, RNA binding	18	0.000003949973	0.0009264881114444443	2.071771	48	0.01232666	29	0.0022077434903448275	1.868997	39	86	0.00856014	
GO Molecular Function	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	21	0.000005842787	0.001174678414952381	2.651998	28	0.00719055	56	0.036200325175	1.847514	26	58	0.00570676	
GO Molecular Function	NADH dehydrogenase activity	23	0.000008763559	0.0016086846129565217	3.004531	22	0.005649718	42	0.020882323623809523	2.016845	23	47	0.005048288	
GO Molecular Function	5'-3' exodeoxyribonuclease activity	26	0.00001394937	0.002265163082307692	7.654389	8	0.002054443	41	0.020960221975609754	4.121378	6	6	0.001316945	
GO Molecular Function	rRNA methyltransferase activity	29	0.00001641511	0.002389813600689655	3.809759	15	0.00385208	62	0.047357322790322585	2.472827	12	20	0.002633889	
GO Molecular Function	NADH dehydrogenase (ubiquinone) activity	31	0.00002157977	0.0029390254496774195	2.913169	21	0.005392912	51	0.02391980722745098	2.014896	22	45	0.004828797	
GO Molecular Function	aminoacyl-tRNA ligase activity	44	0.00007052421	0.00676711851409091	2.430782	25	0.006420134	51	0.02391980722745098	2.014896	22	45	0.004828797	
Human Phenotype	Increased serum lactate	1	9.15844e-10	0.000006111427012000001	2.589014	54	0.01386749	14	0.00028398119275000003	1.937048	47	100	0.01031607	
Human Phenotype	Exercise intolerance	2	2.133951e-9	0.0000071199275115	3.07609	39	0.01001541	89	0.03545984964157303	1.766305	30	70	0.006584723	
Human Phenotype	Hypertrophic cardiomyopathy	3	1.232987e-8	0.00002742574083666667	2.22128	63	0.01617874	50	0.007685359495399999	1.676493	48	118	0.01053556	
Human Phenotype	Increased CSF lactate	4	1.636122e-7	0.00027294605265	2.989636	31	0.007960966	51	0.007847060704313725	1.989631	28	58	0.006145742	
Human Phenotype	Abnormal CNS myelination	5	4.538326e-7	0.00060568498796	2.024727	61	0.01566513	39	0.0053424020889743596	1.681522	51	125	0.01119403	
Human Phenotype	Abnormal CSF metabolite level	7	0.000001267354	0.001208150463142857	2.707448	31	0.007960966	81	0.028994967635802466	1.831724	28	63	0.006145742	
Human Phenotype	Leukodystrophy	8	0.000001999582	0.00166790133575	2.646459	31	0.007960966	54	0.008794871889814815	2.060689	25	50	0.00548727	
Human Phenotype	Mitochondrial inheritance	10	0.000002655166	0.0017717922718	2.974331	25	0.006420134	90	0.03512823644777777	1.873354	25	55	0.00548727	
Mouse Phenotype Single KO	increased hemangiosarcoma incidence	7	4.199063e-7	0.0005492974270142857	3.305286	25	0.006420134	97	0.03515072101443299	2.404137	14	24	0.003072871	
Mouse Phenotype Single KO	decreased mortality induced by ionizing radiation	17	0.00008316955	0.044799033491176476	5.185714	9	0.002311248	63	0.007171306003492064	4.121378	7	7	0.001536435	
Mouse Phenotype	lymphoid hyperplasia	13	0.00003478362	0.025582014678461537	2.440688	27	0.006933744	144	0.0270708958875	2.189482	17	32	0.003731343	
Mouse Phenotype	decreased tumor latency	16	0.00004706127	0.028122050154375	2.120974	35	0.008988187	111	0.011839489662162162	2.060689	23	46	0.005048288	
Mouse Phenotype	increased lung adenoma incidence	19	0.0000561953	0.028278066489473685	2.10156	35	0.008988187	170	0.03714534549	1.839901	25	56	0.00548727	
Mouse Phenotype	abnormal lung adenoma incidence	20	0.00006179695	0.029542031947500002	2.091176	35	0.008988187	188	0.046182315217021284	1.807622	25	57	0.00548727	
Mouse Phenotype	large lymphoid organs	24	0.0001042643	0.0415362905125	2.242204	28	0.00719055	175	0.03950102564571429	2.060689	18	36	0.003950834