# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	ncRNA processing	13	1.388922e-46	1.4059095844615386e-43	2.024255	499	0.04313997	80	2.1735213762500002e-17	1.491335	268	396	0.03145171	
GO Biological Process	regulation of gene expression, epigenetic	18	8.923652e-41	6.523685370444444e-38	2.144862	380	0.03285208	174	5.0786721866666675e-9	1.448343	163	248	0.01912921	
GO Biological Process	multi-organism metabolic process	21	1.139141e-36	7.138074485238095e-34	2.577879	235	0.02031642	181	9.080502448066298e-9	1.57401	105	147	0.0123225	
GO Biological Process	rRNA processing	22	5.770937e-36	3.451807271954546e-33	2.170436	325	0.02809717	138	3.4901606164492755e-11	1.49531	171	252	0.02006807	
GO Biological Process	rRNA metabolic process	23	1.520601e-35	8.699821112608694e-33	2.141291	331	0.02861589	137	3.372595990364963e-11	1.488929	175	259	0.0205375	
GO Biological Process	viral gene expression	29	6.463008e-34	2.9326455955862065e-31	2.763966	192	0.01659895	203	3.3478304552216745e-8	1.596319	92	127	0.01079685	
GO Biological Process	viral transcription	36	4.941323e-32	1.8061908154722224e-29	2.780845	179	0.01547506	178	6.981999064325843e-9	1.657586	85	113	0.009975355	
GO Biological Process	negative regulation of gene expression, epigenetic	42	3.937799e-31	1.233749929547619e-28	2.777928	174	0.01504279	556	0.009632485035791366	1.353097	70	114	0.008214998	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	44	6.452728e-31	1.9298056307272724e-28	2.765747	174	0.01504279	279	0.000004522181849856631	1.531325	82	118	0.009623284	
GO Biological Process	mRNA catabolic process	45	6.385624e-30	1.8672983603555553e-27	2.091721	292	0.02524423	146	1.9397258288356164e-10	1.520804	147	213	0.0172515	
GO Biological Process	nuclear-transcribed mRNA catabolic process	56	7.475322e-27	1.756567182107143e-24	2.083428	263	0.0227371	150	2.8113466596e-10	1.535853	138	198	0.01619528	
GO Biological Process	cotranslational protein targeting to membrane	60	1.395282e-26	3.0600859729999997e-24	2.79144	146	0.01262211	228	2.406956553333333e-7	1.641468	73	98	0.00856707	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	61	2.522408e-26	5.441371618360656e-24	2.391305	191	0.01651249	314	0.00003423099701942675	1.501578	77	113	0.009036498	
GO Biological Process	regulation of hematopoietic progenitor cell differentiation	63	1.120944e-25	2.341349539047619e-23	2.563865	163	0.01409181	299	0.000013394229227759198	1.521079	78	113	0.009153855	
GO Biological Process	gene silencing	66	3.780724e-25	7.537961684242425e-23	2.095443	242	0.02092159	304	0.000017232879226973684	1.407865	115	180	0.01349607	
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	70	1.14734e-24	2.1568352942857144e-22	2.776394	136	0.01175759	257	0.0000012371856269260702	1.628759	68	92	0.007980284	
GO Biological Process	protein targeting to ER	71	1.817731e-24	3.3689467928169014e-22	2.649486	146	0.01262211	226	1.894405157654867e-7	1.636347	75	101	0.008801784	
GO Biological Process	ribonucleoprotein complex export from nucleus	72	2.262659e-24	4.135323580694445e-22	2.397655	175	0.01512925	180	9.119793776111112e-9	1.62186	92	125	0.01079685	
GO Biological Process	positive regulation of gene expression, epigenetic	73	4.41394e-24	7.9565803369863e-22	2.878228	125	0.0108066	340	0.00009343873054705881	1.570075	57	80	0.006689356	
GO Biological Process	regulation of DNA-templated transcription in response to stress	76	1.2024e-23	2.081892315789474e-21	2.213625	200	0.01729057	322	0.00004815135558695652	1.481422	80	119	0.009388569	
GO Cellular Component	ribosomal subunit	24	1.419496e-34	1.02203712e-32	2.433638	246	0.0212674	52	5.114896615384615e-10	1.536575	129	185	0.01513907	
GO Cellular Component	ribosome	29	6.863807e-29	4.08988224e-27	2.051072	295	0.02550359	49	2.1074166073469387e-10	1.484639	159	236	0.01865978	
GO Cellular Component	large ribosomal subunit	38	2.506471e-23	1.1397847073684211e-21	2.50946	153	0.01322728	62	0.0000012412140387096776	1.552111	81	115	0.009505927	
GO Cellular Component	ficolin-1-rich granule lumen	39	6.506152e-23	2.882725809230769e-21	2.253644	186	0.01608023	70	0.000009598526537142856	1.492771	84	124	0.009857998	
GO Cellular Component	Golgi-associated vesicle membrane	43	9.464236e-19	3.8033022809302324e-17	2.698722	106	0.009164001	175	0.02583543661714286	1.454386	33	50	0.003872785	
GO Cellular Component	mitochondrial ribosome	47	1.148534e-17	4.2226952170212773e-16	2.70323	99	0.008558831	90	0.00012001209600000001	1.529568	59	85	0.00692407	
GO Cellular Component	nuclear chromosome, telomeric region	48	1.237151e-17	4.453743600000001e-16	2.128013	159	0.013746	80	0.0000321966792	1.452382	87	132	0.01021007	
GO Cellular Component	Golgi-associated vesicle	54	1.478246e-15	4.7303872e-14	2.130587	138	0.01193049	173	0.023094200601156068	1.354028	51	83	0.005985213	
GO Cellular Component	DNA packaging complex	55	2.07857e-15	6.530489018181819e-14	2.303715	115	0.009942077	190	0.04270848404210526	1.278883	65	112	0.007628213	
GO Cellular Component	cytosolic ribosome	56	2.803171e-15	8.6497848e-14	2.003716	157	0.0135731	72	0.0000112226688	1.514985	77	112	0.009036498	
GO Cellular Component	small ribosomal subunit	58	4.89841e-15	1.4593883586206896e-13	2.436323	100	0.008645284	110	0.0004845304145454546	1.530288	50	72	0.005867856	
GO Cellular Component	host cell	67	3.746604e-13	9.662883152238805e-12	2.201893	106	0.009164001	192	0.042750693	1.361056	42	68	0.004928999	
GO Cellular Component	mitochondrial intermembrane space	68	3.803751e-13	9.666002541176471e-12	2.250609	101	0.008731737	67	0.00000466889351641791	1.638585	58	78	0.006806713	
GO Cellular Component	vesicle coat	71	1.286973e-12	3.1322385126760564e-11	2.174026	104	0.008991095	105	0.000367771392	1.641909	38	51	0.00445957	
GO Cellular Component	mitochondrial large ribosomal subunit	72	1.396379e-12	3.3513096e-11	2.848268	62	0.005360076	105	0.000367771392	1.641909	38	51	0.00445957	
GO Cellular Component	peptidase complex	76	2.079568e-12	4.728280926315789e-11	2.051197	117	0.01011498	58	1.1432903834482757e-7	1.677752	67	88	0.007862927	
GO Cellular Component	COPI-coated vesicle	77	3.324575e-12	7.460864415584416e-11	3.253639	49	0.004236189	115	0.0006647048013913043	1.916187	20	23	0.002347142	
GO Cellular Component	endopeptidase complex	80	5.945216e-12	1.284166656e-10	2.223103	93	0.008040114	69	0.000009483173843478262	1.660695	52	69	0.00610257	
GO Cellular Component	cytosolic large ribosomal subunit	82	1.434479e-11	3.022902087804878e-10	2.253127	87	0.007521397	149	0.005454805433557047	1.481118	41	61	0.004811642	
GO Cellular Component	proteasome complex	88	2.898641e-11	5.691876872727273e-10	2.176523	91	0.007867208	75	0.000014618025216000001	1.652711	51	68	0.005985213	
GO Molecular Function	structural constituent of ribosome	14	5.244248e-30	1.5815153611428571e-27	2.38254	221	0.01910608	18	2.4399500933333334e-9	1.577897	116	162	0.01361343	
GO Molecular Function	rRNA binding	15	5.469551e-27	1.5394962881333334e-24	3.969534	91	0.007867208	39	1.5137353112820514e-7	1.836345	50	60	0.005867856	
GO Molecular Function	unfolded protein binding	17	4.448801e-22	1.1048728130588238e-19	2.530263	142	0.0122763	74	0.0007911600094594594	1.455217	70	106	0.008214998	
GO Molecular Function	nucleosome binding	20	4.992679e-20	1.0539545368999999e-17	2.5067	130	0.01123887	129	0.030688546313178296	1.435688	43	66	0.005046356	
GO Molecular Function	ribonucleoprotein complex binding	26	3.366304e-16	5.466359803076923e-14	2.073159	154	0.01331374	55	0.000026916002283636365	1.513787	79	115	0.009271212	
GO Molecular Function	protein transmembrane transporter activity	44	1.873278e-11	1.7974953899999998e-9	3.281352	45	0.003890378	131	0.035622593221374045	1.836345	15	18	0.001760357	
GO Molecular Function	peptidyl-prolyl cis-trans isomerase activity	62	3.336287e-8	0.0000022719038248387093	2.002951	76	0.006570416	99	0.007368716305050506	1.626477	31	42	0.003638071	
GO Molecular Function	aminoacyl-tRNA ligase activity	70	8.31424e-8	0.0000050146744685714285	2.09489	64	0.005532982	68	0.0005759905099117647	1.713922	35	45	0.004107499	
GO Molecular Function	ubiquitin-like protein conjugating enzyme activity	75	2.2524e-7	0.0000126795104	2.088877	60	0.00518717	93	0.005087378346236559	1.762892	24	30	0.002816571	
GO Molecular Function	ubiquitin conjugating enzyme activity	78	3.499594e-7	0.00001894267418974359	2.074644	59	0.005100718	102	0.00826295484509804	1.747694	23	29	0.002699214	
GO Molecular Function	5'-3' RNA polymerase activity	112	0.000003533989	0.00013321876391071428	2.10354	47	0.004063283	94	0.005918426548936171	1.615984	33	45	0.003872785	
GO Molecular Function	phosphate transmembrane transporter activity	134	0.00001065635	0.00033575455	2.129957	41	0.003544566	81	0.0011879113022222221	1.928163	21	24	0.002464499	
GO Molecular Function	DNA-directed 5'-3' RNA polymerase activity	148	0.00001556637	0.00044406225770270266	2.034185	44	0.003803925	110	0.013442682958181816	1.588652	31	43	0.003638071	
GO Molecular Function	mismatched DNA binding	167	0.00003799501	0.0009605684564071857	2.888788	20	0.001729057	135	0.03672695908148148	2.01998	11	12	0.001290928	
GO Molecular Function	organophosphate ester transmembrane transporter activity	188	0.00005491509	0.0012332527126595744	2.191693	32	0.002766491	98	0.006967902636734694	1.958769	16	18	0.001877714	
GO Molecular Function	nucleotide transmembrane transporter activity	218	0.0001473956	0.002854606528440367	2.162955	29	0.002507132	120	0.021989358160000003	1.928163	14	16	0.001643	
Human Phenotype	Increased serum lactate	24	2.563325e-16	7.127111552083334e-14	2.195102	136	0.01175759	38	0.0017813678863157895	1.476422	67	100	0.007862927	
Human Phenotype	Abnormal CSF metabolite level	34	5.203832e-12	1.0213285569411763e-9	2.381545	81	0.00700268	83	0.016362823101204817	1.504054	43	63	0.005046356	
Human Phenotype	Exercise intolerance	37	2.240047e-11	4.0399550354054054e-9	2.256984	85	0.007348491	107	0.029524451514953268	1.44809	46	70	0.005398427	
Human Phenotype	Increased CSF lactate	43	1.645948e-10	2.5542816288372092e-8	2.337569	72	0.006224604	118	0.035891041529661015	1.481741	39	58	0.004576928	
Human Phenotype	Basal cell carcinoma	62	9.260157e-9	9.96661736467742e-7	2.673887	45	0.003890378	70	0.008138520446857141	1.903122	19	22	0.002229785	
Human Phenotype	Increased muscle lipid content	93	4.220764e-7	0.000030285116313978494	3.057104	28	0.00242068	116	0.033916132274137936	1.855675	16	19	0.001877714	
Mouse Phenotype Single KO	embryonic lethality between somite formation and embryo turning, complete penetrance	7	1.339778e-24	1.7526210208571427e-21	2.362634	182	0.01573442	112	0.019425651624107143	1.45915	49	74	0.005750499	
Mouse Phenotype Single KO	abnormal cellular replicative senescence	18	2.715458e-16	1.381413828111111e-13	2.464207	107	0.009250454	72	0.004190339857222222	1.579257	43	60	0.005046356	
Mouse Phenotype Single KO	increased integument system tumor incidence	21	2.042769e-15	8.907445587142857e-13	2.208125	126	0.01089306	117	0.020470770906837604	1.449746	50	76	0.005867856	
Mouse Phenotype Single KO	early cellular replicative senescence	25	2.034133e-14	7.4506223524e-12	2.454952	94	0.008126567	100	0.013600342679999999	1.567957	37	52	0.004342213	
Mouse Phenotype Single KO	increased skin tumor incidence	45	3.194467e-11	6.500385404222223e-9	2.348611	77	0.006656869	143	0.04297944888391608	1.552547	31	44	0.003638071	
Mouse Phenotype Single KO	increased cellular sensitivity to ultraviolet irradiation	66	3.69513e-9	5.12671294090909e-7	2.724043	46	0.003976831	33	0.000047522970851515144	2.111797	23	24	0.002699214	
Mouse Phenotype Single KO	increased hemangiosarcoma incidence	73	1.172819e-8	0.0000014711648743835618	2.403466	54	0.004668453	148	0.04777274958783784	1.744528	19	24	0.002229785	
Mouse Phenotype Single KO	absent inner cell mass proliferation	75	1.488339e-8	0.0000018171626963999998	2.115382	70	0.006051699	147	0.046975135912925174	1.582082	28	39	0.003285999	
Mouse Phenotype	early cellular replicative senescence	9	1.785651e-26	1.896956579e-23	2.677098	156	0.01348664	53	0.000032010624871698113	1.660258	55	73	0.006454641	
Mouse Phenotype	abnormal cellular replicative senescence	10	1.489712e-24	1.4243136431999998e-21	2.490119	164	0.01417827	58	0.00006001672131206896	1.600244	61	84	0.007158784	
Mouse Phenotype	increased fibroblast apoptosis	16	3.933425e-21	2.3504672765625003e-18	2.854661	110	0.009509812	150	0.00638795906	1.606802	35	48	0.004107499	
Mouse Phenotype	abnormal DNA repair	19	4.991443e-17	2.5117466591052632e-14	2.087908	160	0.01383245	43	0.000010343114258372094	1.535305	85	122	0.009975355	
Mouse Phenotype	increased cellular sensitivity to ultraviolet irradiation	56	9.826473e-11	1.677694792017857e-8	2.739618	55	0.004754906	29	6.064842317586206e-7	2.130161	29	30	0.003403356