# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	61	2.421333e-35	5.2233313027868845e-33	2.274422	290	0.01570539	495	0.002335211026949495	1.319817	82	113	0.007942658	
GO Biological Process	regulation of DNA-templated transcription in response to stress	72	4.108601e-33	7.509038966527777e-31	2.142417	309	0.01673436	392	0.0004905128027295918	1.344974	88	119	0.008523828	
GO Biological Process	cellular response to epidermal growth factor stimulus	81	1.978486e-31	3.2141848486419755e-29	2.547901	205	0.01110209	520	0.0035410666553846153	1.531597	32	38	0.003099574	
GO Biological Process	response to epidermal growth factor	95	6.6479e-29	9.208391168421052e-27	2.407073	209	0.01131871	505	0.002713331079405941	1.515643	35	42	0.003390159	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	100	2.164242e-28	2.8479260477999994e-26	2.280185	229	0.01240184	278	0.00002158741050179856	1.402612	91	118	0.008814413	
GO Biological Process	mitochondrial transmembrane transport	107	9.318056e-28	1.145946718728972e-25	2.384337	204	0.01104793	415	0.0007332762380963855	1.402426	64	83	0.006199148	
GO Biological Process	liver regeneration	127	3.923852e-25	4.065666808503937e-23	2.719662	144	0.007798538	634	0.010568412161514195	1.506982	29	35	0.002808989	
GO Biological Process	protein-lipid complex subunit organization	142	3.86231e-24	3.579164597887324e-22	2.57313	152	0.00823179	815	0.02897652165030675	1.393102	36	47	0.003487021	
GO Biological Process	cotranslational protein targeting to membrane	143	4.150313e-24	3.8191586550349653e-22	2.287601	191	0.01034389	245	0.000004725723995142857	1.466153	79	98	0.007652073	
GO Biological Process	regulation of plasma lipoprotein particle levels	173	2.425792e-22	1.845144331098266e-20	2.172177	197	0.01066883	929	0.04568633407212056	1.295563	52	73	0.005036807	
GO Biological Process	plasma lipoprotein particle organization	181	7.856858e-22	5.712065990165746e-20	2.566635	137	0.007419442	819	0.029585914736263735	1.405415	34	44	0.003293297	
GO Biological Process	protein targeting to ER	190	2.36975e-21	1.6412389605263157e-19	2.159901	190	0.01028974	270	0.000014795882125925924	1.440611	80	101	0.007748935	
GO Biological Process	positive regulation of transcription from RNA polymerase II promoter in response to stress	205	7.327641e-20	4.703630630195121e-18	3.070028	92	0.004982399	942	0.049336569334394904	1.515643	20	24	0.001937234	
GO Biological Process	establishment of protein localization to endoplasmic reticulum	211	1.218492e-19	7.599116695734596e-18	2.022705	203	0.01099377	233	0.000003767666807553648	1.455017	84	105	0.008136381	
GO Biological Process	snRNA metabolic process	215	1.685861e-19	1.0318253441395348e-17	2.194902	166	0.008989981	597	0.00804922804874372	1.332356	63	86	0.006102286	
GO Biological Process	triglyceride homeostasis	219	2.101213e-19	1.2625507701826485e-17	2.898364	98	0.005307338	810	0.02874107551604938	1.477752	26	32	0.002518404	
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	225	3.360319e-19	1.965263898711111e-17	2.161227	169	0.009152451	298	0.00003884507214328859	1.443156	73	92	0.007070903	
GO Biological Process	protein transmembrane transport	315	3.986885e-16	1.6655053877777778e-14	2.100152	149	0.00806932	454	0.0013511733661453747	1.44347	50	63	0.004843084	
GO Biological Process	snRNA transcription from RNA polymerase II promoter	343	2.283481e-15	8.760445037609329e-14	2.07112	146	0.007906851	787	0.02657584617407878	1.325105	51	70	0.004939946	
GO Biological Process	modification by symbiont of host morphology or physiology	346	2.750445e-15	1.0460435189306358e-13	2.102466	140	0.007581912	657	0.012312277435312024	1.431799	37	47	0.003583882	
GO Cellular Component	high-density lipoprotein particle	44	3.161575e-26	1.2416367272727272e-24	4.191598	83	0.004494991	140	0.04690246217142857	1.481962	22	27	0.002130957	
GO Cellular Component	mitochondrial ribosome	74	5.396822e-15	1.260230867027027e-13	2.172316	127	0.006877877	118	0.015991102372881354	1.305236	61	85	0.005908563	
GO Cellular Component	mitochondrial large ribosomal subunit	89	1.058955e-12	2.0560384719101123e-11	2.417352	84	0.004549147	137	0.040456566656934305	1.355163	38	51	0.003680744	
GO Cellular Component	protein-lipid complex	92	1.404486e-12	2.6379910956521736e-11	2.081109	115	0.006227999	139	0.04624058382733813	1.385731	32	42	0.003099574	
GO Molecular Function	nucleotide transmembrane transporter activity	126	1.560424e-8	5.228658831746032e-7	2.429541	52	0.002816139	114	0.036283093966666666	1.705099	15	16	0.001452925	
GO Molecular Function	5S rRNA binding	163	1.696868e-7	0.000004395200426993865	3.288418	27	0.001462226	118	0.049548891084745764	1.818772	11	11	0.001065478	
GO Molecular Function	O-methyltransferase activity	218	0.000001245659	0.00002412464356880734	2.150643	49	0.002653669	100	0.023389719564	1.645555	19	21	0.001840372	
Human Phenotype	Abnormal CSF metabolite level	26	2.697302e-17	6.922729325384616e-15	2.3391	127	0.006877877	208	0.012829888364423076	1.385731	48	63	0.004649361	
Human Phenotype	Abnormality of mitochondrial metabolism	28	1.389954e-16	3.3125582292857145e-14	2.065453	160	0.008665042	198	0.012509306906060606	1.370669	52	69	0.005036807	
Human Phenotype	Abnormality of the mitochondrion	31	4.624123e-16	9.953797670645162e-14	2.030766	161	0.008719198	220	0.014866449116363636	1.357675	53	71	0.005133669	
Human Phenotype	Exercise intolerance	33	1.645565e-15	3.3275318924242425e-13	2.178975	131	0.007094503	235	0.01913419427489362	1.351088	52	70	0.005036807	
Human Phenotype	Increased CSF lactate	35	1.926416e-15	3.6728497051428574e-13	2.318506	114	0.006173842	250	0.021770964119599997	1.379758	44	58	0.004261914	
Human Phenotype	Glycosuria	49	1.015745e-13	1.3832788540816325e-11	2.440993	90	0.004874086	204	0.012318590246568627	1.567907	25	29	0.002421542	
Mouse Phenotype Single KO	decreased circulating free fatty acid level	37	1.844191e-27	4.56412351e-25	2.037196	286	0.01548876	343	0.014175943690962098	1.310298	67	93	0.006489733	
Mouse Phenotype Single KO	pale liver	47	3.228016e-24	6.289136704680851e-22	2.112956	229	0.01240184	455	0.0416570244	1.295875	57	80	0.005521116	
Mouse Phenotype Single KO	abnormal hypoglossal nerve topology	204	2.910563e-13	1.306471832892157e-11	2.846076	66	0.00357433	307	0.009847452713680782	1.717729	17	18	0.001646649	
Mouse Phenotype Single KO	abnormal rostral-caudal body axis extension	255	6.426149e-12	2.307617505607843e-10	2.387595	80	0.004332521	320	0.01196763813375	1.818772	13	13	0.001259202	
Mouse Phenotype Single KO	increased skin tumor incidence	270	1.056747e-11	3.583937881111111e-10	2.063553	108	0.005848903	441	0.03823496006122449	1.405415	34	44	0.003293297	
Mouse Phenotype Single KO	abnormal stapedial artery morphology	515	9.069161e-8	0.0000016125496558640776	2.234561	55	0.002978608	351	0.014859718716809116	1.711785	16	17	0.001549787	
Mouse Phenotype Single KO	absent stapedial artery	610	0.000001019033	0.000015297188821311474	2.129162	51	0.002761982	391	0.022943908006905375	1.705099	15	16	0.001452925	
Mouse Phenotype Single KO	abnormal external auditory canal morphology	643	0.000001919499	0.00002733569571228616	2.018032	55	0.002978608	429	0.03584491641258741	1.69752	14	15	0.001356064	
Mouse Phenotype	decreased circulating free fatty acid level	29	2.858322e-38	9.42359194551724e-36	2.069352	390	0.02112104	220	0.00010288757244545454	1.375542	90	119	0.008717551	
Mouse Phenotype	spontaneous skin ulceration	119	7.89136e-21	6.340276719327732e-19	2.450363	142	0.007690225	685	0.03755418431824817	1.409548	31	40	0.003002712	
Mouse Phenotype	decreased liver cholesterol level	217	7.211006e-15	3.177162597511521e-13	2.253672	116	0.006282155	622	0.027194312334405144	1.477752	26	32	0.002518404	
Mouse Phenotype	abnormal hypoglossal nerve topology	284	2.910563e-13	9.798553817957747e-12	2.846076	66	0.00357433	448	0.007045865839955356	1.717729	17	18	0.001646649	
Mouse Phenotype	increased bile salt level	434	1.500249e-10	3.305041633410138e-9	2.32852	73	0.003953425	635	0.029424828203149605	1.570757	19	22	0.001840372