# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	ncRNA metabolic process	2	6.633697e-39	4.36464094115e-35	2.122798	363	0.06478672	18	7.152294455722222e-19	1.647663	268	555	0.04870071	
GO Biological Process	ribonucleoprotein complex biogenesis	6	3.786609e-32	8.3046646385e-29	2.047613	325	0.05800464	17	2.359130812882353e-21	1.766195	235	454	0.04270398	
GO Biological Process	ncRNA processing	8	8.397248e-32	1.3812423304e-28	2.227648	266	0.04747457	24	1.0761101224999998e-15	1.706069	198	396	0.03598037	
GO Biological Process	ribosome biogenesis	12	2.370806e-29	2.599786346166667e-26	2.280814	233	0.04158487	20	1.8990693768499998e-16	1.806426	171	323	0.03107396	
GO Biological Process	rRNA metabolic process	15	3.568129e-28	3.1302006340666665e-25	2.497408	187	0.03337498	34	1.5807442264705883e-13	1.818051	138	259	0.02507723	
GO Biological Process	rRNA processing	16	1.102377e-27	9.066361839375e-25	2.509199	182	0.0324826	38	4.671289169736842e-13	1.814391	134	252	0.02435035	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	20	1.9066e-24	1.25444747e-21	3.02404	117	0.02088167	184	0.00031963010754347825	1.690971	56	113	0.01017627	
GO Biological Process	regulation of DNA-templated transcription in response to stress	23	5.132148e-23	2.936258066608695e-20	2.810473	123	0.02195253	173	0.00018731380118497108	1.691733	59	119	0.01072142	
GO Biological Process	nuclear-transcribed mRNA catabolic process	24	1.43414e-22	7.863270108333333e-20	2.469447	151	0.02694985	109	4.533722181651377e-7	1.671603	97	198	0.01762675	
GO Biological Process	RNA catabolic process	27	7.390799e-22	3.602056445962963e-19	2.242156	177	0.03159022	96	1.4258105475e-7	1.628199	115	241	0.02089769	
GO Biological Process	mRNA catabolic process	28	1.134463e-21	5.331570934642858e-19	2.351355	159	0.02837765	105	3.8673887431428567e-7	1.650001	103	213	0.01871706	
GO Biological Process	negative regulation of G2/M transition of mitotic cell cycle	35	7.28815e-18	2.740136167142857e-15	2.962424	86	0.01534892	176	0.00020813530486363634	1.801916	47	89	0.008540796	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	36	1.366852e-17	4.996223741111111e-15	2.887659	88	0.01570587	162	0.00005586486931790123	1.734986	60	118	0.01090314	
GO Biological Process	negative regulation of cell cycle G2/M phase transition	37	3.933236e-17	1.3988500682162164e-14	2.876591	86	0.01534892	190	0.0004293084965578948	1.762313	47	91	0.008540796	
GO Biological Process	negative regulation of mitotic cell cycle phase transition	39	5.058289e-17	1.7067185884871795e-14	2.037883	168	0.02998394	133	0.000006154823451654135	1.611764	94	199	0.01708159	
GO Biological Process	regulation of cellular amino acid metabolic process	40	7.592645e-17	2.4977903888749998e-14	3.876445	56	0.009994646	288	0.010291347770486112	1.762938	31	60	0.005633291	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to hypoxia	43	5.1487e-16	1.5756219372093023e-13	2.919086	78	0.01392111	228	0.002124054790657895	1.749815	40	78	0.007268762	
GO Biological Process	regulation of hematopoietic progenitor cell differentiation	45	5.952749e-16	1.7407160909111113e-13	2.760111	85	0.01517044	337	0.019978485798219585	1.509796	50	113	0.009085953	
GO Biological Process	antigen processing and presentation of peptide antigen via MHC class I	46	7.267114e-16	2.0788685462173913e-13	3.027157	73	0.01302873	344	0.02245337383808139	1.571884	41	89	0.007450482	
GO Biological Process	regulation of hematopoietic stem cell differentiation	47	1.355666e-15	3.7955763604255315e-13	2.865014	78	0.01392111	354	0.024429765279096044	1.523868	46	103	0.008359077	
GO Cellular Component	ribosome	22	4.143921e-20	3.2548615854545453e-18	2.267859	158	0.02819918	30	8.697081599999999e-10	1.706069	118	236	0.02144285	
GO Cellular Component	ribosomal subunit	26	8.248159e-19	5.481853366153846e-17	2.491614	122	0.02177405	35	2.8629010285714283e-8	1.733735	94	185	0.01708159	
GO Cellular Component	endopeptidase complex	33	1.804908e-16	9.451154618181818e-15	3.30637	67	0.01195788	49	0.00023634691787755103	1.879149	38	69	0.006905324	
GO Cellular Component	proteasome complex	34	5.898088e-16	2.997616489411765e-14	3.258862	66	0.0117794	52	0.00042486468923076925	1.856605	37	68	0.006723605	
GO Cellular Component	peptidase complex	37	2.892431e-15	1.3508434508108108e-13	2.823034	78	0.01392111	53	0.0004416334369811321	1.744844	45	88	0.008177358	
GO Cellular Component	mitochondrial membrane part	38	3.31566e-15	1.5077527578947368e-13	2.081435	141	0.02516509	54	0.0004946096	1.464644	91	212	0.01653643	
GO Cellular Component	large ribosomal subunit	39	3.022523e-14	1.3392101907692308e-12	2.674952	79	0.01409959	41	0.00002425422485853658	1.750576	59	115	0.01072142	
GO Cellular Component	mitochondrial ribosome	42	9.883514e-13	4.0663600457142854e-11	3.10035	55	0.00981617	55	0.0009221204945454546	1.726141	43	85	0.00781392	
GO Cellular Component	preribosome	44	2.66714e-11	1.0474586181818182e-9	2.691865	60	0.01070855	39	0.000002421422473846154	2.020345	45	76	0.008177358	
GO Cellular Component	spliceosomal snRNP complex	49	3.441774e-9	1.2137521371428572e-7	2.800971	44	0.007852936	96	0.020932056	1.651035	30	62	0.005451572	
GO Cellular Component	spliceosomal tri-snRNP complex	50	3.533068e-9	1.2210283008e-7	3.868721	28	0.004997323	92	0.017758817530434783	2.000219	17	29	0.003089224	
GO Cellular Component	catalytic step 2 spliceosome	51	6.977186e-9	2.364034785882353e-7	2.18204	68	0.01213636	71	0.00485837421971831	1.59944	45	96	0.008177358	
GO Cellular Component	mitochondrial large ribosomal subunit	52	7.339402e-9	2.4389397415384613e-7	3.224544	34	0.006068178	91	0.017441214804395606	1.739522	26	51	0.004724696	
GO Cellular Component	cytosolic ribosome	53	1.525516e-8	4.973757826415095e-7	2.028745	77	0.01374264	44	0.00012358840581818182	1.706069	56	112	0.01017627	
GO Cellular Component	methyltransferase complex	56	3.048466e-8	9.406695085714286e-7	2.09731	68	0.01213636	57	0.0012158790063157897	1.687321	45	91	0.008177358	
GO Cellular Component	small nuclear ribonucleoprotein complex	57	3.391533e-8	0.0000010281700042105264	2.491943	47	0.008388363	90	0.01676815488	1.631892	33	69	0.005996729	
GO Cellular Component	U4/U6 x U5 tri-snRNP complex	59	4.537645e-8	0.000001328991620338983	3.735804	25	0.004461895	116	0.04232727062068965	1.990414	14	24	0.002544067	
GO Cellular Component	proteasome accessory complex	60	4.747707e-8	0.000001367339616	3.854199	24	0.00428342	88	0.014613379854545454	2.132587	15	24	0.002725786	
GO Cellular Component	cytosolic large ribosomal subunit	62	6.814448e-8	0.0000018992526038709679	2.459372	46	0.008209888	58	0.0012931464165517241	1.845911	33	61	0.005996729	
GO Cellular Component	small-subunit processome	64	9.472185e-8	0.0000025574899500000003	3.214536	29	0.005175799	68	0.0038859619764705883	2.047283	21	35	0.0038161	
GO Molecular Function	structural constituent of ribosome	4	3.158643e-18	3.3339476865e-15	2.53719	114	0.02034624	9	3.4420962102222227e-9	1.87457	89	162	0.016173	
GO Molecular Function	rRNA binding	11	6.998633e-10	2.6862025932727274e-7	3.331961	37	0.006603605	48	0.01981156787916667	1.762938	31	60	0.005633291	
GO Molecular Function	ribonucleoprotein complex binding	13	3.694418e-9	0.000001199833292	2.112155	76	0.01356416	45	0.019573473466666668	1.54288	52	115	0.009449391	
GO Molecular Function	ATP-dependent RNA helicase activity	29	0.000002392319	0.00034828864889655165	2.028902	53	0.009459218	33	0.0030849757387878787	1.833388	36	67	0.006541886	
GO Molecular Function	RNA helicase activity	34	0.000003171729	0.00039385411288235295	2.008394	53	0.009459218	36	0.004322416751666667	1.806426	36	68	0.006541886	
Human Phenotype	Increased serum lactate	4	1.643022e-9	0.0000027409714515	2.265817	68	0.01213636	62	0.006406808648548387	1.637827	48	100	0.008722515