# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process loop of Henle development 102 0.00000501168 0.000646555854117647 4.488851 14 0.01194539 109 0.022437917944036698 6.064922 6 12 0.003875969 GO Biological Process pattern specification involved in metanephros development 133 0.00001335017 0.001320863812255639 5.789136 10 0.008532423 74 0.008185107832702704 12.12984 4 4 0.002583979 GO Biological Process regulation of axon extension involved in axon guidance 204 0.0001084139 0.006993227990686275 3.061752 16 0.01365188 55 0.0035333183049090907 6.064922 8 16 0.005167959 GO Biological Process photoreceptor cell differentiation 215 0.0001369544 0.008382246277209304 2.475679 22 0.01877133 110 0.022507907251818178 3.091921 13 51 0.008397933 GO Biological Process regulation of axon guidance 226 0.0001612983 0.009391700573893805 2.742116 18 0.01535836 59 0.004517377643728814 5.198505 9 21 0.005813953 GO Biological Process nephron tubule formation 302 0.0005564583 0.024246472747350995 2.737209 15 0.01279863 134 0.035368573617164174 4.717162 7 18 0.004521964 GO Biological Process membrane invagination 303 0.0005581743 0.02424097562277228 2.633242 16 0.01365188 121 0.028378112138842976 3.164307 12 46 0.007751938 GO Biological Process cell proliferation in forebrain 351 0.001232545 0.046208147165242165 2.524777 15 0.01279863 112 0.02409175568035714 4.043282 9 27 0.005813953 GO Molecular Function transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding 5 1.426964e-13 1.2049284016e-10 2.360807 91 0.07764505 2 0.006762734159 2.146875 40 226 0.02583979 GO Molecular Function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding 6 2.542928e-13 1.7893736693333334e-10 2.780238 67 0.05716724 5 0.023886235207999998 2.371248 26 133 0.01679587 Mouse Phenotype Single KO abnormal ureter physiology 2 2.230353e-20 1.02116712105e-16 11.34752 28 0.02389078 38 0.016625302206052635 8.664175 5 7 0.003229974 Mouse Phenotype Single KO abnormal monocyte cell number 3 3.61513e-16 1.1034581803333332e-12 3.279331 65 0.05546075 48 0.023013505939583335 1.954572 34 211 0.02196382 Mouse Phenotype Single KO abnormal monocyte morphology 5 1.277446e-15 2.3395146044e-12 3.190757 65 0.05546075 64 0.0273802312375 1.909327 34 216 0.02196382 Mouse Phenotype Single KO respiratory distress 16 2.582537e-10 1.4780182068125e-7 2.217773 76 0.06484642 86 0.04744967871395349 1.932777 29 182 0.01873385 Mouse Phenotype Single KO increased neuron number 80 0.000004131601 0.00047291337946249993 2.634839 29 0.02474403 31 0.016578391081612902 2.985808 16 65 0.01033592 Mouse Phenotype Single KO abnormal urination 102 0.00003074163 0.0027598147638235294 2.214963 33 0.028157 62 0.027246653500000002 2.205426 24 132 0.01550388 Mouse Phenotype Single KO abnormal basement membrane morphology 108 0.00004703706 0.003988132948333333 3.29439 16 0.01365188 82 0.042478373798780486 3.46567 10 35 0.006459948 Mouse Phenotype Single KO absent limbs 160 0.0001340528 0.007672009310000001 4.374288 10 0.008532423 61 0.025734067214754103 7.581153 5 8 0.003229974 Mouse Phenotype Single KO increased sensory neuron number 202 0.0003418897 0.015498435558910891 2.496829 19 0.0162116 49 0.024671350032653062 3.60617 11 37 0.007105943 Mouse Phenotype Single KO abnormal noradrenaline level 255 0.001221566 0.043866195537254904 2.185276 20 0.01706485 63 0.027347496779365075 3.091921 13 51 0.008397933 Mouse Phenotype abnormal ureter physiology 1 6.77302e-20 6.475684421999999e-16 10.86615 28 0.02389078 133 0.04817100658195488 6.064922 5 10 0.003229974 Mouse Phenotype abnormal monocyte cell number 4 3.929728e-13 9.393032352e-10 2.680361 70 0.05972696 109 0.03396073340091743 1.758602 39 269 0.0251938 Mouse Phenotype atelectasis 10 8.377147e-12 8.0093902467e-9 2.892597 55 0.04692833 113 0.040784645376106196 2.19592 21 116 0.01356589 Mouse Phenotype abnormal immature B cell number 35 2.203873e-8 0.000006020351358 2.398368 51 0.04351536 139 0.04988623022589928 1.926505 27 170 0.01744186 Mouse Phenotype abnormal zigzag hair morphology 115 0.000006234951 0.0005183684044434782 3.399341 19 0.0162116 107 0.03367043756915888 3.764435 9 29 0.005813953 Mouse Phenotype abnormal kidney apoptosis 157 0.00003247152 0.001977453520509554 2.311814 30 0.02559727 106 0.033494392853773584 2.484426 17 83 0.01098191 Mouse Phenotype increased cranium height 243 0.0002955114 0.01162709668888889 6.848324 6 0.005119454 121 0.04419564348347107 12.12984 3 3 0.001937984 Mouse Phenotype abnormal presphenoid bone morphology 333 0.001056632 0.03033771336936937 2.396973 17 0.01450512 108 0.033675037125 3.46567 10 35 0.006459948 Mouse Phenotype omphalocele 335 0.001076172 0.030714270125373134 2.005393 25 0.02133106 62 0.018106097487096774 2.93464 15 62 0.009689922 Mouse Phenotype abnormal lung lobe morphology 374 0.001633906 0.0417694525828877 2.180575 19 0.0162116 83 0.025569811687951808 3.421238 11 39 0.007105943