# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process liver regeneration 5 6.124966e-307 1.61196855188e-303 22.89889 318 0.06566178 439 0.04027268486332574 2.195113 15 35 0.004091653 GO Biological Process positive regulation of catenin import into nucleus 11 1.474676e-255 1.7641146803636362e-252 22.70454 266 0.05492463 272 0.00948076439007353 3.725041 8 11 0.002182215 GO Biological Process regulation of catenin import into nucleus 15 3.266777e-225 2.865834569533333e-222 14.03617 295 0.06091266 258 0.00848013393604651 2.774379 13 24 0.003546099 GO Biological Process chondrocyte development 26 2.651743e-175 1.3420879283461538e-172 9.575832 287 0.05926079 300 0.011982295902 2.793781 12 22 0.003273322 GO Biological Process glomerulus development 36 1.254029e-138 4.583824336388889e-136 6.681837 293 0.06049969 459 0.045013326725490195 1.932804 20 53 0.005455537 GO Biological Process positive regulation of cell morphogenesis involved in differentiation 40 6.286473e-135 2.0680924551750002e-132 4.301651 425 0.08775552 428 0.03701657445327103 1.570227 42 137 0.01145663 GO Biological Process nephron development 44 1.545071e-131 4.6208157474999997e-129 4.043939 443 0.09147223 199 0.0021752303104522613 1.805271 43 122 0.01172941 GO Biological Process chondrocyte differentiation 48 3.030258e-127 8.30732604625e-125 5.268501 329 0.0679331 324 0.014645597410802468 1.982683 24 62 0.006546645 GO Biological Process embryonic skeletal system development 50 5.730004e-124 1.5080224527199999e-121 4.135234 408 0.0842453 225 0.004401499519466666 1.763288 42 122 0.01145663 GO Biological Process regulation of cellular component size 56 9.133035e-118 2.1461001350892855e-115 3.166282 536 0.1106752 341 0.016632408735190615 1.395449 88 323 0.02400436 GO Biological Process cartilage development 57 1.38761e-114 3.203431577192983e-112 3.763926 420 0.08672311 390 0.024298522011025638 1.570726 46 150 0.01254774 GO Biological Process chordate embryonic development 62 3.633815e-111 7.712479287903226e-109 2.369505 795 0.1641544 93 0.000004586941580860215 1.485822 161 555 0.04391708 GO Biological Process regulation of organ morphogenesis 64 2.521888e-110 5.1852381550000004e-108 3.10916 516 0.1065455 178 0.0007942395372471909 1.58389 77 249 0.02100382 GO Biological Process embryo development ending in birth or egg hatching 65 5.790634e-110 1.1722915816307692e-107 2.356247 795 0.1641544 106 0.000007717122861132076 1.472555 161 560 0.04391708 GO Biological Process positive regulation of cell death 71 4.163149e-103 7.715898266338028e-101 2.356412 749 0.1546562 306 0.01240523441862745 1.282474 161 643 0.04391708 GO Biological Process positive regulation of apoptotic process 75 2.21385e-100 3.8842736200000005e-98 2.40377 705 0.1455709 359 0.018111420806406684 1.282649 148 591 0.04037098 GO Biological Process positive regulation of programmed cell death 77 6.541454e-99 1.1179090024155843e-96 2.383364 706 0.1457774 365 0.019958482427945207 1.278338 149 597 0.04064375 GO Biological Process connective tissue development 81 4.774636e-96 7.756720385679013e-94 3.130004 447 0.09229816 346 0.016952500099710985 1.515674 58 196 0.01582106 GO Biological Process bone development 86 3.482646e-93 5.328853338837209e-91 3.350769 396 0.0817675 212 0.002918954208301887 1.66617 54 166 0.01472995 GO Biological Process kidney development 97 1.494711e-82 2.0277218607216496e-80 2.559909 525 0.1084039 110 0.000009289034998090907 1.720807 85 253 0.02318603 GO Molecular Function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding 30 8.719466e-26 1.2271195150666667e-23 2.199199 219 0.04521991 20 0.00019352157634 1.925538 50 133 0.01363884 GO Molecular Function SUMO transferase activity 188 0.0001467706 0.0032960929425531913 2.873805 17 0.003510221 34 0.004754764245882353 3.234904 12 19 0.003273322 Mouse Phenotype Single KO fused joints 24 1.934566e-121 7.381175359166667e-119 4.509685 365 0.07536651 288 0.04481063796875 1.558849 42 138 0.01145663 Mouse Phenotype Single KO small liver 29 3.155692e-103 9.964369532413793e-101 3.629327 396 0.0817675 135 0.0065292360588888885 1.597161 58 186 0.01582106 Mouse Phenotype Single KO abnormal sternum morphology 31 3.008182e-98 8.885781475483871e-96 3.285406 428 0.08837497 51 0.00020615243874509803 1.809545 59 167 0.01609384 Mouse Phenotype Single KO abnormal pectoral girdle bone morphology 32 3.414592e-98 9.771068420000001e-96 3.02544 479 0.09890564 38 0.00010416309195789475 1.757525 70 204 0.01909438 Mouse Phenotype Single KO decreased embryo size 39 3.405433e-90 7.995782046410256e-88 2.350599 664 0.1371051 128 0.0056912328859375005 1.354308 133 503 0.03627932 Mouse Phenotype Single KO embryonic lethality during organogenesis 44 3.365944e-86 7.004988456363637e-84 2.026251 857 0.1769564 48 0.00020884503439583333 1.361265 198 745 0.05400982 Mouse Phenotype Single KO abnormal embryo size 46 4.978444e-85 9.910350371304348e-83 2.198594 714 0.1474293 88 0.0013600850477272727 1.355805 162 612 0.04418985 Mouse Phenotype Single KO abnormal respiratory system development 49 8.246869e-80 1.5411546823061224e-77 3.372577 337 0.06958497 197 0.01724171994822335 1.63308 44 138 0.01200218 Mouse Phenotype Single KO abnormal joint morphology 52 4.046081e-78 7.124993022500001e-76 2.656167 468 0.09663432 15 0.000003174852161933333 1.7503 95 278 0.0259138 Mouse Phenotype Single KO abnormal thoracic cage morphology 55 1.007371e-77 1.677181135818182e-75 2.341206 581 0.119967 37 0.00010460377681621623 1.507858 126 428 0.03436989 Mouse Phenotype Single KO abnormal liver size 59 4.82001e-74 7.480818910169491e-72 2.542915 478 0.09869915 127 0.005346101748031497 1.426722 100 359 0.02727769 Mouse Phenotype Single KO respiratory distress 69 1.569862e-66 2.083366135362319e-64 2.718801 385 0.07949618 191 0.016753599257591623 1.547836 55 182 0.01500273 Mouse Phenotype Single KO abnormal breathing pattern 98 3.766489e-46 3.5193612013265306e-44 2.179079 404 0.08341937 305 0.04559015104918033 1.404401 68 248 0.01854883 Mouse Phenotype Single KO abnormal intestinal enteroendocrine cell morphology 110 1.857385e-41 1.5461885859090908e-39 10.39483 63 0.01300847 290 0.04491154850344827 4.268276 5 6 0.001363884 Mouse Phenotype Single KO abnormal spleen secondary B follicle morphology 166 5.099189e-30 2.812847811626506e-28 3.245986 131 0.02704935 224 0.027816885235267853 1.70731 34 102 0.009274414 Mouse Phenotype Single KO decreased erythroid progenitor cell number 229 1.056454e-21 4.2244319991266373e-20 3.08134 100 0.02064836 251 0.03274331603984064 2.0086 20 51 0.005455537 Mouse Phenotype Single KO abnormal vibrissa morphology 241 1.282539e-20 4.873116026141079e-19 2.403433 144 0.02973364 49 0.00020843817471428574 2.102688 39 95 0.0106383 Mouse Phenotype Single KO kinked tail 245 2.88033e-20 1.0765380330612244e-18 2.2811 157 0.03241792 89 0.0017968081464044942 1.927063 38 101 0.01036552 Mouse Phenotype Single KO abnormal bone marrow cell number 277 1.191837e-17 3.939946357039711e-16 2.038975 174 0.03592814 120 0.0045414370425 1.719505 47 140 0.01282051 Mouse Phenotype Single KO decreased rib number 310 1.511644e-15 4.46520132516129e-14 2.335856 112 0.02312616 196 0.017145351890816327 1.759047 34 99 0.009274414 Mouse Phenotype caudal vertebral fusion 8 9.681723e-227 1.1570869200374999e-223 16.56295 273 0.05637002 188 0.0030171632443085107 3.314191 11 17 0.003000546 Mouse Phenotype kinked tail 22 4.100599e-169 1.782083047227273e-166 5.231496 438 0.09043981 128 0.000879400612265625 1.843895 45 125 0.01227496 Mouse Phenotype abnormal fibroblast physiology 33 4.47363e-147 1.296132619090909e-144 4.127176 483 0.09973157 507 0.049272208053254433 1.376646 68 253 0.01854883 Mouse Phenotype small liver 41 2.291842e-124 5.344463746829268e-122 3.635479 474 0.09787322 163 0.0020238736531288343 1.577738 69 224 0.0188216 Mouse Phenotype anophthalmia 42 4.430824e-120 1.0086454348571428e-117 4.623433 352 0.07268222 362 0.02296610833756906 1.635575 38 119 0.01036552 Mouse Phenotype abnormal neurocranium morphology 51 3.253953e-107 6.10020483e-105 2.76633 595 0.1228577 292 0.011165659957191782 1.437089 78 278 0.0212766 Mouse Phenotype abnormal lumbar vertebrae morphology 55 2.529705e-103 4.397547182727273e-101 3.751162 381 0.07867025 421 0.03139825586935867 1.463409 56 196 0.0152755 Mouse Phenotype vertebral fusion 59 5.810079e-97 9.415282257457628e-95 3.648359 370 0.07639893 459 0.03696753359477124 1.510313 46 156 0.01254774 Mouse Phenotype abnormal caudal vertebrae morphology 64 1.944268e-93 2.9045541168749997e-91 3.846473 335 0.069172 223 0.005433734959641255 1.68292 46 140 0.01254774 Mouse Phenotype fused joints 65 2.233741e-92 3.2856611847692306e-90 3.408742 384 0.0792897 265 0.00949660215509434 1.58536 52 168 0.0141844 Mouse Phenotype decreased embryo size 66 3.453396e-92 5.002715023636364e-90 2.206763 764 0.1577535 143 0.0014873619795104896 1.342242 163 622 0.04446263 Mouse Phenotype abnormal sphenoid bone morphology 69 4.395035e-91 6.089989802173913e-89 3.64707 348 0.07185629 192 0.00331112319265625 1.86252 36 99 0.009819967 Mouse Phenotype abnormal liver size 73 1.819443e-88 2.3829718524657535e-86 2.43667 611 0.1261615 182 0.00278524695510989 1.374439 128 477 0.03491544 Mouse Phenotype abnormal embryo size 74 2.958787e-88 3.822832771216216e-86 2.096761 814 0.1680776 94 0.00033656459288297874 1.347138 192 730 0.05237316 Mouse Phenotype abnormal tail morphology 77 1.489036e-87 1.848918596883117e-85 2.346022 648 0.1338014 156 0.0017286281871153847 1.404215 122 445 0.03327878 Mouse Phenotype abnormal mandible morphology 78 3.750906e-87 4.5977451623076926e-85 2.790866 481 0.0993186 194 0.0033258283484536087 1.575979 64 208 0.01745772 Mouse Phenotype abnormal joint morphology 80 5.520785e-84 6.598028173125e-82 2.469265 568 0.1172827 16 1.0977569711250001e-7 1.737263 116 342 0.03164212 Mouse Phenotype limb grasping 81 1.682547e-82 1.9860286255555553e-80 2.806926 452 0.09333058 99 0.0003857217408181818 1.617452 78 247 0.0212766 Mouse Phenotype lethality, incomplete penetrance 83 5.369746e-80 6.185559217590362e-78 2.632549 486 0.100351 161 0.001871413130310559 1.50645 85 289 0.02318603 Mouse Phenotype abnormal sternum morphology 84 1.431309e-79 1.6291363510714285e-77 2.744456 452 0.09333058 63 0.00005227463091428572 1.730382 75 222 0.02045827