# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	3	1.09896e-58	4.82040488e-55	3.455834	243	0.0238633	339	0.0012649715646312685	1.48224	66	113	0.008920124	
GO Biological Process	regulation of DNA-templated transcription in response to stress	11	4.392215e-51	5.2542870168181815e-48	3.092817	246	0.02415791	338	0.0011812211388757398	1.471483	69	119	0.009325585	
GO Biological Process	endoplasmic reticulum unfolded protein response	18	7.411042e-41	5.417883426555556e-38	3.023894	202	0.01983698	488	0.011439989674795082	1.402455	63	114	0.008514664	
GO Biological Process	liver regeneration	21	5.904976e-39	3.700170437333333e-36	4.246663	124	0.01217716	625	0.0307769850496	1.667681	23	35	0.003108528	
GO Biological Process	positive regulation of nuclease activity	27	1.590997e-36	7.754047971481482e-34	7.237847	71	0.006972405	647	0.033475946860896444	2.03022	12	15	0.001621841	
GO Biological Process	cellular response to unfolded protein	29	5.929899e-36	2.6907427910689654e-33	2.74643	206	0.02022979	500	0.013435968000200001	1.384241	66	121	0.008920124	
GO Biological Process	cellular response to topologically incorrect protein	30	2.917615e-35	1.2797631928333334e-32	2.625866	218	0.02140823	601	0.02476455924958403	1.332789	73	139	0.009866198	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to hypoxia	37	1.112305e-32	3.955897701351351e-30	3.129974	152	0.01492684	422	0.004786015610900474	1.529172	47	78	0.00635221	
GO Biological Process	regulation of cellular amino acid metabolic process	40	2.22021e-32	7.3039358475e-30	4.075438	107	0.01050771	580	0.022311933028620688	1.522665	36	60	0.004865522	
GO Biological Process	response to unfolded protein	44	1.377775e-31	4.120486642045454e-29	2.346922	240	0.02356869	426	0.004857181504929577	1.364054	86	160	0.01162319	
GO Biological Process	response to topologically incorrect protein	45	3.793172e-31	1.109207785511111e-28	2.275559	252	0.02474713	508	0.013950122706496064	1.311184	93	180	0.01256927	
GO Biological Process	negative regulation of intrinsic apoptotic signaling pathway	46	2.207369e-30	6.314514928478261e-28	2.688504	179	0.01757832	686	0.04687009449854228	1.376878	51	94	0.006892823	
GO Biological Process	platelet-derived growth factor receptor signaling pathway	50	1.16142e-29	3.056625156e-27	3.058377	142	0.01394481	619	0.029617146248788365	1.69185	22	33	0.002973375	
GO Biological Process	regulation of intrinsic apoptotic signaling pathway	51	6.408552e-29	1.6535320738823528e-26	2.253263	238	0.02337229	613	0.02824273451549755	1.30982	80	155	0.01081227	
GO Biological Process	rRNA processing	61	6.822458e-26	1.4717495872459015e-23	2.033028	268	0.02631837	142	1.5805191497887323e-7	1.470298	146	252	0.0197324	
GO Biological Process	regulation of hematopoietic stem cell differentiation	63	1.175993e-25	2.4563320455555553e-23	2.809259	139	0.0136502	546	0.01793378653131868	1.4044	57	103	0.007703744	
GO Biological Process	regulation of hematopoietic progenitor cell differentiation	64	1.377306e-25	2.8318702584375e-23	2.680056	150	0.01473043	463	0.008722728782721382	1.414866	63	113	0.008514664	
GO Biological Process	regulation of mRNA stability	69	4.104898e-24	7.8284569249275365e-22	2.072978	237	0.02327408	226	0.000051127565197787607	1.495775	89	151	0.01202865	
GO Biological Process	positive regulation of endoplasmic reticulum unfolded protein response	71	4.949214e-24	9.172775637464789e-22	4.071625	78	0.007659825	406	0.003738825183497537	2.342562	12	13	0.001621841	
GO Biological Process	cellular response to epidermal growth factor stimulus	76	2.461347e-23	4.2616927859210524e-21	2.817165	125	0.01227536	701	0.04857473088445078	1.602806	24	38	0.003243682	
GO Cellular Component	mitochondrial ribosome	44	8.426935e-21	3.3094872e-19	3.039617	98	0.009623883	68	0.00014556631341176472	1.612234	54	85	0.007298284	
GO Cellular Component	proteasome complex	45	3.082512e-20	1.183684608e-18	2.852701	105	0.0103113	94	0.007156239931914893	1.530129	41	68	0.005541289	
GO Cellular Component	endopeptidase complex	46	3.204944e-20	1.2039441808695653e-18	2.85109	105	0.0103113	102	0.010102609694117647	1.507953	41	69	0.005541289	
GO Cellular Component	PcG protein complex	48	7.193683e-19	2.58972588e-17	2.637489	111	0.01090052	93	0.006499463225806451	1.655071	30	46	0.004054602	
GO Cellular Component	ribosomal subunit	49	2.579747e-18	9.097556767346939e-17	2.045207	182	0.01787293	56	0.0000084527712	1.467794	107	185	0.01446141	
GO Cellular Component	catalytic step 2 spliceosome	52	7.607634e-18	2.5280752984615384e-16	2.330626	132	0.01296278	83	0.00273485563373494	1.480369	56	96	0.00756859	
GO Cellular Component	peptidase complex	53	3.922077e-17	1.2787451049056603e-15	2.389723	120	0.01178435	85	0.0029052985976470587	1.499595	52	88	0.007027977	
GO Cellular Component	methyltransferase complex	55	6.590112e-17	2.0704933701818183e-15	2.257097	133	0.01306098	59	0.000023150680840677964	1.645371	59	91	0.007974051	
GO Cellular Component	ficolin-1-rich granule lumen	56	4.711119e-15	1.4537167200000002e-13	2.036944	148	0.01453403	130	0.02892176196923077	1.330285	65	124	0.008784971	
GO Cellular Component	nucleosome	64	2.567011e-13	6.930929699999999e-12	2.438303	87	0.008543651	108	0.011432616	1.401819	58	105	0.007838897	
GO Cellular Component	spliceosomal snRNP complex	69	9.079161e-13	2.2737377113043477e-11	2.591985	74	0.007267014	95	0.007211747974736842	1.555411	38	62	0.005135829	
GO Cellular Component	mitochondrial large ribosomal subunit	76	6.184288e-12	1.4061117978947367e-10	2.922283	56	0.005499362	104	0.01037525593846154	1.59233	32	51	0.004324909	
GO Cellular Component	large ribosomal subunit	77	9.520479e-12	2.1365438587012987e-10	2.049399	110	0.01080232	69	0.00035468477217391305	1.500598	68	115	0.009190431	
GO Cellular Component	DNA packaging complex	83	7.275932e-11	1.5147964453012048e-9	2.116211	93	0.009132869	109	0.013605377878899082	1.382181	61	112	0.008244357	
GO Cellular Component	endoplasmic reticulum-Golgi intermediate compartment membrane	89	5.92114e-10	1.1496325752808988e-8	2.01929	94	0.009231071	155	0.04963772531612903	1.422692	37	66	0.005000676	
GO Cellular Component	small nuclear ribonucleoprotein complex	98	1.164956e-9	2.054126497959184e-8	2.187995	75	0.007365217	138	0.03654182817391304	1.434395	39	69	0.005270983	
GO Cellular Component	U4 snRNP	104	2.386153e-9	3.9646849846153845e-8	5.459305	20	0.001964058	118	0.02159131606779661	2.283998	9	10	0.001216381	
GO Cellular Component	preribosome	109	6.295078e-9	9.979719985321102e-8	2.024234	82	0.008052637	78	0.0013711210338461538	1.569414	47	76	0.00635221	
GO Cellular Component	small ribosomal subunit	114	2.108001e-8	3.195285726315789e-7	2.047914	74	0.007267014	147	0.046380025469387756	1.409875	40	72	0.005406136	
GO Cellular Component	axon hillock	123	4.987928e-8	7.007430556097562e-7	5.024945	18	0.001767652	116	0.02193645351724138	2.537775	7	7	0.0009460738	
GO Molecular Function	structural constituent of ribosome	16	1.470565e-19	3.88045339375e-17	2.143044	175	0.01718551	40	0.000024613362824999997	1.503867	96	162	0.01297473	
GO Molecular Function	ribonucleoprotein complex binding	20	1.354194e-15	2.858703534e-13	2.125552	139	0.0136502	87	0.02816511729195402	1.39026	63	115	0.008514664	
GO Molecular Function	unfolded protein binding	39	1.667764e-12	1.8054614379487178e-10	2.145498	106	0.01040951	99	0.04168240293131313	1.388594	58	106	0.007838897	
GO Molecular Function	endoribonuclease activity	41	2.959173e-12	3.0472264404878045e-10	2.45638	78	0.007659825	68	0.008853428449999999	1.631427	36	56	0.004865522	
GO Molecular Function	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	126	0.000001033515	0.000034630955	2.126862	51	0.005008347	76	0.015342975765789474	1.736373	26	38	0.003513988	
GO Molecular Function	endoribonuclease activity, producing 5'-phosphomonoesters	178	0.000007611595	0.00018054019151685395	2.096584	44	0.004320927	105	0.04875183609523809	1.75019	20	29	0.002703068	
Human Phenotype	Increased serum lactate	9	1.004524e-18	7.447987391111112e-16	2.401774	131	0.01286458	28	0.000045673443828571423	1.649554	65	100	0.008784971	
Human Phenotype	Progressive external ophthalmoplegia	17	3.495718e-13	1.3721721302352942e-10	4.390245	37	0.003633507	93	0.016670015032258064	2.199405	13	15	0.001756994	
Human Phenotype	External ophthalmoplegia	22	1.009866e-10	3.06310719e-8	2.5792	61	0.005990376	50	0.0012344672308200002	1.982637	25	32	0.003378835	
Mouse Phenotype Single KO	abnormal vitelline vein morphology	88	1.712143e-16	1.781601528522727e-14	2.751371	89	0.008740057	201	0.04429634058756219	1.827198	18	25	0.002432761	
Mouse Phenotype Single KO	decreased bone ossification	98	1.176534e-15	1.0993389630612246e-13	2.6427	90	0.00883826	208	0.04840918488461538	1.785842	19	27	0.002567915	
Mouse Phenotype Single KO	embryonic lethality between somite formation and embryo turning, complete penetrance	129	8.474599e-14	6.01565139868217e-12	2.020183	137	0.0134538	154	0.022236180944155845	1.508948	44	74	0.00594675	
Mouse Phenotype Single KO	spontaneous chromosome breakage	618	0.0001472153	0.0021813114920711976	2.022523	34	0.003338898	139	0.014545235723021584	1.928709	19	25	0.002567915	
Mouse Phenotype	dry eyes	39	3.949905e-27	9.683344026923075e-25	4.27749	84	0.008249043	255	0.02957897068352941	2.061942	13	16	0.001756994	
Mouse Phenotype	abnormal vitelline vein morphology	95	1.712143e-16	1.7231367603157895e-14	2.751371	89	0.008740057	267	0.0348179141247191	1.827198	18	25	0.002432761	
Mouse Phenotype	decreased brown fat cell size	327	6.615339e-8	0.000001934228017706422	2.884569	35	0.003437101	302	0.046678163334437084	2.283998	9	10	0.001216381