# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	2	1.824976e-44	1.2007429592e-40	2.927654	232	0.0202161	293	0.00013066639988054606	1.522708	71	113	0.009163655	
GO Biological Process	regulation of DNA-templated transcription in response to stress	3	3.273481e-41	1.4358578826333335e-37	2.710882	243	0.02117463	279	0.00006135112551971326	1.527393	75	119	0.009679917	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to hypoxia	16	1.116329e-29	9.181108319375e-27	2.868679	157	0.01368072	308	0.00021482161492857146	1.615643	52	78	0.006711409	
GO Biological Process	regulation of intrinsic apoptotic signaling pathway	28	3.611692e-23	1.697366251e-20	2.024591	241	0.02100035	366	0.001225294532431694	1.391537	89	155	0.01148684	
GO Biological Process	liver regeneration	34	3.571612e-21	1.3823188914117646e-18	3.038864	100	0.008713838	599	0.02191614754106845	1.661804	24	35	0.003097574	
GO Biological Process	response to cadmium ion	38	8.796793e-21	3.0462368180789474e-18	2.838775	109	0.009498083	353	0.0006752531530594901	1.671355	40	58	0.005162623	
GO Biological Process	regulation of hematopoietic progenitor cell differentiation	41	1.134326e-19	3.640633130243903e-17	2.330532	147	0.01280934	275	0.00005540886448	1.544154	72	113	0.009292721	
GO Biological Process	endoplasmic reticulum unfolded protein response	45	4.781365e-19	1.3981773785555555e-16	2.178434	164	0.01429069	472	0.006741316669067797	1.403058	66	114	0.008518327	
GO Biological Process	regulation of necrotic cell death	47	6.771073e-19	1.8957563746170212e-16	4.486233	54	0.004705472	696	0.039917429461206896	1.705401	19	27	0.002452246	
GO Biological Process	tumor necrosis factor-mediated signaling pathway	52	1.119779e-18	2.833686896346154e-16	2.108602	173	0.01507494	465	0.0062662648619354845	1.382132	73	128	0.009421786	
GO Biological Process	mitochondrial transmembrane transport	70	3.042534e-17	5.719529272285715e-15	2.350749	125	0.0108923	220	0.000007229632357727272	1.693505	58	83	0.007485803	
GO Biological Process	regulation of necroptotic process	71	3.865689e-17	7.16459176774648e-15	5.050707	43	0.00374695	711	0.04307729129535865	1.817598	15	20	0.001935983	
GO Biological Process	regulation of hematopoietic stem cell differentiation	89	9.142136e-16	1.3517007598202248e-13	2.241673	125	0.0108923	341	0.0005753512271260997	1.505842	64	103	0.008260196	
GO Biological Process	regulation of cholesterol metabolic process	117	3.522266e-14	3.961495580683761e-12	2.392501	97	0.008452422	320	0.00028492672788749996	1.737578	38	53	0.004904491	
GO Biological Process	DNA-templated transcription, elongation	120	5.376394e-14	5.895664053833333e-12	2.071467	131	0.01141513	539	0.012098140462708719	1.387984	63	110	0.008131131	
GO Biological Process	translational termination	130	1.68074e-13	1.701296743076923e-11	2.176991	112	0.009759498	365	0.00116790162830137	1.505099	59	95	0.007614868	
GO Biological Process	transcription elongation from RNA polymerase II promoter	134	2.275197e-13	2.234277412164179e-11	2.133379	116	0.01010805	516	0.00945569527248062	1.428568	56	95	0.007227672	
GO Biological Process	mitochondrial translation	137	3.224115e-13	3.0967977580291976e-11	2.098653	119	0.01036947	408	0.002590346247279412	1.449549	64	107	0.008260196	
GO Biological Process	mitochondrial translational termination	138	3.80696e-13	3.6301294666666664e-11	2.282637	98	0.008539561	449	0.004851948966592428	1.476363	53	87	0.006840475	
GO Biological Process	regulation of cellular amino acid metabolic process	140	7.044136e-13	6.62098468742857e-11	2.568557	76	0.006622517	612	0.02410012795588235	1.49447	37	60	0.004775426	
GO Cellular Component	catalytic step 2 spliceosome	33	7.230094e-19	3.7859401309090905e-17	2.287372	146	0.0127222	67	0.0005443161313432836	1.514665	60	96	0.007743934	
GO Cellular Component	PcG protein complex	41	1.624925e-16	6.8484643902439024e-15	2.403575	114	0.009933775	78	0.002123849796923077	1.685888	32	46	0.004130098	
GO Cellular Component	MLL1 complex	42	2.55985e-16	1.0531954285714286e-14	3.571062	60	0.005228303	130	0.03148875913846154	1.671355	20	29	0.002581311	
GO Cellular Component	methyltransferase complex	43	9.537827e-16	3.832875594418604e-14	2.123259	141	0.01228651	75	0.0016967886336	1.491363	56	91	0.007227672	
GO Cellular Component	mitochondrial ribosome	53	2.724631e-13	8.88332522264151e-12	2.421925	88	0.007668177	99	0.006451344872727273	1.454078	51	85	0.006582344	
GO Cellular Component	mitochondrial large ribosomal subunit	55	1.010302e-12	3.1741851927272724e-11	2.870854	62	0.005402579	105	0.010010876708571429	1.568124	33	51	0.004259164	
GO Cellular Component	peptidase complex	56	1.279022e-12	3.9466964571428574e-11	2.067462	117	0.01019519	66	0.00048117154909090915	1.542204	56	88	0.007227672	
GO Cellular Component	large ribosomal subunit	60	4.259581e-12	1.226759328e-10	2.000342	121	0.01054374	94	0.006257111897872341	1.390858	66	115	0.008518327	
GO Cellular Component	spliceosomal snRNP complex	67	3.298935e-11	8.508298029850746e-10	2.362107	76	0.006622517	132	0.033910219636363634	1.446261	37	62	0.004775426	
GO Cellular Component	small nuclear ribonucleoprotein complex	71	1.681283e-10	4.0919113014084505e-9	2.174451	84	0.007319624	92	0.0062057851826086965	1.510275	43	69	0.005549819	
GO Cellular Component	endopeptidase complex	73	2.123744e-10	5.027163879452055e-9	2.120262	88	0.007668177	108	0.012516502400000002	1.475152	42	69	0.005420754	
GO Cellular Component	proteasome complex	83	4.131191e-9	8.600841021686748e-8	2.02503	84	0.007319624	122	0.01664171645901639	1.461206	41	68	0.005291688	
GO Cellular Component	retromer complex	112	2.101936e-7	0.0000032429869714285715	2.44653	43	0.00374695	124	0.01730466580645161	1.846449	16	21	0.002065049	
GO Cellular Component	outer mitochondrial membrane protein complex	122	5.958688e-7	0.000008439846609836066	3.342726	24	0.002091321	133	0.03429826646616541	1.938771	12	15	0.001548787	
GO Cellular Component	Sin3-type complex	128	0.000001052675	0.000014211112500000001	2.443438	38	0.003311258	125	0.018301192703999998	1.969065	13	16	0.001677852	
GO Cellular Component	proteasome accessory complex	136	0.00000158913	0.00002019129882352941	2.58742	33	0.002875566	139	0.040497445294964025	1.71662	17	24	0.002194115	
GO Cellular Component	mitochondrial nucleoid	151	0.000005895085	0.00006746163496688742	2.010632	50	0.004356919	107	0.012485644620560747	1.615643	28	42	0.003613836	
GO Cellular Component	STAGA complex	187	0.00005208478	0.00048129679058823527	3.019994	18	0.001568491	141	0.04521634314893617	2.019553	10	12	0.001290656	
GO Molecular Function	unfolded protein binding	10	1.46332e-19	6.17813704e-17	2.424606	135	0.01176368	112	0.03767830412857143	1.371772	60	106	0.007743934	
GO Molecular Function	ribonucleoprotein complex binding	12	3.866678e-17	1.3604262096666666e-14	2.116736	156	0.01359359	96	0.0292187995875	1.369784	65	115	0.008389262	
GO Molecular Function	NF-kappaB binding	17	2.434721e-12	6.046701212941177e-10	2.897403	59	0.005141164	117	0.043276871247863245	1.731046	20	28	0.002581311	
Human Phenotype	Increased serum lactate	11	1.528679e-13	9.273522697272729e-11	2.066092	127	0.01106657	63	0.0009663905330000001	1.526782	63	100	0.008131131	
Human Phenotype	Death in infancy	30	3.945345e-10	8.775762395e-8	2.156978	82	0.007145347	128	0.02187178451640625	1.557941	36	56	0.00464636	
Human Phenotype	Ependymoma	230	0.0001311203	0.0038041989647826084	3.318742	14	0.001219937	150	0.037309103342	2.423464	8	8	0.001032525	
Mouse Phenotype Single KO	abnormal inferior vena cava valve morphology	185	0.000002749097	0.0001360728715081081	2.608279	31	0.00270129	230	0.03904484682304348	2.203149	10	11	0.001290656	
Mouse Phenotype Single KO	decreased embryonic cilium length	464	0.0004523448	0.00892698563275862	2.448641	19	0.001655629	230	0.03904484682304348	2.203149	10	11	0.001290656	
Mouse Phenotype	increased embryonic neuroepithelium apoptosis	39	1.239087e-13	3.037669437692308e-11	2.928594	65	0.005663994	378	0.04639814184920634	1.744894	18	25	0.00232318	
Mouse Phenotype	liver degeneration	53	3.913729e-12	7.060219428113207e-10	2.70002	65	0.005663994	377	0.04631406729708222	1.615643	24	36	0.003097574	
Mouse Phenotype	abnormal inferior vena cava valve morphology	233	0.000002749097	0.00011280736659656652	2.608279	31	0.00270129	326	0.02876232990460123	2.203149	10	11	0.001290656	
Mouse Phenotype	decreased embryonic cilium length	268	0.000008189392	0.0002921596153432836	2.934749	23	0.002004183	284	0.01477714157852113	2.221509	11	12	0.001419721	
Mouse Phenotype	decreased abdominal adipose tissue amount	391	0.0001130429	0.0027642024728900256	2.028293	35	0.003049843	378	0.04639814184920634	1.744894	18	25	0.00232318