# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	rRNA processing	14	4.200738e-38	3.948393667285714e-35	2.147449	354	0.02779959	161	1.2058400855900622e-9	1.472816	164	252	0.01976618	
GO Biological Process	rRNA metabolic process	16	1.8288e-36	1.5040737e-33	2.097837	357	0.02803518	166	2.3461442694578312e-9	1.459224	167	259	0.02012776	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	24	7.773539e-32	4.262166654208334e-29	2.479214	218	0.01711952	426	0.00150427448286385	1.421952	71	113	0.00855731	
GO Biological Process	nuclear-transcribed mRNA catabolic process	30	1.487825e-28	6.526096391666667e-26	2.065192	287	0.02253809	175	9.355176746285715e-9	1.508738	132	198	0.01590936	
GO Biological Process	mRNA catabolic process	31	1.84937e-28	7.850277364516129e-26	2.004138	308	0.02418722	170	4.933258012117647e-9	1.498113	141	213	0.01699409	
GO Biological Process	regulation of DNA-templated transcription in response to stress	32	6.248485e-28	2.56949419109375e-25	2.272158	226	0.01774776	360	0.0004200382042222222	1.445346	76	119	0.009159937	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	34	3.702161e-27	1.4328451940882353e-24	2.541158	176	0.01382127	186	5.3396830740860216e-8	1.630204	85	118	0.01024467	
GO Biological Process	multi-organism metabolic process	38	1.159085e-25	4.0137893460526315e-23	2.202129	221	0.01735511	141	4.419473481560284e-11	1.662691	108	147	0.01301675	
GO Biological Process	viral gene expression	43	6.444928e-25	1.9722978500465116e-22	2.3799	182	0.01429245	165	2.131368015090909e-9	1.657236	93	127	0.01120887	
GO Biological Process	regulation of hematopoietic progenitor cell differentiation	49	2.410799e-22	6.474225314489796e-20	2.357477	165	0.01295744	730	0.028950683275342465	1.321815	66	113	0.007954682	
GO Biological Process	viral transcription	53	7.907449e-22	1.9632853092641512e-19	2.328433	165	0.01295744	179	1.765403353463687e-8	1.662282	83	113	0.01000362	
GO Biological Process	mitochondrial translation	61	9.461818e-20	2.0411157879016394e-17	2.336343	147	0.0115439	343	0.0002845387066705539	1.480537	70	107	0.008436784	
GO Biological Process	protein targeting to ER	64	1.404432e-19	2.8876438575e-17	2.357223	143	0.01122978	197	1.8125126443654823e-7	1.658118	74	101	0.008918886	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to hypoxia	65	1.533157e-19	3.103817378923077e-17	2.354746	143	0.01122978	723	0.02724533638865837	1.392681	48	78	0.005785224	
GO Biological Process	mitochondrial translational termination	70	9.276017e-19	1.7437586814714287e-16	2.518939	120	0.00942359	487	0.00311408410513347	1.456713	56	87	0.006749428	
GO Biological Process	translational initiation	71	1.640004e-18	3.039551075492958e-16	2.013046	192	0.01507774	220	0.0000014220650175909092	1.519289	96	143	0.01157045	
GO Biological Process	protein localization to endoplasmic reticulum	74	4.458858e-18	7.928934111081081e-16	2.077929	173	0.01358568	191	9.076086107853402e-8	1.606076	88	124	0.01060624	
GO Biological Process	mitochondrial translational elongation	79	1.180095e-17	1.9656797601265823e-15	2.475344	116	0.009109471	483	0.002924033328364389	1.464363	55	85	0.006628902	
GO Biological Process	positive regulation of mRNA catabolic process	89	6.778281e-17	1.002195502011236e-14	2.816844	88	0.006910633	339	0.0002675983186312684	1.991534	22	25	0.002651561	
GO Biological Process	translational elongation	97	1.529313e-16	2.074662862577319e-14	2.135932	147	0.0115439	400	0.0010450831743500002	1.434648	71	112	0.00855731	
GO Cellular Component	ribosomal subunit	30	1.28498e-28	7.401484800000001e-27	2.210608	246	0.01931836	40	5.70705696e-10	1.553592	127	185	0.01530674	
GO Cellular Component	large ribosomal subunit	35	2.48478e-23	1.2267713828571429e-21	2.428467	163	0.01280038	52	3.3915688615384614e-8	1.633373	83	115	0.01000362	
GO Cellular Component	mitochondrial ribosome	37	5.566846e-22	2.599867537297297e-20	2.852342	115	0.009030941	89	0.0008517457617977527	1.490988	56	85	0.006749428	
GO Cellular Component	mitochondrial large ribosomal subunit	40	1.34662e-20	5.8173983999999995e-19	3.421834	82	0.006439453	114	0.005507648336842105	1.553113	35	51	0.004218392	
GO Cellular Component	peptidase complex	51	3.362624e-14	1.139336131764706e-12	2.086165	131	0.01028742	142	0.021358006985915494	1.363008	53	88	0.006387851	
GO Cellular Component	PcG protein complex	58	6.827347e-13	2.034078554482759e-11	2.128122	112	0.008795351	88	0.0008073204218181818	1.672731	34	46	0.004097867	
GO Cellular Component	integral component of mitochondrial membrane	82	4.042873e-10	8.519615297560976e-9	2.002698	98	0.007695932	157	0.026364668331210192	1.414442	40	64	0.00482102	
GO Cellular Component	mitochondrial nucleoid	148	6.235663e-7	0.000007280557881081082	2.06568	57	0.004476205	95	0.0017141156109473684	1.670389	31	42	0.00373629	
GO Molecular Function	structural constituent of ribosome	8	4.348914e-25	2.2951393635e-22	2.173987	222	0.01743364	13	1.2714991438461538e-9	1.606527	115	162	0.01386043	
GO Molecular Function	unfolded protein binding	9	8.860271e-23	4.156451573555556e-20	2.476422	153	0.01201508	119	0.03921109768067227	1.345054	63	106	0.007593106	
GO Molecular Function	rRNA binding	10	2.875782e-18	1.2141551604e-15	3.169888	80	0.006282394	66	0.0009462346399999999	1.621893	43	60	0.005182596	
GO Molecular Function	NF-kappaB binding	60	1.908529e-7	0.000013429682396666668	2.25711	51	0.004005026	78	0.0023496263574358973	1.858981	23	28	0.002772086	
GO Molecular Function	hydrolase activity, acting on ether bonds	120	0.000008450094	0.00029730247389999997	3.638736	17	0.001335009	99	0.012064697642424242	2.263107	10	10	0.001205255	
GO Molecular Function	adenyl-nucleotide exchange factor activity	159	0.00003339353	0.0008867137337106918	3.785851	14	0.001099419	110	0.02458822945090909	2.263107	9	9	0.001084729	
GO Molecular Function	mismatched DNA binding	236	0.0001356902	0.0024274746796610173	2.624047	20	0.001570598	115	0.03275959204869565	2.074515	11	12	0.00132578	
GO Molecular Function	ether hydrolase activity	263	0.0002521876	0.0040484260349809885	3.277443	13	0.001020889	110	0.02458822945090909	2.263107	9	9	0.001084729	
Human Phenotype	Increased serum lactate	3	2.641226e-19	5.874967032666666e-16	2.257836	154	0.01209361	23	2.522660049608696e-8	1.719961	76	100	0.009159937	
Human Phenotype	Abnormal CSF metabolite level	10	3.308281e-16	2.2076159113e-13	2.590606	97	0.007617402	135	0.004794739815481482	1.54466	43	63	0.005182596	
Human Phenotype	Exercise intolerance	11	5.876752e-16	3.5650514632727273e-13	2.484292	103	0.008088582	86	0.0002738412976744186	1.616505	50	70	0.006026275	
Human Phenotype	Increased CSF lactate	13	6.754628e-15	3.4672025110769232e-12	2.595198	88	0.006910633	144	0.005490345136805555	1.560764	40	58	0.00482102	
Human Phenotype	Generalized amyotrophy	56	2.001826e-9	2.3853901603571424e-7	2.562829	53	0.004162086	273	0.04793604547252747	1.638802	21	29	0.002531035	
Human Phenotype	CNS hypomyelination	58	2.158166e-9	2.483007192758621e-7	2.641624	50	0.003926496	130	0.0034161905059230772	1.810486	24	30	0.002892612	
Human Phenotype	Increased muscle lipid content	109	2.927024e-7	0.000017919294634862385	2.97529	30	0.002355898	124	0.0028984918140322583	2.024885	17	19	0.002048933	
Human Phenotype	Increased serum pyruvate	160	0.000003135257	0.00013075981225625	3.029754	24	0.001884718	170	0.011104668834705882	2.263107	10	10	0.001205255	
Human Phenotype	Abnormality of glycolysis	191	0.000006674391	0.00023318435153403143	2.819978	25	0.001963248	147	0.005670738097278912	2.263107	11	11	0.00132578	
Human Phenotype	Increased intramyocellular lipid droplets	201	0.00001080869	0.0003588377530845771	2.676199	26	0.002041778	163	0.009097006141717792	1.996859	15	17	0.001807882	
Human Phenotype	Hamartomatous polyposis	288	0.0000813601	0.001885124817013889	2.728945	20	0.001570598	206	0.020751792579611652	2.263107	9	9	0.001084729	
Human Phenotype	Increased hepatocellular lipid droplets	321	0.0001553034	0.0032284722373831774	2.596686	20	0.001570598	221	0.026943061811764705	2.074515	11	12	0.00132578	
Human Phenotype	Colon cancer	550	0.002368185	0.028732542736363637	2.223676	17	0.001335009	206	0.020751792579611652	2.263107	9	9	0.001084729	
Mouse Phenotype Single KO	abnormal cellular replicative senescence	13	2.097487e-14	1.4774375737692307e-11	2.280215	109	0.008559761	68	0.00015997992707352942	1.69733	45	60	0.005423647	
Mouse Phenotype Single KO	early cellular replicative senescence	22	1.732538e-12	7.211295666363637e-10	2.253693	95	0.007460342	74	0.00018927271513513515	1.740852	40	52	0.00482102	
Mouse Phenotype Single KO	increased cellular sensitivity to ultraviolet irradiation	131	0.000002090046	0.00014609581085496182	2.259234	42	0.003298257	111	0.0011394847056756757	1.980219	21	24	0.002531035	
Mouse Phenotype Single KO	spontaneous chromosome breakage	179	0.000007965964	0.0004075102365810055	2.093043	44	0.003455316	173	0.014821070289595376	1.810486	20	25	0.00241051	
Mouse Phenotype	early cellular replicative senescence	8	1.353774e-17	1.61792915175e-14	2.22911	143	0.01122978	53	6.078468888679245e-7	1.767084	57	73	0.006869953	
Mouse Phenotype	abnormal cellular replicative senescence	11	1.019645e-16	8.862568949999999e-14	2.1102	153	0.01201508	63	0.000001340376319047619	1.69733	63	84	0.007593106	
Mouse Phenotype	increased cellular sensitivity to ultraviolet irradiation	63	1.066193e-9	1.6180748052380952e-7	2.533794	56	0.004397676	161	0.0007179930935403727	1.885923	25	30	0.003013137	
Mouse Phenotype	increased fibroblast apoptosis	67	1.25999e-9	1.7980245358208955e-7	2.050865	87	0.006832103	206	0.0023771862394660194	1.650182	35	48	0.004218392	
Mouse Phenotype	decreased cellular sensitivity to gamma-irradiation	189	0.000007851808	0.00039720177930158726	2.182788	40	0.003141197	436	0.04784635790366972	1.69733	18	24	0.002169459	
Mouse Phenotype	abnormal cerebellar granule cell migration	245	0.00003794016	0.00148059538677551	2.030869	40	0.003141197	370	0.03096200647297297	1.810486	16	20	0.001928408