# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	mRNA catabolic process	22	8.289894e-33	4.958487052090909e-30	2.37102	244	0.02861499	167	0.0000016590244708383235	1.506485	118	213	0.01708907	
GO Biological Process	RNA catabolic process	25	3.521002e-32	1.85331461272e-29	2.239077	269	0.03154685	164	0.0000013867676340243902	1.478144	131	241	0.01897176	
GO Biological Process	nuclear-transcribed mRNA catabolic process	29	8.590929e-29	3.898208093482759e-26	2.34263	218	0.02556585	215	0.000014564326115813954	1.483273	108	198	0.01564084	
GO Biological Process	liver regeneration	32	1.802547e-27	7.412411241562499e-25	3.885341	95	0.01114108	451	0.013845012807538802	1.786991	23	35	0.00333092	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	35	1.584158e-26	5.955981463428572e-24	2.666403	157	0.0184121	596	0.04412532843456375	1.371699	57	113	0.008254888	
GO Biological Process	activation of signaling protein activity involved in unfolded protein response	39	4.86268e-25	1.6407181056410256e-22	7.570906	46	0.005394629	418	0.010501042552392344	2.719334	8	8	0.001158581	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	42	1.664733e-24	5.2157670349999995e-22	2.824613	131	0.01536296	236	0.0000713641006822034	1.590119	69	118	0.009992759	
GO Biological Process	regulation of DNA-templated transcription in response to stress	46	3.902778e-24	1.1164490369999999e-21	2.462308	164	0.01923302	500	0.0223184693308	1.393944	61	119	0.008834178	
GO Biological Process	rRNA processing	47	4.185114e-24	1.1717428750212765e-21	2.092667	231	0.02709042	207	0.00000879603501642512	1.435204	133	252	0.0192614	
GO Biological Process	rRNA metabolic process	57	9.581451e-23	2.2119704159473684e-20	2.035917	232	0.02720769	224	0.00003222173247901786	1.406914	134	259	0.01940623	
GO Biological Process	regulation of intrinsic apoptotic signaling pathway	63	2.982259e-21	6.229134314444444e-19	2.148167	190	0.02228216	342	0.00419108378508772	1.403527	80	155	0.01158581	
GO Biological Process	cotranslational protein targeting to membrane	71	3.142771e-20	5.824749801267606e-18	2.801068	108	0.01266565	174	0.000002129089143045977	1.748143	63	98	0.009123823	
GO Biological Process	protein targeting to ER	77	1.567538e-19	2.678861369090909e-17	2.707858	110	0.0129002	185	0.000003519464884756757	1.723142	64	101	0.009268646	
GO Biological Process	response to topologically incorrect protein	79	1.723994e-19	2.8716502589873415e-17	2.059683	191	0.02239944	462	0.01588452511991342	1.329452	88	180	0.01274439	
GO Biological Process	response to unfolded protein	88	1.216991e-18	1.8198164282954544e-16	2.078676	178	0.02087487	484	0.01949851953450413	1.342671	79	160	0.01144098	
GO Biological Process	animal organ regeneration	93	2.93713e-18	4.155881039784946e-16	2.173093	157	0.0184121	249	0.00022700939692771085	1.678601	50	81	0.00724113	
GO Biological Process	regulation of tumor necrosis factor-mediated signaling pathway	105	3.927093e-17	4.921582551142858e-15	2.64832	99	0.01161018	251	0.00023412676292031872	1.797526	39	59	0.005648081	
GO Biological Process	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	106	4.293713e-17	5.330280128962264e-15	2.659968	98	0.0114929	570	0.036222202150877195	1.501722	37	67	0.005358436	
GO Biological Process	multi-organism metabolic process	111	9.760244e-17	1.1570725296936937e-14	2.157681	145	0.01700481	188	0.0000045153435627127656	1.590903	86	147	0.01245474	
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	114	2.474957e-16	2.856838523070176e-14	2.630815	95	0.01114108	217	0.000016275724310138247	1.714363	58	92	0.00839971	
GO Cellular Component	ribosomal subunit	41	3.933412e-16	1.6577892526829268e-14	2.066646	154	0.01806028	42	0.000047006496	1.46991	100	185	0.01448226	
GO Cellular Component	catalytic step 2 spliceosome	43	5.061688e-15	2.0340922939534883e-13	2.319374	110	0.0129002	64	0.0046847241	1.501299	53	96	0.007675597	
GO Cellular Component	nuclear chromosome, telomeric region	44	9.520168e-15	3.738829614545454e-13	2.196782	121	0.01419022	89	0.024234636943820224	1.359667	66	132	0.009558291	
GO Cellular Component	chromosome, telomeric region	45	1.433506e-14	5.50466304e-13	2.028044	144	0.01688753	88	0.02381816290909091	1.318958	81	167	0.01173063	
GO Cellular Component	methyltransferase complex	48	6.069213e-14	2.18491668e-12	2.229312	110	0.0129002	68	0.007759007152941177	1.494139	50	91	0.00724113	
GO Cellular Component	Bcl-2 family protein complex	61	7.19825e-11	2.0391108196721316e-9	5.426705	24	0.002814589	81	0.0193635776	2.719334	7	7	0.001013758	
GO Cellular Component	large ribosomal subunit	63	1.02298e-10	2.805888e-9	2.091419	94	0.01102381	51	0.00041647646117647054	1.537015	65	115	0.009413469	
GO Cellular Component	PcG protein complex	65	1.447803e-10	3.848928590769231e-9	2.241683	79	0.009264689	105	0.03322001005714286	1.596131	27	46	0.00391021	
GO Cellular Component	spliceosomal snRNP complex	68	3.879582e-10	9.858702494117648e-9	2.509756	60	0.007036472	111	0.04346508454054054	1.491248	34	62	0.004923968	
GO Cellular Component	methylosome	71	1.063153e-9	2.587504766197183e-8	5.730401	20	0.002345491	90	0.0253674432	2.266112	10	12	0.001448226	
GO Cellular Component	small nuclear ribonucleoprotein complex	73	1.683835e-9	3.98584504109589e-8	2.299368	66	0.00774012	96	0.02628882	1.497604	38	69	0.005503259	
GO Cellular Component	protein-lipid complex	102	2.678056e-7	0.000004536941929411764	2.155325	55	0.0064501	107	0.03618314108411215	1.618651	25	42	0.003620565	
GO Cellular Component	LUBAC complex	128	0.000003884908	0.000052446258	3.86573	17	0.001993667	109	0.039151232587155964	2.719334	6	6	0.0008689356	
GO Molecular Function	unfolded protein binding	9	4.042841e-18	1.8965416335555554e-15	2.610511	108	0.01266565	92	0.04728869456521739	1.410975	55	106	0.007965243	
GO Molecular Function	structural constituent of ribosome	10	1.761934e-15	7.438885348e-13	2.091262	143	0.01677026	32	0.00023241107275	1.493955	89	162	0.01288921	
GO Molecular Function	peroxisome proliferator activated receptor binding	17	6.221158e-13	1.5450428868235292e-10	4.412003	36	0.004221883	86	0.04027649066744186	2.4474	9	10	0.001303403	
GO Molecular Function	thyroid hormone receptor binding	56	6.372743e-8	0.000004804593026071428	2.664795	40	0.004690982	85	0.040705161301176476	1.845262	19	28	0.002751629	
GO Molecular Function	thyroid hormone binding	376	0.002955139	0.033182438452127656	2.236134	16	0.001876393	89	0.0430581239258427	2.719334	7	7	0.001013758	
Human Phenotype	Increased serum lactate	4	4.490352e-18	7.491029724e-15	2.517898	115	0.01348657	21	0.0006081565654761905	1.6316	60	100	0.008689356	
Human Phenotype	Abnormality of the mitochondrion	32	7.764091e-10	1.6190556013437501e-7	2.157814	79	0.009264689	56	0.03042653253392857	1.57032	41	71	0.005937726	
Human Phenotype	Abnormality of mitochondrial metabolism	33	1.396829e-9	2.82455755060606e-7	2.15248	77	0.00903014	58	0.031086676727586207	1.576425	40	69	0.005792904	
Mouse Phenotype Single KO	abnormal branching of the mammary ductal tree	22	5.67415e-16	2.361735979545454e-13	2.410699	109	0.01278292	153	0.015741044594117647	1.789035	25	38	0.003620565	
Mouse Phenotype Single KO	renal glomerulus hypertrophy	32	1.749121e-14	5.0052190615625e-12	3.060321	65	0.007622845	124	0.007300729883387096	2.175467	16	20	0.002317161	
Mouse Phenotype	decreased sensitivity to induced cell death	40	1.58211e-15	3.7816384275e-13	2.076077	146	0.01712208	194	0.002757306153865979	1.549728	53	93	0.007675597	
Mouse Phenotype	abnormal branching of the mammary ductal tree	61	2.478174e-13	3.88423305147541e-11	2.005522	134	0.01571479	184	0.0023155489716847823	1.694011	38	61	0.005503259	
Mouse Phenotype	renal glomerulus hypertrophy	128	2.296329e-10	1.715250122578125e-8	2.193572	81	0.009499238	280	0.008512185617142858	1.839549	23	34	0.00333092	
Mouse Phenotype	early cellular replicative senescence	146	4.900433e-10	3.209112322808219e-8	2.07183	89	0.01043743	277	0.008318680937545127	1.564548	42	73	0.006082549	
Mouse Phenotype	pale lung	157	9.154446e-10	5.5748826882802556e-8	4.763681	24	0.002814589	480	0.04919152426875	2.719334	6	6	0.0008689356	
Mouse Phenotype	abnormal adrenal gland secretion	272	2.140145e-7	0.000007522767038602941	2.106102	59	0.006919198	414	0.03288896242028986	1.89171	16	23	0.002317161	
Mouse Phenotype	early eyelid opening	439	0.00001064854	0.00023191501353075168	2.066713	44	0.00516008	360	0.021788767399166666	2.4474	9	10	0.001303403	
Mouse Phenotype	decreased cellular sensitivity to oxidative stress	509	0.00003767596	0.0007077010875442043	3.098445	18	0.002110942	480	0.04919152426875	2.719334	6	6	0.0008689356	
Mouse Phenotype	ovary hypoplasia	774	0.0006459273	0.007978954670930233	2.442335	18	0.002110942	455	0.042478472340659344	2.417186	8	9	0.001158581