# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process negative regulation of gene expression, epigenetic 31 4.326684e-22 1.8366075727741933e-19 3.238002 95 0.01753415 434 0.028498415979723506 1.474844 50 114 0.008954155 GO Biological Process regulation of gene expression, epigenetic 56 2.128962e-18 5.002680528214286e-16 2.0847 173 0.0319306 385 0.020079095935064937 1.328786 98 248 0.01755014 GO Biological Process chromatin assembly or disassembly 152 9.354248e-13 8.098194041578948e-11 2.029742 123 0.0227021 422 0.02623993158199052 1.379062 73 178 0.01307307 GO Biological Process nucleosome assembly 168 5.268711e-12 4.12684333625e-10 2.132729 102 0.01882614 508 0.04525139197047244 1.397155 59 142 0.0105659 GO Biological Process production of molecular mediator of immune response 210 1.130472e-10 7.08375288e-9 2.353787 72 0.01328904 345 0.013367720811014493 1.681322 34 68 0.006088825 GO Biological Process regulation of megakaryocyte differentiation 216 1.80872e-10 1.1018956703703703e-8 2.394981 68 0.01255076 357 0.014234606339215687 1.637076 37 76 0.006626074 GO Biological Process iron ion transport 251 1.615276e-9 8.468293579282868e-8 2.475634 57 0.01052049 254 0.004510035877086614 1.828806 31 57 0.005551576 GO Biological Process positive regulation of intrinsic apoptotic signaling pathway 290 1.043472e-8 4.7348441544827583e-7 2.535298 49 0.009043928 237 0.0036941810379746837 1.868135 30 54 0.005372493 GO Biological Process JAK-STAT cascade 309 2.462278e-8 0.0000010485798123624596 2.196677 62 0.01144334 400 0.02117373568125 1.78864 25 47 0.004477077 GO Biological Process pH reduction 338 8.092874e-8 0.0000031507138747337278 2.566451 42 0.007751938 220 0.0024809075414090912 1.973725 27 46 0.004835244 GO Biological Process positive regulation of CD4-positive, alpha-beta T cell activation 350 1.133623e-7 0.000004262098587714285 2.272939 52 0.009597638 517 0.048291442885880075 1.905498 17 30 0.003044413 GO Biological Process negative regulation of transcription from RNA polymerase II promoter in response to stress 366 1.555894e-7 0.000005593991569945355 3.871758 22 0.004060539 391 0.02021064559309463 2.586649 10 13 0.001790831 GO Biological Process carbohydrate phosphorylation 370 1.834964e-7 0.000006526024669189189 3.271234 27 0.004983389 427 0.02718585608126464 2.101652 15 24 0.002686246 GO Biological Process intracellular pH reduction 381 2.028051e-7 0.000007004494254330708 2.509539 41 0.007567368 250 0.00437808720212 1.942861 26 45 0.00465616 GO Biological Process transferrin transport 393 2.968207e-7 0.000009938584201781169 2.908095 31 0.005721669 340 0.01286524467647059 1.961542 21 36 0.003760745 GO Biological Process ferric iron transport 413 4.738635e-7 0.000015098231952784503 2.736928 33 0.006090808 367 0.016558278058038146 1.896876 22 39 0.003939828 GO Biological Process cytokine production involved in immune response 471 0.00000107261 0.000029967038195329084 2.786281 30 0.005537099 365 0.01643899791917808 2.193028 15 23 0.002686246 GO Biological Process regulation of proton transport 495 0.000001761212 0.00004681977516767677 3.334342 22 0.004060539 387 0.02029805672273902 2.373631 12 17 0.002148997 GO Biological Process negative regulation of TOR signaling 529 0.000003078179 0.00007657042998298676 2.112449 47 0.008674788 232 0.003264669059439655 2.001573 25 42 0.004477077 GO Biological Process vesicle docking involved in exocytosis 632 0.00001089642 0.00022687656768987342 2.225407 37 0.006829088 146 0.0001832910800890411 2.241762 26 39 0.00465616 GO Cellular Component melanosome 54 2.679843e-11 8.5754976e-10 2.087581 100 0.018457 52 0.0012148248738461538 1.633284 51 105 0.009133238 GO Cellular Component Golgi-associated vesicle 69 2.491926e-9 6.240649460869565e-8 2.241356 68 0.01255076 88 0.02799522981818182 1.539523 38 83 0.006805158 GO Cellular Component sorting endosome 79 1.04829e-8 2.2929685063291139e-7 4.184743 24 0.004429679 82 0.01454872952195122 3.362643 6 6 0.001074499 GO Cellular Component proton-transporting V-type ATPase complex 211 0.0006449913 0.005282203632227488 2.260537 21 0.003875969 87 0.026817050482758623 1.992677 16 27 0.00286533 GO Molecular Function nucleobase-containing compound transmembrane transporter activity 70 0.000004742252 0.00028602554205714285 2.377904 35 0.006459948 46 0.03050945695652174 1.961542 21 36 0.003760745 Mouse Phenotype Single KO abnormal T cell activation 27 3.718618e-27 1.2611624083703704e-24 2.031613 278 0.05131045 120 0.000048770578803333335 1.45443 125 289 0.02238539 Mouse Phenotype Single KO abnormal erythropoiesis 40 1.009446e-20 2.3108742555000003e-18 2.33195 154 0.02842377 81 0.000005317998971111111 1.834169 60 110 0.01074499 Mouse Phenotype Single KO abnormal circulating cytokine level 41 2.041213e-20 4.558874985609756e-18 2.069066 197 0.03636028 121 0.00005501847986942149 1.475969 115 262 0.02059456 Mouse Phenotype Single KO decreased erythroid progenitor cell number 48 6.885385e-19 1.3135306342708333e-16 2.781867 101 0.01864157 152 0.00024686657517105265 2.04396 31 51 0.005551576 Mouse Phenotype Single KO abnormal mean corpuscular hemoglobin 51 9.616215e-19 1.7265819755882354e-16 2.135109 167 0.03082318 116 0.000044763323512931035 1.594854 83 175 0.0148639 Mouse Phenotype Single KO abnormal platelet activation 52 2.265235e-18 3.9889917105769226e-16 2.684866 104 0.01919528 420 0.02575829216190476 1.54286 39 85 0.006984241 Mouse Phenotype Single KO decreased T cell proliferation 59 7.943244e-18 1.2328183950508473e-15 2.107307 163 0.0300849 266 0.004906530591353384 1.479563 66 150 0.01181948 Mouse Phenotype Single KO abnormal platelet aggregation 61 1.016e-17 1.5251659016393441e-15 2.684397 100 0.018457 452 0.03192026879867257 1.551989 36 78 0.006446991 Mouse Phenotype Single KO enlarged lymph nodes 76 3.761622e-16 4.532259559736842e-14 2.148147 140 0.02583979 297 0.007392406018855219 1.491699 59 133 0.0105659 Mouse Phenotype Single KO abnormal platelet physiology 81 2.427143e-15 2.7438701791358025e-13 2.236546 121 0.02233296 315 0.009991060257777778 1.528474 50 110 0.008954155 Mouse Phenotype Single KO abnormal circulating interleukin level 83 8.565533e-15 9.449950082048193e-13 2.003795 150 0.02768549 164 0.00032005819993292684 1.492686 91 205 0.01629656 Mouse Phenotype Single KO decreased platelet aggregation 87 1.596413e-14 1.6802705564367816e-12 2.841089 73 0.01347361 466 0.03594191275751073 1.625278 29 60 0.00519341 Mouse Phenotype Single KO abnormal embryonic hematopoiesis 92 1.655379e-13 1.6476419024999998e-11 2.424589 89 0.01642673 399 0.02199260557869674 1.713045 27 53 0.004835244 Mouse Phenotype Single KO abnormal circulating interferon level 100 1.263554e-12 1.1570363978e-10 2.608118 72 0.01328904 292 0.007221065945890412 1.606596 43 90 0.007700573 Mouse Phenotype Single KO abnormal interferon level 103 1.791965e-12 1.59310907815534e-10 2.413905 82 0.01513474 309 0.00936565513592233 1.539902 49 107 0.008775072 Mouse Phenotype Single KO embryonic lethality between somite formation and embryo turning, complete penetrance 108 2.439743e-12 2.0685858010185184e-10 2.355731 85 0.01568845 409 0.023845947437652813 1.590439 35 74 0.006267908 Mouse Phenotype Single KO abnormal interleukin-1 beta secretion 110 2.948101e-12 2.454160077909091e-10 2.521406 74 0.01365818 112 0.000040254548091071434 1.969548 41 70 0.007342407 Mouse Phenotype Single KO abnormal circulating interleukin-6 level 122 1.320689e-11 9.912745223770492e-10 2.143365 97 0.01790329 263 0.004771792780228137 1.561227 52 112 0.009312321 Mouse Phenotype Single KO abnormal NK cell physiology 126 2.020479e-11 1.4683750954761905e-9 2.010513 111 0.02048726 267 0.005010223398501872 1.596406 47 99 0.008416905 Mouse Phenotype Single KO increased mean corpuscular hemoglobin 141 5.718688e-11 3.7139025543262408e-9 2.049596 101 0.01864157 329 0.010588055403343465 1.537208 48 105 0.008595989 Mouse Phenotype decreased inflammatory response 29 3.607221e-29 1.1892634476206897e-26 2.206568 248 0.04577335 183 0.0000905641953114754 1.425226 128 302 0.02292264 Mouse Phenotype abnormal erythropoiesis 48 1.314309e-22 2.6179392393749997e-20 2.238491 184 0.03396087 74 1.0304391006486487e-7 1.805446 80 149 0.01432665 Mouse Phenotype abnormal platelet aggregation 56 2.264274e-19 3.8658435203571424e-17 2.687455 110 0.02030269 493 0.014248963871196754 1.53823 43 94 0.007700573 Mouse Phenotype abnormal platelet activation 58 3.102693e-19 5.1146289263793106e-17 2.661382 111 0.02048726 609 0.026775195862068966 1.479563 44 100 0.007879656 Mouse Phenotype decreased erythroid progenitor cell number 64 2.999836e-18 4.481473749375e-16 2.469338 120 0.02214839 227 0.00036879678995154185 1.814058 41 76 0.007342407 Mouse Phenotype abnormal mean corpuscular hemoglobin 66 1.083211e-17 1.569178844090909e-15 2.043134 174 0.03211517 146 0.000023737009567808216 1.589945 87 184 0.01558023 Mouse Phenotype abnormal platelet physiology 68 2.129147e-17 2.9936433039705883e-15 2.244013 138 0.02547065 338 0.0026362768767159766 1.528474 60 132 0.01074499 Mouse Phenotype decreased platelet aggregation 88 8.783455e-16 9.543024233522727e-14 2.82149 81 0.01495017 562 0.021962008286476868 1.587915 34 72 0.006088825 Mouse Phenotype abnormal circulating interferon level 98 2.1753e-14 2.122249316326531e-12 2.548863 87 0.01605759 372 0.004245163674999999 1.559044 51 110 0.009133238 Mouse Phenotype abnormal interferon level 101 4.420973e-14 4.185041866633664e-12 2.329275 101 0.01864157 434 0.008037073531797233 1.477525 58 132 0.01038682 Mouse Phenotype abnormal circulating interferon-gamma level 115 2.220032e-13 1.845715300173913e-11 2.731764 71 0.01310447 389 0.005008044426478149 1.623345 42 87 0.00752149 Mouse Phenotype abnormal circulating tumor necrosis factor level 118 3.84605e-13 3.1162783093220343e-11 2.141569 112 0.02067183 212 0.0002586676686084906 1.589194 69 146 0.01235673 Mouse Phenotype increased circulating interferon-gamma level 125 1.19149e-12 9.113468712e-11 3.250703 51 0.009413068 397 0.005705600203526449 1.810654 28 52 0.005014327 Mouse Phenotype abnormal lymph node cortex morphology 130 1.745446e-12 1.2837084004615385e-10 2.531864 75 0.01384275 648 0.033963327833333334 1.579423 31 66 0.005551576 Mouse Phenotype abnormal circulating interleukin-1 beta level 131 2.006219e-12 1.4642335770229008e-10 2.971539 57 0.01052049 262 0.0006459407950763358 1.92151 32 56 0.005730659 Mouse Phenotype abnormal circulating interleukin-1 level 134 2.466665e-12 1.7599838854477612e-10 2.831477 61 0.01125877 258 0.0006239497482558139 1.868135 35 63 0.006267908 Mouse Phenotype increased circulating tumor necrosis factor level 138 4.372312e-12 3.029251813913044e-10 2.370095 82 0.01513474 350 0.0029356668060000002 1.612696 47 98 0.008416905 Mouse Phenotype abnormal embryonic hematopoiesis 142 7.201671e-12 4.848956086690141e-10 2.209451 93 0.01716501 445 0.009413513517977529 1.708884 31 61 0.005551576 Mouse Phenotype abnormal interleukin-1 beta secretion 151 1.542145e-11 9.76453532781457e-10 2.221051 89 0.01642673 167 0.00005133169221556887 1.805208 51 95 0.009133238 Mouse Phenotype increased circulating interleukin-6 level 157 3.103887e-11 1.8902078730573245e-9 2.137642 94 0.01734958 190 0.00012427050648947368 1.769812 50 95 0.008954155