# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	mRNA catabolic process	30	2.292585e-53	1.0056042005e-50	2.203954	475	0.02659872	116	4.6874104970689656e-11	1.415408	170	213	0.01605591	
GO Biological Process	nuclear-transcribed mRNA catabolic process	33	5.093101e-51	2.0309126078484847e-48	2.242291	437	0.02447083	124	9.603673788548388e-11	1.424112	159	198	0.015017	
GO Biological Process	RNA catabolic process	41	1.49309e-48	4.792090563414634e-46	2.042883	514	0.02878262	117	5.1847787147008544e-11	1.390776	189	241	0.0178504	
GO Biological Process	endoplasmic reticulum unfolded protein response	53	5.118951e-44	1.2709486077169813e-41	2.526678	296	0.0165752	440	0.00126523785	1.322289	85	114	0.008027956	
GO Biological Process	cellular response to epidermal growth factor stimulus	59	9.490251e-42	2.1166476764237287e-39	2.878679	224	0.0125434	560	0.006196368665535713	1.493409	32	38	0.003022289	
GO Biological Process	cellular response to topologically incorrect protein	68	7.901548e-41	1.5290657372352941e-38	2.287195	333	0.0186471	449	0.0015174176293763922	1.288602	101	139	0.009539101	
GO Biological Process	response to epidermal growth factor	72	1.731903e-40	3.1652932745833337e-38	2.762787	232	0.01299138	549	0.004923134244808744	1.477852	35	42	0.003305629	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	73	2.466206e-40	4.4455896923287666e-38	2.615079	254	0.01422332	164	1.2885766203048781e-8	1.487872	99	118	0.009350208	
GO Biological Process	cellular response to unfolded protein	78	2.635067e-39	4.445493160641025e-37	2.333902	307	0.01719117	422	0.0009313556655687204	1.319075	90	121	0.008500189	
GO Biological Process	response to topologically incorrect protein	97	2.815446e-36	3.819428238556701e-34	2.018443	392	0.02195095	589	0.00833388290220713	1.221691	124	180	0.01171137	
GO Biological Process	regulation of intrinsic apoptotic signaling pathway	99	5.865825e-36	7.79680718939394e-34	2.040656	378	0.02116698	809	0.03963832380964153	1.201351	105	155	0.009916887	
GO Biological Process	response to unfolded protein	106	3.058984e-34	3.797468910943396e-32	2.029699	364	0.02038302	561	0.006240387175044562	1.241396	112	160	0.01057801	
GO Biological Process	multi-organism metabolic process	110	6.988168e-34	8.359754791999999e-32	2.174223	306	0.01713518	84	5.819216843333333e-13	1.532141	127	147	0.01199471	
GO Biological Process	liver regeneration	111	1.261686e-33	1.4957230697297297e-31	3.105032	159	0.008903573	441	0.0012759921248072562	1.570746	31	35	0.002927843	
GO Biological Process	viral gene expression	117	1.339158e-32	1.5061521471794871e-30	2.340416	251	0.01405533	79	1.7523640416455698e-13	1.577927	113	127	0.01067246	
GO Biological Process	protein targeting to ER	126	2.084708e-30	2.1771962358730157e-28	2.468403	210	0.01175944	160	9.735529886874999e-9	1.527602	87	101	0.008216849	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to hypoxia	129	5.929563e-30	6.048613916046512e-28	2.454067	209	0.01170344	748	0.03028241263368984	1.295963	57	78	0.005383453	
GO Biological Process	translational elongation	130	6.412833e-30	6.491266880538461e-28	2.351949	227	0.01271139	426	0.0009996268328638497	1.330067	84	112	0.00793351	
GO Biological Process	viral transcription	132	9.79465e-30	9.764227223484848e-28	2.324469	231	0.01293538	103	1.3806090631067962e-11	1.569401	100	113	0.009444654	
GO Biological Process	cotranslational protein targeting to membrane	135	1.287635e-29	1.2551102937037038e-27	2.489198	201	0.01125546	157	7.417331015541401e-9	1.538173	85	98	0.008027956	
GO Cellular Component	ribosomal subunit	40	2.904878e-34	1.254907296e-32	2.114573	330	0.01847911	39	4.2749271138461537e-10	1.418738	148	185	0.01397809	
GO Cellular Component	large ribosomal subunit	50	1.723186e-26	5.955330816e-25	2.273477	214	0.01198342	61	0.00000698544566557377	1.403317	91	115	0.008594635	
GO Cellular Component	mitochondrial ribosome	58	2.409865e-21	7.179735724137931e-20	2.493761	141	0.007895621	99	0.0015870760145454547	1.356147	65	85	0.006139025	
GO Cellular Component	nuclear ubiquitin ligase complex	88	2.629689e-14	5.163752945454546e-13	2.56458	86	0.004815769	166	0.047306019469879515	1.374403	31	40	0.002927843	
GO Cellular Component	endopeptidase complex	102	2.430821e-13	4.1180967529411765e-12	2.028317	131	0.007335648	148	0.022948447135135136	1.310791	51	69	0.004816774	
GO Cellular Component	cytosolic large ribosomal subunit	107	4.226604e-13	6.825767955140188e-12	2.063286	123	0.006887669	71	0.0000341027858028169	1.51177	52	61	0.00491122	
GO Cellular Component	mitochondrial small ribosomal subunit	248	0.000001693699	0.000011801257548387096	2.207677	45	0.002519879	129	0.01305344193488372	1.520077	24	28	0.002266717	
GO Cellular Component	nuclear pore outer ring	478	0.003791912	0.013707999866108787	2.120221	17	0.0009519543	153	0.03663736094117647	1.773423	10	10	0.0009444654	
GO Molecular Function	structural constituent of ribosome	10	5.551313e-34	2.3437643486e-31	2.1647	310	0.01735917	12	2.935768403666667e-10	1.466905	134	162	0.01265584	
GO Molecular Function	rRNA binding	22	7.376022e-22	1.4155256765454545e-19	2.994966	106	0.005935715	73	0.0018575348326027395	1.448295	49	60	0.004627881	
GO Molecular Function	ribonuclease activity	23	1.127033e-21	2.068840576521739e-19	2.08367	210	0.01175944	123	0.04069307765853658	1.271849	71	99	0.006705705	
GO Molecular Function	exonuclease activity	29	4.427855e-17	6.44634614137931e-15	2.046857	169	0.009463546	127	0.04525482014173228	1.306733	56	76	0.005289006	
GO Molecular Function	thyroid hormone receptor binding	70	1.197112e-11	7.22029552e-10	2.41758	76	0.004255796	116	0.03546755521896552	1.520077	24	28	0.002266717	
GO Molecular Function	C-acyltransferase activity	100	9.370706e-10	3.9563120732e-8	2.32038	67	0.00375182	66	0.0006703889906060607	1.773423	20	20	0.001888931	
Human Phenotype	Skin rash	14	5.150813e-21	2.4550982249285716e-18	3.277324	89	0.004983761	144	0.02416333152638889	1.612202	20	22	0.001888931	
Human Phenotype	Abnormal CSF metabolite level	34	4.182995e-16	8.209742833823529e-14	2.304342	121	0.006775675	125	0.017326764804	1.379329	49	63	0.004627881	
Mouse Phenotype Single KO	decreased circulating free fatty acid level	19	1.192584e-31	5.747627204210526e-29	2.150632	292	0.01635122	153	0.0010910942552941178	1.372972	72	93	0.006800151	
Mouse Phenotype Single KO	decreased fatty acid level	22	2.175302e-31	9.05420018818182e-29	2.015925	338	0.01892709	165	0.0022082216493939395	1.315289	89	120	0.008405742	
Mouse Phenotype Single KO	decreased sensitivity to induced cell death	68	3.563793e-24	4.799066544264705e-22	2.055932	244	0.01366334	328	0.048056103506097556	1.295963	57	78	0.005383453	
Mouse Phenotype Single KO	absent segment of posterior cerebral artery	154	3.900251e-17	2.3191297666883114e-15	2.952629	83	0.004647777	256	0.018651399680468753	1.612202	20	22	0.001888931	
Mouse Phenotype Single KO	increased skin tumor incidence	278	1.538801e-12	5.068633365827338e-11	2.133694	108	0.00604771	243	0.012958786679423868	1.450982	36	44	0.003400076	
Mouse Phenotype Single KO	decreased circulating chloride level	349	7.554107e-11	1.9820331747564472e-9	2.045556	101	0.005655729	324	0.04552560819135803	1.402241	34	43	0.003211182	
Mouse Phenotype	decreased circulating free fatty acid level	29	2.578879e-38	8.502297282413794e-36	2.090312	381	0.02133498	116	0.000015067550800862068	1.400855	94	119	0.008877975	
Mouse Phenotype	abnormal cellular replicative senescence	99	1.374361e-25	1.3272995475757574e-23	2.193153	223	0.0124874	156	0.00010873737557692308	1.435628	68	84	0.006422365	
Mouse Phenotype	early cellular replicative senescence	112	3.992431e-24	3.4081814991964287e-22	2.234208	201	0.01125546	168	0.00015678184710714283	1.457608	60	73	0.005666793	
Mouse Phenotype	abnormal transitional stage T2 B cell morphology	150	4.968762e-21	3.1670888987999997e-19	2.61715	127	0.007111659	522	0.04800378454597701	1.46766	24	29	0.002266717	
Mouse Phenotype	absent segment of posterior cerebral artery	230	3.900251e-17	1.6213173830869563e-15	2.952629	83	0.004647777	370	0.01347410023945946	1.612202	20	22	0.001888931	
Mouse Phenotype	spleen atrophy	269	7.344018e-16	2.6102660259479555e-14	2.417057	108	0.00604771	509	0.04291927264833006	1.500588	22	26	0.002077824	
Mouse Phenotype	increased cellular sensitivity to ultraviolet irradiation	325	5.548995e-14	1.6324289598461537e-12	2.613366	81	0.004535782	482	0.03476155452074689	1.477852	25	30	0.002361164	
Mouse Phenotype	abnormal kidney arterial blood vessel morphology	453	8.765023e-11	1.849942271589404e-9	2.408085	70	0.003919812	515	0.0432093893184466	1.655195	14	15	0.001322252