# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	13	2.712249e-42	2.7454218916153846e-39	2.650849	260	0.0183047	371	0.0011891749284097034	1.385634	77	113	0.008338748	
GO Biological Process	cellular response to topologically incorrect protein	17	5.57998e-39	4.3192327541176475e-36	2.42654	281	0.01978316	258	0.000031827459083720934	1.419036	97	139	0.01050466	
GO Biological Process	regulation of DNA-templated transcription in response to stress	20	2.533321e-37	1.66679855195e-34	2.42458	269	0.01893833	328	0.0003919954970640244	1.40121	82	119	0.008880225	
GO Biological Process	endoplasmic reticulum unfolded protein response	22	2.751976e-37	1.6460569174545455e-34	2.575678	240	0.01689665	279	0.00007734841334050179	1.444829	81	114	0.00877193	
GO Biological Process	regulation of intrinsic apoptotic signaling pathway	23	2.042513e-36	1.1685838507391304e-33	2.192313	323	0.02274007	211	0.000004219974677582938	1.429984	109	155	0.0118042	
GO Biological Process	response to topologically incorrect protein	32	8.18968e-35	3.3677499724999997e-32	2.129847	329	0.02316249	314	0.0002595182358503185	1.333048	118	180	0.01277886	
GO Biological Process	cellular response to unfolded protein	33	3.038153e-34	1.2114865250606062e-31	2.399054	251	0.01767108	234	0.000016443064637179484	1.462077	87	121	0.009421702	
GO Biological Process	cellular response to epidermal growth factor stimulus	35	5.589416e-34	2.1014607184000003e-31	2.892147	179	0.01260208	545	0.014000396117981652	1.551854	29	38	0.003140567	
GO Biological Process	IRE1-mediated unfolded protein response	36	1.829452e-33	6.687155241111111e-31	3.400446	139	0.009785976	676	0.03474853915532544	1.402388	40	58	0.004331817	
GO Biological Process	response to epidermal growth factor	44	1.835835e-31	5.490398355681819e-29	2.724915	182	0.01281329	594	0.022297305210437712	1.50089	31	42	0.003357158	
GO Biological Process	nuclear-transcribed mRNA catabolic process	51	1.096431e-29	2.829006966470588e-27	2.025641	314	0.02210645	226	0.000012024298265486725	1.365912	133	198	0.01440329	
GO Biological Process	negative regulation of intrinsic apoptotic signaling pathway	52	1.690796e-29	4.278689339230769e-27	2.368893	220	0.01548859	400	0.00221213514585	1.406118	65	94	0.007039203	
GO Biological Process	response to unfolded protein	53	4.853479e-29	1.2050364181320754e-26	2.061103	294	0.02069839	295	0.00018883874247796608	1.359879	107	160	0.01158761	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	59	1.575842e-27	3.514661843728814e-25	2.459387	190	0.01337651	239	0.000019263939109623428	1.464783	85	118	0.009205112	
GO Biological Process	protein targeting to ER	65	3.680881e-26	7.451802012153847e-24	2.527057	171	0.01203886	193	0.0000015120665993264246	1.550264	77	101	0.008338748	
GO Biological Process	multi-organism metabolic process	68	7.70754e-26	1.4915223361764706e-23	2.135023	239	0.01682625	165	3.404525190545454e-7	1.48014	107	147	0.01158761	
GO Biological Process	regulation of endoplasmic reticulum unfolded protein response	74	2.282934e-25	4.0596119602702704e-23	3.234709	111	0.0078147	460	0.0051978593523913045	1.768229	20	23	0.002165909	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to hypoxia	80	6.710867e-25	1.1038537356625e-22	2.480113	168	0.01182765	382	0.0013827925019371727	1.459922	56	78	0.006064544	
GO Biological Process	cotranslational protein targeting to membrane	83	2.203316e-24	3.4931849691566264e-22	2.506752	161	0.01133484	214	0.00000515850140364486	1.535472	74	98	0.008013862	
GO Biological Process	viral gene expression	90	1.676879e-23	2.451783417888889e-21	2.25083	192	0.01351732	252	0.000027822434005952378	1.441037	90	127	0.009746589	
GO Cellular Component	ribosomal subunit	38	6.137931e-24	2.79114336e-22	2.022109	251	0.01767108	53	0.000004226078309433962	1.384953	126	185	0.01364522	
GO Cellular Component	large ribosomal subunit	43	3.106035e-19	1.2481926697674419e-17	2.190497	164	0.01154604	65	0.00007652554338461538	1.432265	81	115	0.00877193	
GO Cellular Component	PRC1 complex	45	3.229173e-18	1.2400024320000001e-16	6.240266	38	0.002675303	135	0.0342317952	1.864008	11	12	0.00119125	
GO Cellular Component	mitochondrial ribosome	51	4.404743e-16	1.4924305694117646e-14	2.423731	109	0.007673895	120	0.0195838992	1.339693	56	85	0.006064544	
GO Cellular Component	peptidase complex	54	1.222317e-14	3.9114144000000003e-13	2.041585	143	0.01006759	108	0.0083479552	1.363345	59	88	0.00638943	
GO Cellular Component	endopeptidase complex	55	1.39889e-14	4.3950580363636363e-13	2.238641	115	0.008096311	132	0.032465402181818176	1.355642	46	69	0.00498159	
GO Cellular Component	proteasome complex	56	3.054932e-14	9.426647314285715e-13	2.220429	114	0.008025908	140	0.042237047314285715	1.345674	45	68	0.004873294	
GO Cellular Component	mitochondrial large ribosomal subunit	60	8.880345e-13	2.55753936e-11	2.656181	71	0.004998592	122	0.022197434754098362	1.435386	36	51	0.003898635	
GO Cellular Component	ESCRT complex	137	2.442649e-7	0.0000030809470598540143	2.377328	45	0.003168122	73	0.00022150607079452053	1.815592	25	28	0.002707386	
GO Cellular Component	proteasome accessory complex	176	0.000003653442	0.00003587015781818182	2.343876	37	0.0026049	133	0.03350977876691729	1.609825	19	24	0.002057613	
GO Cellular Component	ESCRT III complex	221	0.00003328011	0.000260217330678733	2.677964	23	0.001619262	93	0.003703787767741935	2.033463	12	12	0.001299545	
GO Molecular Function	unfolded protein binding	10	9.379676e-24	3.9600992072e-21	2.423281	167	0.01175725	117	0.024088144671794872	1.323669	69	106	0.007472385	
GO Molecular Function	structural constituent of ribosome	13	2.243948e-21	7.287652658461538e-19	2.001672	228	0.01605182	35	0.00005349610553714286	1.393299	111	162	0.01202079	
GO Molecular Function	ribonuclease activity	17	6.525771e-19	1.6206944212941177e-16	2.133182	171	0.01203886	37	0.00005959874474054054	1.499422	73	99	0.007905566	
GO Molecular Function	rRNA binding	25	2.397092e-14	4.048208969599999e-12	2.735262	77	0.005421008	122	0.02976580943442623	1.423424	42	60	0.004548408	
GO Molecular Function	endoribonuclease activity	36	1.087854e-11	1.2758109966666667e-9	2.167391	96	0.00675866	86	0.010512097606976745	1.488786	41	56	0.004440113	
GO Molecular Function	cyclin-dependent protein serine/threonine kinase regulator activity	134	2.968329e-7	0.000009352451520895521	2.05746	61	0.004294565	121	0.029901449664462808	1.612747	23	29	0.002490795	
Human Phenotype	Increased serum lactate	12	4.936391e-15	2.745044761916667e-12	2.011024	153	0.01077161	67	0.004510015771940298	1.40309	69	100	0.007472385	
Human Phenotype	Abnormal CSF metabolite level	13	5.792688e-15	2.9734313095384617e-12	2.418272	101	0.007110673	63	0.003539328483015873	1.517028	47	63	0.005089885	
Human Phenotype	Increased CSF lactate	28	2.225325e-12	5.303426330357143e-10	2.326616	88	0.006195438	61	0.0032029601427868855	1.542627	44	58	0.004764999	
Mouse Phenotype Single KO	decreased circulating chloride level	129	3.349068e-11	2.3773190446511626e-9	2.215295	87	0.006125035	109	0.016878988888073394	1.560565	33	43	0.003573749	
Mouse Phenotype	decreased circulating chloride level	189	9.443164e-11	4.777041852063492e-9	2.168188	87	0.006125035	261	0.030818275347126438	1.491206	33	45	0.003573749