# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process mesoderm formation 82 3.999725e-7 0.00006418583082317073 2.057581 59 0.02102637 89 1.255095809494382e-7 2.696188 36 67 0.009620524 GO Biological Process paraxial mesoderm development 88 7.882303e-7 0.00011786730133750001 3.281709 24 0.0085531 296 0.00038742572203716215 3.54205 12 17 0.003206841 GO Biological Process paraxial mesoderm morphogenesis 97 0.000002304005 0.00031256084324742266 3.387902 21 0.007483963 170 0.000007574667952411765 5.017905 10 10 0.002672368 GO Biological Process negative regulation of cardiac muscle hypertrophy in response to stress 112 0.000005459098 0.0006413952730535714 4.801824 13 0.004632929 674 0.03064738909495549 4.181587 5 6 0.001336184 GO Biological Process signal transduction involved in regulation of gene expression 150 0.0000378806 0.0033231387693333334 2.649735 23 0.008196721 535 0.013317990235514018 2.759848 11 20 0.002939604 GO Biological Process determination of heart left/right asymmetry 166 0.00005608275 0.0044457404051204815 2.008218 39 0.01389879 635 0.02642246380944882 1.861481 23 62 0.006146446 GO Biological Process autophagosome organization 167 0.00005695098 0.004487532609700599 2.366844 27 0.009622238 587 0.019622472142759795 1.936735 22 57 0.005879209 GO Biological Process autophagosome assembly 186 0.0001064517 0.0075311716145161295 2.318675 26 0.009265859 607 0.02198680294892916 1.951407 21 54 0.005611972 GO Biological Process interleukin-10 production 196 0.000147348 0.00989261393877551 7.815489 6 0.002138275 683 0.030349721081991212 5.017905 4 4 0.001068947 GO Biological Process response to muscle inactivity 257 0.0004154076 0.02126983894319066 3.509623 11 0.003920171 706 0.03571552035269122 3.193212 7 11 0.001870657 GO Biological Process regulation of lipoprotein particle clearance 264 0.0004546617 0.02266247466022727 3.747297 10 0.003563792 526 0.01189304415893536 2.951709 10 17 0.002672368 GO Biological Process osteoblast development 282 0.0005572356 0.02600235198723404 2.34057 20 0.007127584 751 0.04386355527829561 2.656538 9 17 0.002405131 GO Biological Process positive regulation of pri-miRNA transcription from RNA polymerase II promoter 283 0.0005596996 0.02602504253144876 2.741466 15 0.005345688 755 0.04373703017218543 2.508952 10 20 0.002672368 GO Biological Process regulation of transcription from RNA polymerase II promoter involved in heart development 285 0.0005807012 0.0268120950554386 2.39391 19 0.006771205 320 0.0006335018116562501 3.859927 10 13 0.002672368 GO Biological Process dorsal aorta morphogenesis 340 0.0009053921 0.035041337187941175 4.120006 8 0.002851033 626 0.02530385310702875 3.763429 6 8 0.001603421 GO Biological Process regulation of microvillus assembly 389 0.001179603 0.0399033313033419 3.081442 11 0.003920171 674 0.03064738909495549 4.181587 5 6 0.001336184 GO Cellular Component transcriptional repressor complex 27 0.000001350206 0.000086413184 2.065669 53 0.0188881 47 0.015600770042553192 1.813701 30 83 0.008017103 GO Molecular Function Rho guanyl-nucleotide exchange factor activity 16 7.549935e-8 0.00001992239098125 2.23763 55 0.01960086 34 0.0026599208464705877 2.032569 32 79 0.008551577 GO Molecular Function ATP-dependent microtubule motor activity, minus-end-directed 39 0.00000688618 0.0007454731271794872 3.050458 22 0.007840342 74 0.05014666236486487 2.787725 10 18 0.002672368 Mouse Phenotype Single KO rectal prolapse 31 0.000005560434 0.001642480456064516 2.776832 26 0.009265859 304 0.006540173385855263 2.601877 14 27 0.003741315 Mouse Phenotype Single KO abnormal hippocampal mossy fiber morphology 67 0.0001000344 0.013671865683582089 2.17608 30 0.01069138 583 0.03539134950600343 2.315956 12 26 0.003206841 Mouse Phenotype Single KO abnormal Langerhans cell morphology 87 0.000192985 0.020312225804597704 3.582549 12 0.00427655 555 0.0316154252018018 3.193212 7 11 0.001870657 Mouse Phenotype Single KO abnormal thyroid cartilage morphology 111 0.0003122481 0.025759061727027025 2.391864 21 0.007483963 446 0.018045706059417042 2.787725 10 18 0.002672368 Mouse Phenotype Single KO abnormal choriocapillaris morphology 121 0.0004281678 0.03240274830247934 3.776831 10 0.003563792 341 0.008422810000293254 5.017905 5 5 0.001336184 Mouse Phenotype Single KO decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 124 0.0004490817 0.03316323489435484 2.324683 21 0.007483963 570 0.03317913643684211 2.249406 13 29 0.003474078 Mouse Phenotype Single KO abnormal Bruch membrane morphology 144 0.0005888529 0.03744531948125 3.155707 12 0.00427655 441 0.01748085211995465 3.512533 7 10 0.001870657 Mouse Phenotype Single KO abnormal lymph node germinal center morphology 148 0.0006051565 0.03744201398986487 2.6188 16 0.005702067 597 0.03698498495477387 2.399868 11 23 0.002939604 Mouse Phenotype Single KO abnormal sinus venosus morphology 171 0.0008514361 0.04559415419707602 3.21139 11 0.003920171 358 0.009272657002513967 4.301061 6 7 0.001603421 Mouse Phenotype rectal prolapse 62 0.00001090307 0.0016813589075806452 2.422846 31 0.01104775 647 0.015525615811437405 2.169905 16 37 0.004275788 Mouse Phenotype decreased threshold for auditory brainstem response 70 0.00001619629 0.0022121818384285715 2.552191 27 0.009622238 824 0.03246548940291262 2.007162 16 40 0.004275788 Mouse Phenotype abnormal hippocampal mossy fiber morphology 77 0.00003174405 0.003941621585064936 2.086454 38 0.01354241 791 0.028302542305941848 2.090794 15 36 0.004008552 Mouse Phenotype abnormal GABAergic neuron morphology 151 0.00027178 0.017208533642384106 2.262303 24 0.0085531 554 0.009681292567148014 2.422437 14 29 0.003741315 Mouse Phenotype abnormal thyroid cartilage morphology 159 0.0003272181 0.019676303484905656 2.152667 26 0.009265859 564 0.009770518126595743 2.508952 13 26 0.003474078 Mouse Phenotype abnormal lymph node germinal center morphology 161 0.0003338222 0.019824062448447203 2.50833 19 0.006771205 740 0.0241204908 2.195333 14 32 0.003741315 Mouse Phenotype abnormal choriocapillaris morphology 174 0.0004281678 0.023527082389655174 3.776831 10 0.003563792 488 0.006145279851024589 5.017905 5 5 0.001336184 Mouse Phenotype abnormal lymphatic vessel endothelial cell morphology 185 0.0004848446 0.025057293084324323 2.367511 20 0.007127584 747 0.02452570569076305 3.193212 7 11 0.001870657 Mouse Phenotype abnormal lymph node secondary follicle morphology 200 0.000575926 0.027532142430000003 2.3956 19 0.006771205 874 0.04042452060411899 2.066196 14 34 0.003741315 Mouse Phenotype aerophagia 207 0.0006040406 0.02789967235072464 3.146363 12 0.00427655 712 0.02107918504213483 4.181587 5 6 0.001336184 Mouse Phenotype abnormal gastric chief cell morphology 218 0.0006849827 0.030041833003211012 2.502009 17 0.006058446 703 0.020746445180654337 2.641003 10 19 0.002672368 Mouse Phenotype abnormal lymphatic vessel endothelium morphology 219 0.000697997 0.03047282793150685 2.297211 20 0.007127584 882 0.04129308094897959 2.927111 7 12 0.001870657 Mouse Phenotype abnormal Langerhans cell morphology 221 0.0007159835 0.0309751956719457 2.576727 16 0.005702067 481 0.005905038581912683 2.905103 11 19 0.002939604 Mouse Phenotype abnormal circulating fructosamine level 275 0.001276791 0.04439054091272727 2.135223 21 0.007483963 923 0.045121974156012996 1.980752 15 38 0.004008552 Mouse Phenotype decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 283 0.001334046 0.04507001344876325 2.085105 22 0.007840342 963 0.05009306743302181 2.007162 14 35 0.003741315