# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	intrinsic apoptotic signaling pathway in response to DNA damage	144	1.307408e-18	1.1947348522222223e-16	2.046509	186	0.00898247	789	0.004922139794169836	1.326426	56	69	0.004874228	
GO Biological Process	pyrimidine deoxyribonucleotide catabolic process	149	2.226838e-18	1.9666416940939595e-16	5.103531	46	0.002221471	1145	0.031573359822707425	1.634346	12	12	0.001044477	
GO Biological Process	pyrimidine nucleotide catabolic process	156	1.091217e-17	9.204695194230769e-16	4.785711	47	0.002269764	1047	0.021118322324737347	1.634346	13	13	0.001131517	
GO Biological Process	axonal transport	167	3.589476e-17	2.8283781247904193e-15	2.27955	133	0.006422949	823	0.005677844680437424	1.424814	34	39	0.002959352	
GO Biological Process	axo-dendritic transport	183	1.255807e-16	9.030144433333333e-15	2.131295	149	0.007195634	600	0.00056711276505	1.4567	41	46	0.003568631	
GO Biological Process	heterochromatin organization	185	2.465996e-16	1.7540562899459457e-14	3.25978	68	0.003283914	1047	0.021118322324737347	1.634346	13	13	0.001131517	
GO Biological Process	positive regulation of transcription from RNA polymerase II promoter in response to stress	197	1.613129e-15	1.0775210411675128e-13	2.648358	89	0.004298063	1293	0.04946699120340294	1.430053	21	24	0.001827835	
GO Biological Process	cytoplasmic pattern recognition receptor signaling pathway	206	5.208477e-15	3.327104312766991e-13	2.1039	137	0.00661612	817	0.0056634322689106485	1.447564	31	35	0.002698233	
GO Biological Process	deoxyribose phosphate catabolic process	221	3.301913e-14	1.966057609366516e-12	3.052218	64	0.003090742	1284	0.04979122711915888	1.470911	18	20	0.001566716	
GO Biological Process	spliceosomal snRNP assembly	299	4.173309e-11	1.8366746866555186e-9	2.229882	85	0.004104892	871	0.007707437810907005	1.4193	33	38	0.002872313	
GO Biological Process	positive regulation by host of viral transcription	371	1.153199e-9	4.09028184393531e-8	2.325166	66	0.003187328	1254	0.04502285740191388	1.532199	15	16	0.001305597	
GO Biological Process	negative regulation of cyclin-dependent protein serine/threonine kinase activity	381	1.448126e-9	5.001545940682415e-8	2.09644	82	0.003960014	958	0.013178439057202505	1.49815	22	24	0.001914875	
GO Biological Process	ribosomal small subunit assembly	390	1.733555e-9	5.849192370512821e-8	3.108213	39	0.001883421	1065	0.022084422269483567	1.543549	17	18	0.001479676	
GO Biological Process	regulation of receptor biosynthetic process	428	6.013761e-9	1.848950490630841e-7	2.431654	55	0.002656107	1284	0.04979122711915888	1.470911	18	20	0.001566716	
GO Biological Process	intra-S DNA damage checkpoint	467	1.355673e-8	3.8199788023554604e-7	2.973835	37	0.001786835	834	0.006064448219784173	1.634346	16	16	0.001392636	
GO Biological Process	positive regulation of protein localization to chromosome, telomeric region	654	5.030223e-7	0.000010121208632568807	3.746218	21	0.00101415	1266	0.04668722770853081	1.634346	11	11	0.0009574375	
GO Biological Process	error-free translesion synthesis	678	7.145019e-7	0.000013867449118141593	2.12084	53	0.002559521	982	0.015395359989816702	1.548328	18	19	0.001566716	
GO Biological Process	cellular response to nitrogen starvation	882	0.000008459292	0.00012620841658503401	2.227346	38	0.001835128	1145	0.031573359822707425	1.634346	12	12	0.001044477	
GO Biological Process	regulation of protein localization to chromosome, telomeric region	1312	0.0002150083	0.002156474252820122	2.181106	27	0.001303907	1047	0.021118322324737347	1.634346	13	13	0.001131517	
GO Biological Process	ER overload response	1399	0.0003324179	0.0031267241930664756	2.086862	28	0.0013522	1266	0.04668722770853081	1.634346	11	11	0.0009574375	
GO Cellular Component	axon cytoplasm	40	2.467225e-17	1.0658412000000002e-15	2.282739	134	0.006471242	145	0.0029360865103448277	1.430053	35	40	0.003046392	
GO Cellular Component	U5 snRNP	183	0.00002965102	0.00027998340196721313	2.034608	41	0.001980007	189	0.019886866285714285	1.485769	20	22	0.001740796	
GO Molecular Function	DNA N-glycosylase activity	24	7.490841e-19	1.31776377925e-16	4.731082	51	0.002462935	158	0.02746055603797468	1.634346	14	14	0.001218557	
GO Molecular Function	Ral GTPase binding	207	0.00005089957	0.0010381545146859903	2.02354	39	0.001883421	171	0.041486359602339186	1.634346	13	13	0.001131517	
Human Phenotype	Bronchomalacia	28	1.162599e-9	2.770722545357143e-7	2.075551	85	0.004104892	300	0.03737516159333334	1.634346	13	13	0.001131517	
Mouse Phenotype Single KO	early cellular replicative senescence	12	1.990246e-19	1.5187235518333333e-16	2.26126	155	0.007485391	452	0.0043184229670353985	1.382908	44	52	0.00382975	
Mouse Phenotype Single KO	abnormal cellular replicative senescence	13	4.365943e-19	3.075303080846154e-16	2.161256	168	0.008113198	441	0.0036346396294784583	1.361955	50	60	0.004351989	
Mouse Phenotype Single KO	increased embryonic neuroepithelium apoptosis	264	5.272934e-7	0.000018289491150757577	2.008593	62	0.002994157	710	0.03576782237323944	1.538208	16	17	0.001392636	
Mouse Phenotype Single KO	thin hypoglossal nerve	412	0.00001358987	0.00030204475628640775	2.010754	46	0.002221471	537	0.010717110659590317	1.634346	15	15	0.001305597	
Mouse Phenotype	early cellular replicative senescence	19	2.815699e-21	1.4168893757368422e-18	2.051431	214	0.01033467	428	0.0001866765591869159	1.388075	62	73	0.005396466	
Mouse Phenotype	increased thyroid tumor incidence	31	3.022293e-18	9.321336571935484e-16	2.538134	115	0.005553678	1059	0.03020076135127479	1.438224	22	25	0.001914875	
Mouse Phenotype	abnormal third pharyngeal arch artery morphology	60	5.48123e-15	8.734340005e-13	2.135985	132	0.006374656	499	0.0006296441576753507	1.634346	21	21	0.001827835	
Mouse Phenotype	increased skin papilloma incidence	64	8.919063e-15	1.332424395984375e-12	2.02925	147	0.007099049	392	0.00008657905013265306	1.517607	39	42	0.003394551	
Mouse Phenotype	tachypnea	104	2.017339e-12	1.854594055673077e-10	2.651576	69	0.003332207	945	0.018083574225396824	1.543549	17	18	0.001479676	
Mouse Phenotype	ectopic ureteric bud	126	2.934438e-11	2.2266795014285714e-9	2.065944	103	0.004974163	1006	0.026110112090457258	1.634346	12	12	0.001044477	
Mouse Phenotype	abnormal ureteric bud invasion	168	5.887601e-10	3.350675783392857e-8	2.005172	96	0.004636113	1090	0.037634359062385325	1.532199	15	16	0.001305597	
Mouse Phenotype	thick aortic valve cusps	236	1.44889e-8	5.869846309322034e-7	2.015736	79	0.003815135	773	0.007773607537645536	1.634346	15	15	0.001305597	
Mouse Phenotype	fusion of vertebral bodies	291	8.199758e-8	0.000002694085437731959	2.72051	38	0.001835128	1098	0.039111987286885246	1.634346	11	11	0.0009574375	
Mouse Phenotype	abnormal internal carotid artery morphology	449	0.000002408655	0.0000512898673830735	2.031846	53	0.002559521	925	0.01736779940108108	1.634346	13	13	0.001131517	
Mouse Phenotype	increased kidney tumor incidence	556	0.00001076138	0.00018505315500000002	2.067342	44	0.002124885	1090	0.037634359062385325	1.532199	15	16	0.001305597	
Mouse Phenotype	thin hypoglossal nerve	579	0.00001358987	0.0002244088895854922	2.010754	46	0.002221471	773	0.007773607537645536	1.634346	15	15	0.001305597