# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process hemostasis 19 1.981156e-27 1.3721069370526315e-24 2.308267 209 0.05993691 169 0.004286126899467456 1.475863 88 311 0.02444444 GO Biological Process blood coagulation 25 2.425569e-26 1.27672249884e-23 2.282598 205 0.05878979 215 0.008931558021395348 1.448843 85 306 0.02361111 GO Biological Process coagulation 26 2.740438e-26 1.3869778323846154e-23 2.280256 205 0.05878979 229 0.010635414099563319 1.439435 85 308 0.02361111 GO Biological Process platelet activation 97 4.157584e-15 5.640169882061856e-13 2.324649 109 0.03125896 160 0.0037428086129375005 1.738611 47 141 0.01305556 GO Biological Process phagocytosis 124 1.205173e-12 1.2789412505645162e-10 2.064406 116 0.03326642 377 0.046372001859416444 1.490238 52 182 0.01444444 GO Biological Process head morphogenesis 268 5.92047e-8 0.0000029069949526119404 2.593711 42 0.01204474 341 0.03709851267947214 2.19614 16 38 0.004444444 GO Biological Process positive regulation of sprouting angiogenesis 301 1.747512e-7 0.00000763970445448505 3.27658 27 0.007743046 238 0.011465215540336134 3.019693 11 19 0.003055556 GO Biological Process granulocyte differentiation 303 1.834919e-7 0.000007968877597689768 4.587429 18 0.00516203 145 0.0019276119965517243 3.585885 11 16 0.003055556 GO Biological Process negative regulation of intrinsic apoptotic signaling pathway 426 0.000002576145 0.00007957627242957747 2.105342 48 0.01376541 351 0.03847399177777778 1.720115 31 94 0.008611111 GO Biological Process regulation of sprouting angiogenesis 447 0.000003784237 0.00011140218049888143 2.276094 39 0.0111844 319 0.027875613092163014 2.255495 16 37 0.004444444 GO Biological Process body morphogenesis 466 0.000005568568 0.00015724632255793993 2.099256 45 0.01290508 376 0.0463184550930851 2.040978 18 46 0.005 GO Biological Process regulation of endothelial cell chemotaxis 629 0.0000395972 0.0008283935688394277 2.37643 28 0.008029825 362 0.040527429897790054 2.745175 10 19 0.002777778 GO Biological Process microspike assembly 651 0.00004816785 0.0009736416868663594 6.41182 8 0.002294236 379 0.04684933843007916 5.215833 4 4 0.001111111 GO Biological Process cellular response to epinephrine stimulus 744 0.0001124481 0.0019888501987903227 2.741249 19 0.00544881 335 0.03629405394328358 3.209744 8 13 0.002222222 GO Biological Process corpus callosum development 799 0.000171363 0.0028222349399249064 2.946489 16 0.004588471 299 0.02477260087859532 3.1295 9 15 0.0025 GO Biological Process regulation of interleukin-4 production 891 0.0003535964 0.005222194194837262 2.221206 24 0.006882707 186 0.005827048570752688 2.808526 14 26 0.003888889 GO Biological Process mitral valve morphogenesis 1230 0.001769492 0.018930687177235773 2.637775 13 0.003728133 312 0.027728699629166666 3.651083 7 10 0.001944444 GO Biological Process megakaryocyte differentiation 1381 0.00324742 0.030943374207096308 2.098864 18 0.00516203 317 0.02747871512429022 2.732103 11 21 0.003055556 GO Biological Process embryonic viscerocranium morphogenesis 1475 0.004549332 0.04058621002576271 2.355045 13 0.003728133 312 0.027728699629166666 3.651083 7 10 0.001944444 GO Molecular Function 1-acylglycerol-3-phosphate O-acyltransferase activity 45 1.984753e-7 0.000018621393702222225 3.444869 25 0.007169487 38 0.023039387336842104 3.019693 11 19 0.003055556 GO Molecular Function lysophosphatidic acid acyltransferase activity 48 2.323575e-7 0.0000204377784375 3.415037 25 0.007169487 49 0.032832796583673475 2.868708 11 20 0.003055556 GO Molecular Function protein serine/threonine kinase inhibitor activity 148 0.0001050642 0.002997169272972973 2.279608 27 0.007743046 53 0.04141994693207548 2.370833 15 33 0.004166667 Mouse Phenotype Single KO decreased spleen red pulp amount 41 1.399798e-17 3.1263293380487803e-15 8.02564 30 0.008603384 153 0.03368850125555556 3.1295 9 15 0.0025 Mouse Phenotype Single KO abnormal embryonic erythropoiesis 63 4.373127e-15 6.356305387142857e-13 4.291684 44 0.0126183 143 0.023706691773426575 2.517989 14 29 0.003888889 Mouse Phenotype Single KO abnormal circulating cytokine level 68 1.718779e-14 2.3145381327941175e-12 2.105159 129 0.03699455 67 0.0029594959316417914 1.552805 78 262 0.02166667 Mouse Phenotype Single KO abnormal embryonic erythrocyte morphology 69 2.132964e-14 2.830659615652174e-12 3.941231 46 0.01319186 138 0.020857608899275366 2.384381 16 35 0.004444444 Mouse Phenotype Single KO abnormal circulating interleukin-6 level 72 3.627861e-14 4.613933774583334e-12 2.677972 78 0.0223688 113 0.012497036008849558 1.769658 38 112 0.01055556 Mouse Phenotype Single KO abnormal mean corpuscular hemoglobin 78 1.518407e-13 1.7825708844871798e-11 2.185161 110 0.03154574 183 0.0455004224568306 1.520043 51 175 0.01416667 Mouse Phenotype Single KO abnormal circulating interleukin level 80 2.787089e-13 3.190171746625e-11 2.200163 106 0.03039862 116 0.012957999654310345 1.552028 61 205 0.01694444 Mouse Phenotype Single KO increased circulating interleukin-1 beta level 83 5.528932e-13 6.09981088240964e-11 5.968361 27 0.007743046 162 0.0368273230191358 2.607917 12 24 0.003333333 Mouse Phenotype Single KO abnormal erythroid progenitor cell morphology 92 1.73566e-12 1.7275476760869566e-10 2.312507 89 0.02552337 172 0.04256685753139535 1.77952 29 85 0.008055556 Mouse Phenotype Single KO abnormal embryonic hematopoiesis 99 4.212857e-12 3.896679954444444e-10 2.709038 64 0.01835389 109 0.012408045833944954 2.165063 22 53 0.006111111 Mouse Phenotype Single KO abnormal myelopoiesis 111 2.437674e-11 2.010971244864865e-9 2.230274 86 0.02466303 126 0.01656115397857143 1.754417 37 110 0.01027778 Mouse Phenotype Single KO decreased interleukin-2 secretion 143 1.244291e-9 7.967813067832168e-8 2.564414 54 0.01548609 60 0.0018050873604999998 2.328497 25 56 0.006944444 Mouse Phenotype Single KO arrested B cell differentiation 151 2.035648e-9 1.234465479205298e-7 2.608584 51 0.01462575 111 0.012703481351351352 2.304671 19 43 0.005277778 Mouse Phenotype Single KO decreased IgM level 158 4.967281e-9 2.878822285886076e-7 2.212231 67 0.01921422 197 0.04857351567005076 1.687475 33 102 0.009166667 Mouse Phenotype Single KO abnormal interleukin-2 secretion 180 1.228738e-8 6.250863258888889e-7 2.057481 75 0.02150846 149 0.03023736042818792 1.722209 35 106 0.009722222 Mouse Phenotype Single KO abnormal bone marrow morphology 217 1.003465e-7 0.000004234437329493087 2.650483 39 0.0111844 111 0.012703481351351352 2.304671 19 43 0.005277778 Mouse Phenotype Single KO increased fatty acid level 220 1.304581e-7 0.000005430021916818182 2.022596 67 0.01921422 84 0.005537944297142858 1.852352 38 107 0.01055556 Mouse Phenotype Single KO increased NK cell number 253 6.223368e-7 0.00002252465643320158 2.530032 37 0.01061084 139 0.021124685153956834 2.033291 23 59 0.006388889 Mouse Phenotype Single KO lordosis 281 0.000001899133 0.00006188740527046263 2.75918 29 0.008316605 176 0.04479097643295454 2.355538 14 31 0.003888889 Mouse Phenotype Single KO decreased circulating total protein level 372 0.00001814609 0.0004466767369086022 2.19679 36 0.01032406 165 0.03708658256 1.97842 22 58 0.006111111 Mouse Phenotype abnormal platelet physiology 5 2.737783e-42 5.235188652600001e-39 3.815139 151 0.0433037 317 0.041852086145110406 1.580556 40 132 0.01111111 Mouse Phenotype decreased platelet aggregation 28 9.390311e-26 3.20645583825e-23 4.275704 79 0.02265558 310 0.04141822115806451 1.811053 25 72 0.006944444 Mouse Phenotype abnormal hemostasis 30 1.126798e-24 3.591105226e-22 2.174974 212 0.06079725 296 0.03559272823986486 1.389686 77 289 0.02138889 Mouse Phenotype abnormal blood coagulation 36 4.090983e-24 1.0864969017499999e-21 2.16066 210 0.06022369 320 0.04239162155625 1.381196 76 287 0.02111111 Mouse Phenotype abnormal immature B cell number 46 7.130933e-20 1.4821489220217392e-17 2.323479 147 0.04215658 140 0.007985422322142858 1.626113 53 170 0.01472222 Mouse Phenotype abnormal immature B cell morphology 47 8.247818e-20 1.677816763787234e-17 2.311773 148 0.04244336 174 0.012164861422413794 1.582331 54 178 0.015 Mouse Phenotype abnormal pre-B cell morphology 55 1.200145e-17 2.086288426363636e-15 2.373263 124 0.03556065 211 0.01905126219383886 1.647105 42 133 0.01166667 Mouse Phenotype abnormal embryonic erythrocyte morphology 58 1.99433e-17 3.28754985e-15 4.055034 55 0.01577287 138 0.00797880692173913 2.407308 18 39 0.005 Mouse Phenotype decreased pre-B cell number 59 2.055329e-17 3.3306780625423724e-15 2.533835 108 0.03097218 197 0.015932911463451778 1.755329 35 104 0.009722222 Mouse Phenotype abnormal embryonic erythropoiesis 73 3.077678e-16 4.0309149805479455e-14 4.192368 49 0.01405219 176 0.012061880548295455 2.52379 15 31 0.004166667 Mouse Phenotype abnormal wound healing 81 1.272072e-15 1.5015160977777778e-13 2.012518 156 0.0447376 332 0.04492575668674699 1.433179 61 222 0.01694444 Mouse Phenotype abnormal mean corpuscular hemoglobin 94 5.291914e-14 5.382552101489361e-12 2.152864 118 0.03383998 232 0.022464117609051724 1.530734 54 184 0.015 Mouse Phenotype extramedullary hematopoiesis 100 1.267034e-13 1.2114112074e-11 2.14821 115 0.03297964 31 0.00003677913143225807 1.8777 63 175 0.0175 Mouse Phenotype thrombocytopenia 105 2.197865e-13 2.0013130728571427e-11 2.009629 132 0.03785489 141 0.008065103570212765 1.56223 62 207 0.01722222 Mouse Phenotype abnormal circulating tumor necrosis factor level 110 4.006417e-13 3.4823048124545455e-11 2.465922 83 0.0238027 220 0.021088193574545454 1.60762 45 146 0.0125 Mouse Phenotype decreased erythroid progenitor cell number 113 4.547878e-13 3.847987748495575e-11 2.525884 79 0.02265558 319 0.04171859927586207 1.784364 26 76 0.007222222 Mouse Phenotype abnormal erythroid progenitor cell morphology 122 1.596987e-12 1.251540385819672e-10 2.172556 102 0.02925151 239 0.024273086760251045 1.66556 38 119 0.01055556 Mouse Phenotype abnormal circulating interleukin-6 level 126 2.008287e-12 1.5239073021428574e-10 2.257789 93 0.02667049 199 0.016512120857788946 1.621137 46 148 0.01277778 Mouse Phenotype abnormal embryonic hematopoiesis 130 3.506633e-12 2.578993701e-10 2.583964 70 0.02007456 172 0.011286588179651162 2.052131 24 61 0.006666667 Mouse Phenotype abnormal myelopoiesis 139 1.770347e-11 1.2177185371942446e-9 2.03953 107 0.0306854 152 0.008918104521710525 1.640199 50 159 0.01388889