# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	18	5.87696e-116	4.2963842577777783e-113	2.70677	709	0.01869085	340	5.897476770588235e-7	1.271725	107	113	0.007653244	
GO Biological Process	regulation of DNA-templated transcription in response to stress	21	3.97384e-102	2.4900838361904762e-99	2.473897	733	0.01932354	312	1.474943807275641e-7	1.275321	113	119	0.008082398	
GO Biological Process	endoplasmic reticulum unfolded protein response	31	1.021565e-96	4.336378656451613e-94	2.579935	642	0.01692458	403	0.000010248856130024813	1.248789	106	114	0.007581718	
GO Biological Process	regulation of intrinsic apoptotic signaling pathway	34	2.805352e-90	1.085753734352941e-87	2.165375	852	0.02246065	604	0.0007516050430794702	1.178407	136	155	0.009727487	
GO Biological Process	mRNA catabolic process	36	5.202954e-87	1.9018242135000004e-84	2.046747	937	0.02470145	165	2.3045268973333336e-13	1.273678	202	213	0.01444818	
GO Biological Process	positive regulation of transcription from RNA polymerase II promoter in response to stress	38	5.908127e-86	2.0459221892894738e-83	4.40206	271	0.007144175	879	0.012558296889647326	1.343037	24	24	0.001716615	
GO Biological Process	IRE1-mediated unfolded protein response	40	1.633891e-85	5.37509291725e-83	3.389348	370	0.00975404	629	0.001116016672845787	1.27357	55	58	0.00393391	
GO Biological Process	nuclear-transcribed mRNA catabolic process	41	4.174918e-85	1.3399450234634145e-82	2.094331	867	0.02285609	193	7.655251659067357e-12	1.268424	187	198	0.0133753	
GO Biological Process	cellular response to unfolded protein	42	1.321556e-84	4.1405608104761897e-82	2.365709	661	0.01742546	373	0.00000223651775152815	1.254241	113	121	0.008082398	
GO Biological Process	cellular response to topologically incorrect protein	45	2.859944e-83	8.363111799111111e-81	2.276393	704	0.01855904	350	8.27345807e-7	1.246416	129	139	0.009226808	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	67	2.401893e-73	4.717389550298508e-71	2.496169	515	0.01357657	290	3.0287344286206896e-8	1.286129	113	118	0.008082398	
GO Biological Process	response to topologically incorrect protein	68	4.459776e-73	8.630322409411764e-71	2.00471	827	0.0218016	388	0.000004290003574742268	1.208733	162	180	0.01158715	
GO Biological Process	response to unfolded protein	70	4.365563e-71	8.206634788142858e-69	2.034453	775	0.02043076	396	0.000006560542400252525	1.217127	145	160	0.01037122	
GO Biological Process	liver regeneration	71	6.743694e-71	1.2498629485352113e-68	3.135011	341	0.008989534	599	0.0007144789989816361	1.343037	35	35	0.002503397	
GO Biological Process	negative regulation of intrinsic apoptotic signaling pathway	76	9.540489e-70	1.65188545725e-67	2.306281	572	0.01507922	1004	0.024627540336653386	1.171585	82	94	0.005865103	
GO Biological Process	cellular response to epidermal growth factor stimulus	78	1.311188e-69	2.212041396410256e-67	2.649933	438	0.01154667	723	0.003431224720470263	1.307694	37	38	0.002646449	
GO Biological Process	mitochondrial membrane organization	82	2.892078e-67	4.641079805121951e-65	2.054685	715	0.01884902	426	0.000018461116331220656	1.234728	114	124	0.008153923	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to hypoxia	86	2.71647e-66	4.1565149686046513e-64	2.520696	456	0.0120212	630	0.0011250970064761905	1.239726	72	78	0.005149846	
GO Biological Process	response to epidermal growth factor	88	6.003913e-66	8.977896723522727e-64	2.528434	451	0.01188938	646	0.0012923466121981424	1.31106	41	42	0.002932551	
GO Biological Process	cotranslational protein targeting to membrane	106	1.393873e-61	1.730374981792453e-59	2.50113	429	0.01130941	338	5.818793004142011e-7	1.288219	94	98	0.00672341	
GO Cellular Component	ribosomal subunit	40	7.761563e-63	3.3529952159999996e-61	2.042269	677	0.01784726	44	4.086433309090909e-13	1.28496	177	185	0.01266004	
GO Cellular Component	large ribosomal subunit	45	5.546305e-49	2.1297811199999998e-47	2.20062	440	0.0115994	64	4.9157469e-10	1.308001	112	115	0.008010872	
GO Cellular Component	mitochondrial ribosome	57	2.616859e-40	7.933214652631579e-39	2.431276	292	0.007697783	63	3.3289014857142855e-10	1.343037	85	85	0.00607968	
GO Cellular Component	mitochondrial large ribosomal subunit	71	7.748084e-32	1.8857308664788734e-30	2.675631	191	0.005035194	98	0.000005054682122448979	1.343037	51	51	0.003647808	
GO Cellular Component	spliceosomal snRNP complex	91	8.165738e-26	1.5505928861538462e-24	2.172058	231	0.006089684	135	0.00025358566399999997	1.278051	59	62	0.004220013	
GO Cellular Component	DNA-directed RNA polymerase III complex	137	2.899441e-19	3.657105144525548e-18	3.54037	73	0.001924446	229	0.027712713222707422	1.343037	19	19	0.001358987	
GO Cellular Component	endoribonuclease complex	152	1.740909e-18	1.979138652631579e-17	2.338884	137	0.003611631	173	0.0019130288462427746	1.343037	29	29	0.002074244	
GO Cellular Component	spliceosomal tri-snRNP complex	178	8.863176e-15	8.604251757303371e-14	2.285761	112	0.002952574	173	0.0019130288462427746	1.343037	29	29	0.002074244	
GO Cellular Component	ESCRT complex	200	1.498536e-12	1.2947351039999999e-11	2.136455	108	0.002847125	224	0.021091258285714284	1.295071	27	28	0.001931192	
GO Cellular Component	U5 snRNP	219	2.111664e-11	1.666189676712329e-10	2.275497	84	0.002214431	209	0.012520674602870813	1.343037	22	22	0.001573564	
GO Cellular Component	mitochondrial small ribosomal subunit	245	1.749627e-10	1.2340226351020409e-9	2.101745	91	0.002398967	179	0.0024844199329608937	1.343037	28	28	0.002002718	
GO Molecular Function	structural constituent of ribosome	11	1.203934e-58	4.620917589090909e-56	2.051333	624	0.01645006	40	3.559348656e-10	1.276714	154	162	0.01101495	
GO Molecular Function	unfolded protein binding	16	1.562373e-50	4.12271175375e-48	2.282076	420	0.01107215	111	0.003067356029189189	1.203665	95	106	0.006794936	
GO Molecular Function	ribonuclease activity	22	1.96931e-40	3.7792849181818185e-38	2.031957	435	0.01146759	73	0.00002547375509589041	1.261641	93	99	0.006651885	
GO Molecular Function	rRNA binding	23	3.77653e-39	6.932395504347826e-37	2.846528	214	0.005641526	103	0.0013346615093203884	1.275885	57	60	0.004076962	
GO Molecular Function	endoribonuclease activity	35	3.351944e-28	4.0434021622857144e-26	2.16421	256	0.006748741	115	0.003197947291652174	1.271089	53	56	0.003790859	
GO Molecular Function	snRNA binding	46	4.459467e-22	4.0930151465217386e-20	2.576507	138	0.003637993	159	0.03458667710691824	1.272351	36	38	0.002574923	
GO Molecular Function	mRNA 5'-UTR binding	135	1.484492e-12	4.642611277037037e-11	2.128365	109	0.002873487	160	0.039960280050000005	1.343037	22	22	0.001573564	
Human Phenotype	Abnormal CSF metabolite level	23	1.466953e-24	4.256077116956521e-22	2.106906	235	0.006195134	167	0.00008360573729341317	1.300401	61	63	0.004363064	
Human Phenotype	Increased CSF lactate	52	2.754848e-19	3.535211673846154e-17	2.009701	203	0.005351541	187	0.00027974272260962565	1.296725	56	58	0.004005436	
Human Phenotype	Abnormality of transition element cation homeostasis	56	8.974839e-19	1.0694482258392856e-16	2.649136	110	0.00289985	416	0.033696163665865385	1.296725	28	29	0.002002718	
Human Phenotype	Aplasia/hypoplasia of the femur	69	1.854235e-17	1.7932333557971013e-15	2.004928	183	0.004824295	339	0.01427435405899705	1.302339	32	33	0.002288821	
Mouse Phenotype Single KO	decreased circulating free fatty acid level	32	1.0282e-57	2.9422585625e-55	2.073481	598	0.01576464	278	0.010672391271223021	1.198624	83	93	0.005936628	
Mouse Phenotype Single KO	absent segment of posterior cerebral artery	63	8.900039e-46	1.2936136051269841e-43	3.332726	199	0.005246092	364	0.03809623941758242	1.343037	22	22	0.001573564	
Mouse Phenotype Single KO	pale liver	85	6.295944e-41	6.782583436235294e-39	2.016663	449	0.01183666	288	0.01402433975972222	1.208733	72	80	0.005149846	
Mouse Phenotype	extramedullary hematopoiesis	3	7.079599e-112	2.2562682013e-108	2.053737	1196	0.03152928	609	0.046748972635467984	1.120477	146	175	0.01044274	
Mouse Phenotype	absent segment of posterior cerebral artery	91	8.900039e-46	9.350909107582418e-44	3.332726	199	0.005246092	515	0.028114241172815534	1.343037	22	22	0.001573564	
Mouse Phenotype	abnormal hair follicle outer root sheath morphology	105	2.737615e-43	2.4927940014285714e-41	2.479026	303	0.007987768	596	0.04385951538926174	1.295071	27	28	0.001931192	
Mouse Phenotype	increased cellular sensitivity to ultraviolet irradiation	213	2.613521e-27	1.1731396376056337e-25	2.597329	171	0.004507948	521	0.029588946040307103	1.298269	29	30	0.002074244