# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	transmembrane receptor protein tyrosine kinase signaling pathway	33	9.896981e-42	3.9464961508787875e-39	2.203927	343	0.1340891	102	0.0012703841800882354	1.472433	113	513	0.04022784	
GO Biological Process	liver development	42	8.692409e-38	2.723414524547619e-35	3.628288	142	0.05551212	263	0.022569191030038023	1.793425	33	123	0.01174795	
GO Biological Process	hepaticobiliary system development	43	3.301162e-37	1.0102323432093023e-34	3.562249	143	0.05590305	242	0.018055170269421487	1.803777	34	126	0.01210395	
GO Biological Process	regulation of dendrite development	56	5.355617e-31	1.2584743589821428e-28	2.871	160	0.06254887	206	0.011461744514563107	1.823069	36	132	0.01281595	
GO Biological Process	regulation of cellular component size	61	4.833729e-30	1.0427383591967214e-27	2.3822	213	0.08326818	299	0.03202393164314381	1.448672	70	323	0.0249199	
GO Biological Process	negative regulation of intracellular signal transduction	67	1.8634e-27	3.659773223880597e-25	2.055444	264	0.1032056	239	0.017853371391631796	1.383018	102	493	0.03631185	
GO Biological Process	positive regulation of transcription from RNA polymerase II promoter in response to stress	72	8.924589e-27	1.631092592375e-24	9.876138	41	0.01602815	237	0.01718303330464135	3.063768	11	24	0.003915984	
GO Biological Process	endoplasmic reticulum unfolded protein response	89	9.234293e-24	1.3653265346853931e-21	4.290649	72	0.02814699	89	0.0008362704182247191	2.110922	36	114	0.01281595	
GO Biological Process	embryonic skeletal system development	93	2.921122e-23	4.133230580430108e-21	2.628902	137	0.05355747	205	0.010960297994634145	1.862917	34	122	0.01210395	
GO Biological Process	cellular response to unfolded protein	100	1.343572e-21	1.7680063948e-19	3.874354	73	0.02853792	101	0.0012599476714257425	2.044047	37	121	0.01317195	
GO Biological Process	cellular response to topologically incorrect protein	102	1.681643e-21	2.169484336960784e-19	3.692172	77	0.03010164	99	0.001172326936090909	1.971712	41	139	0.01459594	
GO Biological Process	connective tissue development	122	8.318538e-19	8.972429634590164e-17	2.147664	162	0.06333073	171	0.005821038325964913	1.705251	50	196	0.01779993	
GO Biological Process	regulation of organ morphogenesis	127	6.969754e-18	7.221652983149607e-16	2.019206	177	0.06919468	236	0.017194536325	1.557052	58	249	0.02064792	
GO Biological Process	response to endoplasmic reticulum stress	166	1.740262e-14	1.3795245577108433e-12	2.328988	103	0.04026583	157	0.004135188090955414	1.64375	60	244	0.02135991	
GO Biological Process	transferrin transport	232	1.693735e-10	9.606835717672415e-9	4.967357	25	0.00977326	19	0.000013172920836842104	3.713658	20	36	0.007119972	
GO Biological Process	platelet-derived growth factor receptor signaling pathway	244	7.077008e-10	3.816653617704918e-8	3.258078	38	0.01485536	275	0.026301931664727274	2.633321	13	33	0.004627981	
GO Biological Process	ferric iron transport	256	1.974344e-9	1.0148590896875e-7	4.391652	25	0.00977326	29	0.00005164367527241379	3.427992	20	39	0.007119972	
GO Biological Process	cellular response to insulin stimulus	265	4.844774e-9	2.4057502289056604e-7	2.126091	73	0.02853792	78	0.0005655245581025641	1.987309	44	148	0.01566394	
GO Biological Process	regulation of macroautophagy	267	5.810135e-9	2.8635043619850187e-7	2.184117	68	0.02658327	15	0.000005547083459733334	2.214269	53	160	0.01886792	
GO Biological Process	insulin receptor signaling pathway	268	6.433161e-9	3.1587300596641793e-7	2.485941	52	0.02032838	143	0.003248819988741259	2.201022	27	82	0.009611962	
GO Cellular Component	proton-transporting two-sector ATPase complex	54	0.000003226367	0.000103243744	3.20342	22	0.008600469	42	0.018394123885714285	2.270237	18	53	0.006407974	
GO Cellular Component	proton-transporting V-type ATPase complex	55	0.00000367778	0.00011554916072727273	3.875963	17	0.006645817	34	0.0023548746917647057	3.218504	13	27	0.004627981	
GO Cellular Component	vacuolar proton-transporting V-type ATPase complex	82	0.00006425426	0.0013540409912195122	4.039173	12	0.004691165	55	0.040664772654545454	3.008063	9	20	0.003203987	
GO Cellular Component	eukaryotic translation initiation factor 4F complex	101	0.0003085521	0.005278990384158416	5.629645	7	0.002736513	47	0.022879392817021275	4.45639	6	9	0.002135991	
GO Cellular Component	MLL1 complex	110	0.0005158001	0.008102750661818182	3.204184	12	0.004691165	44	0.02071173730909091	2.766035	12	29	0.004271983	
GO Cellular Component	Bcl-2 family protein complex	134	0.002455975	0.03167108059701493	4.522431	6	0.002345582	53	0.039226838943396236	4.774704	5	7	0.001779993	
GO Molecular Function	nucleotide transmembrane transporter activity	37	5.655907e-7	0.00006453848474054054	5.058957	15	0.005863956	15	0.00048782620506666673	4.595652	11	16	0.003915984	
GO Molecular Function	phosphate transmembrane transporter activity	39	5.778625e-7	0.00006255731987179487	4.228436	18	0.007036747	22	0.0017212048095454546	3.620817	13	24	0.004627981	
GO Molecular Function	organophosphate ester transmembrane transporter activity	50	0.000001593349	0.00013454238956	4.645593	15	0.005863956	23	0.0017309722730434781	4.085024	11	18	0.003915984	
GO Molecular Function	hydrogen-exporting ATPase activity	68	0.00004911856	0.003049684710588235	3.452541	15	0.005863956	27	0.005153290323703703	3.48761	12	23	0.004271983	
GO Molecular Function	phosphatidylinositol-3,5-bisphosphate binding	70	0.00005186659	0.003128296328285714	2.660548	22	0.008600469	32	0.012484059506875	3.208601	12	25	0.004271983	
GO Molecular Function	adenine nucleotide transmembrane transporter activity	73	0.00007792056	0.004506583620821918	4.687026	10	0.003909304	41	0.032413931312195124	4.253827	7	11	0.00249199	
GO Molecular Function	purine ribonucleotide transmembrane transporter activity	73	0.00007792056	0.004506583620821918	4.687026	10	0.003909304	41	0.032413931312195124	4.253827	7	11	0.00249199	
GO Molecular Function	purine nucleotide transmembrane transporter activity	77	0.0001034314	0.005671264555844156	4.525374	10	0.003909304	59	0.04706717086101696	3.899341	7	12	0.00249199	
GO Molecular Function	nucleobase-containing compound transmembrane transporter activity	83	0.0001153476	0.005867440568674699	2.734125	19	0.007427678	33	0.012622116787878787	2.785244	15	36	0.005339979	
GO Molecular Function	GDP binding	89	0.0001789108	0.00848720671460674	2.045418	32	0.01250977	38	0.025144898736842104	2.265961	20	59	0.007119972	
GO Molecular Function	nucleoside transmembrane transporter activity	96	0.0002482593	0.010918237131250001	3.482632	12	0.004691165	53	0.039625612864150936	3.342293	9	18	0.003203987	
GO Molecular Function	proton-transporting ATPase activity, rotational mechanism	102	0.0003377166	0.013978818482352941	3.598507	11	0.004300235	47	0.0357406493106383	3.183136	10	21	0.003559986	
GO Molecular Function	hydrogen-exporting ATPase activity, phosphorylative mechanism	125	0.0008716201	0.029439840497599998	4.144477	8	0.003127443	39	0.02572896543076923	5.013439	6	8	0.002135991	
Mouse Phenotype Single KO	embryonic lethality during organogenesis, incomplete penetrance	40	1.837433e-25	4.20634349525e-23	2.309468	191	0.07466771	100	0.020869160123	1.581001	57	241	0.02029192	
Mouse Phenotype Single KO	enlarged axillary lymph nodes	57	7.823527e-18	1.2568427498070176e-15	13.51844	22	0.008600469	76	0.009000189989605265	6.684585	5	5	0.001779993	
Mouse Phenotype Single KO	respiratory distress	73	4.324496e-15	5.42457669479452e-13	2.005496	150	0.05863956	96	0.017254172635416665	1.689511	46	182	0.01637593	
Mouse Phenotype Single KO	pale liver	194	0.00000279902	0.00013211662958762885	2.397763	36	0.01407349	42	0.0015072565895714286	2.339605	28	80	0.00996796	
Mouse Phenotype Single KO	decreased T follicular helper cell number	246	0.00003426303	0.0012753925435365855	8.070122	7	0.002736513	134	0.03416341395074627	6.684585	4	4	0.001423994	
Mouse Phenotype	abnormal Purkinje cell dendrite morphology	18	7.387961e-58	3.9242386178333334e-55	5.815289	135	0.05277561	272	0.038238340731617644	1.960812	22	75	0.007831969	
Mouse Phenotype	abnormal Purkinje cell morphology	47	3.215644e-31	6.541440911489362e-29	2.618776	187	0.07310399	108	0.001994541456666667	1.68519	60	238	0.02135991	
Mouse Phenotype	abnormal neurite morphology	50	3.418366e-30	6.5365994652e-28	2.016875	303	0.1184519	184	0.01678698555978261	1.406485	93	442	0.03310787	
Mouse Phenotype	small liver	53	8.182746e-28	1.4761365001132076e-25	2.541179	175	0.06841282	278	0.04060787126978417	1.521937	51	224	0.01815593	
Mouse Phenotype	abnormal cerebellar layer morphology	58	1.212791e-26	1.9992232329310342e-24	2.14939	232	0.09069586	87	0.001316385954137931	1.603467	77	321	0.02741189	
Mouse Phenotype	abnormal cerebellar Purkinje cell layer	62	9.350485e-26	1.441935275564516e-23	2.305027	194	0.0758405	88	0.0013123135251136364	1.671146	66	264	0.02349591	
Mouse Phenotype	abnormal autonomic nervous system morphology	64	1.358271e-24	2.0291295360937499e-22	2.686707	140	0.05473026	143	0.007694773032167833	1.918185	33	115	0.01174795	
Mouse Phenotype	embryonic lethality during organogenesis, incomplete penetrance	78	1.552156e-22	1.902585066153846e-20	2.03948	220	0.08600469	102	0.0017876764111764707	1.583733	77	325	0.02741189	
Mouse Phenotype	limb grasping	83	6.550105e-22	7.545247458433735e-20	2.175094	185	0.07232213	237	0.031466493526582276	1.515534	56	247	0.01993592	
Mouse Phenotype	lethality, incomplete penetrance	87	3.778228e-21	4.152142288275862e-19	2.061343	201	0.07857701	58	0.00023578761243103449	1.711624	74	289	0.02634389	
Mouse Phenotype	decreased survivor rate	92	5.306152e-20	5.514360790434783e-18	2.119571	178	0.06958561	127	0.003794090877165354	1.65017	59	239	0.02100392	
Mouse Phenotype	enlarged axillary lymph nodes	114	5.935234e-17	4.9777870415789474e-15	12.23909	22	0.008600469	286	0.04022098747552448	4.774704	5	7	0.001779993	
Mouse Phenotype	abnormal forelimb zeugopod morphology	116	6.024584e-17	4.965607553793104e-15	2.276821	128	0.05003909	305	0.047142626459016394	1.71258	31	121	0.01103596	
Mouse Phenotype	decreased bone ossification	300	0.000001304894	0.00004158697178	2.381028	39	0.01524629	312	0.04971064213461539	2.228195	15	45	0.005339979	
Mouse Phenotype	pale liver	315	0.000004381948	0.0001330025550095238	2.042671	49	0.01915559	62	0.0003449897172096774	2.187682	36	110	0.01281595	
Mouse Phenotype	increased renal carcinoma incidence	363	0.00001975944	0.0005204407874380165	7.283229	8	0.003127443	291	0.044633376453608244	4.010751	6	10	0.002135991	
Mouse Phenotype	increased kidney tumor incidence	454	0.0004053946	0.008537395970484581	3.803438	10	0.003909304	266	0.0371621692556391	3.342293	8	16	0.002847989