# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	15	3.141694e-47	2.7561034230666665e-44	2.456524	336	0.01696284	231	2.0073558901298698e-8	1.448282	98	113	0.00871576	
GO Biological Process	IRE1-mediated unfolded protein response	19	8.562529e-42	5.930227321631579e-39	3.262902	186	0.009390145	643	0.0032574541712286163	1.382034	48	58	0.004268943	
GO Biological Process	regulation of DNA-templated transcription in response to stress	21	9.123861e-41	5.717185090428572e-38	2.242765	347	0.01751817	225	9.414510050666667e-9	1.445425	103	119	0.009160441	
GO Biological Process	endoplasmic reticulum unfolded protein response	26	2.456025e-38	1.2430320375e-35	2.324113	302	0.01524637	259	2.081791397142857e-7	1.420929	97	114	0.008626823	
GO Biological Process	cellular response to topologically incorrect protein	32	6.912516e-38	2.842556188875e-35	2.161109	349	0.01761914	245	8.094638002040816e-8	1.393633	116	139	0.01031661	
GO Biological Process	positive regulation of transcription from RNA polymerase II promoter in response to stress	35	1.547248e-35	5.817210409142857e-33	3.888421	125	0.006310582	996	0.04454552707329317	1.461213	21	24	0.001867663	
GO Biological Process	cellular response to unfolded protein	39	2.928856e-33	9.88226053948718e-31	2.13841	312	0.01575121	266	2.377416742030075e-7	1.407733	102	121	0.009071505	
GO Biological Process	positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	44	3.887737e-31	1.162698435977273e-28	3.399992	129	0.00651252	695	0.005153371127769785	1.669957	16	16	0.001422981	
GO Biological Process	positive regulation of mRNA catabolic process	46	4.744694e-31	1.3572919205652174e-28	3.06613	149	0.007522213	556	0.00112695829721223	1.603159	24	25	0.002134472	
GO Biological Process	regulation of hematopoietic progenitor cell differentiation	61	4.256143e-29	9.181407497868854e-27	2.241184	244	0.01231826	532	0.0009421010431766917	1.300498	88	113	0.007826396	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to hypoxia	89	3.255141e-25	4.812853979662921e-23	2.233648	211	0.01065226	320	0.000004830430393125	1.45586	68	78	0.00604767	
GO Biological Process	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	95	2.241877e-24	3.1053536255789473e-22	2.278455	195	0.009844507	345	0.00001441549760405797	1.470559	59	67	0.005247243	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	97	3.431446e-24	4.6550925684536075e-22	2.116304	228	0.0115105	456	0.0002728179574890351	1.316153	93	118	0.008271078	
GO Biological Process	positive regulation of mRNA metabolic process	100	4.479842e-24	5.895024087799999e-22	2.315656	186	0.009390145	721	0.006650666281137309	1.380926	43	52	0.003824262	
GO Biological Process	protein targeting to ER	102	7.259583e-24	9.365573793823529e-22	2.193609	207	0.01045032	287	0.0000013378548974216027	1.421944	86	101	0.007648524	
GO Biological Process	DNA-templated transcription, elongation	106	1.675345e-23	2.0797985712264152e-21	2.088774	228	0.0115105	483	0.0003852957924430642	1.320784	87	110	0.00773746	
GO Biological Process	regulation of nuclease activity	111	3.219362e-23	3.816539149369369e-21	3.191204	103	0.005199919	880	0.02279117865227273	1.47727	23	26	0.002045535	
GO Biological Process	regulation of mRNA catabolic process	112	3.901126e-23	4.583474735178571e-21	2.443645	160	0.008077544	655	0.003928104139541985	1.508349	28	31	0.002490217	
GO Biological Process	regulation of mitochondrial membrane permeability	118	1.245013e-22	1.3884005141525422e-20	2.065164	225	0.01135905	329	0.000006975093937386017	1.464072	64	73	0.005691925	
GO Biological Process	translational elongation	120	1.467053e-22	1.6087458689166668e-20	2.073706	222	0.01120759	253	1.1157500496442686e-7	1.431392	96	112	0.008537887	
GO Cellular Component	mitochondrial ribosome	41	2.319503e-25	9.775856546341463e-24	2.567165	161	0.008128029	88	0.000011976991854545453	1.414552	72	85	0.006403415	
GO Cellular Component	nuclear ubiquitin ligase complex	42	1.222971e-24	5.031652114285714e-23	3.091774	115	0.005805735	230	0.04338408459130435	1.335966	32	40	0.002845962	
GO Cellular Component	large ribosomal subunit	44	1.6443e-24	6.457614545454545e-23	2.145443	224	0.01130856	56	5.107128685714286e-9	1.452137	100	115	0.008893632	
GO Cellular Component	peptidase complex	46	7.276089e-24	2.733278650434782e-22	2.170388	212	0.01070275	68	6.021843670588235e-8	1.480189	78	88	0.006937033	
GO Cellular Component	mitochondrial large ribosomal subunit	48	1.285943e-22	4.6293948000000004e-21	2.977778	111	0.005603796	98	0.00002819443591836735	1.506236	46	51	0.004091071	
GO Cellular Component	PcG protein complex	49	1.762097e-22	6.214089012244898e-21	2.247608	184	0.009289176	181	0.008006241202209944	1.37953	38	46	0.00337958	
GO Cellular Component	endopeptidase complex	50	1.930956e-22	6.6733839360000005e-21	2.345125	168	0.008481422	91	0.000015380542523076924	1.452137	60	69	0.005336179	
GO Cellular Component	proteasome complex	51	1.018706e-21	3.4516156235294115e-20	2.318516	166	0.008380452	96	0.000021298014	1.448934	59	68	0.005247243	
GO Cellular Component	methylosome	66	2.449855e-14	6.414165818181818e-13	4.686992	38	0.001918417	197	0.018603288365482234	1.669957	12	12	0.001067236	
GO Cellular Component	signal recognition particle	81	3.303297e-12	7.0470336e-11	4.504024	33	0.001665994	231	0.04427723220779221	1.669957	10	10	0.0008893632	
GO Cellular Component	spliceosomal snRNP complex	86	1.708368e-11	3.4326277953488367e-10	2.016759	112	0.005654281	168	0.0041736929142857145	1.34674	50	62	0.004446816	
GO Cellular Component	CCR4-NOT complex	98	1.036557e-10	1.8277249959183675e-9	2.680541	57	0.002877625	163	0.002885422880981595	1.669957	16	16	0.001422981	
GO Cellular Component	spliceosomal tri-snRNP complex	99	1.246767e-10	2.1761751272727275e-9	2.50132	64	0.003231018	196	0.018553968	1.439618	25	29	0.002223408	
GO Cellular Component	ESCRT complex	113	1.022956e-9	1.564307936283186e-8	2.386641	63	0.003180533	175	0.006690286738285714	1.491033	25	28	0.002223408	
GO Cellular Component	proteasome accessory complex	128	6.158705e-9	8.31425175e-8	2.452995	54	0.002726171	212	0.02748200603773585	1.461213	21	24	0.001867663	
GO Cellular Component	outer mitochondrial membrane protein complex	135	1.226453e-8	1.56985984e-7	2.985666	37	0.001867932	221	0.03933435453393665	1.558627	14	15	0.001245109	
GO Cellular Component	mitochondrial outer membrane translocase complex	140	2.070574e-8	2.555679908571429e-7	3.223087	32	0.001615509	215	0.02847695776744186	1.669957	11	11	0.0009782995	
GO Cellular Component	very-low-density lipoprotein particle	144	3.813812e-8	4.5765744e-7	2.360599	52	0.002625202	213	0.028313133971830984	1.502962	18	20	0.001600854	
GO Cellular Component	U12-type spliceosomal complex	221	0.000005368388	0.00004197545006334841	2.052192	48	0.002423263	233	0.047355120618025756	1.413041	22	26	0.001956599	
GO Cellular Component	U1 snRNP	239	0.00001289535	0.00009323499916317992	2.051443	44	0.002221325	179	0.007743310873743017	1.582065	18	19	0.001600854	
GO Molecular Function	ribonucleoprotein complex binding	9	6.887739e-27	3.231114895333333e-24	2.083234	265	0.01337843	74	0.00006643128721621621	1.350487	93	115	0.008271078	
GO Molecular Function	rRNA binding	12	6.890557e-22	2.4243276378333336e-19	2.878436	113	0.005704766	92	0.001038786845869565	1.419464	51	60	0.004535752	
GO Molecular Function	snRNA binding	32	9.820111e-13	1.2956408950625e-10	2.610067	73	0.00368538	149	0.03240855370469799	1.40628	32	38	0.002845962	
GO Molecular Function	SUMO transferase activity	34	1.801233e-12	2.236707566470588e-10	2.727886	66	0.003331987	141	0.02401790399716312	1.582065	18	19	0.001600854	
GO Molecular Function	O-methyltransferase activity	116	7.293427e-8	0.0000026545559305172415	2.250316	55	0.002776656	129	0.010319720049612404	1.590436	20	21	0.001778726	
GO Molecular Function	phosphate transmembrane transporter activity	129	1.260531e-7	0.000004125551846511627	2.032553	67	0.003382472	110	0.0029390992418181815	1.600376	23	24	0.002045535	
GO Molecular Function	protein transmembrane transporter activity	178	0.000001292776	0.0000306634846741573	2.129073	50	0.002524233	153	0.035178862980392155	1.577182	17	18	0.001511917	
Human Phenotype	Increased serum lactate	8	4.776201e-22	3.983948659125e-19	2.064144	219	0.01105614	58	0.000004802372866724137	1.419464	85	100	0.007559587	
Human Phenotype	Abnormality of transition element cation homeostasis	12	3.89255e-18	2.164582179166667e-15	3.366751	73	0.00368538	238	0.012595531428991596	1.497203	26	29	0.002312344	
Human Phenotype	Exercise intolerance	30	2.232582e-13	4.966006562e-11	2.031239	131	0.006613489	301	0.039017585235880406	1.288253	54	70	0.004802561	
Human Phenotype	Abnormal CSF metabolite level	33	3.82973e-12	7.744178269696969e-10	2.025983	118	0.005957189	137	0.0014026879798540147	1.404885	53	63	0.004713625	
Human Phenotype	Cytochrome C oxidase-negative muscle fibers	64	2.463775e-10	2.5688704023437502e-8	3.116218	43	0.00217084	181	0.0035939590869613265	1.669957	18	18	0.001600854	
Human Phenotype	Diminished motivation	94	6.687925e-9	4.7477152686170217e-7	2.302488	61	0.003079564	245	0.013712639133061226	1.586459	19	20	0.00168979	
Human Phenotype	Apathy	105	1.309353e-8	8.321250065714286e-7	2.294579	59	0.002978595	262	0.02042940987557252	1.582065	18	19	0.001600854	
Human Phenotype	Increased hepatocellular lipid droplets	447	0.0002991252	0.004465464115436241	2.170136	26	0.001312601	313	0.04521567237380192	1.669957	12	12	0.001067236	
Mouse Phenotype Single KO	absent hypoglossal nerve	40	1.089609e-17	2.49438740325e-15	3.643788	64	0.003231018	219	0.01901517950456621	1.669957	15	15	0.001334045	
Mouse Phenotype	absent hypoglossal nerve	54	1.089609e-17	1.929213268333333e-15	3.643788	64	0.003231018	341	0.01275088325366569	1.669957	15	15	0.001334045	
Mouse Phenotype	abnormal vitelline vein morphology	116	1.576565e-12	1.2994429280172414e-10	2.002464	126	0.006361066	453	0.04795297388741722	1.469562	22	25	0.001956599