# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process regulation of cellular senescence 318 0.00003816775 0.0015794006988993712 2.145047 35 0.006970723 400 0.00222243601105 2.23746 19 30 0.003574788 GO Biological Process regulation of cell aging 354 0.00006195184 0.0023028933970621465 2.067397 36 0.007169886 578 0.01965638374204152 1.909639 20 37 0.003762935 GO Biological Process branching morphogenesis of a nerve 449 0.0002253547 0.006604548991759466 2.593128 19 0.003784107 662 0.03607150248187311 3.532832 5 5 0.0009407338 GO Biological Process positive regulation of sodium ion transmembrane transport 521 0.0004115228 0.010393912716314778 2.121348 26 0.005178251 643 0.03312562344167962 2.231262 12 19 0.002257761 GO Biological Process positive regulation of sodium ion transmembrane transporter activity 604 0.0007364972 0.01604564015695364 2.188722 22 0.004381597 594 0.022317198782828285 2.523451 10 14 0.001881468 GO Biological Process regulation of production of miRNAs involved in gene silencing by miRNA 661 0.001109997 0.022097504573373675 2.008435 25 0.004979088 691 0.04294316819971057 2.355221 10 15 0.001881468 GO Biological Process negative regulation of potassium ion transmembrane transporter activity 737 0.001725769 0.030813289377204886 2.083109 21 0.004182434 441 0.004269265975736961 2.649624 12 16 0.002257761 Human Phenotype High, narrow palate 96 0.00000296568 0.00020614565250000002 2.028135 52 0.0103565 69 0.0057896998255072465 2.083465 23 39 0.004327375 Human Phenotype Poor speech 103 0.000003614373 0.000234162243 2.013486 52 0.0103565 159 0.027083247642767296 1.802465 25 49 0.004703669 Human Phenotype Mesoaxial hand polydactyly 598 0.003532911 0.03942326940301004 2.261036 15 0.002987453 150 0.022835637710666667 3.532832 6 6 0.001128881 Mouse Phenotype Single KO increased epididymal fat pad weight 229 0.0000904975 0.0036187144432314414 2.101674 33 0.006572396 726 0.03081336806473829 2.087582 13 22 0.002445908 Mouse Phenotype Single KO decreased molar number 230 0.00009154256 0.0036445879213913043 2.7876 19 0.003784107 561 0.014266862265418897 3.091228 7 8 0.001317027 Mouse Phenotype Single KO abnormal umbilical vein morphology 352 0.0005190613 0.013502966829829545 2.56863 17 0.00338578 765 0.03417081181699346 2.569332 8 11 0.001505174 Mouse Phenotype Single KO abnormal thymus cell ratio 435 0.001099715 0.023149632770114944 2.119819 22 0.004381597 461 0.007164168644902386 2.493763 12 17 0.002257761 Mouse Phenotype Single KO reduced male mating frequency 443 0.001154665 0.02386742077878104 2.111479 22 0.004381597 569 0.014688943255008788 2.428822 11 16 0.002069614 Mouse Phenotype Single KO enlarged allantois 518 0.001914588 0.03384533265637066 2.025451 22 0.004381597 856 0.04805421371378505 2.20802 10 16 0.001881468 Mouse Phenotype Single KO abnormal roof plate morphology 572 0.002505812 0.04011489595104895 2.43295 14 0.002788289 561 0.014266862265418897 3.091228 7 8 0.001317027 Mouse Phenotype increased inguinal fat pad weight 213 0.00002099037 0.0009422015378873238 2.34257 31 0.006174069 1105 0.04519487295746606 2.018761 12 21 0.002257761 Mouse Phenotype increased pulmonary respiratory rate 323 0.0001482644 0.004388718044582044 2.020071 34 0.006771559 1007 0.030593547950347567 1.816885 18 35 0.003386642 Mouse Phenotype abnormal prostate gland weight 344 0.0001875883 0.0052137550473837216 2.069773 31 0.006174069 840 0.018423671389285714 2.231262 12 19 0.002257761 Mouse Phenotype decreased molar number 397 0.0003590878 0.008647955808060454 2.495166 19 0.003784107 982 0.02886823220468432 2.747758 7 9 0.001317027 Mouse Phenotype increased oral papilloma incidence 406 0.0004004773 0.009430944495812808 3.811825 10 0.001991635 857 0.02024518879463244 3.532832 5 5 0.0009407338 Mouse Phenotype abnormal umbilical vein morphology 430 0.0005190613 0.011541267649534885 2.56863 17 0.00338578 974 0.028022564599589322 2.569332 8 11 0.001505174 Mouse Phenotype decreased basophil cell number 455 0.0006767163 0.014219966031428572 2.082816 25 0.004979088 696 0.009508970851293102 2.296341 13 20 0.002445908 Mouse Phenotype increased urine glycosaminoglycan level 619 0.002078713 0.03210755249273021 3.290248 9 0.001792472 982 0.02886823220468432 2.747758 7 9 0.001317027 Mouse Phenotype small hair follicles 671 0.002460961 0.03506594354843517 2.06106 20 0.00398327 1120 0.04626145337946429 2.271106 9 14 0.001693321 Mouse Phenotype inner ear cysts 753 0.003634548 0.046148623410358566 2.076431 18 0.003584943 857 0.02024518879463244 3.532832 5 5 0.0009407338