# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	13	4.907478e-45	4.967500230923077e-42	3.011185	225	0.0207929	241	0.0000804120827219917	1.558174	70	113	0.009377093	
GO Biological Process	regulation of DNA-templated transcription in response to stress	17	8.533606e-40	6.60551302082353e-37	2.732999	231	0.02134738	243	0.000081651595	1.543023	73	119	0.009778969	
GO Biological Process	negative regulation of protein ubiquitination	18	6.850199e-38	5.007876035611112e-35	2.577623	243	0.02245633	184	0.000001811224069402174	1.585757	87	138	0.01165439	
GO Biological Process	liver regeneration	24	1.873867e-33	1.0274256605416667e-30	3.835142	119	0.01099714	358	0.0013017180531564247	1.868537	26	35	0.00348292	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to hypoxia	27	2.287534e-32	1.1148762928148148e-29	3.042322	157	0.01450883	311	0.000492243917363344	1.612396	50	78	0.006697924	
GO Biological Process	negative regulation of protein modification by small protein conjugation or removal	29	8.396075e-32	3.809791411206897e-29	2.313853	249	0.02301081	211	0.00001633500260616114	1.519332	90	149	0.01205626	
GO Biological Process	positive regulation of transcription from RNA polymerase II promoter in response to stress	31	1.060648e-31	4.502279687741935e-29	4.897054	86	0.007947509	619	0.04305720463166398	1.781698	17	24	0.002277294	
GO Biological Process	nuclear-transcribed mRNA catabolic process	33	2.198954e-31	8.768495662424243e-29	2.235527	264	0.02439701	192	0.000004020735876822917	1.473633	116	198	0.01553918	
GO Biological Process	mRNA catabolic process	34	9.8417e-31	3.809027361764706e-28	2.151694	281	0.02596803	202	0.000010156910951485149	1.44071	122	213	0.01634293	
GO Biological Process	endoplasmic reticulum unfolded protein response	36	3.501958e-30	1.2800629256111113e-27	2.620213	186	0.0171888	417	0.004388201469544365	1.434184	65	114	0.008707301	
GO Biological Process	regulation of hematopoietic progenitor cell differentiation	38	5.2195e-30	1.807457907894737e-27	2.791059	166	0.01534054	339	0.0007854195638643067	1.491395	67	113	0.008975218	
GO Biological Process	regulation of intrinsic apoptotic signaling pathway	41	1.424954e-29	4.573407240487805e-27	2.227324	250	0.02310323	259	0.00014716832533590734	1.460519	90	155	0.01205626	
GO Biological Process	negative regulation of intrinsic apoptotic signaling pathway	42	1.681045e-29	5.26687408452381e-27	2.600661	184	0.01700397	317	0.0005629785497160883	1.552017	58	94	0.007769591	
GO Biological Process	RNA catabolic process	44	2.136422e-29	6.389358431363637e-27	2.026769	309	0.02855559	183	0.000001815061137978142	1.440318	138	241	0.01848627	
GO Biological Process	regulation of hematopoietic stem cell differentiation	48	1.150476e-28	3.1539820175e-26	2.871853	151	0.01395435	340	0.0008205789847647058	1.514087	62	103	0.008305425	
GO Biological Process	regulation of mRNA stability	50	1.501672e-28	3.9521003696e-26	2.148301	261	0.02411977	351	0.0010302574745299144	1.415919	85	151	0.01138647	
GO Biological Process	negative regulation of ubiquitin-protein transferase activity	51	4.48976e-28	1.158446114509804e-25	2.918222	144	0.01330746	274	0.000222373508770073	1.617003	54	84	0.007233758	
GO Biological Process	cellular response to topologically incorrect protein	52	8.506043e-28	2.15251961225e-25	2.357696	208	0.01922188	355	0.0012195138464225353	1.429581	79	139	0.01058272	
GO Biological Process	regulation of cellular amino acid metabolic process	54	8.831587e-27	2.152126913574074e-24	3.620097	101	0.009333703	487	0.013138404949075975	1.551125	37	60	0.004956463	
GO Biological Process	regulation of RNA stability	55	8.883118e-27	2.125326359309091e-24	2.066924	267	0.02467424	330	0.000671753791	1.414878	90	160	0.01205626	
GO Cellular Component	mitochondrial ribosome	39	1.772471e-20	7.85340996923077e-19	2.947967	101	0.009333703	116	0.00934312915862069	1.450019	49	85	0.006563965	
GO Cellular Component	endopeptidase complex	41	2.641598e-19	1.1133369131707315e-17	2.734096	107	0.00988818	99	0.005423382109090909	1.531075	42	69	0.005626256	
GO Cellular Component	mitochondrial large ribosomal subunit	44	1.769435e-18	6.949053818181817e-17	3.48659	71	0.006561316	165	0.04722449105454546	1.479611	30	51	0.004018754	
GO Cellular Component	proteasome complex	47	1.407935e-17	5.176407829787233e-16	2.633374	103	0.009518529	107	0.00781258838130841	1.516601	41	68	0.005492297	
GO Cellular Component	PRC1 complex	49	8.748835e-17	3.085303444897959e-15	6.897834	32	0.002957213	137	0.033480933372262774	2.096115	10	12	0.001339585	
GO Cellular Component	peptidase complex	54	2.160937e-16	6.9149984e-15	2.305047	123	0.01136679	88	0.0036547219636363635	1.486336	52	88	0.006965841	
GO Cellular Component	spliceosomal snRNP complex	60	2.349719e-15	6.76719072e-14	2.735818	83	0.007670271	89	0.003686524907865168	1.582229	39	62	0.00522438	
GO Cellular Component	catalytic step 2 spliceosome	61	3.561653e-15	1.0089403908196722e-13	2.159983	130	0.01201368	65	0.0001430998006153846	1.572086	60	96	0.008037508	
GO Cellular Component	large ribosomal subunit	62	4.369647e-15	1.2178629058064517e-13	2.191554	125	0.01155161	90	0.0037730169599999998	1.421713	65	115	0.008707301	
GO Cellular Component	very-low-density lipoprotein particle	67	2.651227e-13	6.837791426865672e-12	3.739423	45	0.004158581	96	0.0052147386	2.012271	16	20	0.002143336	
GO Cellular Component	nuclear ubiquitin ligase complex	70	7.466257e-13	1.8430988708571427e-11	2.952802	60	0.005544774	101	0.006045957196039604	1.697853	27	40	0.003616879	
GO Cellular Component	small nuclear ribonucleoprotein complex	73	1.82442e-12	4.3186270684931507e-11	2.360978	86	0.007947509	119	0.010704331240336136	1.494621	41	69	0.005492297	
GO Cellular Component	signal recognition particle, endoplasmic reticulum targeting	81	7.396305e-11	1.5778784e-9	7.16267	19	0.001755845	126	0.021491273142857144	2.515338	7	7	0.0009377093	
GO Cellular Component	signal recognition particle	89	3.455094e-10	6.708317339325843e-9	5.496454	22	0.002033084	127	0.021624845102362206	2.263804	9	10	0.001205626	
GO Cellular Component	cytoplasmic stress granule	91	6.736978e-10	1.2792854927472527e-8	2.203774	76	0.00702338	117	0.009950292184615387	1.637895	28	43	0.003750837	
GO Cellular Component	high-density lipoprotein particle	92	6.840582e-10	1.2848397495652173e-8	3.274666	38	0.00351169	162	0.045322143999999995	1.676892	18	27	0.002411253	
GO Cellular Component	plasma lipoprotein particle	110	1.385947e-8	2.177196741818182e-7	2.159758	67	0.006191664	147	0.03540873012244898	1.572086	25	40	0.003348962	
GO Cellular Component	protein-lipid complex	117	3.081087e-8	4.5505284923076926e-7	2.099848	68	0.006284077	148	0.03540765405405406	1.557114	26	42	0.00348292	
GO Cellular Component	U2 snRNP	149	4.669257e-7	0.000005415084628187919	3.116684	27	0.002495148	112	0.009096023828571428	1.985793	15	19	0.002009377	
GO Cellular Component	U1 snRNP	152	7.451284e-7	0.000008470933389473685	2.731052	32	0.002957213	141	0.034978923574468086	1.853407	14	19	0.001875419	
GO Molecular Function	unfolded protein binding	10	5.474521e-26	2.3113427662e-23	2.76184	145	0.01339987	51	0.0026390041478431374	1.494965	63	106	0.008439384	
GO Molecular Function	7S RNA binding	21	4.534744e-13	9.116994841904763e-11	7.822694	22	0.002033084	92	0.028574422573913044	2.515338	8	8	0.001071668	
GO Molecular Function	DNA polymerase binding	39	2.682982e-11	2.9045000010256407e-9	4.842847	28	0.002587561	98	0.03756913957959184	2.043712	13	16	0.00174146	
GO Molecular Function	rRNA binding	54	3.701654e-10	2.8941450348148146e-8	2.611196	56	0.005175122	108	0.04649629961111111	1.509203	36	60	0.004822505	
GO Molecular Function	aminoacyl-tRNA editing activity	113	6.556528e-7	0.000024497045323893804	3.43065	23	0.002125497	68	0.007927624564705882	2.321851	12	13	0.001607502	
GO Molecular Function	mismatched DNA binding	177	0.0000151814	0.0003621235638418079	3.087941	20	0.001848258	83	0.015153612573493977	2.305727	11	12	0.001473543	
Human Phenotype	Abnormal CNS myelination	7	3.321483e-18	3.166322294142857e-15	2.07833	174	0.01607984	10	8.270429451e-9	1.750675	87	125	0.01165439	
Human Phenotype	Increased serum lactate	9	1.027989e-16	7.62196733e-14	2.260167	131	0.01210609	56	0.00025443005057142854	1.584663	63	100	0.008439384	
Human Phenotype	Exercise intolerance	16	7.982351e-15	3.3291392639375002e-12	2.554497	90	0.008317161	111	0.011896876891891891	1.545136	43	70	0.005760214	
Human Phenotype	Increased CSF lactate	27	9.324041e-12	2.304419466407407e-9	2.498721	72	0.006653729	86	0.001608626745	1.691348	39	58	0.00522438	
Human Phenotype	Abnormal CSF metabolite level	42	1.151015e-10	1.828743594047619e-8	2.325727	74	0.006838555	96	0.0029003256109375003	1.636966	41	63	0.005492297	
Human Phenotype	Abnormality of the mitochondrion	43	1.248388e-10	1.9373239823255814e-8	2.06627	96	0.008871638	97	0.0032798345350515466	1.594228	45	71	0.006028131	
Human Phenotype	Abnormality of mitochondrial metabolism	49	3.643166e-10	4.961397289387755e-8	2.048614	93	0.0085944	104	0.007936057740384615	1.56753	43	69	0.005760214	
Human Phenotype	Leukodystrophy	87	7.896679e-8	0.000006056843559425287	2.058292	67	0.006191664	59	0.0004276969999661017	1.811044	36	50	0.004822505	
Human Phenotype	Hypolipoproteinemia	109	4.445047e-7	0.000027212659294495415	2.191565	51	0.004713058	140	0.028100818059285715	1.985793	15	19	0.002009377	
Human Phenotype	Progressive macrocephaly	220	0.00003242363	0.0009834676499545455	2.365741	29	0.002679974	100	0.0064798213211	1.991309	19	24	0.002545211	
Human Phenotype	Acute necrotizing encephalopathy	292	0.0001000693	0.0022868576674657535	2.332206	26	0.002402735	118	0.016383215950000002	2.012271	16	20	0.002143336	
Mouse Phenotype Single KO	increased cellular sensitivity to ultraviolet irradiation	389	0.00002054913	0.0004837233506683805	2.215529	35	0.003234452	163	0.027547615439263803	1.886504	18	24	0.002411253	
Mouse Phenotype Single KO	decreased cellular sensitivity to gamma-irradiation	619	0.0004821354	0.007132332565105009	2.007437	29	0.002679974	176	0.0398584751375	1.916448	16	21	0.002143336	
Mouse Phenotype	dry eyes	52	2.390799e-16	4.395851776730769e-14	3.258569	68	0.006284077	156	0.007136416203846154	2.200921	14	16	0.001875419	
Mouse Phenotype	increased cellular sensitivity to ultraviolet irradiation	60	9.01481e-15	1.4365099735e-12	3.247959	61	0.005637187	129	0.003217613729069768	1.928426	23	30	0.003081045