# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process regulation of gene expression, epigenetic 7 4.611564e-15 8.669081525142858e-12 2.910693 72 0.04458204 31 0.014927764862580645 1.836936 46 248 0.0242616 GO Biological Process nucleosome assembly 12 2.68323e-14 2.9423852975e-11 3.577438 51 0.03157895 16 0.008577027975625 2.23177 32 142 0.01687764 GO Biological Process protein-DNA complex subunit organization 13 3.024341e-14 3.061331016846154e-11 2.686404 77 0.04767802 39 0.014575799163076924 1.822241 46 250 0.0242616 GO Biological Process nucleosome organization 16 3.906516e-14 3.21286525275e-11 3.299038 56 0.03467492 34 0.014354951844705881 2.027028 35 171 0.01845992 GO Biological Process gene silencing 20 2.152017e-13 1.41591958515e-10 3.286885 53 0.03281734 54 0.026971222507407407 1.925677 35 180 0.01845992 GO Biological Process protein-DNA complex assembly 21 7.973143e-13 4.996123273190476e-10 2.698497 68 0.04210526 30 0.014840790381333334 1.899298 42 219 0.0221519 GO Biological Process chromatin assembly 22 1.690968e-12 1.0114294505454546e-9 3.19489 51 0.03157895 49 0.025959943609999998 2.005768 32 158 0.01687764 GO Biological Process chromatin assembly or disassembly 27 4.527217e-12 2.206431426037037e-9 2.989483 54 0.03343653 65 0.03980674429538462 1.891676 34 178 0.01793249 GO Biological Process negative regulation of gene expression, epigenetic 30 1.508332e-11 6.616046929333334e-9 4.002101 35 0.02167183 43 0.016765609539302326 2.258689 26 114 0.01371308 GO Biological Process regulation of defense response to virus 95 2.800095e-7 0.00003878573695263158 3.034066 29 0.01795666 68 0.04194810538823529 2.24615 22 97 0.01160338 GO Biological Process protein sumoylation 189 0.000007944283 0.0005531154497195768 2.779146 25 0.01547988 61 0.032199619985245904 2.47587 19 76 0.0100211 GO Biological Process JAK-STAT cascade 296 0.00006498677 0.002889057116317568 2.614952 22 0.01362229 32 0.0147538831365625 3.160685 15 47 0.007911392 GO Biological Process regulation of mast cell activation 376 0.0001927297 0.00674502692101064 2.910548 16 0.009907121 70 0.045128621312857144 3.127415 12 38 0.006329114 GO Biological Process regulation of CD4-positive, alpha-beta T cell activation 538 0.0008037563 0.019659161992007432 2.215414 21 0.0130031 64 0.0395462697984375 2.888515 14 48 0.007383966 GO Cellular Component nucleosome 15 6.822414e-17 7.859420927999999e-15 6.185001 35 0.02167183 5 0.000008397644544 2.923885 31 105 0.01635021 GO Cellular Component DNA packaging complex 18 2.887864e-14 2.77234944e-12 5.021659 35 0.02167183 10 0.00002162486592 2.741142 31 112 0.01635021 GO Cellular Component nuclear chromatin 24 2.460912e-11 1.77185664e-9 2.123861 94 0.05820433 16 0.0005437231920000001 1.817728 58 316 0.03059072 GO Cellular Component protein-DNA complex 43 2.438485e-7 0.000009799307162790698 2.335086 46 0.02848297 24 0.0086013072 1.863031 38 202 0.02004219 GO Cellular Component uropod 54 0.00000565096 0.00018083072 7.342935 9 0.005572755 35 0.04758746605714286 4.570837 6 13 0.003164557 GO Cellular Component small ribosomal subunit 55 0.000008975611 0.0002819973783272727 3.315406 19 0.01176471 32 0.0361023642 2.338322 17 72 0.008966245 Mouse Phenotype Single KO increased lymphocyte cell number 10 5.025184e-20 4.6015609888e-17 2.060532 185 0.1145511 11 0.00010521442947272726 1.666762 103 612 0.05432489 Mouse Phenotype Single KO abnormal platelet aggregation 17 1.57465e-18 8.481805911764705e-16 4.592863 51 0.03157895 73 0.027009073253424658 2.412386 19 78 0.0100211 Mouse Phenotype Single KO abnormal platelet activation 18 1.631612e-18 8.300372824444445e-16 4.503593 52 0.03219814 77 0.029172120863636367 2.330231 20 85 0.01054852 Mouse Phenotype Single KO abnormal platelet physiology 23 3.661756e-16 1.4578565083478262e-13 3.596558 58 0.03591331 74 0.02665476481891892 2.160759 24 110 0.01265823 Mouse Phenotype Single KO cortical renal glomerulopathies 31 6.978625e-14 2.061395778225807e-11 3.027668 62 0.03839009 88 0.03714094808522727 1.995478 27 134 0.01424051 Mouse Phenotype Single KO decreased susceptibility to autoimmune disorder 43 1.075122e-11 2.2895098032558137e-9 2.885301 55 0.03405573 36 0.007055460869166667 2.078508 34 162 0.01793249 Mouse Phenotype Single KO abnormal hemostasis 46 4.623787e-11 9.20435164326087e-9 2.287785 78 0.04829721 65 0.024223772835384613 1.800633 40 220 0.02109705 Mouse Phenotype Single KO abnormal blood coagulation 49 9.260328e-11 1.7305474182857142e-8 2.267074 77 0.04767802 80 0.03321712051625 1.771724 39 218 0.02056962 Mouse Phenotype Single KO altered susceptibility to autoimmune disorder 60 1.011001e-9 1.5429560261666667e-7 2.228402 71 0.04396285 24 0.0025014241762083334 1.897219 50 261 0.02637131 Mouse Phenotype Single KO autoimmune response 68 8.917281e-9 0.0000012008167958382353 2.006282 80 0.0495356 30 0.006477851044666667 1.735353 58 331 0.03059072 Mouse Phenotype Single KO increased circulating interferon-gamma level 95 6.944257e-8 0.000006693532773578948 4.637957 19 0.01176471 46 0.010089379674565217 3.224389 14 43 0.007383966 Mouse Phenotype Single KO abnormal circulating interferon level 132 5.409634e-7 0.00003752728677121212 3.159618 26 0.01609907 70 0.025718153978571426 2.310812 21 90 0.01107595 Mouse Phenotype Single KO abnormal circulating interferon-gamma level 136 6.408053e-7 0.000043145986265441184 3.42147 23 0.01424149 68 0.02459481323235294 2.510742 18 71 0.009493671 Mouse Phenotype Single KO abnormal circulating interleukin-10 level 138 7.462828e-7 0.00004951964927246377 5.312872 14 0.008668731 96 0.04639753653020833 3.565253 9 25 0.004746835 Mouse Phenotype Single KO abnormal T-helper cell morphology 158 0.000001589039 0.00009209386153797468 2.386443 38 0.02352941 89 0.03733292437977528 2.128786 23 107 0.0121308 Mouse Phenotype Single KO abnormal interferon level 172 0.000002575375 0.00013710877252906976 2.765227 28 0.01733746 89 0.03733292437977528 2.128786 23 107 0.0121308 Mouse Phenotype Single KO abnormal CD4-positive, alpha-beta T cell physiology 233 0.00002436029 0.0009573698520600858 2.04122 41 0.025387 66 0.02434899022121212 1.993989 30 149 0.01582278 Mouse Phenotype Single KO abnormal T-helper 2 physiology 238 0.0000269429 0.0010366224172268907 2.70583 23 0.01424149 59 0.0220721259220339 2.731995 16 58 0.008438819 Mouse Phenotype Single KO improved central nervous system regeneration 251 0.00004414973 0.0016106736159760956 7.744172 7 0.004334365 95 0.04593076980105264 7.922785 4 5 0.002109705 Mouse Phenotype Single KO altered susceptibility to parasitic infection 326 0.000260823 0.0073262460460122684 2.079915 29 0.01795666 64 0.0244309189234375 2.152931 25 115 0.01318565 Mouse Phenotype abnormal platelet activation 22 1.665995e-18 7.24026281590909e-16 4.343547 54 0.03343653 122 0.026863737622131147 2.178766 22 100 0.01160338 Mouse Phenotype abnormal platelet aggregation 25 3.435125e-18 1.313729205e-15 4.344011 53 0.03281734 128 0.02775730846171875 2.21248 21 94 0.01107595 Mouse Phenotype abnormal platelet physiology 28 4.364778e-17 1.4904158020714286e-14 3.491345 64 0.03962848 56 0.00278811906375 2.250791 30 132 0.01582278 Mouse Phenotype cortical renal glomerulopathies 30 1.72207e-16 5.4882370899999995e-14 2.875191 81 0.0501548 63 0.0045893285638095235 1.980696 38 190 0.02004219 Mouse Phenotype atherosclerotic lesions 47 2.002063e-13 4.0727073070212766e-11 3.293193 53 0.03281734 100 0.01777657608 2.180583 24 109 0.01265823 Mouse Phenotype arteriosclerosis 55 1.564133e-12 2.7190319296363635e-10 3.116391 53 0.03281734 130 0.027854855598461542 2.084943 24 114 0.01265823 Mouse Phenotype increased circulating interferon-gamma level 67 3.615297e-11 5.159082778656716e-9 5.345811 25 0.01547988 44 0.00035237239336363636 3.428128 18 52 0.009493671 Mouse Phenotype abnormal wound healing 71 8.809468e-11 1.1863003316619717e-8 2.228357 80 0.0495356 133 0.030426157206766915 1.739801 39 222 0.02056962 Mouse Phenotype decreased susceptibility to autoimmune disorder 74 1.518595e-10 1.962065783108108e-8 2.574939 59 0.03653251 88 0.016053929423863637 1.844766 38 204 0.02004219 Mouse Phenotype abnormal circulating interleukin-10 level 78 2.229812e-10 2.73323494e-8 5.604491 22 0.01362229 48 0.000649656803625 3.961392 14 35 0.007383966 Mouse Phenotype increased circulating tumor necrosis factor level 81 3.055727e-10 3.606889610740741e-8 3.490767 36 0.02229102 79 0.01097459142949367 2.324286 23 98 0.0121308 Mouse Phenotype abnormal circulating interferon-gamma level 95 3.491166e-9 3.5135829606315785e-7 3.743254 29 0.01795666 66 0.0055595273827272725 2.504329 22 87 0.01160338 Mouse Phenotype abnormal NK cell number 98 4.341126e-9 4.2352556822448983e-7 2.346853 59 0.03653251 113 0.024009050153097348 1.918799 31 160 0.01635021 Mouse Phenotype abnormal circulating tumor necrosis factor level 101 6.704184e-9 6.34640625980198e-7 2.758348 43 0.02662539 114 0.023827865492105263 1.96713 29 146 0.01529536 Mouse Phenotype abnormal NK cell morphology 115 2.756508e-8 0.0000022917367815652174 2.22416 59 0.03653251 149 0.03929846279798657 1.838371 31 167 0.01635021 Mouse Phenotype abnormal circulating interferon level 118 3.133905e-8 0.000002539259805508475 3.145167 32 0.01981424 75 0.0102374942916 2.250791 25 110 0.01318565 Mouse Phenotype increased circulating interleukin-10 level 119 3.266705e-8 0.0000026246190340336137 5.87196 16 0.009907121 47 0.0005511344874255319 4.570837 12 26 0.006329114 Mouse Phenotype abnormal urine protein level 126 5.898549e-8 0.0000044758751578571425 2.111566 63 0.03900929 71 0.00932078593478873 1.928573 37 190 0.01951477 Mouse Phenotype abnormal granulocyte physiology 127 6.302701e-8 0.0000047448916740944875 2.015971 70 0.04334365 155 0.041671643173548385 1.632442 45 273 0.02373418 Mouse Phenotype abnormal regulatory T cell number 136 1.281918e-7 0.000009012072057352941 2.173526 56 0.03467492 111 0.02391700515675676 1.878246 33 174 0.01740506