# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	8	1.28704e-20	2.11701992e-17	2.783996	111	0.01922411	337	0.034478262946290805	1.53166	45	113	0.009217534	
GO Biological Process	regulation of DNA-templated transcription in response to stress	17	4.163194e-18	3.222557049764706e-15	2.527685	114	0.01974368	334	0.033453952347904194	1.519075	47	119	0.009627202	
GO Biological Process	mitochondrial translation	18	2.481992e-17	1.8144740404444446e-14	2.944331	84	0.01454797	128	0.00004302959074453125	1.869167	52	107	0.01065137	
GO Biological Process	rRNA processing	25	4.213504e-16	2.21781996544e-13	2.06029	154	0.02667129	133	0.00006251916094285715	1.54152	101	252	0.02068824	
GO Biological Process	rRNA metabolic process	31	2.62228e-15	1.1131155651612903e-12	2.008738	155	0.02684448	145	0.0001321991255724138	1.514708	102	259	0.02089308	
GO Biological Process	mRNA catabolic process	34	6.286366e-15	2.433008535117647e-12	2.052111	143	0.02476619	146	0.0001318466005	1.570971	87	213	0.01782057	
GO Biological Process	mitochondrial translational termination	38	1.127774e-14	3.905362648947368e-12	3.055403	66	0.01143055	188	0.001220168275	1.812563	41	87	0.008398197	
GO Biological Process	translational elongation	40	2.535506e-14	8.3411808635e-12	2.627677	82	0.01420159	254	0.008604447329527557	1.614018	47	112	0.009627202	
GO Biological Process	mitochondrial translational elongation	48	1.603645e-13	4.3963259489583334e-11	2.964874	63	0.01091098	242	0.007789170981818182	1.719464	38	85	0.007783695	
GO Biological Process	nuclear-transcribed mRNA catabolic process	52	3.178144e-13	8.042537864615385e-11	2.031312	128	0.02216834	184	0.0008711114967391304	1.534583	79	198	0.01618189	
GO Biological Process	antigen processing and presentation of peptide antigen via MHC class I	61	1.829974e-12	3.947643912459016e-10	2.696067	67	0.01160374	299	0.019673752438795985	1.642185	38	89	0.007783695	
GO Biological Process	regulation of ubiquitin protein ligase activity	63	2.056466e-12	4.295402554603175e-10	2.561083	73	0.01264288	196	0.002410401839132653	1.75586	42	92	0.008603032	
GO Biological Process	DNA-templated transcription, termination	66	2.810503e-12	5.60354681469697e-10	2.471581	77	0.01333564	253	0.008608243314624507	1.623154	46	109	0.009422368	
GO Biological Process	translational termination	68	3.860885e-12	7.471380252205881e-10	2.627007	68	0.01177693	200	0.00247335313895	1.740898	43	95	0.008807866	
GO Biological Process	cotranslational protein targeting to membrane	70	5.576645e-12	1.048329593642857e-9	2.604524	68	0.01177693	202	0.002550501483118812	1.726852	44	98	0.0090127	
GO Biological Process	negative regulation of ubiquitin protein ligase activity	72	6.097959e-12	1.114486701125e-9	2.715809	63	0.01091098	216	0.004172283921944444	1.798209	36	77	0.007374027	
GO Biological Process	anaphase-promoting complex-dependent catabolic process	74	7.785505e-12	1.3844521661486486e-9	2.563357	69	0.01195012	192	0.00191876108015625	1.826931	38	80	0.007783695	
GO Biological Process	positive regulation of ubiquitin protein ligase activity	75	9.784237e-12	1.7166769957733333e-9	2.549712	69	0.01195012	233	0.0059527757987124464	1.739934	38	84	0.007783695	
GO Biological Process	termination of RNA polymerase II transcription	82	2.101717e-11	3.372743171097561e-9	2.959056	52	0.009005888	312	0.02155146435448718	1.727989	31	69	0.006349857	
GO Biological Process	liver regeneration	84	2.524744e-11	3.9551317019047615e-9	3.019917	50	0.008659508	354	0.04212697726271186	1.97803	18	35	0.003687014	
GO Cellular Component	peptidase complex	30	1.664302e-15	9.58637952e-14	2.80967	80	0.01385521	54	0.00078383712	1.791965	41	88	0.008398197	
GO Cellular Component	mitochondrial ribosome	31	2.630371e-15	1.4662197058064517e-13	3.336735	61	0.0105646	65	0.0038081504492307695	1.719464	38	85	0.007783695	
GO Cellular Component	proteasome complex	32	7.592861e-15	4.10014494e-13	3.114435	65	0.01125736	73	0.008842320394520547	1.753401	31	68	0.006349857	
GO Cellular Component	endopeptidase complex	33	7.787178e-15	4.07764957090909e-13	3.112676	65	0.01125736	76	0.011618194357894735	1.727989	31	69	0.006349857	
GO Cellular Component	ribosome	36	1.363178e-14	6.543254399999999e-13	2.019626	145	0.02511257	35	0.000003036610944	1.613436	99	236	0.02027857	
GO Cellular Component	ribosomal subunit	37	1.872617e-14	8.745627502702704e-13	2.23946	113	0.01957049	46	0.00019141675826086954	1.580048	76	185	0.01556739	
GO Cellular Component	mitochondrial large ribosomal subunit	41	2.140991e-12	9.023493775609757e-11	3.773263	41	0.007100797	91	0.01812479451428571	1.809962	24	51	0.004916018	
GO Cellular Component	large ribosomal subunit	46	9.211596e-11	3.4603560626086953e-9	2.36573	72	0.01246969	83	0.01449066031807229	1.538468	46	115	0.009422368	
GO Cellular Component	nuclear ubiquitin ligase complex	47	3.725035e-10	1.3695447829787234e-8	3.412522	37	0.006408036	69	0.007770878608695651	2.019239	21	40	0.004301516	
GO Cellular Component	methyltransferase complex	51	4.256279e-9	1.4421274729411764e-7	2.154915	72	0.01246969	56	0.0008022925028571429	1.775155	42	91	0.008603032	
GO Cellular Component	preribosome	56	2.282768e-8	7.043969828571429e-7	2.35093	54	0.009352269	43	0.000026324854325581396	2.0243	40	76	0.008193363	
GO Cellular Component	PcG protein complex	59	7.574477e-8	0.000002218423094237288	2.262874	54	0.009352269	64	0.0036036171000000004	2.006697	24	46	0.004916018	
GO Cellular Component	anaphase-promoting complex	62	1.0125e-7	0.0000028219354838709677	4.137663	21	0.003636993	79	0.012208720283544305	2.380962	13	21	0.002662843	
GO Cellular Component	catalytic step 2 spliceosome	65	2.06766e-7	0.000005496794584615384	2.024002	65	0.01125736	80	0.01260294768	1.602571	40	96	0.008193363	
GO Cellular Component	proteasome accessory complex	75	0.000001133608	0.000026118328319999998	3.428384	22	0.003810184	112	0.046930011428571436	2.083342	13	24	0.002662843	
GO Cellular Component	MHC class I peptide loading complex	83	0.000004808911	0.00010011805069879517	37.77529	4	0.0006927607	93	0.022042460903225806	3.84617	5	5	0.00102417	
GO Cellular Component	small ribosomal subunit	101	0.00001969559	0.0003369700942574257	2.049879	42	0.007273987	110	0.04225245905454546	1.602571	30	72	0.006145023	
GO Cellular Component	cytoplasmic stress granule	122	0.00008613881	0.0012200644563934427	2.010693	37	0.006408036	71	0.008818346636619718	1.967808	22	43	0.00450635	
GO Cellular Component	mitochondrial nucleoid	128	0.0001086647	0.00146697345	2.237867	28	0.004849325	84	0.014982640457142857	1.923085	21	42	0.004301516	
GO Cellular Component	preribosome, large subunit precursor	146	0.0002349731	0.002781051484931507	2.584628	19	0.003290613	70	0.008368829897142856	2.307702	15	25	0.003072511	
GO Molecular Function	structural constituent of ribosome	6	8.691752e-13	6.116096157333333e-10	2.202887	102	0.0176654	18	0.0001447683221888889	1.685667	71	162	0.01454322	
GO Molecular Function	unfolded protein binding	7	2.473428e-12	1.4918304308571428e-9	2.570122	72	0.01246969	54	0.012861197133333334	1.632808	45	106	0.009217534	
GO Molecular Function	protein transporter activity	25	3.348119e-8	0.0000056543033672	2.010013	75	0.01298926	61	0.01866704698032787	1.642635	41	96	0.008398197	
GO Molecular Function	endoribonuclease activity	40	9.311164e-7	0.00009827933601999999	2.332648	42	0.007273987	79	0.04107979812911392	1.785722	26	56	0.005325686	
GO Molecular Function	histone methyltransferase binding	62	0.000008498995	0.0005787541433870969	8.208506	8	0.001385521	63	0.020654714263492063	3.84617	6	6	0.001229005	
Human Phenotype	Increased serum lactate	16	1.1741e-8	0.000004896730812500001	2.16638	67	0.01160374	14	0.03377550389428571	1.692315	44	100	0.0090127	
Human Phenotype	Increased serum pyruvate	72	0.00002436135	0.0022578234520833334	3.897734	14	0.002424662	12	0.02301032795333333	3.461553	9	10	0.001843507	
Mouse Phenotype Single KO	absent hypoglossal nerve	15	4.856763e-11	2.9648919194e-8	5.078207	26	0.004502944	40	0.00433475668475	3.076936	12	15	0.002458009	
Mouse Phenotype Single KO	decreased level of surface class I molecules	38	1.683866e-8	0.000004057673937368421	8.102033	13	0.002251472	43	0.00881186202232558	3.461553	9	10	0.001843507	
Mouse Phenotype Single KO	abnormal antigen presentation via MHC class I	45	3.05455e-8	0.000006215669855555556	5.524359	17	0.002944233	50	0.010759804652	3.02199	11	14	0.002253175	
Mouse Phenotype Single KO	abnormal vitelline vein morphology	60	2.510893e-7	0.00003832041200166666	2.398892	44	0.007620367	79	0.03929571228734177	2.307702	15	25	0.003072511	
Mouse Phenotype Single KO	abnormal level of surface class I molecules	64	2.807245e-7	0.0000401655351015625	5.790218	14	0.002424662	47	0.010531035126170213	3.205141	10	12	0.002048341	
Mouse Phenotype	pale lung	18	1.775296e-11	9.429780586666668e-9	6.448721	22	0.003810184	94	0.03134851525851064	3.84617	6	6	0.001229005	
Mouse Phenotype	absent hypoglossal nerve	21	4.856763e-11	2.2112148115714287e-8	5.078207	26	0.004502944	45	0.004023113699333333	3.076936	12	15	0.002458009	
Mouse Phenotype	decreased level of surface class I molecules	31	7.897247e-10	2.4356638247419356e-7	8.447303	15	0.002597852	30	0.001060764267	3.525655	11	12	0.002253175	
Mouse Phenotype	abnormal antigen presentation via MHC class I	34	1.964985e-9	5.52565340735294e-7	5.848926	19	0.003290613	34	0.0016911111547941178	3.125013	13	16	0.002662843	
Mouse Phenotype	abnormal level of surface class I molecules	47	1.697763e-8	0.000003453683413404255	6.179872	16	0.002771043	33	0.0014411787836363635	3.296717	12	14	0.002458009	
Mouse Phenotype	abnormal vitelline vein morphology	63	2.510893e-7	0.00003810579043333334	2.398892	44	0.007620367	96	0.033763785115625	2.307702	15	25	0.003072511	
Mouse Phenotype	absent hypoglossal canal	84	7.839466e-7	0.00008922992193571429	5.757996	13	0.002251472	100	0.047320123446	3.365398	7	8	0.001433839