# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	1	2.240713e-88	2.9485542367000002e-84	10.32249	137	0.0437141	1	9.345400737199999e-21	3.748861	61	92	0.01836796	
GO Biological Process	cotranslational protein targeting to membrane	2	7.447744e-86	4.9002431648e-82	9.738146	138	0.04403318	2	1.03142018465e-20	3.634727	63	98	0.01897019	
GO Biological Process	protein targeting to ER	3	5.11706e-85	2.2445130846666667e-81	9.376884	140	0.04467135	3	9.639893016333335e-21	3.582745	64	101	0.0192713	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	4	1.696594e-83	5.5813701115e-80	8.565206	146	0.04658583	9	1.8687651502222223e-18	3.210333	67	118	0.02017465	
GO Biological Process	translational initiation	5	7.444207e-82	1.9591663982599998e-78	7.029142	165	0.05264837	7	1.1619225933e-18	3.004934	76	143	0.02288467	
GO Biological Process	protein localization to endoplasmic reticulum	6	3.161779e-81	6.934308310166666e-78	7.564532	155	0.04945756	6	5.515568532000001e-19	3.191785	70	124	0.02107799	
GO Biological Process	viral gene expression	7	1.085695e-80	2.040951500714286e-77	7.916613	149	0.04754308	10	2.1452288683e-18	3.116389	70	127	0.02107799	
GO Biological Process	establishment of protein localization to endoplasmic reticulum	8	9.508143e-80	1.5639706717125e-76	8.336337	142	0.04530951	4	2.131556996275e-20	3.500108	65	105	0.01957242	
GO Biological Process	DNA replication-dependent nucleosome assembly	9	2.947116e-79	4.309011049333333e-76	48.72045	61	0.01946394	134	2.444164444179104e-9	4.063827	23	32	0.006925625	
GO Biological Process	viral transcription	10	1.837618e-78	2.4181215261999997e-75	8.142053	142	0.04530951	11	2.336727369090909e-18	3.252312	65	113	0.01957242	
GO Biological Process	chromatin silencing at rDNA	11	2.834404e-73	3.3907202032727277e-70	25.22915	72	0.02297384	40	1.0264908232500001e-13	4.554627	29	36	0.00873231	
GO Biological Process	nuclear-transcribed mRNA catabolic process	12	3.660604e-73	4.0141573363333333e-70	5.379752	184	0.05871091	19	3.046626393736842e-16	2.541453	89	198	0.02679916	
GO Biological Process	mRNA catabolic process	13	2.292986e-72	2.321030982615385e-69	5.076261	192	0.06126356	17	1.6232601814117647e-16	2.495201	94	213	0.02830473	
GO Biological Process	chromatin silencing	14	4.215052e-72	3.961847804857143e-69	10.09995	113	0.03605616	30	1.552593126166667e-14	3.147599	54	97	0.01626016	
GO Biological Process	multi-organism metabolic process	15	2.181092e-70	1.9133993085333332e-67	6.275497	155	0.04945756	20	4.3376426208499994e-16	2.807779	73	147	0.02198133	
GO Biological Process	RNA catabolic process	16	1.788378e-69	1.470829131375e-66	4.597377	203	0.06477345	18	1.8366637697222225e-16	2.392988	102	241	0.03071364	
GO Biological Process	rRNA processing	17	1.20539e-67	9.330427652941176e-65	4.732456	192	0.06126356	25	5.8738196752e-15	2.288532	102	252	0.03071364	
GO Biological Process	rRNA metabolic process	18	1.352564e-67	9.887994264444445e-65	4.655905	195	0.0622208	23	1.846320981826087e-15	2.29217	105	259	0.03161698	
GO Biological Process	protein targeting to membrane	19	2.55925e-66	1.7724826710526318e-63	6.220563	147	0.04690491	13	3.2451926137692306e-18	3.037981	72	134	0.02168022	
GO Biological Process	negative regulation of gene expression, epigenetic	20	1.576664e-63	1.0373660788e-60	7.306598	124	0.03956605	24	2.4539621462083335e-15	3.025397	61	114	0.01836796	
GO Cellular Component	intracellular ribonucleoprotein complex	1	7.585709e-89	1.3108105152000002e-85	2.89097	452	0.1442246	17	2.447387745882353e-16	1.687871	243	814	0.07317073	
GO Cellular Component	ribonucleoprotein complex	2	1.128197e-88	9.74762208e-86	2.887289	452	0.1442246	16	2.0774469599999999e-16	1.688593	244	817	0.07347185	
GO Cellular Component	ribosomal subunit	3	2.840794e-77	1.636297344e-74	6.243652	171	0.05456286	27	9.7133952e-14	2.414419	79	185	0.02378802	
GO Cellular Component	nucleosome	4	4.898604e-76	2.116196928e-73	10.56339	116	0.0370134	4	4.3531430399999997e-23	3.607803	67	105	0.02017465	
GO Cellular Component	cytosolic ribosome	5	6.802908e-74	2.3510850048e-71	7.018505	149	0.04754308	5	7.457491583999999e-21	3.382315	67	112	0.02017465	
GO Cellular Component	DNA packaging complex	6	1.346659e-66	3.87837792e-64	8.576513	116	0.0370134	5	7.457491583999999e-21	3.382315	67	112	0.02017465	
GO Cellular Component	nuclear nucleosome	7	8.972058e-66	2.2148166034285716e-63	22.28703	68	0.02169751	34	2.239285214117647e-9	3.675113	26	40	0.007828967	
GO Cellular Component	ribosome	8	1.074735e-64	2.3214276e-62	4.721701	184	0.05871091	30	1.060808256e-11	2.132236	89	236	0.02679916	
GO Cellular Component	cytosolic part	10	1.926916e-54	3.329710848e-52	3.950531	187	0.05966816	24	5.79965256e-14	2.23805	95	240	0.02860584	
GO Cellular Component	protein-DNA complex	13	4.860495e-51	6.460719507692308e-49	4.237734	162	0.05169113	13	1.948292086153846e-17	2.547108	91	202	0.02740139	
GO Cellular Component	small ribosomal subunit	14	3.314339e-47	4.09084128e-45	7.823047	87	0.02776005	45	0.000001222468608	2.591426	33	72	0.009936766	
GO Cellular Component	cytosolic small ribosomal subunit	16	8.372891e-44	9.04272228e-42	9.394875	71	0.02265475	42	3.84357312e-8	3.341012	26	44	0.007828967	
GO Cellular Component	chromatin	17	9.527506e-44	9.684429628235294e-42	2.421819	304	0.09700064	10	2.9636910720000005e-18	1.977744	170	486	0.0511894	
GO Cellular Component	cytosolic large ribosomal subunit	20	3.639461e-40	3.1444943040000003e-38	7.360017	77	0.02456924	26	9.083391507692306e-14	3.614865	39	61	0.01174345	
GO Cellular Component	nuclear chromatin	22	5.829372e-39	4.578706734545454e-37	2.666289	229	0.07306956	20	4.422564576e-15	2.111311	118	316	0.03553147	
GO Cellular Component	nuclear chromosome, telomeric region	24	8.495754e-36	6.116942880000001e-34	4.840886	98	0.03126994	55	0.0003210834501818182	1.884673	44	132	0.01324902	
GO Cellular Component	chromosome, telomeric region	25	1.871156e-35	1.2933430272e-33	4.253389	111	0.035418	58	0.0009816794813793104	1.726677	51	167	0.01535682	
GO Cellular Component	large ribosomal subunit	26	2.983727e-35	1.9830308676923075e-33	5.327129	88	0.02807913	43	1.791400721860465e-7	2.310773	47	115	0.01415236	
GO Cellular Component	nuclear chromosome part	30	6.178272e-33	3.558684672e-31	2.183206	281	0.08966177	29	5.033786151724138e-12	1.749006	159	514	0.04787715	
GO Cellular Component	nuclear chromosome	35	8.195339e-30	4.046155940571428e-28	2.062774	288	0.09189534	31	2.9056058012903226e-11	1.696206	165	550	0.04968383	
GO Molecular Function	RNA binding	1	2.512973e-89	1.0609772006e-85	2.105629	771	0.2460115	2	2.277091369e-20	1.536043	445	1638	0.1339958	
GO Molecular Function	structural constituent of ribosome	2	1.159807e-72	2.448352577e-69	6.326549	159	0.05073389	5	7.043674905199999e-15	2.652503	76	162	0.02288467	
GO Molecular Function	nucleosomal DNA binding	3	1.782134e-61	2.508056582666667e-58	10.83169	92	0.02935546	25	0.0000035040100576	3.072837	25	46	0.007527853	
GO Molecular Function	nucleosome binding	5	4.823446e-47	4.0729178023999996e-44	6.832065	96	0.03063178	31	0.00008834791043870968	2.484342	29	66	0.00873231	
GO Molecular Function	structural molecule activity	7	3.273413e-41	1.9743356694285716e-38	2.210256	342	0.1091257	32	0.0000913894383875	1.405474	175	704	0.05269497	
GO Molecular Function	chromatin DNA binding	8	1.531149e-39	8.080638847500001e-37	4.575964	115	0.03669432	22	0.000002539678850909091	2.33772	43	104	0.01294791	
GO Molecular Function	structure-specific DNA binding	9	4.007086e-39	1.8797685657777777e-36	3.794775	140	0.04467135	8	4.056165117500001e-9	2.399908	59	139	0.01776573	
GO Molecular Function	histone binding	13	9.940953e-31	3.228515658923077e-28	2.963068	152	0.04850032	11	9.716434036363636e-8	2.056007	72	198	0.02168022	
GO Molecular Function	mRNA binding	16	1.948101e-19	5.14055151375e-17	2.375708	137	0.0437141	20	0.0000019712838872	1.962794	67	193	0.02017465	
GO Molecular Function	mRNA 5'-UTR binding	17	6.25692e-18	1.5539244847058823e-15	7.562892	32	0.01021059	40	0.0017197419824999997	3.341012	13	22	0.003914484	
GO Molecular Function	single-stranded DNA binding	35	2.458586e-9	2.965757169142857e-7	2.31978	63	0.02010211	43	0.0078042472130232556	1.903333	34	101	0.01023788	
GO Molecular Function	mRNA 3'-UTR binding	51	6.574739e-8	0.000005442852560392157	2.354991	50	0.01595405	53	0.049721187569811316	1.97034	23	66	0.006925625	
GO Molecular Function	double-stranded RNA binding	57	2.250022e-7	0.000016665952428070175	2.463439	42	0.0134014	44	0.007727184042272728	2.141674	25	66	0.007527853	
GO Molecular Function	protein phosphatase activator activity	69	0.000001884887	0.00011533323063768116	4.90879	14	0.004467135	51	0.05094059894901961	4.240515	6	8	0.001806685	
GO Molecular Function	supercoiled DNA binding	109	0.0003537187	0.013700920655045872	4.253314	9	0.002871729	48	0.01518495075	5.65402	5	5	0.001505571	
Mouse Phenotype Single KO	increased cellular sensitivity to oxidative stress	20	4.168893e-7	0.00019087276600500002	3.406186	24	0.007657945	147	0.04091551919455782	2.355842	15	36	0.004516712	
Mouse Phenotype Single KO	increased cellular sensitivity to hydrogen peroxide	31	0.000001032816	0.00030508051974193547	4.521181	16	0.005105297	137	0.038352771079562045	2.9758	10	19	0.003011141	
Mouse Phenotype	macrocytic anemia	4	1.0344e-9	0.0000024724746000000002	3.65891	32	0.01021059	190	0.008998370374736843	2.949923	12	23	0.003613369	
Mouse Phenotype	increased mammary adenocarcinoma incidence	7	3.579816e-9	0.000004889517253714286	2.651127	48	0.01531589	324	0.03693210686111111	1.983867	20	57	0.006022282	
Mouse Phenotype	increased cellular sensitivity to ultraviolet irradiation	9	1.708157e-8	0.000018146321196666665	4.228408	23	0.007338864	201	0.011422274594029851	2.638543	14	30	0.004215598	
Mouse Phenotype	increased embryonic neuroepithelium apoptosis	19	1.1468e-7	0.000057708183157894745	3.794593	23	0.007338864	241	0.019233911306639002	2.71393	12	25	0.003613369	
Mouse Phenotype	increased cellular sensitivity to oxidative stress	22	4.28872e-7	0.0001863838723636364	3.04822	28	0.008934269	289	0.029528476914186853	2.120257	18	48	0.005420054	
Mouse Phenotype	increased fibroblast apoptosis	25	5.659965e-7	0.00021645970145999998	2.873458	30	0.009572431	208	0.013365753983653845	2.23805	19	48	0.005721168	
Mouse Phenotype	abnormal fibroblast apoptosis	30	8.718711e-7	0.00027786531957	2.308118	43	0.01372049	124	0.0022432295777419357	2.180836	27	70	0.008130081	
Mouse Phenotype	increased cellular sensitivity to hydrogen peroxide	33	0.000001105131	0.0003201865906363637	4.249768	17	0.005424378	285	0.029075913488421055	2.704096	11	23	0.003312255	
Mouse Phenotype	embryonic lethality between implantation and somite formation, incomplete penetrance	124	0.0002037155	0.01570745077016129	2.35844	23	0.007338864	265	0.023362657076603774	2.534561	13	29	0.003914484