# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	16	7.225518e-59	5.942536960125e-56	2.700834	355	0.01864986	312	0.000009163033462820514	1.396242	91	113	0.008402585	
GO Biological Process	regulation of DNA-templated transcription in response to stress	19	2.480906e-52	1.718223266e-49	2.475083	368	0.01933281	264	0.0000013421556941287878	1.413261	97	119	0.008956602	
GO Biological Process	endoplasmic reticulum unfolded protein response	26	8.196992e-48	4.148623758769231e-45	2.546626	318	0.01670607	474	0.0006558864800210971	1.323159	87	114	0.008033241	
GO Biological Process	nuclear-transcribed mRNA catabolic process	30	2.423089e-46	1.0628476050333335e-43	2.132526	443	0.02327292	129	2.811956910775194e-12	1.436073	164	198	0.01514312	
GO Biological Process	regulation of intrinsic apoptotic signaling pathway	31	3.984739e-46	1.6914574355161291e-43	2.162647	427	0.02243236	279	0.0000032688201152688167	1.353479	121	155	0.01117267	
GO Biological Process	mRNA catabolic process	32	3.022894e-45	1.2430706920625e-42	2.054617	472	0.02479643	134	5.735701711343283e-12	1.41634	174	213	0.01606648	
GO Biological Process	cellular response to topologically incorrect protein	35	3.813121e-44	1.4336245496857145e-41	2.30042	357	0.01875493	505	0.0010310211998613861	1.284755	103	139	0.009510619	
GO Biological Process	cellular response to unfolded protein	38	1.10706e-41	3.8336322473684214e-39	2.332233	327	0.01717888	516	0.0010751925627713178	1.303928	91	121	0.008402585	
GO Biological Process	regulation of nuclease activity	47	3.153024e-38	8.827796343829787e-36	4.094574	127	0.00667192	916	0.04852332406550218	1.467057	22	26	0.002031394	
GO Biological Process	negative regulation of intrinsic apoptotic signaling pathway	48	3.348104e-38	9.178687611666667e-36	2.354226	293	0.0153927	503	0.0009838680832007952	1.346458	73	94	0.006740536	
GO Biological Process	response to topologically incorrect protein	49	5.69004e-38	1.5280660481632653e-35	2.009573	416	0.02185448	459	0.000502244627385621	1.261817	131	180	0.01209603	
GO Biological Process	regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	66	1.090558e-33	2.1743413215151514e-31	3.207675	152	0.00798529	820	0.029408359054878045	1.454151	26	31	0.002400739	
GO Biological Process	cellular response to epidermal growth factor stimulus	69	1.891305e-33	3.6069105065217393e-31	2.580114	214	0.01124245	679	0.008935740074815906	1.460038	32	38	0.002954755	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	70	2.727971e-33	5.128195769857143e-31	2.385767	247	0.0129761	340	0.00003994747295294118	1.366466	93	118	0.008587258	
GO Biological Process	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	73	4.24047e-33	7.643882839726027e-31	2.577683	212	0.01113738	221	9.790748526696832e-8	1.57853	61	67	0.005632502	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to hypoxia	83	1.088351e-32	1.725495278192771e-30	2.478578	225	0.01182033	389	0.00013920933162210798	1.422601	64	78	0.005909511	
GO Biological Process	regulation of hematopoietic progenitor cell differentiation	87	7.033808e-32	1.0638836720919539e-29	2.341755	245	0.01287103	793	0.023680275960907944	1.242809	81	113	0.007479224	
GO Biological Process	response to epidermal growth factor	92	9.889776e-31	1.414560460695652e-28	2.435543	218	0.01145259	786	0.021333066100508908	1.403548	34	42	0.003139428	
GO Biological Process	RNA phosphodiester bond hydrolysis	93	1.575984e-30	2.2299326296774195e-28	2.116165	292	0.01534016	223	1.1969650634080717e-7	1.42093	109	133	0.01006464	
GO Biological Process	regulation of hematopoietic stem cell differentiation	95	4.791407e-30	6.636855232947368e-28	2.389418	221	0.01161019	835	0.03207667782634731	1.245639	74	103	0.006832872	
GO Cellular Component	mitochondrial ribosome	43	9.837996e-24	3.953501648372093e-22	2.538675	153	0.008037825	100	0.0001973132352	1.387036	68	85	0.006278855	
GO Cellular Component	large ribosomal subunit	46	1.544366e-23	5.801444452173913e-22	2.142866	215	0.01129498	89	0.00005201547937078651	1.356883	90	115	0.008310249	
GO Cellular Component	mitochondrial large ribosomal subunit	52	1.749447e-21	5.813546953846154e-20	2.959123	106	0.005568689	85	0.00004349369901176471	1.529819	45	51	0.004155125	
GO Cellular Component	endopeptidase complex	54	1.004036e-20	3.2129152e-19	2.309625	159	0.008353034	113	0.00047338376495575224	1.407138	56	69	0.005170822	
GO Cellular Component	proteasome complex	56	5.156468e-20	1.5911386971428572e-18	2.281862	157	0.008247964	117	0.0006489594092307692	1.402334	55	68	0.005078486	
GO Cellular Component	peptidase complex	57	3.828359e-19	1.1605972547368421e-17	2.045458	192	0.01008668	84	0.00002621952	1.41856	72	88	0.006648199	
GO Cellular Component	PcG protein complex	66	1.037242e-15	2.7156881454545454e-14	2.021099	159	0.008353034	195	0.025125323815384612	1.356883	36	46	0.0033241	
GO Cellular Component	spliceosomal snRNP complex	82	7.47328e-14	1.5748570536585366e-12	2.17361	116	0.006094037	114	0.0005249357810526316	1.426186	51	62	0.004709141	
GO Cellular Component	spliceosomal tri-snRNP complex	109	6.780683e-11	1.074955983853211e-9	2.562227	63	0.003309693	111	0.00043477414054054054	1.614223	27	29	0.002493075	
GO Cellular Component	CCR4-NOT complex	119	5.107575e-10	7.416713949579832e-9	2.642586	54	0.002836879	182	0.018080852043956045	1.625433	15	16	0.001385042	
GO Cellular Component	U5 snRNP	131	3.005406e-9	3.9643828763358777e-8	2.645193	49	0.002574205	205	0.03476016140487805	1.497368	19	22	0.001754386	
GO Cellular Component	U4/U6 x U5 tri-snRNP complex	172	2.306533e-7	0.0000023172610604651164	2.243272	51	0.002679275	142	0.0037117123605633806	1.589312	22	24	0.002031394	
GO Cellular Component	proteasome accessory complex	194	8.588548e-7	0.000007650005641237114	2.221716	47	0.002469136	179	0.017052801787709498	1.517071	21	24	0.001939058	
GO Cellular Component	DNA polymerase complex	242	0.00001252305	0.0000894207867768595	2.213615	37	0.001943788	210	0.03952603337142857	1.541151	16	18	0.001477378	
GO Cellular Component	Ino80 complex	265	0.00002711467	0.00017680811230188682	2.532239	26	0.001365905	182	0.018080852043956045	1.625433	15	16	0.001385042	
GO Cellular Component	nuclear pore outer ring	440	0.003166981	0.012437598109090911	2.106127	18	0.0009456265	204	0.034448628705882355	1.733795	10	10	0.000923361	
GO Molecular Function	ribonuclease activity	11	4.068628e-28	1.5616134014545456e-25	2.224782	239	0.01255582	62	0.000060976194141935486	1.401046	80	99	0.007386888	
GO Molecular Function	exonuclease activity	22	5.484585e-20	1.0525417213636363e-17	2.113459	186	0.009771474	96	0.0034180194929166667	1.368786	60	76	0.005540166	
GO Molecular Function	endoribonuclease activity	33	5.671319e-17	7.255851156969698e-15	2.257504	134	0.007039664	143	0.024977077422377623	1.362268	44	56	0.004062789	
GO Molecular Function	3'-5'-exoribonuclease activity	72	1.111872e-10	6.519893866666667e-9	2.21963	82	0.004307854	140	0.01983793854142857	1.502622	26	30	0.002400739	
GO Molecular Function	exoribonuclease activity, producing 5'-phosphomonoesters	98	2.841223e-9	1.2240452557142858e-7	2.024729	86	0.004517993	123	0.009693849300813009	1.517071	28	32	0.002585411	
GO Molecular Function	K63-linked polyubiquitin binding	166	1.59322e-7	0.000004052153518072289	2.112457	60	0.003152088	150	0.03471697121333333	1.568672	19	21	0.001754386	
Human Phenotype	Abnormal CSF metabolite level	8	2.286018e-23	1.9068247642499998e-20	2.590655	145	0.007617547	98	0.00044317701313265306	1.458589	53	63	0.004893813	
Human Phenotype	Increased serum lactate	9	4.597651e-23	3.408902791444444e-20	2.118544	216	0.01134752	60	0.000021513529566666667	1.421712	82	100	0.00757156	
Human Phenotype	Exercise intolerance	12	1.99686e-21	1.110420565e-18	2.420297	150	0.007880221	133	0.003402348461578947	1.387036	56	70	0.005170822	
Human Phenotype	Increased CSF lactate	17	2.396167e-18	9.405660230000001e-16	2.446366	124	0.006514316	123	0.002347668276504065	1.434865	48	58	0.004432133	
Human Phenotype	Glycosuria	76	6.830523e-12	5.997378944605263e-10	2.288968	87	0.004570528	214	0.031105073175700937	1.494651	25	29	0.002308403	
Human Phenotype	Aplasia/Hypoplasia involving the femoral head and neck	93	7.177367e-11	5.1499537624731184e-9	2.419811	70	0.003677436	193	0.025649912510880828	1.533742	23	26	0.00212373	
Human Phenotype	Aplasia/hypoplasia of the femur	116	5.866686e-10	3.37486169637931e-8	2.030462	93	0.004885737	197	0.028243387817258884	1.471099	28	33	0.002585411	
Mouse Phenotype Single KO	decreased circulating free fatty acid level	25	6.739877e-30	2.4686821475599996e-27	2.072929	300	0.01576044	299	0.04407922546488294	1.267721	68	93	0.006278855	
Mouse Phenotype Single KO	increased skin tumor incidence	179	1.377118e-11	7.044843310614525e-10	2.03883	110	0.005778828	99	0.00012438637562626264	1.576177	40	44	0.003693444	
Mouse Phenotype Single KO	abnormal hypoglossal nerve topology	465	0.000004458019	0.00008778941931827957	2.049723	49	0.002574205	170	0.0026714427114117646	1.733795	18	18	0.00166205	
Mouse Phenotype	abnormal hypoglossal nerve topology	548	0.000004458019	0.0000777794154361314	2.049723	49	0.002574205	226	0.002098149604513274	1.733795	18	18	0.00166205	
Mouse Phenotype	decreased embryonic cilium length	813	0.0002029891	0.002387181777490775	2.153966	28	0.001470975	399	0.03239192516541353	1.733795	12	12	0.001108033