# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	12	1.697306e-54	1.8612374711666665e-51	3.170194	254	0.02189089	224	0.0007442125320982143	1.479869	70	113	0.008905852	
GO Biological Process	regulation of DNA-templated transcription in response to stress	19	3.302224e-47	2.287050821894737e-44	2.846717	258	0.02223563	206	0.00037864588125242714	1.485554	74	119	0.009414758	
GO Biological Process	liver regeneration	30	1.105409e-42	4.848692343666667e-40	4.177787	139	0.01197966	455	0.0367656965032967	1.638124	24	35	0.003053435	
GO Biological Process	cellular response to topologically incorrect protein	34	1.334299e-40	5.164129570882353e-38	2.642783	250	0.02154615	409	0.027513776668948657	1.323365	77	139	0.009796438	
GO Biological Process	platelet-derived growth factor receptor signaling pathway	39	1.147063e-37	3.870308209487179e-35	3.213343	170	0.01465138	449	0.03321360907349666	1.665013	23	33	0.002926209	
GO Biological Process	response to topologically incorrect protein	53	4.327912e-34	1.0745470567547168e-31	2.250667	284	0.02447643	399	0.023649859393233084	1.287369	97	180	0.01234097	
GO Biological Process	response to unfolded protein	55	1.385491e-32	3.314850194363636e-30	2.274253	265	0.02283892	469	0.04317487540298508	1.284051	86	160	0.01094148	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to hypoxia	60	1.622014e-31	3.5573470376666666e-29	2.92764	162	0.01396191	268	0.002939717162947761	1.531366	50	78	0.006361323	
GO Biological Process	regulation of endoplasmic reticulum unfolded protein response	61	2.91822e-31	6.295222455737705e-29	3.888473	109	0.009394122	499	0.04916474018637274	1.765732	17	23	0.00216285	
GO Biological Process	nuclear-transcribed mRNA catabolic process	65	2.445924e-30	4.9516790639999995e-28	2.163833	274	0.02361458	153	0.000013499018239215687	1.435772	119	198	0.01513995	
GO Biological Process	mRNA catabolic process	69	4.641806e-29	8.852394949855073e-27	2.070949	290	0.02499354	141	0.000005106543135319148	1.435602	128	213	0.01628499	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	80	2.026628e-26	3.3335497314999996e-24	2.598708	164	0.01413428	199	0.00025042139067839195	1.498143	74	118	0.009414758	
GO Biological Process	cotranslational protein targeting to membrane	104	2.272202e-23	2.8749909728846156e-21	2.649358	139	0.01197966	130	0.0000031808319447692304	1.657626	68	98	0.008651399	
GO Biological Process	regulation of mitochondrial membrane permeability	113	2.769142e-22	3.2247026175221244e-20	2.428701	155	0.01335861	221	0.000668754670316742	1.603529	49	73	0.006234097	
GO Biological Process	protein targeting to ER	127	1.309956e-20	1.357300079055118e-18	2.478448	137	0.01180729	143	0.0000061236142667832175	1.632042	69	101	0.008778626	
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	138	8.254952e-20	7.871515461449276e-18	2.543915	125	0.01077308	144	0.000006233228225555556	1.661865	64	92	0.008142494	
GO Biological Process	multi-organism metabolic process	139	1.041159e-19	9.856554878417265e-18	2.077776	190	0.01637508	165	0.000024110573762424238	1.495113	92	147	0.01170483	
GO Biological Process	protein localization to endoplasmic reticulum	144	1.954398e-19	1.7859668945833333e-17	2.188201	166	0.01430664	99	6.398468048181818e-7	1.618308	84	124	0.01068702	
GO Biological Process	regulation of hematopoietic progenitor cell differentiation	153	6.750824e-19	5.806149870326797e-17	2.289343	146	0.01258295	432	0.03217089169907407	1.353023	64	113	0.008142494	
GO Biological Process	viral transcription	157	8.200019e-19	6.872869428089171e-17	2.276626	147	0.01266914	118	0.0000015570866272881356	1.627856	77	113	0.009796438	
GO Cellular Component	ribosomal subunit	42	8.06748e-21	3.3191917714285717e-19	2.051326	208	0.0179264	45	7.06479744e-7	1.485011	115	185	0.01463104	
GO Cellular Component	large ribosomal subunit	50	9.633934e-17	3.3294875904e-15	2.22371	136	0.01172111	53	0.000029576536030188677	1.537225	74	115	0.009414758	
GO Cellular Component	ficolin-1-rich granule lumen	51	1.036369e-16	3.5114620235294115e-15	2.029234	168	0.01447901	86	0.003878917953488372	1.387121	72	124	0.009160305	
GO Cellular Component	mitochondrial ribosome	53	2.743638e-16	8.945295215094338e-15	2.613181	96	0.008273722	72	0.00106778568	1.517674	54	85	0.006870229	
GO Cellular Component	proteasome core complex	55	3.83048e-15	1.2034671709090908e-13	4.73062	40	0.003447384	140	0.04817496137142857	1.69216	17	24	0.00216285	
GO Cellular Component	DNA-directed RNA polymerase III complex	65	6.194645e-14	1.6468225476923076e-12	5.232228	33	0.002844092	68	0.0005867972894117647	2.137465	17	19	0.00216285	
GO Cellular Component	mitochondrial large ribosomal subunit	71	5.432246e-13	1.3221015616901409e-11	2.885229	63	0.00542963	105	0.013563694079999999	1.545779	33	51	0.004198473	
GO Cellular Component	intercellular bridge	75	2.441811e-12	5.625932544e-11	2.43483	80	0.006894769	97	0.006662950663917526	1.628817	30	44	0.003816794	
GO Cellular Component	spliceosomal snRNP complex	84	5.386778e-11	1.1081371885714286e-9	2.336253	76	0.00655003	103	0.01109953789514563	1.502715	39	62	0.004961832	
GO Cellular Component	endopeptidase complex	87	7.60491e-10	1.5104924689655173e-8	2.073224	87	0.007498061	109	0.017523505321100915	1.454132	42	69	0.005343511	
GO Cellular Component	proteasome complex	95	1.55848e-9	2.8347930947368418e-8	2.050552	86	0.007411876	119	0.023776728201680673	1.440385	41	68	0.005216285	
GO Cellular Component	DNA-directed RNA polymerase I complex	131	2.430295e-7	0.000003205763175572519	3.412287	25	0.002154615	107	0.01599204246728972	2.047655	12	14	0.001526718	
GO Cellular Component	retromer complex	212	0.00004383172	0.0003572698686792453	2.082112	37	0.00318883	115	0.022438891408695653	1.820138	16	21	0.002035623	
GO Molecular Function	structural constituent of ribosome	17	5.111802e-18	1.2695310614117648e-15	2.009741	187	0.01611652	21	0.00025019853466666666	1.445156	98	162	0.01246819	
GO Molecular Function	ribonuclease activity	27	7.10027e-15	1.1102718496296296e-12	2.09215	137	0.01180729	72	0.016058711241666666	1.423707	59	99	0.007506361	
GO Molecular Function	RNA polymerase III activity	49	1.72697e-12	1.4880137428571428e-10	5.076434	30	0.002585538	68	0.013978048588235295	2.090315	14	16	0.00178117	
GO Molecular Function	unfolded protein binding	52	1.951482e-12	1.58445327e-10	2.060562	116	0.009997414	80	0.0209750384925	1.397299	62	106	0.007888041	
GO Molecular Function	mRNA 5'-UTR binding	54	3.947979e-12	3.086734692222222e-10	3.191807	50	0.00430923	86	0.03917073904883721	1.845992	17	22	0.00216285	
GO Molecular Function	quinone binding	438	0.001078935	0.010400145136986302	2.014008	25	0.002154615	85	0.03877954683764706	1.967355	14	17	0.00178117	
Human Phenotype	Increased serum lactate	37	7.259118e-14	1.309191740918919e-11	2.075659	129	0.01111781	10	0.00021541731889	1.600584	67	100	0.008524173	
Human Phenotype	Increased serum pyruvate	236	0.000007173205	0.00020282541086864408	3.047989	22	0.001896061	58	0.0189413105	2.388931	10	10	0.001272265	
Human Phenotype	Abnormality of glycolysis	251	0.00001310141	0.00034830959733067726	2.847267	23	0.001982246	43	0.010686719492093023	2.388931	11	11	0.001399491	
Mouse Phenotype Single KO	cortical renal glomerulopathies	33	3.319542e-33	9.21122608909091e-31	2.127469	313	0.02697578	156	0.038993710949999996	1.337088	75	134	0.009541985	
Mouse Phenotype Single KO	abnormal osteoblast differentiation	48	5.584867e-27	1.0654297316458333e-24	2.562446	172	0.01482375	115	0.01783348045304348	1.645708	31	45	0.00394402	
Mouse Phenotype Single KO	embryonic lethality between somite formation and embryo turning, complete penetrance	123	4.784329e-17	3.5617968010569105e-15	2.083538	161	0.01387572	158	0.04450346625886076	1.452728	45	74	0.005725191	
Mouse Phenotype	extramedullary hematopoiesis	4	2.071142e-63	4.9505471655e-60	2.48132	442	0.0380936	92	0.0016569316923913044	1.378755	101	175	0.01284987	
Mouse Phenotype	abnormal aorta tunica media morphology	233	5.549299e-13	2.2771179287124464e-11	2.143248	111	0.009566491	188	0.022842825890425533	1.592621	32	48	0.004071247	
Mouse Phenotype	abnormal vertebral transverse process morphology	857	0.0001486754	0.0016586761953325552	2.046165	33	0.002844092	242	0.044341073404958686	2.171756	10	11	0.001272265