# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process heterotypic cell-cell adhesion 484 6.03857e-15 1.641767409710744e-13 2.119713 134 0.005901784 393 0.0006855309961323155 1.634752 27 29 0.00252478 GO Biological Process regulation of interleukin-4 production 495 8.809389e-15 2.3418737343636367e-13 2.046777 144 0.006342215 870 0.04108431891149426 1.485714 22 26 0.002057228 Mouse Phenotype Single KO abnormal CD4-positive, alpha-beta T cell physiology 58 4.862664e-51 7.677140387586206e-49 2.007891 567 0.02497247 505 0.004318002389306931 1.249124 106 149 0.0099121 Mouse Phenotype Single KO abnormal T-helper 2 physiology 94 1.807137e-38 1.7604205860638298e-36 2.393259 286 0.01259634 1007 0.046140058810327705 1.301747 43 58 0.004020946 Mouse Phenotype Single KO abnormal circulating tumor necrosis factor level 122 3.610148e-31 2.709682396393443e-29 2.067479 316 0.01391764 626 0.011241096630511184 1.270897 76 105 0.007106789 Mouse Phenotype Single KO increased respiratory quotient 134 1.284327e-28 8.776553984328359e-27 2.443943 201 0.008852676 624 0.01105564525128205 1.397509 39 49 0.003646905 Mouse Phenotype Single KO increased circulating tumor necrosis factor level 142 1.795489e-27 1.157837519225352e-25 2.312449 215 0.00946928 752 0.019169229704787235 1.331043 47 62 0.004394988 Mouse Phenotype Single KO abnormal cytotoxic T cell physiology 176 8.239161e-25 4.2867043907386357e-23 2.043958 255 0.01123101 689 0.015141823820029028 1.323245 52 69 0.00486254 Mouse Phenotype Single KO decreased cytotoxic T cell cytolysis 181 1.953581e-24 9.883392937569061e-23 2.593064 152 0.006694561 1025 0.04736409561560975 1.394347 27 34 0.00252478 Mouse Phenotype Single KO increased circulating interleukin-1 beta level 289 2.090336e-17 6.623254931487889e-16 2.919579 86 0.003787712 727 0.017849612884456672 1.536364 21 24 0.001963718 Mouse Phenotype Single KO abnormal erythrocyte osmotic lysis 292 2.475022e-17 7.761567278767123e-16 2.534229 109 0.004800705 899 0.03199213378865406 1.453113 24 29 0.002244249 Mouse Phenotype Single KO decreased circulating interleukin-6 level 293 2.678685e-17 8.371576295221844e-16 2.234596 140 0.006166043 808 0.02301694680321782 1.388342 34 43 0.003179353 Mouse Phenotype Single KO abnormal circulating interleukin-1 beta level 301 4.574695e-17 1.391710369269103e-15 2.399085 119 0.005241136 957 0.03827880520585162 1.370415 32 41 0.002992332 Mouse Phenotype Single KO microcytic anemia 338 6.472697e-16 1.7535646872485208e-14 2.55011 98 0.00431623 599 0.009506876893155259 1.596222 20 22 0.001870208 Mouse Phenotype Single KO increased body temperature 343 1.323584e-15 3.533544806997084e-14 2.157533 135 0.005945827 845 0.02585816512781065 1.4366 27 33 0.00252478 Mouse Phenotype Single KO hemolysis 348 2.238774e-15 5.890934918965517e-14 2.344111 111 0.004888791 1003 0.04586756820338984 1.416004 25 31 0.002337759 Mouse Phenotype Single KO increased hemangiosarcoma incidence 470 8.973274e-12 1.7482610642127662e-10 2.176781 96 0.004228144 727 0.017849612884456672 1.536364 21 24 0.001963718 Mouse Phenotype Single KO abnormal parathyroid gland morphology 472 9.483537e-12 1.8398463624788135e-10 2.286822 86 0.003787712 858 0.027201882386946385 1.571019 17 19 0.001589676 Mouse Phenotype Single KO hypochromic anemia 488 2.724388e-11 5.112135433606556e-10 2.406491 74 0.003259194 858 0.027201882386946385 1.571019 17 19 0.001589676 Mouse Phenotype Single KO increased erythroblast number 517 7.478854e-11 1.3246395759767894e-9 2.030511 103 0.004536446 960 0.038540067446875 1.560751 16 18 0.001496166 Mouse Phenotype Single KO thick aortic valve cusps 699 1.240685e-8 1.625315099427754e-7 2.066494 75 0.003303237 920 0.03567123284565217 1.755844 10 10 0.0009351038 Mouse Phenotype Single KO intestinal ulcer 794 1.127976e-7 0.0000013008660241813602 2.183809 57 0.00251046 1014 0.04696972977021696 1.505009 18 21 0.001683187 Mouse Phenotype increased circulating tumor necrosis factor level 105 2.384658e-40 2.1714014417142855e-38 2.282955 331 0.01457829 687 0.003223824462882096 1.307925 73 98 0.006826258 Mouse Phenotype abnormal circulating tumor necrosis factor level 109 6.777516e-40 5.944938575779817e-38 2.007633 440 0.01937899 699 0.0034305784433476395 1.250738 104 146 0.009725079 Mouse Phenotype abnormal T-helper 2 physiology 140 7.077828e-34 4.8336509648571433e-32 2.154625 313 0.01378551 1206 0.027444303477611943 1.291062 50 68 0.004675519 Mouse Phenotype abnormal spleen physiology 171 1.569062e-29 8.772983498245615e-28 2.000475 324 0.01426998 971 0.012579016791967044 1.286258 63 86 0.005891154 Mouse Phenotype increased respiratory quotient 172 1.677123e-29 9.322658722674418e-28 2.341692 226 0.009953755 666 0.0028165313481981983 1.410946 45 56 0.004207967 Mouse Phenotype abnormal circulating interleukin-1 beta level 181 3.186527e-28 1.6832256711049723e-26 2.450701 197 0.008676503 826 0.006779775707869249 1.379592 44 56 0.004114457 Mouse Phenotype abnormal splenocyte physiology 184 4.368004e-28 2.2697003393478265e-26 2.014034 302 0.01330104 926 0.010744189237580993 1.300625 60 81 0.005610623 Mouse Phenotype decreased cytotoxic T cell cytolysis 189 1.892698e-27 9.574648453968255e-26 2.354557 207 0.009116935 800 0.0058835525700000006 1.419619 38 47 0.003553394 Mouse Phenotype increased circulating interleukin-1 beta level 201 1.204093e-26 5.727528941791045e-25 2.663937 159 0.007002863 660 0.002616319845 1.511977 31 36 0.002898822 Mouse Phenotype abnormal circulating interleukin-1 level 215 1.036473e-25 4.609171326976744e-24 2.281749 206 0.009072891 1158 0.023011584883419686 1.309916 47 63 0.004394988 Mouse Phenotype increased body temperature 276 5.276745e-21 1.8279332951086956e-19 2.266548 168 0.007399251 937 0.011304816198505869 1.454843 29 35 0.002711801 Mouse Phenotype decreased circulating interleukin-6 level 282 1.20933e-20 4.1001433085106384e-19 2.146568 186 0.008192028 1327 0.03655836760060286 1.301747 43 58 0.004020946 Mouse Phenotype lymph node hypoplasia 295 3.078323e-20 9.976897017966102e-19 2.067236 199 0.008764589 1006 0.01425248575944334 1.38226 37 47 0.003459884 Mouse Phenotype decreased B cell apoptosis 347 6.181936e-18 1.7033282448414988e-16 2.396414 126 0.005549438 423 0.00016454379287234044 1.755844 21 21 0.001963718 Mouse Phenotype abnormal circulating interleukin-10 level 355 1.655092e-17 4.457559045633802e-16 2.337514 129 0.005681568 937 0.011304816198505869 1.454843 29 35 0.002711801 Mouse Phenotype microcytic anemia 375 1.352598e-16 3.4485838608e-15 2.44678 111 0.004888791 871 0.008485096608495982 1.513659 25 29 0.002337759 Mouse Phenotype abnormal thrombopoiesis 672 4.717563e-10 6.711997000446428e-9 2.173815 80 0.003523453 1419 0.04291751652008457 1.549274 15 17 0.001402656 Mouse Phenotype abnormal meiotic spindle morphology 857 3.833026e-8 4.276261561960327e-7 2.45855 48 0.002114072 1082 0.01802883838170055 1.755844 11 11 0.001028614 Mouse Phenotype reticulocytopenia 859 3.9848e-8 4.435235483119907e-7 2.17124 62 0.002730676 848 0.0074546057172169816 1.755844 13 13 0.001215635