# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	12	1.877233e-68	2.0585424205833334e-65	2.932324	362	0.02024835	256	0.000001215957395	1.468033	89	113	0.008834624	
GO Biological Process	regulation of DNA-templated transcription in response to stress	13	7.2037e-63	7.291806792307691e-60	2.706872	378	0.0211433	240	3.9885060589999995e-7	1.47233	94	119	0.009330951	
GO Biological Process	endoplasmic reticulum unfolded protein response	20	4.458265e-51	2.93331545675e-48	2.668802	313	0.01750755	435	0.000252951978183908	1.373405	84	114	0.008338297	
GO Biological Process	liver regeneration	21	1.69583e-48	1.0626393795238096e-45	3.647745	187	0.01045978	645	0.005984001185891473	1.54438	29	35	0.002878698	
GO Biological Process	cellular response to topologically incorrect protein	23	1.618795e-47	9.26161887173913e-45	2.40813	351	0.01963307	429	0.00021934964085081586	1.34094	100	139	0.009926544	
GO Biological Process	cellular response to unfolded protein	26	3.587293e-46	1.815584176423077e-43	2.467979	325	0.01817877	413	0.0001637527626150121	1.370973	89	121	0.008834624	
GO Biological Process	IRE1-mediated unfolded protein response	30	2.219397e-44	9.735015041e-42	3.498527	180	0.01006824	784	0.018145824604591833	1.381862	43	58	0.004268414	
GO Biological Process	positive regulation of transcription from RNA polymerase II promoter in response to stress	35	1.136153e-43	4.2716106648571433e-41	4.514984	131	0.007327442	879	0.035893590222980665	1.553256	20	24	0.001985309	
GO Biological Process	nuclear-transcribed mRNA catabolic process	36	1.279537e-43	4.677063161944445e-41	2.13215	416	0.02326882	301	0.000012385272658803986	1.327328	141	198	0.01399643	
GO Biological Process	regulation of intrinsic apoptotic signaling pathway	38	2.000636e-43	6.927991874736842e-41	2.162401	401	0.0224298	276	0.000004912569371739131	1.382899	115	155	0.01141553	
GO Biological Process	mRNA catabolic process	41	1.626255e-42	5.219485254878048e-40	2.053177	443	0.02477906	336	0.000029908750375892857	1.30386	149	213	0.01479055	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to hypoxia	44	3.508871e-42	1.0493916702045454e-39	2.791457	238	0.01331245	366	0.00006436476770491802	1.481567	62	78	0.006154457	
GO Biological Process	regulation of hematopoietic progenitor cell differentiation	46	4.447513e-42	1.2722787731956522e-39	2.645957	260	0.01454301	535	0.001567921168	1.336075	81	113	0.0080405	
GO Biological Process	response to topologically incorrect protein	49	2.687961e-41	7.21854669367347e-39	2.098478	408	0.02282134	322	0.000020703818902795033	1.3358	129	180	0.01280524	
GO Biological Process	regulation of mRNA stability	54	1.317998e-39	3.211765867037037e-37	2.052581	412	0.02304508	378	0.00007520152664550264	1.345469	109	151	0.01081993	
GO Biological Process	negative regulation of endoplasmic reticulum unfolded protein response	57	1.96288e-39	4.531497880701755e-37	6.682393	82	0.004586643	975	0.049622683474871795	1.863907	9	9	0.0008933889	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	59	5.366821e-39	1.1969830091355933e-36	2.581301	251	0.0140396	340	0.00003214360927911765	1.405828	89	118	0.008834624	
GO Biological Process	response to unfolded protein	61	2.537752e-38	5.4744718963934425e-36	2.099837	377	0.02108737	305	0.000013004733375737703	1.362982	117	160	0.01161406	
GO Biological Process	regulation of cellular amino acid metabolic process	73	1.709973e-35	3.082402014657534e-33	3.31924	153	0.008558004	618	0.004148029805339806	1.428995	46	60	0.00456621	
GO Biological Process	regulation of hematopoietic stem cell differentiation	76	6.499744e-35	1.1253964644210527e-32	2.578587	224	0.01252937	688	0.010401491384447676	1.302925	72	103	0.007147111	
GO Cellular Component	proteasome core complex	34	3.04627e-39	1.5482219294117647e-37	6.447461	84	0.004698512	96	0.0013145484600000001	1.708581	22	24	0.00218384	
GO Cellular Component	proteasome complex	41	5.62157e-30	2.369286087804878e-28	2.708082	175	0.009788567	58	0.000004537233434482758	1.562393	57	68	0.00565813	
GO Cellular Component	endopeptidase complex	42	5.986469e-30	2.4630043885714286e-28	2.706552	175	0.009788567	64	0.000011257574399999999	1.539749	57	69	0.00565813	
GO Cellular Component	peptidase complex	44	5.772828e-27	2.267146996363636e-25	2.336633	206	0.01152254	55	8.690900596363636e-7	1.525015	72	88	0.007147111	
GO Cellular Component	catalytic step 2 spliceosome	47	2.221262e-25	8.166682417021278e-24	2.202417	219	0.01224969	82	0.00027239391219512196	1.39793	72	96	0.007147111	
GO Cellular Component	large ribosomal subunit	50	1.410012e-22	4.873001472000001e-21	2.154203	203	0.01135474	87	0.0006870887503448276	1.345255	83	115	0.008239031	
GO Cellular Component	mitochondrial ribosome	54	1.047387e-21	3.3516384e-20	2.508638	142	0.007942723	131	0.013743760122137405	1.315699	60	85	0.005955926	
GO Cellular Component	nuclear ubiquitin ligase complex	57	4.42438e-20	1.3412857263157896e-18	2.948946	99	0.005537532	139	0.01985719389928058	1.444528	31	40	0.003077229	
GO Cellular Component	mitochondrial large ribosomal subunit	60	4.451718e-19	1.282094784e-17	2.88312	97	0.005425663	125	0.009022561228800002	1.425341	39	51	0.003871352	
GO Cellular Component	PcG protein complex	65	5.334031e-17	1.4180316258461537e-15	2.111295	156	0.008725808	120	0.0069396983999999995	1.45871	36	46	0.003573556	
GO Cellular Component	MLL1 complex	80	3.488046e-13	7.53417936e-12	2.71254	71	0.003971361	132	0.013649550545454546	1.542544	24	29	0.00238237	
GO Cellular Component	DNA-directed RNA polymerase III complex	85	5.043396e-12	1.0252927397647059e-10	3.910278	38	0.002125517	77	0.0001620212745974026	1.863907	19	19	0.001886043	
GO Cellular Component	signal recognition particle	186	5.236839e-7	0.000004865192361290322	3.478053	23	0.001286497	143	0.023826787804195806	1.863907	10	10	0.0009926544	
GO Cellular Component	Ino80 complex	314	0.0001782141	0.0009807451108280257	2.385026	23	0.001286497	172	0.04926887665116279	1.630919	14	16	0.001389716	
GO Molecular Function	threonine-type endopeptidase activity	10	1.731116e-34	7.308771752000001e-32	5.515868	84	0.004698512	119	0.017470188964705882	1.630919	21	24	0.002084574	
GO Molecular Function	NF-kappaB binding	14	9.973834e-22	3.007823367714286e-19	3.120784	99	0.005537532	85	0.0031876671211764707	1.664203	25	28	0.002481636	
GO Molecular Function	ribonuclease activity	15	2.683832e-21	7.554092469333333e-19	2.071428	209	0.01169035	100	0.007297228804	1.336741	71	99	0.007047846	
GO Molecular Function	unfolded protein binding	18	2.741687e-20	6.4307791744444435e-18	2.132803	185	0.01034791	132	0.03153962898939394	1.283634	73	106	0.007246377	
GO Molecular Function	endoribonuclease activity	26	3.411553e-17	5.539837217692307e-15	2.313915	129	0.007215572	90	0.004524179329555555	1.464498	44	56	0.004367679	
GO Molecular Function	cyclin-dependent protein serine/threonine kinase regulator activity	31	4.923272e-15	6.705178833548387e-13	2.518959	94	0.005257859	135	0.032608663911111106	1.542544	24	29	0.00238237	
GO Molecular Function	RNA polymerase III activity	83	7.781998e-10	3.9585054886746984e-8	3.624122	33	0.001845844	81	0.0024425609572839508	1.863907	16	16	0.001588247	
GO Molecular Function	DNA-directed 5'-3' RNA polymerase activity	95	2.150372e-9	9.556705877894738e-8	2.183546	73	0.004083231	118	0.01752830923559322	1.473787	34	43	0.003375025	
GO Molecular Function	5'-3' RNA polymerase activity	100	3.613404e-9	1.5255791688e-7	2.142824	74	0.004139165	127	0.023653917896062995	1.449706	35	45	0.00347429	
GO Molecular Function	DNA polymerase binding	214	0.000002827277	0.0000557792686635514	2.826539	27	0.001510236	125	0.0234933933072	1.747413	15	16	0.001488982	
Human Phenotype	Abnormal CSF metabolite level	46	6.631891e-13	9.620567096304348e-11	2.130559	112	0.006264683	91	0.0014314369627472527	1.479291	50	63	0.004963272	
Human Phenotype	Increased CSF lactate	60	1.071676e-11	1.1918823246666666e-9	2.121559	101	0.005649401	108	0.002686191435185185	1.478271	46	58	0.00456621	
Human Phenotype	Progressive macrocephaly	364	0.00001558739	0.0002857545425	2.0738	42	0.002349256	74	0.0006272892330540541	1.786244	23	24	0.002283105	
Mouse Phenotype Single KO	pale liver	46	6.118546e-23	1.2179896896086956e-20	2.096563	220	0.01230563	261	0.03359904332988506	1.328034	57	80	0.00565813	
Mouse Phenotype Single KO	absent hypoglossal nerve	64	1.974336e-20	2.82484293e-18	4.10023	65	0.003635753	272	0.041126679238970586	1.739647	14	15	0.001389716	
Mouse Phenotype Single KO	abnormal pharyngeal muscle morphology	141	1.283616e-13	8.336221072340426e-12	3.629998	48	0.002684864	264	0.036676074249999996	1.863907	11	11	0.00109192	
Mouse Phenotype Single KO	abnormal vitelline vein morphology	143	1.771415e-13	1.1343249758741259e-11	2.112989	120	0.00671216	287	0.04830087777351916	1.565682	21	25	0.002084574	
Mouse Phenotype Single KO	increased cellular sensitivity to ultraviolet irradiation	460	0.000001160093	0.000023093416523913045	2.068958	54	0.003020472	232	0.019435314119827584	1.630919	21	24	0.002084574	
Mouse Phenotype	absent hypoglossal nerve	84	1.974336e-20	2.2472174399999997e-18	4.10023	65	0.003635753	425	0.027482340868235294	1.739647	14	15	0.001389716	
Mouse Phenotype	abnormal vitelline vein morphology	202	1.771415e-13	8.384405353960395e-12	2.112989	120	0.00671216	441	0.03282074497278911	1.565682	21	25	0.002084574	
Mouse Phenotype	abnormal infrahyoid muscle morphology	208	2.130302e-13	9.792219914423076e-12	3.700024	46	0.002572995	474	0.039772489234177213	1.863907	10	10	0.0009926544	
Mouse Phenotype	abnormal pharyngeal muscle morphology	214	3.453296e-13	1.5428487409345795e-11	3.421539	50	0.002796733	358	0.015142920112290502	1.863907	12	12	0.001191185	
Mouse Phenotype	increased cellular sensitivity to ultraviolet irradiation	296	2.300044e-10	7.4292975283783785e-9	2.320393	72	0.004027296	272	0.004893963058455882	1.615386	26	30	0.002580901	
Mouse Phenotype	small sebaceous gland	326	9.814968e-10	2.8785554922699384e-8	4.249031	27	0.001510236	474	0.039772489234177213	1.863907	10	10	0.0009926544	
Mouse Phenotype	abnormal level of surface class I molecules	694	0.00001168217	0.00016094124981268012	2.869097	23	0.001286497	484	0.042219420340909086	1.730771	13	14	0.001290451	
Mouse Phenotype	abnormal lipoprotein lipase activity	703	0.00001360665	0.00018505431102418208	2.262182	35	0.001957713	474	0.039772489234177213	1.863907	10	10	0.0009926544