# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	IRE1-mediated unfolded protein response	13	7.778669e-42	7.873808105461538e-39	4.383874	129	0.01261614	430	0.009060571305581395	1.595222	36	58	0.004927457	
GO Biological Process	endoplasmic reticulum unfolded protein response	28	5.139311e-34	2.4152926231785713e-31	2.802758	188	0.01838631	425	0.008774003208235294	1.420307	63	114	0.00862305	
GO Biological Process	multi-organism metabolic process	33	6.577237e-32	2.62272308130303e-29	2.556344	206	0.0201467	76	4.213184556447368e-10	1.73087	99	147	0.01355051	
GO Biological Process	mRNA catabolic process	34	9.701514e-32	3.754771256647059e-29	2.212285	273	0.02669927	207	0.00004520572297246377	1.4238	118	213	0.01615111	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	35	2.605084e-31	9.794371530285713e-29	2.912967	162	0.01584352	235	0.00012786437912340427	1.546404	71	118	0.00971804	
GO Biological Process	nuclear-transcribed mRNA catabolic process	38	4.913036e-31	1.7013326506315788e-28	2.267256	253	0.02474328	179	0.000011430238212849163	1.466762	113	198	0.01546674	
GO Biological Process	cellular response to topologically incorrect protein	42	4.660997e-30	1.4603347505476191e-27	2.471131	206	0.0201467	482	0.020421995386514524	1.349754	73	139	0.009991788	
GO Biological Process	rRNA processing	46	1.555766e-29	4.4505053900000004e-27	2.115335	280	0.02738386	123	6.609850217154471e-8	1.489014	146	252	0.01998358	
GO Biological Process	cellular response to unfolded protein	48	7.055486e-29	1.9342320890416665e-26	2.52271	190	0.01858191	469	0.01825286012302772	1.380621	65	121	0.008896797	
GO Biological Process	rRNA metabolic process	50	1.881011e-28	4.9504447498e-26	2.071055	283	0.02767726	128	8.450470265078126e-8	1.47854	149	259	0.0203942	
GO Biological Process	response to topologically incorrect protein	52	4.8859e-28	1.2364145788461539e-25	2.194268	244	0.02386308	395	0.006208952554177215	1.342153	94	180	0.01286614	
GO Biological Process	viral gene expression	53	1.142968e-27	2.8377954550943395e-25	2.670747	164	0.01603912	121	4.815395759834711e-8	1.699895	84	127	0.0114974	
GO Biological Process	viral transcription	56	4.388697e-27	1.0312654254107143e-24	2.724037	155	0.01515892	112	9.30402747830357e-9	1.774037	78	113	0.01067616	
GO Biological Process	RNA catabolic process	57	6.022884e-27	1.3904408869473683e-24	2.006077	289	0.02826406	222	0.00008317276354504504	1.38635	130	241	0.01779359	
GO Biological Process	response to unfolded protein	60	3.041984e-26	6.671577909333334e-24	2.20094	226	0.02210269	392	0.005881018937244898	1.365355	85	160	0.01163427	
GO Biological Process	protein targeting to ER	61	8.223192e-26	1.7739177627540985e-23	2.832992	138	0.01349633	145	5.944983910206897e-7	1.73035	68	101	0.009307419	
GO Biological Process	cotranslational protein targeting to membrane	62	1.62764e-25	3.4545346387096773e-23	2.876633	133	0.01300733	150	9.385323388666666e-7	1.73087	66	98	0.009033671	
GO Biological Process	regulation of mRNA stability	81	1.443261e-23	2.344675493703704e-21	2.055752	236	0.02308068	386	0.005515881211658031	1.378652	81	151	0.01108678	
GO Biological Process	establishment of protein localization to endoplasmic reticulum	85	6.972761e-23	1.079465435282353e-20	2.573112	143	0.01398533	134	2.2449470043283584e-7	1.737863	71	105	0.00971804	
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	87	2.31162e-22	3.4963916758620693e-20	2.794377	121	0.01183374	172	0.000007045340840930232	1.704074	61	92	0.008349302	
GO Cellular Component	ribosomal subunit	34	6.762727e-28	3.437056545882353e-26	2.350161	210	0.0205379	37	5.375938767567568e-9	1.597617	115	185	0.01574049	
GO Cellular Component	mitochondrial ribosome	43	9.151892e-19	3.6777835758139535e-17	2.903576	94	0.009193154	68	0.0002554174588235294	1.60252	53	85	0.007254312	
GO Cellular Component	large ribosomal subunit	47	5.78575e-18	2.1271863829787234e-16	2.374959	128	0.01251834	54	0.000007024464	1.609093	72	115	0.009854914	
GO Cellular Component	proteasome complex	48	7.297302e-18	2.6270287199999997e-16	2.705698	100	0.009779951	110	0.010727031272727273	1.511811	40	68	0.005474952	
GO Cellular Component	endopeptidase complex	49	7.565195e-18	2.667889175510204e-16	2.70417	100	0.009779951	115	0.015308276869565218	1.489901	40	69	0.005474952	
GO Cellular Component	peptidase complex	51	3.0255e-16	1.0251105882352942e-14	2.340242	118	0.01154034	103	0.008219684970873786	1.460272	50	88	0.00684369	
GO Cellular Component	nuclear ubiquitin ligase complex	60	2.214474e-12	6.377685119999999e-11	2.968671	57	0.005574572	92	0.0043855344	1.734804	27	40	0.003695593	
GO Cellular Component	catalytic step 2 spliceosome	64	7.322019e-12	1.9769451299999998e-10	2.022129	115	0.01124694	84	0.0018110026285714283	1.499213	56	96	0.007664933	
GO Cellular Component	DNA-directed RNA polymerase III complex	67	1.09923e-11	2.8350290149253735e-10	5.037763	28	0.002738386	132	0.029381589818181814	1.893743	14	19	0.001916233	
GO Cellular Component	small ribosomal subunit	72	1.988174e-11	4.7716176e-10	2.287549	83	0.008117359	88	0.0021799564363636365	1.570604	44	72	0.006022447	
GO Cellular Component	mitochondrial large ribosomal subunit	73	2.125639e-11	5.031649578082192e-10	2.85831	55	0.005378973	102	0.00814338974117647	1.612599	32	51	0.004379962	
GO Cellular Component	cytosolic large ribosomal subunit	96	2.177072e-9	3.9187296e-8	2.167981	74	0.007237164	71	0.0005391875966197183	1.685298	40	61	0.005474952	
GO Cellular Component	proteasome accessory complex	102	4.341086e-9	7.3543104e-8	3.167982	36	0.003520782	126	0.021013042285714285	1.820473	17	24	0.002326855	
GO Cellular Component	cytosolic small ribosomal subunit	124	2.129002e-7	0.0000029668673032258063	2.190091	54	0.005281174	113	0.011846953911504426	1.635505	28	44	0.003832466	
GO Cellular Component	ESCRT complex	137	9.207855e-7	0.000011613995211678831	2.568573	35	0.003422983	127	0.02468171792125984	1.743982	19	28	0.002600602	
GO Cellular Component	anaphase-promoting complex	138	9.259689e-7	0.000011594741008695652	3.004091	27	0.002640587	108	0.009241576	1.958156	16	21	0.002189981	
GO Cellular Component	ESCRT III complex	148	0.000002277186	0.00002658768518918919	3.396593	21	0.00205379	129	0.029356496372093022	2.141733	10	12	0.001368738	
GO Cellular Component	proteasome regulatory particle	193	0.00004828525	0.0004323156062176166	2.395441	27	0.002640587	136	0.03264435952941176	1.835771	15	21	0.002053107	
GO Cellular Component	death-inducing signaling complex	266	0.0004755003	0.003088964354887218	2.78935	15	0.001466993	140	0.03809716662857143	2.284515	8	9	0.00109499	
GO Cellular Component	nuclear pore outer ring	331	0.002811248	0.014676243335347434	2.613864	12	0.001173594	119	0.019236967260504202	2.313071	9	10	0.001231864	
GO Molecular Function	structural constituent of ribosome	11	4.207768e-21	1.6150178632727274e-18	2.195219	180	0.01760391	33	0.0000025819973642424244	1.554739	98	162	0.01341363	
GO Molecular Function	snRNA binding	27	2.179171e-13	3.407577763703704e-11	3.463188	50	0.004889976	101	0.02994723540792079	1.690842	25	38	0.003421845	
GO Molecular Function	C-acyltransferase activity	250	0.0001087092	0.0018358809696	2.056519	34	0.003325183	107	0.0452438989906542	1.92756	15	20	0.002053107	
GO Molecular Function	fatty acid ligase activity	303	0.0003434885	0.004786166491749174	2.149171	26	0.002542787	98	0.024883886397959184	1.958156	16	21	0.002189981	
Human Phenotype	Increased serum lactate	13	2.490065e-16	1.278169518846154e-13	2.282355	125	0.01222494	74	0.0032801068377027024	1.516347	59	100	0.008075554	
Human Phenotype	Increased serum pyruvate	34	4.837254e-11	9.493822335882354e-9	4.559273	29	0.002836186	196	0.04510294318367347	2.313071	9	10	0.001231864	
Human Phenotype	Abnormal CSF metabolite level	35	5.85123e-11	1.1155787939999999e-8	2.394769	72	0.007041565	187	0.03980908398395722	1.509412	37	63	0.005064331	
Human Phenotype	Abnormality of glycolysis	39	1.438554e-10	2.46140278e-8	4.21433	30	0.002933985	151	0.02490320291788079	2.336436	10	11	0.001368738	
Human Phenotype	Vertebral arch anomaly	91	4.818016e-8	0.000003533035249230769	3.411797	28	0.002738386	114	0.01192859626491228	2.570079	9	9	0.001231864	
Human Phenotype	Leukodystrophy	92	4.854518e-8	0.000003521108545	2.113243	65	0.006356968	123	0.015458226933333334	1.644851	32	50	0.004379962	
Human Phenotype	Glycosuria	106	1.357151e-7	0.000008543649644339623	2.350993	48	0.004694377	178	0.037702524977528094	1.772469	20	29	0.002737476	
Human Phenotype	Basal cell carcinoma	280	0.000076877	0.0018321436464285713	2.150988	32	0.003129584	197	0.045789787269035535	1.869149	16	22	0.002189981	
Mouse Phenotype Single KO	abnormal osteoblast differentiation	26	6.271328e-23	2.2087134806153845e-20	2.51895	149	0.01457213	167	0.025212439658083834	1.656273	29	45	0.00396934	
Mouse Phenotype Single KO	embryonic lethality between somite formation and embryo turning, complete penetrance	89	2.667111e-14	2.744127576067416e-12	2.041255	139	0.01359413	117	0.008614248174358975	1.562886	45	74	0.006159321	
Mouse Phenotype Single KO	pale liver	114	2.561181e-12	2.0572574050000002e-10	2.016166	121	0.01183374	179	0.029008992326815645	1.477796	46	80	0.006296195	
Mouse Phenotype Single KO	abnormal urine magnesium level	339	0.000004665841	0.00012603276117109145	2.956948	24	0.002347188	178	0.0289897347494382	2.336436	10	11	0.001368738	
Mouse Phenotype Single KO	abnormal DNA replication	463	0.00004808074	0.0009509186526565874	2.177078	33	0.003227384	54	0.00046867747420370373	2.234852	20	23	0.002737476	
Mouse Phenotype	pancytopenia	48	2.502116e-19	4.983902307500001e-17	3.224047	83	0.008117359	272	0.035351164786764706	1.772469	20	29	0.002737476	
Mouse Phenotype	abnormal lipoprotein lipase activity	698	0.0003517368	0.004817987886532951	2.3732	21	0.00205379	301	0.04208008919601329	2.313071	9	10	0.001231864	
Mouse Phenotype	abnormal conotruncus septation	841	0.001376582	0.01564982223781213	2.280053	18	0.001760391	303	0.04252770665346535	2.570079	7	7	0.0009581166