# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	21	6.863064e-50	4.3005266274285713e-47	2.499868	344	0.01726214	303	0.00003375287408613861	1.367701	91	113	0.008230825	
GO Biological Process	endoplasmic reticulum unfolded protein response	25	6.053188e-46	3.1861560356799996e-43	2.470756	323	0.01620835	647	0.006737485286244204	1.266316	85	114	0.007688133	
GO Biological Process	nuclear-transcribed mRNA catabolic process	27	3.466611e-45	1.6895234870000003e-42	2.087544	454	0.02278202	217	3.2316824256682024e-7	1.329519	155	198	0.01401954	
GO Biological Process	regulation of DNA-templated transcription in response to stress	31	1.360955e-44	5.777034466129032e-42	2.306352	359	0.01801485	290	0.000015022164659655173	1.370101	96	119	0.008683068	
GO Biological Process	regulation of intrinsic apoptotic signaling pathway	36	3.355459e-42	1.2265134716944445e-39	2.075412	429	0.0215275	423	0.0006895092017021277	1.271026	116	155	0.01049204	
GO Biological Process	cellular response to unfolded protein	38	1.43364e-41	4.964544410526316e-39	2.295848	337	0.01691088	546	0.002924165987179487	1.277274	91	121	0.008230825	
GO Biological Process	cellular response to topologically incorrect protein	42	7.90898e-41	2.477958757619048e-38	2.209645	359	0.01801485	609	0.005387795895238095	1.246274	102	139	0.00922576	
GO Biological Process	liver regeneration	45	1.323284e-39	3.869576479111111e-37	3.185001	182	0.009132878	424	0.0006925668599056604	1.552781	32	35	0.002894356	
GO Biological Process	positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress	48	2.373555e-39	6.507002134375e-37	7.75071	73	0.003663187	948	0.0408522265464135	1.698354	11	11	0.0009949349	
GO Biological Process	positive regulation of transcription from RNA polymerase II promoter in response to stress	50	6.620596e-39	1.74240845528e-36	4.050526	131	0.006573665	681	0.008819324113656388	1.556824	22	24	0.00198987	
GO Biological Process	negative regulation of intrinsic apoptotic signaling pathway	56	2.706196e-36	6.3590773507142864e-34	2.279429	297	0.01490365	603	0.005056665450414594	1.300867	72	94	0.006512301	
GO Biological Process	mitochondrial membrane organization	63	3.979443e-35	8.311982609047618e-33	2.034865	372	0.0186672	478	0.0015313574274476987	1.287462	94	124	0.008502171	
GO Biological Process	regulation of endoplasmic reticulum unfolded protein response	69	1.820923e-33	3.47268489231884e-31	3.177976	153	0.00767764	1004	0.049689865042828685	1.476829	20	23	0.001808973	
GO Biological Process	regulation of mitochondrial membrane permeability	74	4.687746e-33	8.33595265054054e-31	2.335549	256	0.01284625	670	0.008408722769850746	1.326112	57	73	0.005155572	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	77	1.189613e-32	2.0330022684415583e-30	2.334214	253	0.0126957	384	0.0003139990642213541	1.32414	92	118	0.008321274	
GO Biological Process	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	88	6.421542e-31	9.602394452045455e-29	2.473788	213	0.01068848	457	0.00124285200107221	1.394171	55	67	0.004974674	
GO Biological Process	regulation of membrane permeability	102	3.851727e-29	4.969105450294118e-27	2.150229	268	0.01344841	712	0.011844852069101124	1.299975	62	81	0.005607815	
GO Biological Process	negative regulation of response to endoplasmic reticulum stress	104	1.112014e-28	1.4070184832692308e-26	2.690009	169	0.00848053	651	0.007291719252227342	1.443601	34	40	0.003075253	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to hypoxia	118	4.739664e-27	5.285528692881355e-25	2.283331	217	0.0108892	445	0.0009676886119550562	1.371747	63	78	0.005698263	
GO Biological Process	viral gene expression	135	2.728795e-25	2.6598676596296294e-23	2.080596	249	0.01249498	358	0.00015735763768994412	1.323914	99	127	0.008954414	
GO Cellular Component	mitochondrial ribosome	46	9.810559e-21	3.6853578156521735e-19	2.377367	150	0.007527098	155	0.027077247174193547	1.25878	63	85	0.005698263	
GO Cellular Component	cleavage furrow	57	4.000184e-17	1.2126873599999999e-15	2.040021	171	0.008580891	135	0.0087989568	1.371747	42	52	0.003798842	
GO Cellular Component	spliceosomal snRNP complex	105	5.730686e-12	9.431071817142858e-11	2.040411	114	0.005720594	172	0.040091669581395345	1.287462	47	62	0.004251085	
GO Cellular Component	pronucleus	172	2.937322e-8	2.9509839627906977e-7	2.538047	46	0.00230831	176	0.03982703236363637	1.58513	14	15	0.001266281	
GO Cellular Component	platelet dense tubular network	315	0.0001360992	0.0007466013257142857	2.03211	34	0.001706142	162	0.03139278933333333	1.698354	11	11	0.0009949349	
GO Cellular Component	Ino80 complex	317	0.0001405941	0.0007663930750788643	2.325736	25	0.001254516	156	0.02805375876923077	1.592207	15	16	0.001356729	
GO Cellular Component	nucleotide-activated protein kinase complex	330	0.0002102465	0.0011009271272727273	2.184259	27	0.001354878	184	0.04695879443478261	1.698354	10	10	0.0009044863	
GO Cellular Component	DNA-directed RNA polymerase I complex	340	0.0002759181	0.0014023131670588235	2.145734	27	0.001354878	131	0.007914203065648854	1.698354	14	14	0.001266281	
GO Molecular Function	ribonucleoprotein complex binding	14	2.593666e-24	7.821755608571428e-22	2.015992	258	0.01294661	84	0.0010896811109523809	1.314378	89	115	0.008049928	
GO Molecular Function	ribonuclease activity	16	2.839994e-22	7.4940341675e-20	2.036171	229	0.01149137	58	0.00006556656810344828	1.389562	81	99	0.007326339	
GO Molecular Function	rRNA binding	33	3.284905e-15	4.2026875484848485e-13	2.481311	98	0.004917704	140	0.03602897982857143	1.330377	47	60	0.004251085	
GO Molecular Function	thyroid hormone receptor binding	65	5.455281e-11	3.543414828e-9	2.28048	80	0.004014452	124	0.0161708933	1.516387	25	28	0.002261216	
GO Molecular Function	O-methyltransferase activity	124	1.622242e-8	5.523472358064516e-7	2.318102	57	0.002860297	149	0.049193497234899325	1.536606	19	21	0.001718524	
GO Molecular Function	protein anchor	339	0.00005378013	0.0006697926515044247	2.136677	34	0.001706142	147	0.04975035345578231	1.698354	12	12	0.001085384	
GO Molecular Function	RNA polymerase I activity	537	0.0009576153	0.007528960515083798	2.104223	23	0.001154155	147	0.04975035345578231	1.698354	12	12	0.001085384	
Human Phenotype	Abnormal CSF metabolite level	11	1.213726e-19	7.362903270909091e-17	2.389234	140	0.007025291	100	0.0034835388877	1.401816	52	63	0.004703329	
Human Phenotype	Increased CSF lactate	24	2.021729e-15	5.621249007083333e-13	2.261362	120	0.006021678	137	0.013908280618248175	1.376252	47	58	0.004251085	
Human Phenotype	Exercise intolerance	26	3.984583e-15	1.0226585522692308e-12	2.111481	137	0.006874749	183	0.037248685999999996	1.310159	54	70	0.004884226	
Mouse Phenotype Single KO	pale liver	20	4.995647e-30	2.28725697895e-27	2.21432	259	0.01299679	265	0.012173792655094341	1.316224	62	80	0.005607815	
Mouse Phenotype Single KO	spontaneous chromosome breakage	370	5.609488e-8	0.000001388272476108108	2.066976	68	0.003412284	362	0.0423395649198895	1.494551	22	25	0.00198987	
Mouse Phenotype	extramedullary hematopoiesis	2	9.453549e-58	4.5192690994499996e-54	2.033094	622	0.03121236	285	0.0018666383125263157	1.242225	128	175	0.01157742	
Mouse Phenotype	abnormal hair follicle outer root sheath morphology	67	3.760064e-23	5.365667448358209e-21	2.460646	158	0.007928543	415	0.010941898685783132	1.516387	25	28	0.002261216	
Mouse Phenotype	abnormal Peyer's patch germinal center morphology	463	1.022382e-7	0.0000021112298708423327	2.15717	59	0.002960658	484	0.019314707486157025	1.604001	17	18	0.001537627